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Protein

Low-density lipoprotein receptor

Gene

LDLR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. In case of HIV-1 infection, functions as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells.

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • clathrin heavy chain binding Source: BHF-UCL
  • glycoprotein binding Source: BHF-UCL
  • low-density lipoprotein particle binding Source: Ensembl
  • low-density lipoprotein receptor activity Source: BHF-UCL
  • very-low-density lipoprotein particle receptor activity Source: BHF-UCL

GO - Biological processi

  • cholesterol homeostasis Source: BHF-UCL
  • cholesterol import Source: BHF-UCL
  • cholesterol metabolic process Source: UniProtKB-KW
  • cholesterol transport Source: HGNC
  • endocytosis Source: ProtInc
  • intestinal cholesterol absorption Source: HGNC
  • lipid metabolic process Source: ProtInc
  • lipoprotein catabolic process Source: Ensembl
  • lipoprotein metabolic process Source: Reactome
  • low-density lipoprotein particle clearance Source: BHF-UCL
  • phospholipid transport Source: BHF-UCL
  • phototransduction, visible light Source: Reactome
  • positive regulation of triglyceride biosynthetic process Source: BHF-UCL
  • receptor-mediated endocytosis Source: Reactome
  • regulation of cholesterol homeostasis Source: Ensembl
  • regulation of phosphatidylcholine catabolic process Source: BHF-UCL
  • retinoid metabolic process Source: Reactome
  • small molecule metabolic process Source: Reactome
  • viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Cholesterol metabolism, Endocytosis, Host-virus interaction, Lipid metabolism, Lipid transport, Steroid metabolism, Sterol metabolism, Transport

Enzyme and pathway databases

ReactomeiREACT_24968. Retinoid metabolism and transport.
REACT_6841. Chylomicron-mediated lipid transport.
REACT_6934. LDL-mediated lipid transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Low-density lipoprotein receptor
Short name:
LDL receptor
Gene namesi
Name:LDLR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:6547. LDLR.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 788767ExtracellularSequence AnalysisAdd
BLAST
Transmembranei789 – 81022HelicalSequence AnalysisAdd
BLAST
Topological domaini811 – 86050CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • apical part of cell Source: BHF-UCL
  • basolateral plasma membrane Source: BHF-UCL
  • cell surface Source: UniProtKB
  • clathrin-coated endocytic vesicle membrane Source: Reactome
  • coated pit Source: BHF-UCL
  • early endosome Source: UniProtKB
  • endosome membrane Source: Reactome
  • external side of plasma membrane Source: BHF-UCL
  • Golgi apparatus Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
  • late endosome Source: UniProtKB
  • low-density lipoprotein particle Source: UniProtKB-KW
  • lysosome Source: UniProtKB
  • membrane Source: UniProtKB
  • plasma membrane Source: Reactome
  • receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Coated pit, Endosome, Golgi apparatus, LDL, Lysosome, Membrane

Pathology & Biotechi

Involvement in diseasei

Familial hypercholesterolemia (FH)49 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionCommon autosomal semi-dominant disease that affects about 1 in 500 individuals. The receptor defect impairs the catabolism of LDL, and the resultant elevation in plasma LDL-cholesterol promotes deposition of cholesterol in the skin (xanthelasma), tendons (xanthomas), and coronary arteries (atherosclerosis).

