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P01128

- TSIS_WMSV

UniProt

P01128 - TSIS_WMSV

Protein

PDGF-related-transforming protein sis

Gene

V-SIS

Organism
Woolly monkey sarcoma virus (WMSV) (Smian sarcoma-associated virus)
Status
Reviewed - Annotation score: 1 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (21 Jul 1986)
      Previous versions | rss
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    Functioni

    Keywords - Molecular functioni

    Growth factor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    PDGF-related-transforming protein sis
    Alternative name(s):
    p28sis
    Gene namesi
    Name:V-SIS
    OrganismiWoolly monkey sarcoma virus (WMSV) (Smian sarcoma-associated virus)
    Taxonomic identifieri11970 [NCBI]
    Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirus
    Virus hostiLagothrix (woolly monkeys) [TaxID: 9518]

    Subcellular locationi

    GO - Cellular componenti

    1. membrane Source: InterPro

    Pathology & Biotechi

    Keywords - Diseasei

    Oncogene

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 226226PDGF-related-transforming protein sisPRO_0000162360Add
    BLAST

    Proteomic databases

    PRIDEiP01128.

    Structurei

    3D structure databases

    ProteinModelPortaliP01128.
    SMRiP01128. Positions 75-170.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PDGF/VEGF growth factor family.Curated

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    InterProiIPR029034. Cystine-knot_cytokine.
    IPR023581. PD_growth_factor_CS.
    IPR000072. PDGF/VEGF_dom.
    IPR006782. PDGF_N.
    [Graphical view]
    PfamiPF00341. PDGF. 1 hit.
    PF04692. PDGF_N. 1 hit.
    [Graphical view]
    SMARTiSM00141. PDGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF57501. SSF57501. 1 hit.
    PROSITEiPS00249. PDGF_1. 1 hit.
    PS50278. PDGF_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P01128-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTLTWQGDPI PEELYKMLSG HSIRSFDDLQ RLLQGDSGKE DGAELDLNMT    50
    RSHSGGELES LARGKRSLGS LSVAEPAMIA ECKTRTEVFE ISRRLIDRTN 100
    ANFLVWPPCV EVQRCSGCCN NRNVQCRPTQ VQLRPVQVRK IEIVRKKPIF 150
    KKATVTLEDH LACKCEIVAA ARAVTRSPGT SQEQRAKTTQ SRVTIRTVRV 200
    RRPPKGKHRK CKHTHDKTAL KETLGA 226
    Length:226
    Mass (Da):25,411
    Last modified:July 21, 1986 - v1
    Checksum:iA16813ABB95B90C5
    GO

    Sequence cautioni

    The sequence CAA24516.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    V01201 Genomic DNA. Translation: CAA24516.1. Different initiation.
    PIRiA01381. TVMVSS.
    RefSeqiYP_001165471.2. NC_009424.4.
    YP_003580185.1. NC_009424.4.

    Genome annotation databases

    GeneIDi5176147.
    9538324.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    V01201 Genomic DNA. Translation: CAA24516.1 . Different initiation.
    PIRi A01381. TVMVSS.
    RefSeqi YP_001165471.2. NC_009424.4.
    YP_003580185.1. NC_009424.4.

    3D structure databases

    ProteinModelPortali P01128.
    SMRi P01128. Positions 75-170.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P01128.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 5176147.
    9538324.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    InterProi IPR029034. Cystine-knot_cytokine.
    IPR023581. PD_growth_factor_CS.
    IPR000072. PDGF/VEGF_dom.
    IPR006782. PDGF_N.
    [Graphical view ]
    Pfami PF00341. PDGF. 1 hit.
    PF04692. PDGF_N. 1 hit.
    [Graphical view ]
    SMARTi SM00141. PDGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57501. SSF57501. 1 hit.
    PROSITEi PS00249. PDGF_1. 1 hit.
    PS50278. PDGF_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of the simian sarcoma virus genome: demonstration that its acquired cellular sequences encode the transforming gene product p28sis."
      Devare S.G., Reddy E.P., Law J.D., Robbins K.C., Aaronson S.A.
      Proc. Natl. Acad. Sci. U.S.A. 80:731-735(1983) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiTSIS_WMSV
    AccessioniPrimary (citable) accession number: P01128
    Secondary accession number(s): O41283
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3