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P01117

- RASK_MSVKI

UniProt

P01117 - RASK_MSVKI

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Protein

GTPase KRas

Gene
K-RAS, KIS
Organism
Kirsten murine sarcoma virus
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Enzyme regulationi

Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 178GTP
Nucleotide bindingi57 – 615GTP
Nucleotide bindingi116 – 1194GTP

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW

GO - Biological processi

  1. GTP catabolic process Source: InterPro
  2. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTPase KRas
Alternative name(s):
Ki-Ras
Transforming protein p21/K-Ras
Gene namesi
Name:K-RAS
Synonyms:KIS
OrganismiKirsten murine sarcoma virus
Taxonomic identifieri11808 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirus
Virus hostiMus musculus (Mouse) [TaxID: 10090]

Subcellular locationi

GO - Cellular componenti

  1. host cell plasma membrane Source: UniProtKB-SubCell
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane

Pathology & Biotechi

Keywords - Diseasei

Oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 186186GTPase KRasPRO_0000030189Add
BLAST
Propeptidei187 – 1893Removed in mature form InferredPRO_0000030190

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei59 – 591Phosphothreonine; by autocatalysis1 Publication
Lipidationi180 – 1801S-palmitoyl cysteine; by host Reviewed prediction
Modified residuei186 – 1861Cysteine methyl ester; by host Inferred
Lipidationi186 – 1861S-farnesyl cysteine; by host Inferred

Keywords - PTMi

Lipoprotein, Methylation, Palmitate, Phosphoprotein, Prenylation

Proteomic databases

PRIDEiP01117.

Structurei

3D structure databases

ProteinModelPortaliP01117.
SMRiP01117. Positions 1-166.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi32 – 409Effector region

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00173. RAS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01117-1 [UniParc]FASTAAdd to Basket

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MTEYKLVVVG ASGVGKSALT IQLIQNHFVD EYDPTIQDSY RKQVVIDGET    50
CLLDILDTTG QEEYSAMRDQ YMRTGEGFLC VFAINNTKSF EDIHHYREQL 100
KRVKDSEDVP MVLVGNKCDL PSRTVDTKQA QELARSYGIP FIETSAKTRQ 150
RVEDAFYTLV REIRQYRLKK ISKEEKTPGC VKIKKCVIM 189
Length:189
Mass (Da):21,715
Last modified:July 21, 1986 - v1
Checksum:iBBA3FB03EC374A4E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J02228 Genomic RNA. Translation: AAA46572.1.
PIRiA01366. TVMV2K.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J02228 Genomic RNA. Translation: AAA46572.1 .
PIRi A01366. TVMV2K.

3D structure databases

ProteinModelPortali P01117.
SMRi P01117. Positions 1-166.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P01117.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view ]
PANTHERi PTHR24070. PTHR24070. 1 hit.
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SMARTi SM00173. RAS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51421. RAS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of the oncogene encoding the p21 transforming protein of Kirsten murine sarcoma virus."
    Tsuchida N., Ryder T., Ohtsubo E.
    Science 217:937-939(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. Cited for: REVIEW.
  3. "Characterization of the phosphorylation sites and the surrounding amino acid sequences of the p21 transforming proteins coded for by the Harvey and Kirsten strains of murine sarcoma viruses."
    Shih T.Y., Stokes P.E., Smythers G.W., Dhar R., Oroszlan S.
    J. Biol. Chem. 257:11767-11773(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 50-64, PHOSPHORYLATION AT THR-59.

Entry informationi

Entry nameiRASK_MSVKI
AccessioniPrimary (citable) accession number: P01117
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: April 16, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

This p21 transforming protein was generated by a transduction of rodent cellular K-Ras-2 gene.

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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