See also OMIM:143890
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti27 – 271C → W in FH; San Francisco. 1 Publication
VAR_005304
Natural varianti46 – 461C → S in FH; Japanese patient. 1 Publication
VAR_013949
Natural varianti47 – 482Missing in FH; Cape Town-1; retards receptor transport from the endoplasmic reticulum to the cell surface. 2 Publications
VAR_005305
Natural varianti50 – 501A → S in FH; German patient. 1 Publication
Corresponds to variant rs137853960 [ dbSNP | Ensembl ].
VAR_007979
Natural varianti50 – 501A → T in FH; unknown pathological significance. 1 Publication
VAR_072827
Natural varianti56 – 561S → P in FH. 1 Publication
VAR_007980
Natural varianti78 – 781R → C in FH. 1 Publication
VAR_005307
Natural varianti87 – 871W → G in FH; French Canadian-4. 3 Publications
VAR_005308
Natural varianti89 – 891C → Y in FH. 2 Publications
VAR_005309
Natural varianti90 – 901D → G in FH; London-4. 1 Publication
VAR_005310
Natural varianti90 – 901D → N in FH. 1 Publication
VAR_005311
Natural varianti90 – 901D → Y in FH; Durban-1. 1 Publication
VAR_005312
Natural varianti92 – 921Q → E in FH; Spanish patient. 1 Publication
VAR_005313
Natural varianti95 – 951C → G in FH; Spanish patient. 1 Publication
VAR_005314
Natural varianti101 – 1011E → K in FH; Lancashire; 6% of American English. 2 Publications
VAR_005315
Natural varianti116 – 1161C → R in FH; does not affect receptor expression at the cell surface; results in reduced LDL binding; results in reduced LDL uptake and internalization. 2 Publications
VAR_005317
Natural varianti134 – 1341C → F in FH. 1 Publication
VAR_062371
Natural varianti134 – 1341C → W in FH. 1 Publication
VAR_062372
Natural varianti140 – 1401E → K in FH; Philippines/Durban-2/Japan. 3 Publications
VAR_005318
Natural varianti143 – 1431C → R in FH. 1 Publication
VAR_072828
Natural varianti148 – 1481C → Y in FH. 1 Publication
VAR_072829
Natural varianti155 – 1551C → Y in FH; results in defective LDL binding; does not affect receptor expression at the cell surface. 2 Publications
VAR_072830
Natural varianti160 – 1601C → Y in FH; unknown pathological significance. 2 Publications
VAR_005320
Natural varianti168 – 1681D → A in FH; unknown pathological significance. 1 Publication
VAR_072831
Natural varianti168 – 1681D → H in FH; Sephardic/Safed; 10% of the Sephardic Jews. 1 Publication
VAR_005321
Natural varianti168 – 1681D → N in FH; does not affect receptor expression at the cell surface; results in reduced LDL binding; results in reduced LDL uptake and internalization. 2 Publications
VAR_005322
Natural varianti168 – 1681D → Y in FH. 1 Publication
VAR_005323
Natural varianti172 – 1721D → N in FH; does not affect receptor expression at the cell surface; results in reduced LDL binding; results in reduced LDL uptake and internalization. 2 Publications
VAR_072832
Natural varianti173 – 1731C → W in FH. 1 Publication
VAR_005325
Natural varianti175 – 1751D → N in FH; Afrikaner-3; 5-10% of Afrikaners. 1 Publication
VAR_005326
Natural varianti175 – 1751D → Y in FH. 1 Publication
VAR_007981
Natural varianti177 – 1771S → L in FH; Puerto Rico. 4 Publications
VAR_005327
Natural varianti184 – 1841C → W in FH. 1 Publication
VAR_072833
Natural varianti184 – 1841C → Y in FH; Glasco. 2 Publications
VAR_013951
Natural varianti197 – 1971C → R in FH; British patient. 1 Publication
VAR_005330
Natural varianti211 – 2111H → L in FH; unknown pathological significance. 1 Publication
VAR_072834
Natural varianti218 – 2181Missing in FH; Piscataway/Lithuania. 3 Publications
VAR_005331
Natural varianti221 – 2211D → G in FH; Padova. 6 Publications
VAR_005332
Natural varianti221 – 2211D → N in FH; German patient. 2 Publications
VAR_007982
Natural varianti221 – 2211D → Y in FH; Cologne patient. 2 Publications
VAR_005333
Natural varianti222 – 2221C → Y in FH. 1 Publication
VAR_062373
Natural varianti224 – 2241D → V in FH; Cologne patient. 1 Publication
VAR_005336
Natural varianti227 – 2271D → E in FH; Afrikaner-1/Maine; 65-70% of Afrikaner Americans. 2 Publications
VAR_005338
Natural varianti228 – 2281E → K in FH; French Canadian-3/Mexico; 2% of French Canadians. 2 Publications
VAR_005341
Natural varianti228 – 2281E → Q in FH; Tulsa-2; unknown pathological significance. 1 Publication
VAR_005340
Natural varianti231 – 2311C → G in FH; Norwegian patient. 1 Publication
VAR_005342
Natural varianti243 – 2431C → R in FH; unknown pathological significance. 1 Publication
VAR_072835
Natural varianti248 – 2481C → Y in FH; British patient. 1 Publication
VAR_005345
Natural varianti254 – 2541Q → P in FH. 2 Publications
VAR_062374
Natural varianti261 – 2611C → F in FH; rare mutation; strongly reduced receptor activity. 1 Publication
