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P01129

- CDC10_SCHPO

UniProt

P01129 - CDC10_SCHPO

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Protein

Start control protein cdc10

Gene
cdc10, SPBC336.12c
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Major component of the cell cycle transcription factor complex MBF (MCB binding factor, also known as DSC1), that controls G1-S phase specific gene expression. Involved in the control of rRNA production, via interaction with pol5. May be involved in the transcriptional regulation of the cdc22 and cdt1 genes. In fission yeast, two genes, cdc10 and cdc2, are required for the cell cycle control called start, the point early in the G1 phase at which cells become committed to the mitotic cycle.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi98 – 11922H-T-H motif By similarityAdd
BLAST

GO - Molecular functioni

  1. chromatin binding Source: PomBase
  2. DNA binding Source: InterPro
  3. protein binding Source: UniProtKB
  4. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. mitotic nuclear division Source: UniProtKB-KW
  2. negative regulation of transcription, DNA-templated Source: UniProtKB
  3. positive regulation of transcription, DNA-templated Source: UniProtKB
  4. positive regulation of transcription involved in G1/S transition of mitotic cell cycle Source: PomBase
  5. regulation of transcription involved in G1/S transition of mitotic cell cycle Source: PomBase
  6. rRNA transcription Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Start control protein cdc10
Gene namesi
Name:cdc10
ORF Names:SPBC336.12c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome II

Organism-specific databases

PomBaseiSPBC336.12c.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: PomBase
  2. MBF transcription complex Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 767767Start control protein cdc10PRO_0000067060Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei252 – 2521Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP01129.

Interactioni

Subunit structurei

DSC1 contains cdc10 and sct1/res1. Interacts with pol5.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
pol5O600942EBI-1009350,EBI-1009362
res2P414123EBI-1009350,EBI-1149177
yox1P409234EBI-1009350,EBI-8530485

Protein-protein interaction databases

BioGridi276766. 54 interactions.
DIPiDIP-353N.
IntActiP01129. 4 interactions.
MINTiMINT-4686691.
STRINGi4896.SPBC336.12c-1.

Structurei

3D structure databases

ProteinModelPortaliP01129.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini66 – 173108HTH APSES-typeAdd
BLAST
Repeati356 – 38530ANK 1Add
BLAST
Repeati483 – 51230ANK 2Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi261 – 2644Nuclear localization signal Reviewed prediction

Sequence similaritiesi

Contains 2 ANK repeats.

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiCOG0666.
KOiK06867.
OMAiWHFELEL.
OrthoDBiEOG7ZSJ36.
PhylomeDBiP01129.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
3.10.260.10. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR003163. Tscrpt_reg_HTH_APSES-type.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 2 hits.
SSF54616. SSF54616. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
PS51299. HTH_APSES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P01129-1 [UniParc]FASTAAdd to Basket

« Hide

MASANFIRQF ELGNDSFSYQ KRPEDEPSQP LSNRNINKLN DSSTLKDSSS    50
RIFINSQVLR DGRPVELYAV ECSGMKYMEL SCGDNVALRR CPDSYFNISQ 100
ILRLAGTSSS ENAKELDDII ESGDYENVDS KHPQIDGVWV PYDRAISIAK 150
RYGVYEILQP LISFNLDLFP KFSKQQQIES SSISKNLNTS SFNTRSPLRN 200
HNFSNPSKSS KNGVHTINNM QSSPSPSSSF LLPLTQIDSQ NVKRSNNYLS 250
TSPPILEQRL KRHRIDVSDE DLHPSSQLND NEASSLFPDT PRLNHSLSFV 300
SLVSSLPPLD QNIMQDYHTS KDILTSIFLD VNFADSSALE AKLSDSLDLD 350
VPIDELGHAA LHWAAAVAKM PLLQALIHKG ANPLRGNLTG ETALMRSVLV 400
TNHLNQNSFG DLLDLLYASL PCTDRAGRTV VHHICLTAGI KGRGSASRYY 450
LETLLNWAKK HASGNNGYML KDFINYLNHQ DKNGDTALNI AARIGNKNIV 500
EVLMQAGASA YIPNRAGLSV ANFGIFVENA LKQPEDSKQT KVSLMSENLS 550
SKEKTAVPPR QKSRDIIASV TDVISSLDKD FQDEMAAKQS MIDSAYTQLR 600
ESTKKLSDLR EQLHVSETQR TLFLELRQRC KNLMTSIEEQ KSELSNLYES 650
FDPNGIHDSL SLDADAPFTV NENNNKNLSI AELKFQVAAY ERNEARLNEL 700
ANKLWQRNSN IKSKCRRVVS LCTGVDESRV DSLLESLLQA VESDGQQGEV 750
DMGRVAGFLR VVKEHQA 767
Length:767
Mass (Da):85,513
Last modified:July 21, 1986 - v1
Checksum:i0E514EE1BE218EFA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X02175 Genomic DNA. Translation: CAA26116.1.
CU329671 Genomic DNA. Translation: CAB58164.1.
AB027889 Genomic DNA. Translation: BAA87193.1.
PIRiA01382. COZPCD.
RefSeqiNP_596132.1. NM_001022050.2.

