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P01115

- RASH_MSVHA

UniProt

P01115 - RASH_MSVHA

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Protein
Transforming protein p29
Gene
H-RAS
Organism
Harvey murine sarcoma virus
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Enzyme regulationi

Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. GTP catabolic process Source: InterPro
  2. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transforming protein p29
Cleaved into the following chain:
Gene namesi
Name:H-RAS
OrganismiHarvey murine sarcoma virus
Taxonomic identifieri11807 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirus
Virus hostiMus musculus (Mouse) [TaxID: 10090]

Subcellular locationi

Host cell membrane; Lipid-anchor; Cytoplasmic side
Note: Inner surface of plasma membrane.

GO - Cellular componenti

  1. host cell plasma membrane Source: UniProtKB-SubCell
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane

Pathology & Biotechi

Keywords - Diseasei

Oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 238238Transforming protein p29
PRO_0000030183Add
BLAST
Chaini53 – 238186Transforming protein p21
PRO_0000030184Add
BLAST
Propeptidei239 – 2413Removed in mature form Inferred
PRO_0000030185

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi233 – 2331S-palmitoyl cysteine; by host Reviewed prediction
Lipidationi236 – 2361S-palmitoyl cysteine; by host Reviewed prediction
Modified residuei238 – 2381Cysteine methyl ester; by host Inferred
Lipidationi238 – 2381S-farnesyl cysteine; by host Inferred

Keywords - PTMi

Lipoprotein, Methylation, Palmitate, Prenylation

Proteomic databases

PRIDEiP01115.

Structurei

3D structure databases

ProteinModelPortaliP01115.
SMRiP01115. Positions 53-218.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00173. RAS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01115-1 [UniParc]FASTAAdd to Basket

« Hide

MPAARAAPAA DEPMRDPVAP VRAPALPRPA PGAVAPASGG ARAPGLAAPV    50
EAMTEYKLVV VGARGVGKSA LTIQLIQNHF VDEYDPTIED SYRKQVVIDG 100
ETCLLDILDT TGQEEYSAMR DQYMRTGEGF LCVFAINNTK SFEDIHQYRE 150
QIKRVKDSDD VPMVLVGNKC DLAGRTVESR QAQDLARSYG IPYIETSAKT 200
RQGVEDAFYT LVREIRQHKL RKLNPPDESG PGCMSCKCVL S 241
Length:241
Mass (Da):26,328
Last modified:July 21, 1986 - v1
Checksum:i5A8983BFCD826C04
GO

Sequence cautioni

The sequence AAA46570.1 differs from that shown. Reason: Erroneous initiation.
The sequence CAA25322.1 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti174 – 1741G → A in CAA25322. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X00740 Genomic DNA. Translation: CAA25322.1. Different initiation.
J02207 Genomic RNA. Translation: AAA46569.1.
J02207 Genomic RNA. Translation: AAA46570.1. Different initiation.
M24154 Genomic RNA. Translation: AAA46568.1.
PIRiA01363. TVMV3H.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X00740 Genomic DNA. Translation: CAA25322.1 . Different initiation.
J02207 Genomic RNA. Translation: AAA46569.1 .
J02207 Genomic RNA. Translation: AAA46570.1 . Different initiation.
M24154 Genomic RNA. Translation: AAA46568.1 .
PIRi A01363. TVMV3H.

3D structure databases

ProteinModelPortali P01115.
SMRi P01115. Positions 53-218.
ModBasei Search...

Proteomic databases

PRIDEi P01115.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view ]
PANTHERi PTHR24070. PTHR24070. 1 hit.
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SMARTi SM00173. RAS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51421. RAS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of the p21 transforming protein of Harvey murine sarcoma virus."
    Dhar R., Ellis R.W., Shih T.Y., Oroszlan S., Shapiro B., Maizel J., Lowy D., Scolnick E.
    Science 217:934-937(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "An altered DNA sequence encompassing the ras gene of Harvey murine sarcoma virus."
    Yasuda S., Furuichi M., Soeda E.
    Nucleic Acids Res. 12:5583-5588(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Cited for: REVIEW.
  4. "Localization of the src gene product of the Harvey strain of MSV to plasma membrane of transformed cells by electron microscopic immunocytochemistry."
    Willingham M.C., Pastan I., Shih T.Y., Scolnick E.M.
    Cell 19:1005-1014(1980) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.

Entry informationi

Entry nameiRASH_MSVHA
AccessioniPrimary (citable) accession number: P01115
Secondary accession number(s): O40604
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: April 16, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

This p21 transforming protein was generated by a transduction of rodent cellular H-ras-1 gene.

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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