VAR_013953
Natural varianti266 – 2661D → E in FH; Cincinnati-1; unknown pathological significance. 1 Publication
VAR_005347
Natural varianti276 – 2761C → R in FH. 1 Publication
VAR_062375
Natural varianti276 – 2761C → W in FH; unknown pathological significance. 1 Publication
VAR_072837
Natural varianti276 – 2761C → Y in FH; Syrian patient. 1 Publication
VAR_005349
Natural varianti277 – 2771E → K in FH; patients from Sweden and La Havana; unknown pathological significance. 4 Publications
Corresponds to variant rs148698650 [ dbSNP | Ensembl ].
VAR_005350
Natural varianti285 – 2851H → Y in FH; unknown pathological significance. 1 Publication
VAR_072838
Natural varianti286 – 2861S → R in FH; Greece-2; unknown pathological significance. 2 Publications
VAR_005351
Natural varianti288 – 2881E → K in FH; German patient. 1 Publication
VAR_007983
Natural varianti300 – 3001R → G in FH; does not affect receptor expression at the cell surface; results in reduced LDL binding; results in reduced LDL uptake and internalization. 2 Publications
VAR_072839
Natural varianti301 – 3011D → A in FH; Greek patient. 1 Publication
VAR_005352
Natural varianti301 – 3011D → G in FH; does not affect receptor expression at the cell surface; results in reduced LDL binding; results in reduced LDL uptake and internalization. 3 Publications
VAR_072840
Natural varianti302 – 3021C → W in FH; Iraki patient. 1 Publication
VAR_005354
Natural varianti302 – 3021C → Y in FH; Spanish patient. 1 Publication
VAR_005353
Natural varianti306 – 3061S → L in FH; Amsterdam; unknown pathological significance. 1 Publication
Corresponds to variant rs11547917 [ dbSNP | Ensembl ].
VAR_005357
Natural varianti313 – 3131C → Y in FH. 1 Publication
VAR_005358
Natural varianti314 – 3141G → R in FH; unknown pathological significance. 1 Publication
VAR_072841
Natural varianti318 – 3181C → F in FH; Trieste. 2 Publications
VAR_005360
Natural varianti318 – 3181C → R in FH. 1 Publication
VAR_062376
Natural varianti326 – 3261S → C in FH; unknown pathological significance. 1 Publication
VAR_072842
Natural varianti327 – 3271H → Y in FH. 1 Publication
VAR_005361
Natural varianti329 – 3291C → F in FH. 1 Publication
VAR_067196
Natural varianti329 – 3291C → Y in FH; Chinese patient. 1 Publication
VAR_005362
Natural varianti338 – 3381C → S in FH; Japanese patients. 2 Publications
VAR_005364
Natural varianti342 – 3421D → N in FH; unknown pathological significance. 1 Publication
Corresponds to variant rs139361635 [ dbSNP | Ensembl ].
VAR_005366
Natural varianti343 – 3431G → S in FH; Picardie; unknown pathological significance. 1 Publication
VAR_005367
Natural varianti350 – 3501R → P in FH. 2 Publications
VAR_005368
Natural varianti352 – 3521C → R in FH; unknown pathological significance. 1 Publication
VAR_072843
Natural varianti356 – 3561D → Y in FH. 2 Publications
VAR_007984
Natural varianti358 – 3581C → Y in FH. 2 Publications
VAR_062377
Natural varianti366 – 3661Q → R in FH. 1 Publication
VAR_007985
Natural varianti368 – 3681C → R in FH; French Canadian patient. 1 Publication
VAR_005374
Natural varianti368 – 3681C → Y in FH; unknown pathological significance. 1 Publication
VAR_072844
Natural varianti370 – 3701N → T in FH. 1 Publication
VAR_062378
Natural varianti373 – 3731G → D in FH; unknown pathological significance. 1 Publication
VAR_072845
Natural varianti379 – 3791C → Y in FH. 1 Publication
VAR_007986
Natural varianti399 – 3991A → D in FH. 1 Publication
VAR_005376
Natural varianti401 – 4011L → V in FH. 1 Publication
VAR_007987
Natural varianti403 – 4031F → L in FH; Japanese patient. 1 Publication
VAR_008995
Natural varianti404 – 4041T → P in FH; unknown pathological significance. 1 Publication
VAR_072846
Natural varianti406 – 4061R → W in FH; unknown pathological significance. 1 Publication
VAR_072847
Natural varianti408 – 4081E → K in FH; Algeria-1; unknown pathological significance. 2 Publications
VAR_005378
Natural varianti414 – 4141L → R in FH; Chinese patient. 1 Publication
VAR_005379
Natural varianti415 – 4151D → G in FH. 1 Publication
VAR_062379
Natural varianti416 – 4161R → Q in FH; German patient. 1 Publication
VAR_005380
Natural varianti416 – 4161R → W in FH; results in reduced receptor expression at the cell surface due to defective receptor recycling. 4 Publications
VAR_005381
Natural varianti423 – 4231I → T in FH; Swedish patient. 1 Publication
VAR_005382
Natural varianti429 – 4291V → M in FH; Afrikaner-2; 20-30% of Afrikaners and 2% of FH Dutch. 5 Publications
Corresponds to variant rs28942078 [ dbSNP | Ensembl ].
VAR_005383
