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P01128 (TSIS_WMSV) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
PDGF-related-transforming protein sis
Alternative name(s):
p28sis
Gene names
Name:V-SIS
OrganismWoolly monkey sarcoma virus (WMSV) (Smian sarcoma-associated virus)
Taxonomic identifier11970 [NCBI]
Taxonomic lineageVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirus
Virus hostLagothrix (woolly monkeys) [TaxID: 9518]

Protein attributes

Sequence length226 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the PDGF/VEGF growth factor family.

Sequence caution

The sequence CAA24516.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   DiseaseOncogene
   Molecular functionGrowth factor
Gene Ontology (GO)
   Cellular_componentmembrane

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 226226PDGF-related-transforming protein sis
PRO_0000162360

Sequences

Sequence LengthMass (Da)Tools
P01128 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: A16813ABB95B90C5

FASTA22625,411
        10         20         30         40         50         60 
MTLTWQGDPI PEELYKMLSG HSIRSFDDLQ RLLQGDSGKE DGAELDLNMT RSHSGGELES 

        70         80         90        100        110        120 
LARGKRSLGS LSVAEPAMIA ECKTRTEVFE ISRRLIDRTN ANFLVWPPCV EVQRCSGCCN 

       130        140        150        160        170        180 
NRNVQCRPTQ VQLRPVQVRK IEIVRKKPIF KKATVTLEDH LACKCEIVAA ARAVTRSPGT 

       190        200        210        220 
SQEQRAKTTQ SRVTIRTVRV RRPPKGKHRK CKHTHDKTAL KETLGA 

« Hide

References

[1]"Nucleotide sequence of the simian sarcoma virus genome: demonstration that its acquired cellular sequences encode the transforming gene product p28sis."
Devare S.G., Reddy E.P., Law J.D., Robbins K.C., Aaronson S.A.
Proc. Natl. Acad. Sci. U.S.A. 80:731-735(1983) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
V01201 Genomic DNA. Translation: CAA24516.1. Different initiation.
PIRTVMVSS. A01381.
RefSeqYP_001165471.2. NC_009424.4.
YP_003580185.1. NC_009424.4.

3D structure databases

ProteinModelPortalP01128.
SMRP01128. Positions 75-170.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP01128.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5176147.
9538324.

Family and domain databases

Gene3D2.10.90.10. 1 hit.
InterProIPR029034. Cystine-knot_cytokine.
IPR023581. PD_growth_factor_CS.
IPR000072. PDGF/VEGF_dom.
IPR006782. PDGF_N.
[Graphical view]
PfamPF00341. PDGF. 1 hit.
PF04692. PDGF_N. 1 hit.
[Graphical view]
SMARTSM00141. PDGF. 1 hit.
[Graphical view]
SUPFAMSSF57501. SSF57501. 1 hit.
PROSITEPS00249. PDGF_1. 1 hit.
PS50278. PDGF_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTSIS_WMSV
AccessionPrimary (citable) accession number: P01128
Secondary accession number(s): O41283
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: June 11, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families