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P01126

- REL_AVIRE

UniProt

P01126 - REL_AVIRE

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Protein

Transforming protein rel polyprotein

Gene

V-REL

Organism
Avian reticuloendotheliosis virus
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

This transforming protein appears to have a protein-kinase activity.

GO - Molecular functioni

  1. sequence-specific DNA binding transcription factor activity Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Transforming protein rel polyprotein
Alternative name(s):
p58 V-rel
Cleaved into the following 3 chains:
Gene namesi
Name:V-REL
OrganismiAvian reticuloendotheliosis virus
Taxonomic identifieri11636 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirus
Virus hostiGalliformes [TaxID: 8976]

Subcellular locationi

GO - Cellular componenti

  1. host cell cytoplasm Source: UniProtKB-KW
  2. nucleus Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Host cytoplasm

Pathology & Biotechi

Keywords - Diseasei

Oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 1212Env polyprotein N-terminalPRO_0000030307Add
BLAST
Chaini13 – 484472Transforming protein relPRO_0000030308Add
BLAST
Chaini485 – 50319Env polyprotein C-terminalPRO_0000030309Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei275 – 2751Phosphoserine; by host PKASequence Analysis

Keywords - PTMi

Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliP01126.
SMRiP01126. Positions 16-290.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 305290RHDPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi298 – 3036Nuclear localization signalSequence Analysis

Sequence similaritiesi

Contains 1 RHD (Rel-like) domain.PROSITE-ProRule annotation

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
2.60.40.340. 1 hit.
InterProiIPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR000451. NF_Rel_Dor.
IPR008967. p53-like_TF_DNA-bd.
IPR011539. RHD.
[Graphical view]
PfamiPF00554. RHD. 1 hit.
[Graphical view]
PRINTSiPR00057. NFKBTNSCPFCT.
SMARTiSM00429. IPT. 1 hit.
[Graphical view]
SUPFAMiSSF49417. SSF49417. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEiPS01204. REL_1. 1 hit.
PS50254. REL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01126 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDFLTNLRFT EGISEPYIEI FEQPRQRGTR FRYKCEGRSA GSIPGEHSTD
60 70 80 90 100
NNKTFPSIQI LNYFGKVKIR TTLVTKNEPY KPHPHDLVGK GCRDGYYEAE
110 120 130 140 150
FGPERQVLSF QNLGIQCVKK KDLKESISLR ISKKINPFNV PEEQLHNIDE
160 170 180 190 200
YDLNVVRLCF QAFLPDEHGN YTLALPPLIS NPIYDNRAPN TAELRICRVN
210 220 230 240 250
KNCGSVKGGD EIFLLCDKVQ KDDIEVRFVL GNWEAKGSFS QADVHRQVAI
260 270 280 290 300
VFRTPPFLGD ITEPITVKMQ LRRPSDQAVS EPVDFRYLPD EEDPSGNKAK
310 320 330 340 350
RQRSTLAWQK PIQDCGSAVT ERPKAAPIPT VNPEGKLKKE PNMFSPTLML
360 370 380 390 400
PGLGTLSSSQ MYPACSQMPT QPAQLGPGKQ DTLHSCWQQL YSPSPSASSL
410 420 430 440 450
LSLHSHSSFT AEVPQPGAQG SSSLPAYNPL NWPDEKNSSF YRNFGNTHGM
460 470 480 490 500
GAALVSAAGM QSVSSSSIVQ GTHQASATTA SIMTMPRTPG EVPFLRQQVG

YRS
Length:503
Mass (Da):55,910
Last modified:July 21, 1986 - v1
Checksum:i3F407A25C4FC0AD1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X02759 Genomic RNA. Translation: CAA26534.1.
PIRiA93974. VCVDA.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X02759 Genomic RNA. Translation: CAA26534.1 .
PIRi A93974. VCVDA.

3D structure databases

ProteinModelPortali P01126.
SMRi P01126. Positions 16-290.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
2.60.40.340. 1 hit.
InterProi IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR000451. NF_Rel_Dor.
IPR008967. p53-like_TF_DNA-bd.
IPR011539. RHD.
[Graphical view ]
Pfami PF00554. RHD. 1 hit.
[Graphical view ]
PRINTSi PR00057. NFKBTNSCPFCT.
SMARTi SM00429. IPT. 1 hit.
[Graphical view ]
SUPFAMi SSF49417. SSF49417. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEi PS01204. REL_1. 1 hit.
PS50254. REL_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of v-rel: the oncogene of reticuloendotheliosis virus."
    Stephens R.M., Rice N.R., Hiebsch R.R., Bose H.R. Jr., Gilden R.V.
    Proc. Natl. Acad. Sci. U.S.A. 80:6229-6233(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "Nucleic acid sequences of the oncogene v-rel in reticuloendotheliosis virus strain T and its cellular homolog, the proto-oncogene c-rel."
    Wilhelmsen K.C., Eggleton K., Temin H.M.
    J. Virol. 52:172-182(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: T.

Entry informationi

Entry nameiREL_AVIRE
AccessioniPrimary (citable) accession number: P01126
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: October 29, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3