Natural varianti431 – 4311A → T in FH; Algeria-2; unknown pathological significance. 2 Publications
Corresponds to variant rs28942079 [ dbSNP | Ensembl ].
VAR_005384
Natural varianti432 – 4321L → V in FH; German patient. 1 Publication
VAR_007988
Natural varianti433 – 4331D → H in FH; Osaka-3. 1 Publication
VAR_005385
Natural varianti434 – 4341T → K in FH; Algeria-3; unknown pathological significance. 1 Publication
VAR_005386
Natural varianti442 – 4421Y → H in FH; unknown pathological significance. 1 Publication
VAR_072848
Natural varianti451 – 4511I → T in FH. 2 Publications
VAR_062380
Natural varianti454 – 4541T → N in FH; results in reduced receptor expression at the cell surface due to defective receptor recycling. 2 Publications
VAR_072849
Natural varianti479 – 4791L → P in FH. 1 Publication
VAR_062381
Natural varianti482 – 4821D → H in FH. 2 Publications
VAR_005391
Natural varianti483 – 4831W → R in FH. 1 Publication
VAR_005392
Natural varianti487 – 4871Missing in FH; Norwegian patient. 1 Publication
VAR_005393
Natural varianti492 – 4921D → N in FH; unknown pathological significance. 1 Publication
VAR_072850
Natural varianti523 – 5231V → M in FH; Kuwait. 1 Publication
Corresponds to variant rs28942080 [ dbSNP | Ensembl ].
VAR_005395
Natural varianti526 – 5261P → S in FH; Cincinnati-3; unknown pathological sgnificance. 1 Publication
VAR_005396
Natural varianti549 – 5491G → D in FH; Genoa. 2 Publications
Corresponds to variant rs28941776 [ dbSNP | Ensembl ].
VAR_005398
Natural varianti564 – 5641N → H in FH; French, German and Danish patients. 5 Publications
Corresponds to variant rs28942086 [ dbSNP | Ensembl ].
VAR_005399
Natural varianti564 – 5641N → S in FH; Sicily. 1 Publication
VAR_005400
Natural varianti568 – 5681L → V in FH; Japanese patient. 1 Publication
VAR_008996
Natural varianti574 – 5741R → C in FH. 1 Publication
VAR_072851
Natural varianti574 – 5741R → H in FH; unknown pathological significance. 1 Publication
VAR_072852
Natural varianti577 – 5771W → G in FH; results in loss of receptor expression at the cell surface. 2 Publications
VAR_072853
Natural varianti577 – 5771W → S in FH; unknown pathological significance. 1 Publication
VAR_072854
Natural varianti579 – 5791D → N in FH; Cincinnati-4; less than 2% receptor activity. 2 Publications
VAR_005402
Natural varianti579 – 5791D → Y in FH. 1 Publication
VAR_062382
Natural varianti585 – 5851I → T in FH; unknown pathological significance. 1 Publication
VAR_072855
Natural varianti592 – 5921G → E in FH; Sicily. 1 Publication
VAR_005403
Natural varianti595 – 5951R → W in FH; unknown pathological significance. 1 Publication
VAR_072856
Natural varianti601 – 6011D → H in FH; unknown pathological significance. 1 Publication
VAR_072857
Natural varianti608 – 6081P → S in FH. 1 Publication
VAR_007989
Natural varianti633 – 6331R → C in FH. 1 Publication
VAR_005405
Natural varianti639 – 6391V → D in FH. 1 Publication
VAR_072858
Natural varianti649 – 6491P → L in FH. 1 Publication
VAR_005406
Natural varianti667 – 6671C → Y in FH; French Canadian-2; 5% of French Canadians. 2 Publications
Corresponds to variant rs28942083 [ dbSNP | Ensembl ].
VAR_005407
Natural varianti677 – 6771C → R in FH; New York-3. 1 Publication
VAR_005408
Natural varianti685 – 6851P → L in FH; Gujerat/Zambia/Belgian/Dutch/Sweden/Japan. 7 Publications
Corresponds to variant rs28942084 [ dbSNP | Ensembl ].
VAR_005410
Natural varianti699 – 6991P → L in FH; unknown pathological significance. 2 Publications
VAR_013955
Natural varianti700 – 7001D → E in FH; Spanish patient. 1 Publication
VAR_005412
Natural varianti714 – 7141E → K in FH; Japanese patient. 1 Publication
VAR_008997
Natural varianti726 – 7261T → I in FH; Paris-9; unknown pathological significance. 2 Publications
Corresponds to variant rs45508991 [ dbSNP | Ensembl ].
VAR_005413
Natural varianti797 – 7971V → M in FH; La Havana patient. 2 Publications
VAR_005415
Natural varianti799 – 8013Missing in FH; Danish patient. 1 Publication
VAR_005416
Natural varianti806 – 8061V → D in FH; unknown pathological significance. 1 Publication
VAR_072860
Natural varianti814 – 8141R → Q in FH; unknown pathological significance. 3 Publications
Corresponds to variant rs5928 [ dbSNP | Ensembl ].
VAR_011864
Natural varianti820 – 8223Missing in FH.
VAR_005417
Natural varianti825 – 8251N → K in FH; does not affect receptor expression at the cell surface; does not affect LDL binding; results in impaired LDL uptake and internalization. 2 Publications
VAR_072861
Natural varianti826 – 8261P → S in FH. 1 Publication
VAR_062383
Natural varianti828 – 8281Y → C in FH; J.D.Bari/Syria. 1 Publication
Corresponds to variant rs28942085 [ dbSNP | Ensembl ].
VAR_005419

