Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

GTPase NRas

Gene

NRAS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.

Enzyme regulationi

Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 18GTP1 Publication9
Nucleotide bindingi29 – 30GTP1 Publication2
Nucleotide bindingi57 – 61GTPSequence analysis5
Nucleotide bindingi116 – 119GTP1 Publication4

GO - Molecular functioni

  • GTP binding Source: UniProtKB-KW
  • protein complex binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000168638-MONOMER.
ReactomeiR-HSA-112412. SOS-mediated signalling.
R-HSA-1169092. Activation of RAS in B cells.
R-HSA-1236382. Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants.
R-HSA-1250196. SHC1 events in ERBB2 signaling.
R-HSA-1250347. SHC1 events in ERBB4 signaling.
R-HSA-1433557. Signaling by SCF-KIT.
R-HSA-167044. Signalling to RAS.
R-HSA-171007. p38MAPK events.
R-HSA-179812. GRB2 events in EGFR signaling.
R-HSA-180336. SHC1 events in EGFR signaling.
R-HSA-186763. Downstream signal transduction.
R-HSA-1963640. GRB2 events in ERBB2 signaling.
R-HSA-210993. Tie2 Signaling.
R-HSA-2179392. EGFR Transactivation by Gastrin.
R-HSA-2424491. DAP12 signaling.
R-HSA-2428933. SHC-related events triggered by IGF1R.
R-HSA-2871796. FCERI mediated MAPK activation.
R-HSA-375165. NCAM signaling for neurite out-growth.
R-HSA-5218921. VEGFR2 mediated cell proliferation.
R-HSA-5621575. CD209 (DC-SIGN) signaling.
R-HSA-5637810. Constitutive Signaling by EGFRvIII.
R-HSA-5654688. SHC-mediated cascade:FGFR1.
R-HSA-5654693. FRS-mediated FGFR1 signaling.
R-HSA-5654699. SHC-mediated cascade:FGFR2.
R-HSA-5654700. FRS-mediated FGFR2 signaling.
R-HSA-5654704. SHC-mediated cascade:FGFR3.
R-HSA-5654706. FRS-mediated FGFR3 signaling.
R-HSA-5654712. FRS-mediated FGFR4 signaling.
R-HSA-5654719. SHC-mediated cascade:FGFR4.
R-HSA-5655253. Signaling by FGFR2 in disease.
R-HSA-5655291. Signaling by FGFR4 in disease.
R-HSA-5655302. Signaling by FGFR1 in disease.
R-HSA-5658442. Regulation of RAS by GAPs.
R-HSA-5673000. RAF activation.
R-HSA-5673001. RAF/MAP kinase cascade.
R-HSA-5674135. MAP2K and MAPK activation.
R-HSA-5675221. Negative regulation of MAPK pathway.
R-HSA-6798695. Neutrophil degranulation.
R-HSA-6802946. Signaling by moderate kinase activity BRAF mutants.
R-HSA-6802948. Signaling by high-kinase activity BRAF mutants.
R-HSA-6802949. Signaling by RAS mutants.
R-HSA-6802952. Signaling by BRAF and RAF fusions.
R-HSA-6802953. RAS signaling downstream of NF1 loss-of-function variants.
R-HSA-6802955. Paradoxical activation of RAF signaling by kinase inactive BRAF.
R-HSA-74751. Insulin receptor signalling cascade.
R-HSA-8849471. PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases.
R-HSA-8851805. MET activates RAS signaling.
R-HSA-8853334. Signaling by FGFR3 fusions in cancer.
R-HSA-8853338. Signaling by FGFR3 point mutants in cancer.
SignaLinkiP01111.
SIGNORiP01111.

Names & Taxonomyi

Protein namesi
Recommended name:
GTPase NRas
Alternative name(s):
Transforming protein N-Ras
Gene namesi
Name:NRAS
Synonyms:HRAS1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:7989. NRAS.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • Golgi apparatus Source: CACAO
  • Golgi membrane Source: UniProtKB-SubCell
  • membrane Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

