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P01128

- TSIS_WMSV

UniProt

P01128 - TSIS_WMSV

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Protein

PDGF-related-transforming protein sis

Gene
V-SIS
Organism
Woolly monkey sarcoma virus (WMSV) (Smian sarcoma-associated virus)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Keywords - Molecular functioni

Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
PDGF-related-transforming protein sis
Alternative name(s):
p28sis
Gene namesi
Name:V-SIS
OrganismiWoolly monkey sarcoma virus (WMSV) (Smian sarcoma-associated virus)
Taxonomic identifieri11970 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirus
Virus hostiLagothrix (woolly monkeys) [TaxID: 9518]

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: InterPro
Complete GO annotation...

Pathology & Biotechi

Keywords - Diseasei

Oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 226226PDGF-related-transforming protein sisPRO_0000162360Add
BLAST

Proteomic databases

PRIDEiP01128.

Structurei

3D structure databases

ProteinModelPortaliP01128.
SMRiP01128. Positions 75-170.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR023581. PD_growth_factor_CS.
IPR000072. PDGF/VEGF_dom.
IPR006782. PDGF_N.
[Graphical view]
PfamiPF00341. PDGF. 1 hit.
PF04692. PDGF_N. 1 hit.
[Graphical view]
SMARTiSM00141. PDGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00249. PDGF_1. 1 hit.
PS50278. PDGF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P01128-1 [UniParc]FASTAAdd to Basket

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MTLTWQGDPI PEELYKMLSG HSIRSFDDLQ RLLQGDSGKE DGAELDLNMT    50
RSHSGGELES LARGKRSLGS LSVAEPAMIA ECKTRTEVFE ISRRLIDRTN 100
ANFLVWPPCV EVQRCSGCCN NRNVQCRPTQ VQLRPVQVRK IEIVRKKPIF 150
KKATVTLEDH LACKCEIVAA ARAVTRSPGT SQEQRAKTTQ SRVTIRTVRV 200
RRPPKGKHRK CKHTHDKTAL KETLGA 226
Length:226
Mass (Da):25,411
Last modified:July 21, 1986 - v1
Checksum:iA16813ABB95B90C5
GO

Sequence cautioni

The sequence CAA24516.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
V01201 Genomic DNA. Translation: CAA24516.1. Different initiation.
PIRiA01381. TVMVSS.
RefSeqiYP_001165471.2. NC_009424.4.
YP_003580185.1. NC_009424.4.

Genome annotation databases

GeneIDi5176147.
9538324.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
V01201 Genomic DNA. Translation: CAA24516.1 . Different initiation.
PIRi A01381. TVMVSS.
RefSeqi YP_001165471.2. NC_009424.4.
YP_003580185.1. NC_009424.4.

3D structure databases

ProteinModelPortali P01128.
SMRi P01128. Positions 75-170.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P01128.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5176147.
9538324.

Family and domain databases

Gene3Di 2.10.90.10. 1 hit.
InterProi IPR029034. Cystine-knot_cytokine.
IPR023581. PD_growth_factor_CS.
IPR000072. PDGF/VEGF_dom.
IPR006782. PDGF_N.
[Graphical view ]
Pfami PF00341. PDGF. 1 hit.
PF04692. PDGF_N. 1 hit.
[Graphical view ]
SMARTi SM00141. PDGF. 1 hit.
[Graphical view ]
SUPFAMi SSF57501. SSF57501. 1 hit.
PROSITEi PS00249. PDGF_1. 1 hit.
PS50278. PDGF_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of the simian sarcoma virus genome: demonstration that its acquired cellular sequences encode the transforming gene product p28sis."
    Devare S.G., Reddy E.P., Law J.D., Robbins K.C., Aaronson S.A.
    Proc. Natl. Acad. Sci. U.S.A. 80:731-735(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiTSIS_WMSV
AccessioniPrimary (citable) accession number: P01128
Secondary accession number(s): O41283
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: June 11, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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