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P01129

- CDC10_SCHPO

UniProt

P01129 - CDC10_SCHPO

Protein

Start control protein cdc10

Gene

cdc10

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 1 (21 Jul 1986)
      Previous versions | rss
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    Functioni

    Major component of the cell cycle transcription factor complex MBF (MCB binding factor, also known as DSC1), that controls G1-S phase specific gene expression. Involved in the control of rRNA production, via interaction with pol5. May be involved in the transcriptional regulation of the cdc22 and cdt1 genes. In fission yeast, two genes, cdc10 and cdc2, are required for the cell cycle control called start, the point early in the G1 phase at which cells become committed to the mitotic cycle.2 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi98 – 11922H-T-H motifPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. chromatin binding Source: PomBase
    2. DNA binding Source: InterPro
    3. protein binding Source: UniProtKB
    4. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. mitotic nuclear division Source: UniProtKB-KW
    2. negative regulation of transcription, DNA-templated Source: UniProtKB
    3. positive regulation of transcription, DNA-templated Source: UniProtKB
    4. positive regulation of transcription involved in G1/S transition of mitotic cell cycle Source: PomBase
    5. regulation of transcription involved in G1/S transition of mitotic cell cycle Source: PomBase
    6. rRNA transcription Source: UniProtKB

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Start control protein cdc10
    Gene namesi
    Name:cdc10
    ORF Names:SPBC336.12c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome II

    Organism-specific databases

    PomBaseiSPBC336.12c.

    Subcellular locationi

    Nucleus 1 PublicationPROSITE-ProRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: PomBase
    2. MBF transcription complex Source: PomBase

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 767767Start control protein cdc10PRO_0000067060Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei252 – 2521Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP01129.

    Interactioni

    Subunit structurei

    DSC1 contains cdc10 and sct1/res1. Interacts with pol5.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    pol5O600942EBI-1009350,EBI-1009362
    res2P414123EBI-1009350,EBI-1149177
    yox1P409234EBI-1009350,EBI-8530485

    Protein-protein interaction databases

    BioGridi276766. 54 interactions.
    DIPiDIP-353N.
    IntActiP01129. 4 interactions.
    MINTiMINT-4686691.
    STRINGi4896.SPBC336.12c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliP01129.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini66 – 173108HTH APSES-typePROSITE-ProRule annotationAdd
    BLAST
    Repeati356 – 38530ANK 1Add
    BLAST
    Repeati483 – 51230ANK 2Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi261 – 2644Nuclear localization signalSequence Analysis

    Sequence similaritiesi

    Contains 2 ANK repeats.PROSITE-ProRule annotation
    Contains 1 HTH APSES-type DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    ANK repeat, Repeat

    Phylogenomic databases

    eggNOGiCOG0666.
    KOiK06867.
    OMAiWHFELEL.
    OrthoDBiEOG7ZSJ36.
    PhylomeDBiP01129.

    Family and domain databases

    Gene3Di1.25.40.20. 1 hit.
    3.10.260.10. 1 hit.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR003163. Tscrpt_reg_HTH_APSES-type.
    [Graphical view]
    PfamiPF00023. Ank. 1 hit.
    [Graphical view]
    SMARTiSM00248. ANK. 2 hits.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 2 hits.
    SSF54616. SSF54616. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 2 hits.
    PS51299. HTH_APSES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P01129-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASANFIRQF ELGNDSFSYQ KRPEDEPSQP LSNRNINKLN DSSTLKDSSS    50
    RIFINSQVLR DGRPVELYAV ECSGMKYMEL SCGDNVALRR CPDSYFNISQ 100
    ILRLAGTSSS ENAKELDDII ESGDYENVDS KHPQIDGVWV PYDRAISIAK 150
    RYGVYEILQP LISFNLDLFP KFSKQQQIES SSISKNLNTS SFNTRSPLRN 200
    HNFSNPSKSS KNGVHTINNM QSSPSPSSSF LLPLTQIDSQ NVKRSNNYLS 250
    TSPPILEQRL KRHRIDVSDE DLHPSSQLND NEASSLFPDT PRLNHSLSFV 300
    SLVSSLPPLD QNIMQDYHTS KDILTSIFLD VNFADSSALE AKLSDSLDLD 350
    VPIDELGHAA LHWAAAVAKM PLLQALIHKG ANPLRGNLTG ETALMRSVLV 400
    TNHLNQNSFG DLLDLLYASL PCTDRAGRTV VHHICLTAGI KGRGSASRYY 450
    LETLLNWAKK HASGNNGYML KDFINYLNHQ DKNGDTALNI AARIGNKNIV 500
    EVLMQAGASA YIPNRAGLSV ANFGIFVENA LKQPEDSKQT KVSLMSENLS 550
    SKEKTAVPPR QKSRDIIASV TDVISSLDKD FQDEMAAKQS MIDSAYTQLR 600
    ESTKKLSDLR EQLHVSETQR TLFLELRQRC KNLMTSIEEQ KSELSNLYES 650
    FDPNGIHDSL SLDADAPFTV NENNNKNLSI AELKFQVAAY ERNEARLNEL 700
    ANKLWQRNSN IKSKCRRVVS LCTGVDESRV DSLLESLLQA VESDGQQGEV 750
    DMGRVAGFLR VVKEHQA 767
    Length:767
    Mass (Da):85,513
    Last modified:July 21, 1986 - v1
    Checksum:i0E514EE1BE218EFA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X02175 Genomic DNA. Translation: CAA26116.1.
    CU329671 Genomic DNA. Translation: CAB58164.1.
    AB027889 Genomic DNA. Translation: BAA87193.1.
    PIRiA01382. COZPCD.
    RefSeqiNP_596132.1. NM_001022050.2.

