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Protein

Transforming protein p29

Gene

RAS

Organism
Rasheed rat sarcoma virus
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Miscellaneous

This p21 transforming protein was generated by a transduction of rodent cellular H-ras-1 gene.

Enzyme regulationi

Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transforming protein p29
Cleaved into the following chain:
Gene namesi
Name:RAS
OrganismiRasheed rat sarcoma virus
Taxonomic identifieri11816 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirusMurine leukemia virus
Virus hostiRattus norvegicus (Rat) [TaxID: 10116]

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane

Pathology & Biotechi

Keywords - Diseasei

Oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000301861 – 245Transforming protein p29Add BLAST245
ChainiPRO_000003018759 – 245Transforming protein p21Add BLAST187
PropeptideiPRO_0000030188246 – 248Removed in mature formCurated3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi240S-palmitoyl cysteine; by hostSequence analysis1
Lipidationi243S-palmitoyl cysteine; by hostSequence analysis1
Modified residuei245Cysteine methyl ester; by hostCurated1
Lipidationi245S-farnesyl cysteine; by hostSequence analysis1

Keywords - PTMi

Lipoprotein, Methylation, Palmitate, Prenylation

Proteomic databases

PRIDEiP01114.

Structurei

3D structure databases

ProteinModelPortaliP01114.
SMRiP01114.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ras family.Curated

Family and domain databases

Gene3Di1.10.150.180. 1 hit.
InterProiView protein in InterPro
IPR000840. G_retro_matrix.
IPR036946. G_retro_matrix_sf.
IPR027417. P-loop_NTPase.
IPR010999. Retrovr_matrix.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiView protein in Pfam
PF01140. Gag_MA. 1 hit.
PF00071. Ras. 1 hit.
SUPFAMiSSF47836. SSF47836. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiView protein in PROSITE
PS51421. RAS. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01114-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGQSLTTPLS LTLDHWKDVR DRARDQSVEI KKGPLRRSGT VAPASGGAGA
60 70 80 90 100
PGLAAPVEAM TEYKLVVVGA RGVGKSALTI QLIQNHFVDE YDPTIEDSYR
110 120 130 140 150
KQVVIDGETC LLDILDTAGQ EEYSAMRDQY MRTGEGFLCV FAINNTKSFE
160 170 180 190 200
DIHQYREQIK RVKDSDDVPM VLVGNKCDLA AHTVESRQAQ DLARSYGIPY
210 220 230 240
IETSAKTRPG VEDAFYTLVR EIRQHKLRKL NPPDESGPGC MSCKCVLS
Length:248
Mass (Da):27,424
Last modified:July 21, 1986 - v1
Checksum:i9A0CC2CD8EFD7F5C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02294 Genomic RNA. Translation: AAA47420.1.
PIRiA01362. TVMVRS.

Similar proteinsi

Entry informationi

Entry nameiRASH_RRASV
AccessioniPrimary (citable) accession number: P01114
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: October 25, 2017
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families