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P01114

- RASH_RRASV

UniProt

P01114 - RASH_RRASV

Protein

Transforming protein p29

Gene

RAS

Organism
Rasheed rat sarcoma virus
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (21 Jul 1986)
      Previous versions | rss
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    Functioni

    Enzyme regulationi

    Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-KW
    2. structural molecule activity Source: InterPro

    GO - Biological processi

    1. GTP catabolic process Source: InterPro
    2. small GTPase mediated signal transduction Source: InterPro

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transforming protein p29
    Cleaved into the following chain:
    Gene namesi
    Name:RAS
    OrganismiRasheed rat sarcoma virus
    Taxonomic identifieri11816 [NCBI]
    Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirusMurine leukemia virus
    Virus hostiRattus norvegicus (Rat) [TaxID: 10116]

    Subcellular locationi

    GO - Cellular componenti

    1. host cell plasma membrane Source: UniProtKB-SubCell
    2. membrane Source: UniProtKB-KW
    3. viral capsid Source: InterPro

    Keywords - Cellular componenti

    Host cell membrane, Host membrane, Membrane

    Pathology & Biotechi

    Keywords - Diseasei

    Oncogene

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 245245Transforming protein p29PRO_0000030186Add
    BLAST
    Chaini59 – 245187Transforming protein p21PRO_0000030187Add
    BLAST
    Propeptidei246 – 2483Removed in mature formCuratedPRO_0000030188

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi240 – 2401S-palmitoyl cysteine; by hostSequence Analysis
    Lipidationi243 – 2431S-palmitoyl cysteine; by hostSequence Analysis
    Modified residuei245 – 2451Cysteine methyl ester; by hostCurated
    Lipidationi245 – 2451S-farnesyl cysteine; by hostCurated

    Keywords - PTMi

    Lipoprotein, Methylation, Palmitate, Prenylation

    Structurei

    3D structure databases

    ProteinModelPortaliP01114.
    SMRiP01114. Positions 7-36, 60-225.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Ras family.Curated

    Family and domain databases

    Gene3Di1.10.150.180. 1 hit.
    3.40.50.300. 1 hit.
    InterProiIPR000840. G_retro_matrix_N.
    IPR027417. P-loop_NTPase.
    IPR010999. Retrovr_matrix_N.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR020849. Small_GTPase_Ras.
    [Graphical view]
    PANTHERiPTHR24070. PTHR24070. 1 hit.
    PfamiPF01140. Gag_MA. 1 hit.
    PF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SMARTiSM00173. RAS. 1 hit.
    [Graphical view]
    SUPFAMiSSF47836. SSF47836. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51421. RAS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P01114-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGQSLTTPLS LTLDHWKDVR DRARDQSVEI KKGPLRRSGT VAPASGGAGA    50
    PGLAAPVEAM TEYKLVVVGA RGVGKSALTI QLIQNHFVDE YDPTIEDSYR 100
    KQVVIDGETC LLDILDTAGQ EEYSAMRDQY MRTGEGFLCV FAINNTKSFE 150
    DIHQYREQIK RVKDSDDVPM VLVGNKCDLA AHTVESRQAQ DLARSYGIPY 200
    IETSAKTRPG VEDAFYTLVR EIRQHKLRKL NPPDESGPGC MSCKCVLS 248
    Length:248
    Mass (Da):27,424
    Last modified:July 21, 1986 - v1
    Checksum:i9A0CC2CD8EFD7F5C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J02294 Genomic RNA. Translation: AAA47420.1.
    PIRiA01362. TVMVRS.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J02294 Genomic RNA. Translation: AAA47420.1 .
    PIRi A01362. TVMVRS.

    3D structure databases

    ProteinModelPortali P01114.
    SMRi P01114. Positions 7-36, 60-225.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.10.150.180. 1 hit.
    3.40.50.300. 1 hit.
    InterProi IPR000840. G_retro_matrix_N.
    IPR027417. P-loop_NTPase.
    IPR010999. Retrovr_matrix_N.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR020849. Small_GTPase_Ras.
    [Graphical view ]
    PANTHERi PTHR24070. PTHR24070. 1 hit.
    Pfami PF01140. Gag_MA. 1 hit.
    PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SMARTi SM00173. RAS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47836. SSF47836. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51421. RAS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of the Rasheed rat sarcoma virus oncogene: new mutations."
      Rasheed S., Norman G.L., Heidecker G.
      Science 221:155-157(1983) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    2. Cited for: REVIEW.

    Entry informationi

    Entry nameiRASH_RRASV
    AccessioniPrimary (citable) accession number: P01114
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    This p21 transforming protein was generated by a transduction of rodent cellular H-ras-1 gene.

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3