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P01126

- REL_AVIRE

UniProt

P01126 - REL_AVIRE

Protein

Transforming protein rel polyprotein

Gene

V-REL

Organism
Avian reticuloendotheliosis virus
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (21 Jul 1986)
      Previous versions | rss
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    Functioni

    This transforming protein appears to have a protein-kinase activity.

    GO - Molecular functioni

    1. sequence-specific DNA binding transcription factor activity Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transforming protein rel polyprotein
    Alternative name(s):
    p58 V-rel
    Cleaved into the following 3 chains:
    Gene namesi
    Name:V-REL
    OrganismiAvian reticuloendotheliosis virus
    Taxonomic identifieri11636 [NCBI]
    Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirus
    Virus hostiGalliformes [TaxID: 8976]

    Subcellular locationi

    GO - Cellular componenti

    1. host cell cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: InterPro

    Keywords - Cellular componenti

    Host cytoplasm

    Pathology & Biotechi

    Keywords - Diseasei

    Oncogene

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 1212Env polyprotein N-terminalPRO_0000030307Add
    BLAST
    Chaini13 – 484472Transforming protein relPRO_0000030308Add
    BLAST
    Chaini485 – 50319Env polyprotein C-terminalPRO_0000030309Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei275 – 2751Phosphoserine; by host PKASequence Analysis

    Keywords - PTMi

    Phosphoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliP01126.
    SMRiP01126. Positions 16-290.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini16 – 305290RHDPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi298 – 3036Nuclear localization signalSequence Analysis

    Sequence similaritiesi

    Contains 1 RHD (Rel-like) domain.PROSITE-ProRule annotation

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    2.60.40.340. 1 hit.
    InterProiIPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR002909. IPT.
    IPR000451. NF_Rel_Dor.
    IPR008967. p53-like_TF_DNA-bd.
    IPR011539. RHD.
    [Graphical view]
    PfamiPF00554. RHD. 1 hit.
    [Graphical view]
    PRINTSiPR00057. NFKBTNSCPFCT.
    SMARTiSM00429. IPT. 1 hit.
    [Graphical view]
    SUPFAMiSSF49417. SSF49417. 1 hit.
    SSF81296. SSF81296. 1 hit.
    PROSITEiPS01204. REL_1. 1 hit.
    PS50254. REL_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P01126-1 [UniParc]FASTAAdd to Basket

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    MDFLTNLRFT EGISEPYIEI FEQPRQRGTR FRYKCEGRSA GSIPGEHSTD    50
    NNKTFPSIQI LNYFGKVKIR TTLVTKNEPY KPHPHDLVGK GCRDGYYEAE 100
    FGPERQVLSF QNLGIQCVKK KDLKESISLR ISKKINPFNV PEEQLHNIDE 150
    YDLNVVRLCF QAFLPDEHGN YTLALPPLIS NPIYDNRAPN TAELRICRVN 200
    KNCGSVKGGD EIFLLCDKVQ KDDIEVRFVL GNWEAKGSFS QADVHRQVAI 250
    VFRTPPFLGD ITEPITVKMQ LRRPSDQAVS EPVDFRYLPD EEDPSGNKAK 300
    RQRSTLAWQK PIQDCGSAVT ERPKAAPIPT VNPEGKLKKE PNMFSPTLML 350
    PGLGTLSSSQ MYPACSQMPT QPAQLGPGKQ DTLHSCWQQL YSPSPSASSL 400
    LSLHSHSSFT AEVPQPGAQG SSSLPAYNPL NWPDEKNSSF YRNFGNTHGM 450
    GAALVSAAGM QSVSSSSIVQ GTHQASATTA SIMTMPRTPG EVPFLRQQVG 500
    YRS 503
    Length:503
    Mass (Da):55,910
    Last modified:July 21, 1986 - v1
    Checksum:i3F407A25C4FC0AD1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X02759 Genomic RNA. Translation: CAA26534.1.
    PIRiA93974. VCVDA.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X02759 Genomic RNA. Translation: CAA26534.1 .
    PIRi A93974. VCVDA.

    3D structure databases

    ProteinModelPortali P01126.
    SMRi P01126. Positions 16-290.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    2.60.40.340. 1 hit.
    InterProi IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR002909. IPT.
    IPR000451. NF_Rel_Dor.
    IPR008967. p53-like_TF_DNA-bd.
    IPR011539. RHD.
    [Graphical view ]
    Pfami PF00554. RHD. 1 hit.
    [Graphical view ]
    PRINTSi PR00057. NFKBTNSCPFCT.
    SMARTi SM00429. IPT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49417. SSF49417. 1 hit.
    SSF81296. SSF81296. 1 hit.
    PROSITEi PS01204. REL_1. 1 hit.
    PS50254. REL_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of v-rel: the oncogene of reticuloendotheliosis virus."
      Stephens R.M., Rice N.R., Hiebsch R.R., Bose H.R. Jr., Gilden R.V.
      Proc. Natl. Acad. Sci. U.S.A. 80:6229-6233(1983) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    2. "Nucleic acid sequences of the oncogene v-rel in reticuloendotheliosis virus strain T and its cellular homolog, the proto-oncogene c-rel."
      Wilhelmsen K.C., Eggleton K., Temin H.M.
      J. Virol. 52:172-182(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
      Strain: T.

    Entry informationi

    Entry nameiREL_AVIRE
    AccessioniPrimary (citable) accession number: P01126
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3