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P01126 (REL_AVIRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Transforming protein rel polyprotein
Alternative name(s):
p58 V-rel

Cleaved into the following 3 chains:

  1. Env polyprotein N-terminal
  2. Transforming protein rel
  3. Env polyprotein C-terminal
Gene names
Name:V-REL
OrganismAvian reticuloendotheliosis virus
Taxonomic identifier11636 [NCBI]
Taxonomic lineageViruses › Retro-transcribing viruses › Retroviridae › Orthoretrovirinae › Gammaretrovirus ›
Virus hostGalliformes [TaxID: 8976]

Protein attributes

Sequence length503 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existencePredicted

General annotation (Comments)

Function

This transforming protein appears to have a protein-kinase activity.

Subcellular location

Host cytoplasm.

Sequence similarities

Contains 1 RHD (Rel-like) domain.

Ontologies

Keywords
   Cellular componentHost cytoplasm
   DiseaseOncogene
   PTMPhosphoprotein
Gene Ontology (GO)
   Cellular_componenthost cell cytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

host cell nucleus

Inferred from electronic annotation. Source: InterPro

   Molecular_functionsequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 1212Env polyprotein N-terminal
PRO_0000030307
Chain13 – 484472Transforming protein rel
PRO_0000030308
Chain485 – 50319Env polyprotein C-terminal
PRO_0000030309

Regions

Domain16 – 305290RHD
Motif298 – 3036Nuclear localization signal Potential

Amino acid modifications

Modified residue2751Phosphoserine; by host PKA Potential

Sequences

Sequence LengthMass (Da)Tools
P01126 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: 3F407A25C4FC0AD1

FASTA50355,910
        10         20         30         40         50         60 
MDFLTNLRFT EGISEPYIEI FEQPRQRGTR FRYKCEGRSA GSIPGEHSTD NNKTFPSIQI 

        70         80         90        100        110        120 
LNYFGKVKIR TTLVTKNEPY KPHPHDLVGK GCRDGYYEAE FGPERQVLSF QNLGIQCVKK 

       130        140        150        160        170        180 
KDLKESISLR ISKKINPFNV PEEQLHNIDE YDLNVVRLCF QAFLPDEHGN YTLALPPLIS 

       190        200        210        220        230        240 
NPIYDNRAPN TAELRICRVN KNCGSVKGGD EIFLLCDKVQ KDDIEVRFVL GNWEAKGSFS 

       250        260        270        280        290        300 
QADVHRQVAI VFRTPPFLGD ITEPITVKMQ LRRPSDQAVS EPVDFRYLPD EEDPSGNKAK 

       310        320        330        340        350        360 
RQRSTLAWQK PIQDCGSAVT ERPKAAPIPT VNPEGKLKKE PNMFSPTLML PGLGTLSSSQ 

       370        380        390        400        410        420 
MYPACSQMPT QPAQLGPGKQ DTLHSCWQQL YSPSPSASSL LSLHSHSSFT AEVPQPGAQG 

       430        440        450        460        470        480 
SSSLPAYNPL NWPDEKNSSF YRNFGNTHGM GAALVSAAGM QSVSSSSIVQ GTHQASATTA 

       490        500 
SIMTMPRTPG EVPFLRQQVG YRS

« Hide

References

[1]"Nucleotide sequence of v-rel: the oncogene of reticuloendotheliosis virus."
Stephens R.M., Rice N.R., Hiebsch R.R., Bose H.R. Jr., Gilden R.V.
Proc. Natl. Acad. Sci. U.S.A. 80:6229-6233(1983) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[2]"Nucleic acid sequences of the oncogene v-rel in reticuloendotheliosis virus strain T and its cellular homolog, the proto-oncogene c-rel."
Wilhelmsen K.C., Eggleton K., Temin H.M.
J. Virol. 52:172-182(1984) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: T.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X02759 Genomic RNA. Translation: CAA26534.1.
PIRVCVDA. A93974.

3D structure databases

ProteinModelPortalP01126.
SMRP01126. Positions 16-290.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.60.40.10. 1 hit.
2.60.40.340. 1 hit.
InterProIPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT_TIG_rcpt.
IPR000451. NF_Rel_Dor.
IPR008967. p53-like_TF_DNA-bd.
IPR011539. RHD.
[Graphical view]
PfamPF00554. RHD. 1 hit.
[Graphical view]
PRINTSPR00057. NFKBTNSCPFCT.
SMARTSM00429. IPT. 1 hit.
[Graphical view]
SUPFAMSSF81296. Ig_E-set. 1 hit.
SSF49417. P53_like_DNA_bnd. 1 hit.
PROSITEPS01204. REL_1. 1 hit.
PS50254. REL_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameREL_AVIRE
AccessionPrimary (citable) accession number: P01126
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: April 3, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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