Genome annotation databases

EnsemblFungiiSPBC336.12c.1; SPBC336.12c.1:pep; SPBC336.12c.
GeneIDi2540234.
KEGGispo:SPBC336.12c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X02175 Genomic DNA. Translation: CAA26116.1 .
CU329671 Genomic DNA. Translation: CAB58164.1 .
AB027889 Genomic DNA. Translation: BAA87193.1 .
PIRi A01382. COZPCD.
RefSeqi NP_596132.1. NM_001022050.2.

3D structure databases

ProteinModelPortali P01129.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 276766. 54 interactions.
DIPi DIP-353N.
IntActi P01129. 4 interactions.
MINTi MINT-4686691.
STRINGi 4896.SPBC336.12c-1.

Proteomic databases

MaxQBi P01129.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPBC336.12c.1 ; SPBC336.12c.1:pep ; SPBC336.12c .
GeneIDi 2540234.
KEGGi spo:SPBC336.12c.

Organism-specific databases

PomBasei SPBC336.12c.

Phylogenomic databases

eggNOGi COG0666.
KOi K06867.
OMAi WHFELEL.
OrthoDBi EOG7ZSJ36.
PhylomeDBi P01129.

Miscellaneous databases

NextBioi 20801365.

Family and domain databases

Gene3Di 1.25.40.20. 1 hit.
3.10.260.10. 1 hit.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR003163. Tscrpt_reg_HTH_APSES-type.
[Graphical view ]
Pfami PF00023. Ank. 1 hit.
[Graphical view ]
SMARTi SM00248. ANK. 2 hits.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 2 hits.
SSF54616. SSF54616. 1 hit.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
PS51299. HTH_APSES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, sequencing and transcriptional control of the Schizosaccharomyces pombe cdc10 'start' gene."
    Aves S.J., Durkacz B.W., Carr A., Nurse P.
    EMBO J. 4:457-463(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  3. "Large-scale screening of intracellular protein localization in living fission yeast cells by the use of a GFP-fusion genomic DNA library."
    Ding D.-Q., Tomita Y., Yamamoto A., Chikashige Y., Haraguchi T., Hiraoka Y.
    Genes Cells 5:169-190(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 76-310, SUBCELLULAR LOCATION.
    Strain: ATCC 38364 / 968.
  4. "Positive and negative roles for cdc10 in cell cycle gene expression."
    McInerny C.J., Kersey P.J., Creanor J., Fantes P.A.
    Nucleic Acids Res. 23:4761-4768(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "Pol5p, a novel binding partner to Cdc10p in fission yeast involved in rRNA production."
    Nadeem F.K., Blair D., McInerny C.J.
    Mol. Genet. Genomics 276:391-401(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH POL5.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-252, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiCDC10_SCHPO
AccessioniPrimary (citable) accession number: P01129
Secondary accession number(s): Q9UU04
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: September 3, 2014
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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