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P01128

- TSIS_WMSV

UniProt

P01128 - TSIS_WMSV

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Protein

PDGF-related-transforming protein sis

Gene

V-SIS

Organism
Woolly monkey sarcoma virus (WMSV) (Smian sarcoma-associated virus)
Status
Reviewed - Annotation score: 1 out of 5- Protein inferred from homologyi

Functioni

Keywords - Molecular functioni

Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
PDGF-related-transforming protein sis
Alternative name(s):
p28sis
Gene namesi
Name:V-SIS
OrganismiWoolly monkey sarcoma virus (WMSV) (Smian sarcoma-associated virus)
Taxonomic identifieri11970 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirus
Virus hostiLagothrix (woolly monkeys) [TaxID: 9518]

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: InterPro
Complete GO annotation...

Pathology & Biotechi

Keywords - Diseasei

Oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 226226PDGF-related-transforming protein sisPRO_0000162360Add
BLAST

Proteomic databases

PRIDEiP01128.

Structurei

3D structure databases

ProteinModelPortaliP01128.
SMRiP01128. Positions 75-170.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PDGF/VEGF growth factor family.Curated

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR023581. PD_growth_factor_CS.
IPR000072. PDGF/VEGF_dom.
IPR006782. PDGF_N.
[Graphical view]
PfamiPF00341. PDGF. 1 hit.
PF04692. PDGF_N. 1 hit.
[Graphical view]
SMARTiSM00141. PDGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00249. PDGF_1. 1 hit.
PS50278. PDGF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P01128-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTLTWQGDPI PEELYKMLSG HSIRSFDDLQ RLLQGDSGKE DGAELDLNMT
60 70 80 90 100
RSHSGGELES LARGKRSLGS LSVAEPAMIA ECKTRTEVFE ISRRLIDRTN
110 120 130 140 150
ANFLVWPPCV EVQRCSGCCN NRNVQCRPTQ VQLRPVQVRK IEIVRKKPIF
160 170 180 190 200
KKATVTLEDH LACKCEIVAA ARAVTRSPGT SQEQRAKTTQ SRVTIRTVRV
210 220
RRPPKGKHRK CKHTHDKTAL KETLGA
Length:226
Mass (Da):25,411
Last modified:July 21, 1986 - v1
Checksum:iA16813ABB95B90C5
GO

Sequence cautioni

The sequence CAA24516.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
V01201 Genomic DNA. Translation: CAA24516.1. Different initiation.
PIRiA01381. TVMVSS.
RefSeqiYP_001165471.2. NC_009424.4.
YP_003580185.1. NC_009424.4.

Genome annotation databases

GeneIDi5176147.
9538324.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
V01201 Genomic DNA. Translation: CAA24516.1 . Different initiation.
PIRi A01381. TVMVSS.
RefSeqi YP_001165471.2. NC_009424.4.
YP_003580185.1. NC_009424.4.

3D structure databases

ProteinModelPortali P01128.
SMRi P01128. Positions 75-170.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P01128.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5176147.
9538324.

Family and domain databases

Gene3Di 2.10.90.10. 1 hit.
InterProi IPR029034. Cystine-knot_cytokine.
IPR023581. PD_growth_factor_CS.
IPR000072. PDGF/VEGF_dom.
IPR006782. PDGF_N.
[Graphical view ]
Pfami PF00341. PDGF. 1 hit.
PF04692. PDGF_N. 1 hit.
[Graphical view ]
SMARTi SM00141. PDGF. 1 hit.
[Graphical view ]
SUPFAMi SSF57501. SSF57501. 1 hit.
PROSITEi PS00249. PDGF_1. 1 hit.
PS50278. PDGF_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of the simian sarcoma virus genome: demonstration that its acquired cellular sequences encode the transforming gene product p28sis."
    Devare S.G., Reddy E.P., Law J.D., Robbins K.C., Aaronson S.A.
    Proc. Natl. Acad. Sci. U.S.A. 80:731-735(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiTSIS_WMSV
AccessioniPrimary (citable) accession number: P01128
Secondary accession number(s): O41283
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: October 1, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3