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi811 – 8111K → R: No change. No change; when associated with R-816 and R-830. Insensitive to MYLIP-triggered degradation; when associated with R-816; R-830 and A-839. 1 Publication
Mutagenesisi816 – 8161K → R: No change. No change; when associated with R-830. No change; when associated with R-811 and R-830. Insensitive to MYLIP-triggered degradation; when associated with R-830 and A-839. Insensitive to MYLIP-triggered degradation; when associated with R-811; R-830 and A-839. 1 Publication
Mutagenesisi828 – 8281Y → A: Abolishes interaction with ARRB2. 1 Publication
Mutagenesisi830 – 8301K → R: No change. No change; when associated with R-816. No change; when associated with R-811 and R-816. Insensitive to MYLIP-triggered degradation; when associated with A-839. Insensitive to MYLIP-triggered degradation; when associated with R-816 and A-839. Insensitive to MYLIP-triggered degradation; when associated with R-811; R-816 and A-839. 1 Publication
Mutagenesisi839 – 8391C → A: No change. Insensitive to MYLIP-triggered degradation; when associated with R-830. Insensitive to MYLIP-triggered degradation; when associated with R-816 and R-830. Insensitive to MYLIP-triggered degradation; when associated with R-811; R-816 and R-830. 1 Publication
Mutagenesisi854 – 8541S → A: No effect on receptor internalization. 1 Publication
Mutagenesisi854 – 8541S → D: Enhances interaction with ARRB2 and receptor internalization. 1 Publication

