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Protein

Transforming protein rel polyprotein

Gene

V-REL

Organism
Avian reticuloendotheliosis virus
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

This transforming protein appears to have a protein-kinase activity.

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Transforming protein rel polyprotein
Alternative name(s):
p58 V-rel
Cleaved into the following 3 chains:
Gene namesi
Name:V-REL
OrganismiAvian reticuloendotheliosis virus
Taxonomic identifieri11636 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirus
Virus hostiGalliformes [TaxID: 8976]

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm

Pathology & Biotechi

Keywords - Diseasei

Oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000303071 – 12Env polyprotein N-terminalAdd BLAST12
ChainiPRO_000003030813 – 484Transforming protein relAdd BLAST472
ChainiPRO_0000030309485 – 503Env polyprotein C-terminalAdd BLAST19

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei275Phosphoserine; by host PKASequence analysis1

Keywords - PTMi

Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliP01126
SMRiP01126
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 305RHDPROSITE-ProRule annotationAdd BLAST290

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi298 – 303Nuclear localization signalSequence analysis6

Family and domain databases

CDDicd01177 IPT_NFkappaB, 1 hit
Gene3Di2.60.40.10, 1 hit
2.60.40.340, 1 hit
InterProiView protein in InterPro
IPR030505 c-Rel
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR033926 IPT_NFkappaB
IPR000451 NFkB/Dor
IPR008967 p53-like_TF_DNA-bd
IPR030492 RHD_CS
IPR032397 RHD_dimer
IPR011539 RHD_DNA_bind_dom
IPR037059 RHD_DNA_bind_dom_sf
PANTHERiPTHR24169 PTHR24169, 1 hit
PTHR24169:SF4 PTHR24169:SF4, 1 hit
PfamiView protein in Pfam
PF16179 RHD_dimer, 1 hit
PF00554 RHD_DNA_bind, 1 hit
PRINTSiPR00057 NFKBTNSCPFCT
SMARTiView protein in SMART
SM00429 IPT, 1 hit
SUPFAMiSSF49417 SSF49417, 1 hit
SSF81296 SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS01204 REL_1, 1 hit
PS50254 REL_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01126-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFLTNLRFT EGISEPYIEI FEQPRQRGTR FRYKCEGRSA GSIPGEHSTD
60 70 80 90 100
NNKTFPSIQI LNYFGKVKIR TTLVTKNEPY KPHPHDLVGK GCRDGYYEAE
110 120 130 140 150
FGPERQVLSF QNLGIQCVKK KDLKESISLR ISKKINPFNV PEEQLHNIDE
160 170 180 190 200
YDLNVVRLCF QAFLPDEHGN YTLALPPLIS NPIYDNRAPN TAELRICRVN
210 220 230 240 250
KNCGSVKGGD EIFLLCDKVQ KDDIEVRFVL GNWEAKGSFS QADVHRQVAI
260 270 280 290 300
VFRTPPFLGD ITEPITVKMQ LRRPSDQAVS EPVDFRYLPD EEDPSGNKAK
310 320 330 340 350
RQRSTLAWQK PIQDCGSAVT ERPKAAPIPT VNPEGKLKKE PNMFSPTLML
360 370 380 390 400
PGLGTLSSSQ MYPACSQMPT QPAQLGPGKQ DTLHSCWQQL YSPSPSASSL
410 420 430 440 450
LSLHSHSSFT AEVPQPGAQG SSSLPAYNPL NWPDEKNSSF YRNFGNTHGM
460 470 480 490 500
GAALVSAAGM QSVSSSSIVQ GTHQASATTA SIMTMPRTPG EVPFLRQQVG

YRS
Length:503
Mass (Da):55,910
Last modified:July 21, 1986 - v1
Checksum:i3F407A25C4FC0AD1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02759 Genomic RNA Translation: CAA26534.1
PIRiA93974 VCVDA

Entry informationi

Entry nameiREL_AVIRE
AccessioniPrimary (citable) accession number: P01126
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: April 25, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

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