Reviewed,
UniProtKB/Swiss-Prot P01115 (RASH_MSVHA)
Last modified
November 24, 2009.
Version 79.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Transforming protein p29 Cleaved into the following chain: 1- Recommended name: Transforming protein p21 | ||
| Gene names |
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| Organism | Harvey murine sarcoma virus | ||
| Taxonomic identifier | 11807 [NCBI] | ||
| Taxonomic lineage | Viruses › Retro-transcribing viruses › Retroviridae › Orthoretrovirinae › Gammaretrovirus | ||
| Virus host | Mus musculus (Mouse) [TaxID: 10090] |
Protein attributes
| Sequence length | 241 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Enzyme regulation | Alternate between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP). |
| Subcellular location | Host cell membrane; Lipid-anchor; Cytoplasmic side. Note: Inner surface of plasma membrane. |
| Miscellaneous | This p21 transforming protein was generated by a transduction of rodent cellular H-ras-1 gene. |
| Sequence similarities | Belongs to the small GTPase superfamily. Ras family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Host cell membrane Host membrane Membrane |
| Disease | Oncogene |
| Ligand | GTP-binding Nucleotide-binding |
| PTM | Lipoprotein Methylation Palmitate Prenylation |
| Gene Ontology (GO) | |
| Biological process | small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro |
| Cellular component | intracellular Inferred from electronic annotation. Source: InterPro plasma membraneInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 238 | 238 | Transforming protein p29 | PRO_0000030183 | |||||
| Chain | 53 – 238 | 186 | Transforming protein p21 | PRO_0000030184 | |||||
| Propeptide | 239 – 241 | 3 | Removed in mature form Probable | PRO_0000030185 | |||||
Amino acid modifications | |||||||||
| Modified residue | 238 | 1 | Cysteine methyl ester; by host Probable | ||||||
| Lipidation | 233 | 1 | S-palmitoyl cysteine; by host Potential | ||||||
| Lipidation | 236 | 1 | S-palmitoyl cysteine; by host Potential | ||||||
| Lipidation | 238 | 1 | S-farnesyl cysteine; by host Probable | ||||||
Experimental info | |||||||||
| Sequence conflict | 174 | 1 | G → A in CAA25322. Ref.2 | ||||||
Sequences
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References
| [1] | "Nucleotide sequence of the p21 transforming protein of Harvey murine sarcoma virus." Dhar R., Ellis R.W., Shih T.Y., Oroszlan S., Shapiro B., Maizel J., Lowy D., Scolnick E. Science 217:934-937(1982) [PubMed: 6287572] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. |
| [2] | "An altered DNA sequence encompassing the ras gene of Harvey murine sarcoma virus." Yasuda S., Furuichi M., Soeda E. Nucleic Acids Res. 12:5583-5588(1984) [PubMed: 6087292] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [3] | "Ras genes." Barbacid M. Annu. Rev. Biochem. 56:779-827(1987) [PubMed: 3304147] [Abstract] Cited for: REVIEW. |
| [4] | "Localization of the src gene product of the Harvey strain of MSV to plasma membrane of transformed cells by electron microscopic immunocytochemistry." Willingham M.C., Pastan I., Shih T.Y., Scolnick E.M. Cell 19:1005-1014(1980) [PubMed: 6247068] [Abstract] Cited for: CHARACTERIZATION. |
Cross-references
Sequence databases | |
|---|---|
| X00740 Genomic DNA. Translation: CAA25322.1. Different initiation. J02207 Genomic RNA. Translation: AAA46569.1. J02207 Genomic RNA. Translation: AAA46570.1. Different initiation. M24154 Genomic RNA. Translation: AAA46568.1. | |
| PIR | TVMV3H. A01363. |
3D structure databases | |
| SMR | P01115. Positions 53-218. |
| ModBase | Search... |
Family and domain databases | |
| InterPro | IPR003577. GTPase_Ras. IPR013753. Ras. IPR001806. Ras_GTPase. IPR015592. Ras_Ras_related. IPR020849. Ras_small_GTPase. IPR005225. Small_GTP_bd. [Graphical view] |
| PANTHER | PTHR11708:SF125. Ras_Ras_related. 1 hit. |
| Pfam | PF00071. Ras. 1 hit. [Graphical view] |
| PRINTS | PR00449. RASTRNSFRMNG. |
| SMART | SM00173. RAS. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00231. small_GTP. 1 hit. |
| PROSITE | PS51421. RAS. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | RASH_MSVHA | ||||||||
| Accession | Primary (citable) accession number: P01115 Secondary accession number(s): O40604 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Virus (Virus annotation project) | ||||||||

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