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi143890. phenotype.
Orphaneti406. Heterozygous familial hypercholesterolemia.
391665. Homozygous familial hypercholesterolemia.
PharmGKBiPA227.

Chemistry

DrugBankiDB00707. Porfimer.

Polymorphism and mutation databases

BioMutaiLDLR.
DMDMi126073.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Add
BLAST
Chaini22 – 860839Low-density lipoprotein receptorPRO_0000017312Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi27 ↔ 39
Disulfide bondi34 ↔ 52
Disulfide bondi46 ↔ 63
Disulfide bondi68 ↔ 82
Disulfide bondi75 ↔ 95
Disulfide bondi89 ↔ 104
Glycosylationi97 – 971N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi109 ↔ 121By similarity
Disulfide bondi116 ↔ 134
Disulfide bondi128 ↔ 143
Disulfide bondi148 ↔ 160
Disulfide bondi155 ↔ 173
Glycosylationi156 – 1561N-linked (GlcNAc...)1 Publication
Disulfide bondi167 ↔ 184
Disulfide bondi197 ↔ 209
Disulfide bondi204 ↔ 222
Disulfide bondi216 ↔ 231
Disulfide bondi236 ↔ 248
Disulfide bondi243 ↔ 261
Disulfide bondi255 ↔ 270
Glycosylationi272 – 2721N-linked (GlcNAc...)1 Publication
Disulfide bondi276 ↔ 289
Disulfide bondi284 ↔ 302
Disulfide bondi296 ↔ 313
Disulfide bondi318 ↔ 329
Disulfide bondi325 ↔ 338
Disulfide bondi340 ↔ 352
Disulfide bondi358 ↔ 368
Disulfide bondi364 ↔ 377
Disulfide bondi379 ↔ 392
Glycosylationi515 – 5151N-linked (GlcNAc...)Sequence Analysis
Glycosylationi657 – 6571N-linked (GlcNAc...)3 Publications
Disulfide bondi667 ↔ 681
Disulfide bondi677 ↔ 696
Disulfide bondi698 ↔ 711
Modified residuei724 – 7241PhosphothreonineBy similarity

Post-translational modificationi

N- and O-glycosylated.4 Publications
Ubiquitinated by MYLIP leading to degradation.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP01130.
PaxDbiP01130.
PRIDEiP01130.

PTM databases

PhosphoSiteiP01130.
UniCarbKBiP01130.

Expressioni

Gene expression databases

BgeeiP01130.
CleanExiHS_LDLR.
ExpressionAtlasiP01130. baseline and differential.
GenevisibleiP01130. HS.

Organism-specific databases

HPAiHPA009647.
HPA013159.

Interactioni

Subunit structurei

Interacts with LDLRAP1, ARRB1, SNX17. Interacts (via NPXY motif) with DAB2 (via PID domain); the interaction is impaired by tyrosine phosphorylation of the NPXY motif. Interacts with the full length immature form of PCSK9 (via C-terminus). Interacts with HCV E1/E2 heterodimer. Interacts with HIV-1 Tat.7 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
APOBP041144EBI-988319,EBI-3926040
APOEP026492EBI-988319,EBI-1222467
PCSK9Q8NBP79EBI-988319,EBI-7539251

Protein-protein interaction databases

BioGridi110141. 27 interactions.
DIPiDIP-29695N.
IntActiP01130. 11 interactions.
MINTiMINT-3003796.
STRINGi9606.ENSP00000454071.

