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P01114 (RASH_RRASV) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transforming protein p29

Cleaved into the following chain:

  1. Transforming protein p21
Gene names
Name:RAS
OrganismRasheed rat sarcoma virus
Taxonomic identifier11816 [NCBI]
Taxonomic lineageVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirusMurine leukemia virus
Virus hostRattus norvegicus (Rat) [TaxID: 10116]

Protein attributes

Sequence length248 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Enzyme regulation

Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).

Subcellular location

Host cell membrane; Lipid-anchor; Cytoplasmic side Potential.

Miscellaneous

This p21 transforming protein was generated by a transduction of rodent cellular H-ras-1 gene.

Sequence similarities

Belongs to the small GTPase superfamily. Ras family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 245245Transforming protein p29
PRO_0000030186
Chain59 – 245187Transforming protein p21
PRO_0000030187
Propeptide246 – 2483Removed in mature form Probable
PRO_0000030188

Amino acid modifications

Modified residue2451Cysteine methyl ester; by host Probable
Lipidation2401S-palmitoyl cysteine; by host Potential
Lipidation2431S-palmitoyl cysteine; by host Potential
Lipidation2451S-farnesyl cysteine; by host Probable

Sequences

Sequence LengthMass (Da)Tools
P01114 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: 9A0CC2CD8EFD7F5C

FASTA24827,424
        10         20         30         40         50         60 
MGQSLTTPLS LTLDHWKDVR DRARDQSVEI KKGPLRRSGT VAPASGGAGA PGLAAPVEAM 

        70         80         90        100        110        120 
TEYKLVVVGA RGVGKSALTI QLIQNHFVDE YDPTIEDSYR KQVVIDGETC LLDILDTAGQ 

       130        140        150        160        170        180 
EEYSAMRDQY MRTGEGFLCV FAINNTKSFE DIHQYREQIK RVKDSDDVPM VLVGNKCDLA 

       190        200        210        220        230        240 
AHTVESRQAQ DLARSYGIPY IETSAKTRPG VEDAFYTLVR EIRQHKLRKL NPPDESGPGC 


MSCKCVLS 

« Hide

References

[1]"Nucleotide sequence of the Rasheed rat sarcoma virus oncogene: new mutations."
Rasheed S., Norman G.L., Heidecker G.
Science 221:155-157(1983) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[2]"Ras genes."
Barbacid M.
Annu. Rev. Biochem. 56:779-827(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J02294 Genomic RNA. Translation: AAA47420.1.
PIRTVMVRS. A01362.

3D structure databases

ProteinModelPortalP01114.
SMRP01114. Positions 7-36, 60-225.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.150.180. 1 hit.
3.40.50.300. 1 hit.
InterProIPR000840. G_retro_matrix_N.
IPR027417. P-loop_NTPase.
IPR010999. Retrovr_matrix_N.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERPTHR24070. PTHR24070. 1 hit.
PfamPF01140. Gag_MA. 1 hit.
PF00071. Ras. 1 hit.
[Graphical view]
PRINTSPR00449. RASTRNSFRMNG.
SMARTSM00173. RAS. 1 hit.
[Graphical view]
SUPFAMSSF47836. SSF47836. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00231. small_GTP. 1 hit.
PROSITEPS51421. RAS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRASH_RRASV
AccessionPrimary (citable) accession number: P01114
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: April 16, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families