    Genome annotation databases

    EnsemblFungiiSPBC336.12c.1; SPBC336.12c.1:pep; SPBC336.12c.
    GeneIDi2540234.
    KEGGispo:SPBC336.12c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X02175 Genomic DNA. Translation: CAA26116.1 .
    CU329671 Genomic DNA. Translation: CAB58164.1 .
    AB027889 Genomic DNA. Translation: BAA87193.1 .
    PIRi A01382. COZPCD.
    RefSeqi NP_596132.1. NM_001022050.2.

    3D structure databases

    ProteinModelPortali P01129.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 276766. 54 interactions.
    DIPi DIP-353N.
    IntActi P01129. 4 interactions.
    MINTi MINT-4686691.
    STRINGi 4896.SPBC336.12c-1.

    Proteomic databases

    MaxQBi P01129.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPBC336.12c.1 ; SPBC336.12c.1:pep ; SPBC336.12c .
    GeneIDi 2540234.
    KEGGi spo:SPBC336.12c.

    Organism-specific databases

    PomBasei SPBC336.12c.

    Phylogenomic databases

    eggNOGi COG0666.
    KOi K06867.
    OMAi WHFELEL.
    OrthoDBi EOG7ZSJ36.
    PhylomeDBi P01129.

    Miscellaneous databases

    NextBioi 20801365.

    Family and domain databases

    Gene3Di 1.25.40.20. 1 hit.
    3.10.260.10. 1 hit.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR003163. Tscrpt_reg_HTH_APSES-type.
    [Graphical view ]
    Pfami PF00023. Ank. 1 hit.
    [Graphical view ]
    SMARTi SM00248. ANK. 2 hits.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 2 hits.
    SSF54616. SSF54616. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 2 hits.
    PS51299. HTH_APSES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, sequencing and transcriptional control of the Schizosaccharomyces pombe cdc10 'start' gene."
      Aves S.J., Durkacz B.W., Carr A., Nurse P.
      EMBO J. 4:457-463(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    3. "Large-scale screening of intracellular protein localization in living fission yeast cells by the use of a GFP-fusion genomic DNA library."
      Ding D.-Q., Tomita Y., Yamamoto A., Chikashige Y., Haraguchi T., Hiraoka Y.
      Genes Cells 5:169-190(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 76-310, SUBCELLULAR LOCATION.
      Strain: ATCC 38364 / 968.
    4. "Positive and negative roles for cdc10 in cell cycle gene expression."
      McInerny C.J., Kersey P.J., Creanor J., Fantes P.A.
      Nucleic Acids Res. 23:4761-4768(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    5. "Pol5p, a novel binding partner to Cdc10p in fission yeast involved in rRNA production."
      Nadeem F.K., Blair D., McInerny C.J.
      Mol. Genet. Genomics 276:391-401(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH POL5.
    6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-252, IDENTIFICATION BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiCDC10_SCHPO
    AccessioniPrimary (citable) accession number: P01129
    Secondary accession number(s): Q9UU04
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 130 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3