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Protein

Transforming protein rel polyprotein

Gene

V-REL

Organism
Avian reticuloendotheliosis virus
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

This transforming protein appears to have a protein-kinase activity.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Transforming protein rel polyprotein
Alternative name(s):
p58 V-rel
Cleaved into the following 3 chains:
Gene namesi
Name:V-REL
OrganismiAvian reticuloendotheliosis virus
Taxonomic identifieri11636 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirus
Virus hostiGalliformes [TaxID: 8976]

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host cytoplasm

Pathology & Biotechi

Keywords - Diseasei

Oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000303071 – 12Env polyprotein N-terminalAdd BLAST12
ChainiPRO_000003030813 – 484Transforming protein relAdd BLAST472
ChainiPRO_0000030309485 – 503Env polyprotein C-terminalAdd BLAST19

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei275Phosphoserine; by host PKASequence analysis1

Keywords - PTMi

Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliP01126.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 305RHDPROSITE-ProRule annotationAdd BLAST290

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi298 – 303Nuclear localization signalSequence analysis6

Sequence similaritiesi

Contains 1 RHD (Rel-like) domain.PROSITE-ProRule annotation

Family and domain databases

CDDicd01177. IPT_NFkappaB. 1 hit.
Gene3Di2.60.40.10. 1 hit.
2.60.40.340. 1 hit.
InterProiIPR030505. c-Rel.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR033926. IPT_NFkappaB.
IPR000451. NFkB/Dor.
IPR008967. p53-like_TF_DNA-bd.
IPR030492. RHD_CS.
IPR032397. RHD_dimer.
IPR011539. RHD_DNA_bind_dom.
[Graphical view]
PANTHERiPTHR24169. PTHR24169. 2 hits.
PTHR24169:SF4. PTHR24169:SF4. 2 hits.
PfamiPF16179. RHD_dimer. 1 hit.
PF00554. RHD_DNA_bind. 1 hit.
[Graphical view]
PRINTSiPR00057. NFKBTNSCPFCT.
SMARTiSM00429. IPT. 1 hit.
[Graphical view]
SUPFAMiSSF49417. SSF49417. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEiPS01204. REL_1. 1 hit.
PS50254. REL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01126-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFLTNLRFT EGISEPYIEI FEQPRQRGTR FRYKCEGRSA GSIPGEHSTD
60 70 80 90 100
NNKTFPSIQI LNYFGKVKIR TTLVTKNEPY KPHPHDLVGK GCRDGYYEAE
110 120 130 140 150
FGPERQVLSF QNLGIQCVKK KDLKESISLR ISKKINPFNV PEEQLHNIDE
160 170 180 190 200
YDLNVVRLCF QAFLPDEHGN YTLALPPLIS NPIYDNRAPN TAELRICRVN
210 220 230 240 250
KNCGSVKGGD EIFLLCDKVQ KDDIEVRFVL GNWEAKGSFS QADVHRQVAI
260 270 280 290 300
VFRTPPFLGD ITEPITVKMQ LRRPSDQAVS EPVDFRYLPD EEDPSGNKAK
310 320 330 340 350
RQRSTLAWQK PIQDCGSAVT ERPKAAPIPT VNPEGKLKKE PNMFSPTLML
360 370 380 390 400
PGLGTLSSSQ MYPACSQMPT QPAQLGPGKQ DTLHSCWQQL YSPSPSASSL
410 420 430 440 450
LSLHSHSSFT AEVPQPGAQG SSSLPAYNPL NWPDEKNSSF YRNFGNTHGM
460 470 480 490 500
GAALVSAAGM QSVSSSSIVQ GTHQASATTA SIMTMPRTPG EVPFLRQQVG

YRS
Length:503
Mass (Da):55,910
Last modified:July 21, 1986 - v1
Checksum:i3F407A25C4FC0AD1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02759 Genomic RNA. Translation: CAA26534.1.
PIRiA93974. VCVDA.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02759 Genomic RNA. Translation: CAA26534.1.
PIRiA93974. VCVDA.

3D structure databases

ProteinModelPortaliP01126.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

CDDicd01177. IPT_NFkappaB. 1 hit.
Gene3Di2.60.40.10. 1 hit.
2.60.40.340. 1 hit.
InterProiIPR030505. c-Rel.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR033926. IPT_NFkappaB.
IPR000451. NFkB/Dor.
IPR008967. p53-like_TF_DNA-bd.
IPR030492. RHD_CS.
IPR032397. RHD_dimer.
IPR011539. RHD_DNA_bind_dom.
[Graphical view]
PANTHERiPTHR24169. PTHR24169. 2 hits.
PTHR24169:SF4. PTHR24169:SF4. 2 hits.
PfamiPF16179. RHD_dimer. 1 hit.
PF00554. RHD_DNA_bind. 1 hit.
[Graphical view]
PRINTSiPR00057. NFKBTNSCPFCT.
SMARTiSM00429. IPT. 1 hit.
[Graphical view]
SUPFAMiSSF49417. SSF49417. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEiPS01204. REL_1. 1 hit.
PS50254. REL_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiREL_AVIRE
AccessioniPrimary (citable) accession number: P01126
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 30, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.