P01128 (TSIS_WMSV) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
PDGF-related-transforming protein sis

Alternative name(s):
p28sis

Gene names

Name:

V-SIS

Organism

Woolly monkey sarcoma virus (WMSV) (Smian sarcoma-associated virus)

Taxonomic identifier

11970 [NCBI]

Taxonomic lineage

Viruses › Retro-transcribing viruses › Retroviridae › Orthoretrovirinae › Gammaretrovirus › Mammalian virus group › Replication defective viruses

Virus host

Lagothrix (woolly monkeys) [TaxID: 9518]

Protein attributes

Sequence length	226 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Sequence similarities	Belongs to the PDGF/VEGF growth factor family.
Sequence caution	The sequence CAA24516.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Disease	Oncogene
Molecular function	Growth factor
Gene Ontology (GO)
Cellular_component	membrane Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 226	226	PDGF-related-transforming protein sis		PRO_0000162360

Sequences

	Sequence		Length	Mass (Da)
	P01128 [UniParc]. Last modified July 21, 1986. Version 1. Checksum: A16813ABB95B90C5	FASTA	226	25,411
	10 20 30 40 50 60 MTLTWQGDPI PEELYKMLSG HSIRSFDDLQ RLLQGDSGKE DGAELDLNMT RSHSGGELES 70 80 90 100 110 120 LARGKRSLGS LSVAEPAMIA ECKTRTEVFE ISRRLIDRTN ANFLVWPPCV EVQRCSGCCN 130 140 150 160 170 180 NRNVQCRPTQ VQLRPVQVRK IEIVRKKPIF KKATVTLEDH LACKCEIVAA ARAVTRSPGT 190 200 210 220 SQEQRAKTTQ SRVTIRTVRV RRPPKGKHRK CKHTHDKTAL KETLGA

References

[1]

"Nucleotide sequence of the simian sarcoma virus genome: demonstration that its acquired cellular sequences encode the transforming gene product p28sis." Devare S.G., Reddy E.P., Law J.D., Robbins K.C., Aaronson S.A. Proc. Natl. Acad. Sci. U.S.A. 80:731-735(1983) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	V01201 Genomic DNA. Translation: CAA24516.1. Different initiation.
PIR	TVMVSS. A01381.
RefSeq	YP_001165471.2. NC_009424.4. YP_003580185.1. NC_009424.4.
3D structure databases
ProteinModelPortal	P01128.
SMR	P01128. Positions 75-170.
ModBase	Search...
Proteomic databases
PRIDE	P01128.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5176147. 9538324.
Family and domain databases
InterPro	IPR000072. PD_growth_factor. IPR023581. PD_growth_factor_CS. IPR006782. PDGF_N. [Graphical view]
Pfam	PF00341. PDGF. 1 hit. PF04692. PDGF_N. 1 hit. [Graphical view]
SMART	SM00141. PDGF. 1 hit. [Graphical view]
PROSITE	PS00249. PDGF_1. 1 hit. PS50278. PDGF_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TSIS_WMSV

Accession

Primary (citable) accession number: P01128
Secondary accession number(s): O41283

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	April 3, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program