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P01117 (RASK_MSVKI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTPase KRas
Alternative name(s):
Ki-Ras
Transforming protein p21/K-Ras
Gene names
Name:K-RAS
Synonyms:KIS
OrganismKirsten murine sarcoma virus
Taxonomic identifier11808 [NCBI]
Taxonomic lineageVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirus
Virus hostMus musculus (Mouse) [TaxID: 10090]

Protein attributes

Sequence length189 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Enzyme regulation

Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).

Subcellular location

Host cell membrane; Lipid-anchor; Cytoplasmic side By similarity.

Miscellaneous

This p21 transforming protein was generated by a transduction of rodent cellular K-Ras-2 gene.

Sequence similarities

Belongs to the small GTPase superfamily. Ras family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 186186GTPase KRas
PRO_0000030189
Propeptide187 – 1893Removed in mature form Probable
PRO_0000030190

Regions

Nucleotide binding10 – 178GTP
Nucleotide binding57 – 615GTP
Nucleotide binding116 – 1194GTP
Motif32 – 409Effector region

Amino acid modifications

Modified residue591Phosphothreonine; by autocatalysis Ref.3
Modified residue1861Cysteine methyl ester; by host Probable
Lipidation1801S-palmitoyl cysteine; by host Potential
Lipidation1861S-farnesyl cysteine; by host Probable

Sequences

Sequence LengthMass (Da)Tools
P01117 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: BBA3FB03EC374A4E

FASTA18921,715
        10         20         30         40         50         60 
MTEYKLVVVG ASGVGKSALT IQLIQNHFVD EYDPTIQDSY RKQVVIDGET CLLDILDTTG 

        70         80         90        100        110        120 
QEEYSAMRDQ YMRTGEGFLC VFAINNTKSF EDIHHYREQL KRVKDSEDVP MVLVGNKCDL 

       130        140        150        160        170        180 
PSRTVDTKQA QELARSYGIP FIETSAKTRQ RVEDAFYTLV REIRQYRLKK ISKEEKTPGC 


VKIKKCVIM 

« Hide

References

[1]"Nucleotide sequence of the oncogene encoding the p21 transforming protein of Kirsten murine sarcoma virus."
Tsuchida N., Ryder T., Ohtsubo E.
Science 217:937-939(1982) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[2]"Ras genes."
Barbacid M.
Annu. Rev. Biochem. 56:779-827(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[3]"Characterization of the phosphorylation sites and the surrounding amino acid sequences of the p21 transforming proteins coded for by the Harvey and Kirsten strains of murine sarcoma viruses."
Shih T.Y., Stokes P.E., Smythers G.W., Dhar R., Oroszlan S.
J. Biol. Chem. 257:11767-11773(1982) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 50-64, PHOSPHORYLATION AT THR-59.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J02228 Genomic RNA. Translation: AAA46572.1.
PIRTVMV2K. A01366.

3D structure databases

ProteinModelPortalP01117.
SMRP01117. Positions 1-166.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP01117.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERPTHR24070. PTHR24070. 1 hit.
PfamPF00071. Ras. 1 hit.
[Graphical view]
PRINTSPR00449. RASTRNSFRMNG.
SMARTSM00173. RAS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00231. small_GTP. 1 hit.
PROSITEPS51421. RAS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRASK_MSVKI
AccessionPrimary (citable) accession number: P01117
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: April 16, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families