Structurei

Secondary structure

1
860
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi29 – 335Combined sources
Beta strandi35 – 373Combined sources
Beta strandi39 – 413Combined sources
Turni42 – 465Combined sources
Beta strandi47 – 493Combined sources
Beta strandi51 – 555Combined sources
Helixi56 – 583Combined sources
Turni60 – 623Combined sources
Turni63 – 675Combined sources
Beta strandi70 – 723Combined sources
Beta strandi75 – 773Combined sources
Beta strandi79 – 813Combined sources
Helixi85 – 873Combined sources
Beta strandi88 – 903Combined sources
Beta strandi95 – 973Combined sources
Turni99 – 1035Combined sources
Beta strandi113 – 1153Combined sources
Beta strandi121 – 1233Combined sources
Helixi124 – 1263Combined sources
Beta strandi129 – 1313Combined sources
Turni138 – 1425Combined sources
Helixi143 – 1475Combined sources
Beta strandi148 – 1514Combined sources
Beta strandi152 – 1543Combined sources
Turni156 – 1583Combined sources
Beta strandi160 – 1623Combined sources
Helixi163 – 1653Combined sources
Beta strandi168 – 1703Combined sources
Beta strandi173 – 1764Combined sources
Helixi177 – 1793Combined sources
Helixi181 – 1833Combined sources
Turni189 – 1913Combined sources
Beta strandi201 – 2044Combined sources
Turni205 – 2073Combined sources
Beta strandi208 – 2114Combined sources
Helixi212 – 2143Combined sources
Beta strandi217 – 2193Combined sources
Beta strandi222 – 2243Combined sources
Helixi226 – 2283Combined sources
Beta strandi241 – 2433Combined sources
Turni244 – 2463Combined sources
Beta strandi247 – 2493Combined sources
Helixi251 – 2533Combined sources
Beta strandi254 – 2585Combined sources
Beta strandi260 – 2645Combined sources
Helixi265 – 2673Combined sources
Beta strandi268 – 2703Combined sources
Beta strandi281 – 2833Combined sources
Beta strandi289 – 2924Combined sources
Turni293 – 2964Combined sources
Beta strandi306 – 3083Combined sources
Turni310 – 3123Combined sources
Helixi317 – 3193Combined sources
Helixi321 – 3244Combined sources
Beta strandi326 – 3305Combined sources
Beta strandi333 – 3353Combined sources
Beta strandi337 – 3393Combined sources
Beta strandi341 – 3433Combined sources
Beta strandi345 – 3473Combined sources
Turni348 – 3503Combined sources
Beta strandi351 – 3533Combined sources
Helixi357 – 3593Combined sources
Beta strandi363 – 3697Combined sources
Beta strandi372 – 3743Combined sources
Beta strandi376 – 3783Combined sources
Beta strandi381 – 3855Combined sources
Turni387 – 3893Combined sources
Beta strandi392 – 3943Combined sources
Beta strandi400 – 4045Combined sources
Beta strandi406 – 4138Combined sources
Beta strandi420 – 4234Combined sources
Beta strandi427 – 4359Combined sources
Turni436 – 4394Combined sources
Beta strandi440 – 4456Combined sources
Turni446 – 4494Combined sources
Beta strandi450 – 4556Combined sources
Beta strandi466 – 4694Combined sources
Beta strandi478 – 4825Combined sources
Turni483 – 4864Combined sources
Beta strandi487 – 4926Combined sources
Turni493 – 4964Combined sources
Beta strandi497 – 5026Combined sources
Beta strandi505 – 5139Combined sources
Beta strandi519 – 5257Combined sources
Turni526 – 5294Combined sources
Beta strandi530 – 5356Combined sources
Beta strandi537 – 5393Combined sources
Beta strandi541 – 5466Combined sources
Beta strandi552 – 5565Combined sources
Beta strandi563 – 5697Combined sources
Turni570 – 5734Combined sources
Beta strandi574 – 5796Combined sources
Turni580 – 5834Combined sources
Beta strandi584 – 5896Combined sources
Beta strandi596 – 6005Combined sources
Turni602 – 6054Combined sources
Beta strandi606 – 6149Combined sources
Beta strandi617 – 6226Combined sources
Turni623 – 6264Combined sources
Beta strandi627 – 6326Combined sources