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P01129 (CDC10_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 126. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Start control protein cdc10
Gene names
Name:cdc10
ORF Names:SPBC336.12c
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length767 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Major component of the cell cycle transcription factor complex MBF (MCB binding factor, also known as DSC1), that controls G1-S phase specific gene expression. Involved in the control of rRNA production, via interaction with pol5. May be involved in the transcriptional regulation of the cdc22 and cdt1 genes. In fission yeast, two genes, cdc10 and cdc2, are required for the cell cycle control called start, the point early in the G1 phase at which cells become committed to the mitotic cycle. Ref.4 Ref.5

Subunit structure

DSC1 contains cdc10 and sct1/res1. Interacts with pol5. Ref.5

Subcellular location

Nucleus Ref.3.

Sequence similarities

Contains 2 ANK repeats.

Contains 1 HTH APSES-type DNA-binding domain.

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 767767Start control protein cdc10
PRO_0000067060

Regions

Domain66 – 173108HTH APSES-type
Repeat356 – 38530ANK 1
Repeat483 – 51230ANK 2
DNA binding98 – 11922H-T-H motif By similarity
Motif261 – 2644Nuclear localization signal Potential

Amino acid modifications

Modified residue2521Phosphoserine Ref.6

Sequences

Sequence LengthMass (Da)Tools
P01129 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: 0E514EE1BE218EFA

FASTA76785,513
        10         20         30         40         50         60 
MASANFIRQF ELGNDSFSYQ KRPEDEPSQP LSNRNINKLN DSSTLKDSSS RIFINSQVLR 

        70         80         90        100        110        120 
DGRPVELYAV ECSGMKYMEL SCGDNVALRR CPDSYFNISQ ILRLAGTSSS ENAKELDDII 

       130        140        150        160        170        180 
ESGDYENVDS KHPQIDGVWV PYDRAISIAK RYGVYEILQP LISFNLDLFP KFSKQQQIES 

       190        200        210        220        230        240 
SSISKNLNTS SFNTRSPLRN HNFSNPSKSS KNGVHTINNM QSSPSPSSSF LLPLTQIDSQ 

       250        260        270        280        290        300 
NVKRSNNYLS TSPPILEQRL KRHRIDVSDE DLHPSSQLND NEASSLFPDT PRLNHSLSFV 

       310        320        330        340        350        360 
SLVSSLPPLD QNIMQDYHTS KDILTSIFLD VNFADSSALE AKLSDSLDLD VPIDELGHAA 

       370        380        390        400        410        420 
LHWAAAVAKM PLLQALIHKG ANPLRGNLTG ETALMRSVLV TNHLNQNSFG DLLDLLYASL 

       430        440        450        460        470        480 
PCTDRAGRTV VHHICLTAGI KGRGSASRYY LETLLNWAKK HASGNNGYML KDFINYLNHQ 

       490        500        510        520        530        540 
DKNGDTALNI AARIGNKNIV EVLMQAGASA YIPNRAGLSV ANFGIFVENA LKQPEDSKQT 

       550        560        570        580        590        600 
KVSLMSENLS SKEKTAVPPR QKSRDIIASV TDVISSLDKD FQDEMAAKQS MIDSAYTQLR 

       610        620        630        640        650        660 
ESTKKLSDLR EQLHVSETQR TLFLELRQRC KNLMTSIEEQ KSELSNLYES FDPNGIHDSL 

       670        680        690        700        710        720 
SLDADAPFTV NENNNKNLSI AELKFQVAAY ERNEARLNEL ANKLWQRNSN IKSKCRRVVS 

       730        740        750        760 
LCTGVDESRV DSLLESLLQA VESDGQQGEV DMGRVAGFLR VVKEHQA 

« Hide

References

« Hide 'large scale' references
[1]"Cloning, sequencing and transcriptional control of the Schizosaccharomyces pombe cdc10 'start' gene."
Aves S.J., Durkacz B.W., Carr A., Nurse P.
EMBO J. 4:457-463(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[3]"Large-scale screening of intracellular protein localization in living fission yeast cells by the use of a GFP-fusion genomic DNA library."
Ding D.-Q., Tomita Y., Yamamoto A., Chikashige Y., Haraguchi T., Hiraoka Y.
Genes Cells 5:169-190(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 76-310, SUBCELLULAR LOCATION.
Strain: ATCC 38364 / 968.
[4]"Positive and negative roles for cdc10 in cell cycle gene expression."
McInerny C.J., Kersey P.J., Creanor J., Fantes P.A.
Nucleic Acids Res. 23:4761-4768(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[5]"Pol5p, a novel binding partner to Cdc10p in fission yeast involved in rRNA production."
Nadeem F.K., Blair D., McInerny C.J.
Mol. Genet. Genomics 276:391-401(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH POL5.
[6]"Phosphoproteome analysis of fission yeast."
Wilson-Grady J.T., Villen J., Gygi S.P.
J. Proteome Res. 7:1088-1097(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-252, IDENTIFICATION BY MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X02175 Genomic DNA. Translation: CAA26116.1.
CU329671 Genomic DNA. Translation: CAB58164.1.
AB027889 Genomic DNA. Translation: BAA87193.1.
PIRCOZPCD. A01382.
RefSeqNP_596132.1. NM_001022050.2.

3D structure databases

ProteinModelPortalP01129.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid276766. 54 interactions.
DIPDIP-353N.
IntActP01129. 4 interactions.
MINTMINT-4686691.
STRING4896.SPBC336.12c-1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPBC336.12c.1; SPBC336.12c.1:pep; SPBC336.12c.
GeneID2540234.
KEGGspo:SPBC336.12c.

Organism-specific databases

PomBaseSPBC336.12c.

Phylogenomic databases

eggNOGCOG0666.
KOK06867.
OMADYEEERT.
OrthoDBEOG7ZSJ36.
PhylomeDBP01129.

Family and domain databases

Gene3D1.25.40.20. 1 hit.
3.10.260.10. 1 hit.
InterProIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR003163. Tscrpt_reg_HTH_APSES-type.
[Graphical view]
PfamPF00023. Ank. 1 hit.
[Graphical view]
SMARTSM00248. ANK. 2 hits.
[Graphical view]
SUPFAMSSF48403. SSF48403. 2 hits.
SSF54616. SSF54616. 1 hit.
PROSITEPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
PS51299. HTH_APSES. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20801365.

Entry information

Entry nameCDC10_SCHPO
AccessionPrimary (citable) accession number: P01129
Secondary accession number(s): Q9UU04
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: April 16, 2014
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names