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P01114

- RASH_RRASV

UniProt

P01114 - RASH_RRASV

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Protein
Transforming protein p29
Gene
RAS
Organism
Rasheed rat sarcoma virus
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Enzyme regulationi

Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. structural molecule activity Source: InterPro

GO - Biological processi

  1. GTP catabolic process Source: InterPro
  2. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transforming protein p29
Cleaved into the following chain:
Gene namesi
Name:RAS
OrganismiRasheed rat sarcoma virus
Taxonomic identifieri11816 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirusMurine leukemia virus
Virus hostiRattus norvegicus (Rat) [TaxID: 10116]

Subcellular locationi

GO - Cellular componenti

  1. host cell plasma membrane Source: UniProtKB-SubCell
  2. membrane Source: UniProtKB-KW
  3. viral capsid Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane

Pathology & Biotechi

Keywords - Diseasei

Oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 245245Transforming protein p29
PRO_0000030186Add
BLAST
Chaini59 – 245187Transforming protein p21
PRO_0000030187Add
BLAST
Propeptidei246 – 2483Removed in mature form Inferred
PRO_0000030188

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi240 – 2401S-palmitoyl cysteine; by host Reviewed prediction
Lipidationi243 – 2431S-palmitoyl cysteine; by host Reviewed prediction
Modified residuei245 – 2451Cysteine methyl ester; by host Inferred
Lipidationi245 – 2451S-farnesyl cysteine; by host Inferred

Keywords - PTMi

Lipoprotein, Methylation, Palmitate, Prenylation

Structurei

3D structure databases

ProteinModelPortaliP01114.
SMRiP01114. Positions 7-36, 60-225.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di1.10.150.180. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR000840. G_retro_matrix_N.
IPR027417. P-loop_NTPase.
IPR010999. Retrovr_matrix_N.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF01140. Gag_MA. 1 hit.
PF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00173. RAS. 1 hit.
[Graphical view]
SUPFAMiSSF47836. SSF47836. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01114-1 [UniParc]FASTAAdd to Basket

« Hide

MGQSLTTPLS LTLDHWKDVR DRARDQSVEI KKGPLRRSGT VAPASGGAGA    50
PGLAAPVEAM TEYKLVVVGA RGVGKSALTI QLIQNHFVDE YDPTIEDSYR 100
KQVVIDGETC LLDILDTAGQ EEYSAMRDQY MRTGEGFLCV FAINNTKSFE 150
DIHQYREQIK RVKDSDDVPM VLVGNKCDLA AHTVESRQAQ DLARSYGIPY 200
IETSAKTRPG VEDAFYTLVR EIRQHKLRKL NPPDESGPGC MSCKCVLS 248
Length:248
Mass (Da):27,424
Last modified:July 21, 1986 - v1
Checksum:i9A0CC2CD8EFD7F5C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J02294 Genomic RNA. Translation: AAA47420.1.
PIRiA01362. TVMVRS.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J02294 Genomic RNA. Translation: AAA47420.1 .
PIRi A01362. TVMVRS.

3D structure databases

ProteinModelPortali P01114.
SMRi P01114. Positions 7-36, 60-225.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.10.150.180. 1 hit.
3.40.50.300. 1 hit.
InterProi IPR000840. G_retro_matrix_N.
IPR027417. P-loop_NTPase.
IPR010999. Retrovr_matrix_N.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view ]
PANTHERi PTHR24070. PTHR24070. 1 hit.
Pfami PF01140. Gag_MA. 1 hit.
PF00071. Ras. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SMARTi SM00173. RAS. 1 hit.
[Graphical view ]
SUPFAMi SSF47836. SSF47836. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51421. RAS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of the Rasheed rat sarcoma virus oncogene: new mutations."
    Rasheed S., Norman G.L., Heidecker G.
    Science 221:155-157(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. Cited for: REVIEW.

Entry informationi

Entry nameiRASH_RRASV
AccessioniPrimary (citable) accession number: P01114
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: April 16, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

This p21 transforming protein was generated by a transduction of rodent cellular H-ras-1 gene.

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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