Pathology & Biotechi

Involvement in diseasei

Leukemia, juvenile myelomonocytic (JMML)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn aggressive pediatric myelodysplastic syndrome/myeloproliferative disorder characterized by malignant transformation in the hematopoietic stem cell compartment with proliferation of differentiated progeny. Patients have splenomegaly, enlarged lymph nodes, rashes, and hemorrhages.
See also OMIM:607785
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07112912G → D in KNEN and JMML. 2 PublicationsCorresponds to variant rs121913237dbSNPEnsembl.1
Natural variantiVAR_06308413G → D in RALD and JMML. 2 PublicationsCorresponds to variant rs121434596dbSNPEnsembl.1
Noonan syndrome 6 (NS6)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of Noonan syndrome, a disease characterized by short stature, facial dysmorphic features such as hypertelorism, a downward eyeslant and low-set posteriorly rotated ears, and a high incidence of congenital heart defects and hypertrophic cardiomyopathy. Other features can include a short neck with webbing or redundancy of skin, deafness, motor delay, variable intellectual deficits, multiple skeletal defects, cryptorchidism, and bleeding diathesis. Individuals with Noonan syndrome are at risk of juvenile myelomonocytic leukemia, a myeloproliferative disorder characterized by excessive production of myelomonocytic cells.
See also OMIM:613224
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06308550T → I in NS6; hypermorphic mutation. 1 PublicationCorresponds to variant rs267606921dbSNPEnsembl.1
Natural variantiVAR_06308660G → E in NS6; hypermorphic mutation. 1 PublicationCorresponds to variant rs267606920dbSNPEnsembl.1
RAS-associated autoimmune leukoproliferative disorder (RALD)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder of apoptosis, characterized by chronic accumulation of non-malignant lymphocytes, defective lymphocyte apoptosis, and an increased risk for the development of hematologic malignancies.
See also OMIM:614470
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06308413G → D in RALD and JMML. 2 PublicationsCorresponds to variant rs121434596dbSNPEnsembl.1
Melanocytic nevus syndrome, congenital (CMNS)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA syndrome characterized by congenital pigmentary skin lesions which can occur at any site and can cover most of the body surface. These lesions may or may not be hairy. Congenital melanocytic nevi are associated with neuromelanosis (the presence of melanin-producing cells within the brain parenchyma or leptomeninges). Less commonly they are associated with malignant melanoma in childhood, both in the skin and the central nervous system. CMNS patients also tend to have a characteristic facial appearance, including wide or prominent forehead, periorbital fullness, small short nose with narrow nasal bridge, round face, full cheeks, prominent premaxilla, and everted lower lip.
See also OMIM:137550
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00684513G → R in CMNS and colorectal cancer; somatic mutation. 2 PublicationsCorresponds to variant rs121434595dbSNPEnsembl.1
Natural variantiVAR_00684661Q → K in CMNS and NCMS; somatic mutation. 1 PublicationCorresponds to variant rs121913254dbSNPEnsembl.1
Natural variantiVAR_00684761Q → R in CMNS, NCMS, KNEN and NMTC2; also found in lung carcinoma cell and melanoma. 5 PublicationsCorresponds to variant rs11554290dbSNPEnsembl.1
Melanosis, neurocutaneous (NCMS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare congenital disease characterized by the presence of giant or multiple melanocytic nevi on the skin, foci of melanin-producing cells within the brain parenchyma, and infiltration of leptomeninges by abnormal melanin deposits. Neurologic abnormalities include seizures, hydrocephalus, arachnoid cysts, tumors, and syringomyelia. Some patients may develop malignant melanoma.
See also OMIM:249400
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00684661Q → K in CMNS and NCMS; somatic mutation. 1 PublicationCorresponds to variant rs121913254dbSNPEnsembl.1
Natural variantiVAR_00684761Q → R in CMNS, NCMS, KNEN and NMTC2; also found in lung carcinoma cell and melanoma. 5 PublicationsCorresponds to variant rs11554290dbSNPEnsembl.1
Keratinocytic non-epidermolytic nevus (KNEN)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionEpidermal nevi of the common, non-organoid and non-epidermolytic type are benign skin lesions and may vary in their extent from a single (usually linear) lesion to widespread and systematized involvement. They may be present at birth or develop early during childhood.
See also OMIM:162900
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07112912G → D in KNEN and JMML. 2 PublicationsCorresponds to variant rs121913237dbSNPEnsembl.1
Natural variantiVAR_07113034P → L in KNEN. 1 PublicationCorresponds to variant rs397514553dbSNPEnsembl.1
Natural variantiVAR_00684761Q → R in CMNS, NCMS, KNEN and NMTC2; also found in lung carcinoma cell and melanoma. 5 PublicationsCorresponds to variant rs11554290dbSNPEnsembl.1
Thyroid cancer, non-medullary, 2 (NMTC2)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA form of non-medullary thyroid cancer (NMTC), a cancer characterized by tumors originating from the thyroid follicular cells. NMTCs represent approximately 95% of all cases of thyroid cancer and are classified into papillary, follicular, Hurthle cell, and anaplastic neoplasms.
See also OMIM:188470
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00684761Q → R in CMNS, NCMS, KNEN and NMTC2; also found in lung carcinoma cell and melanoma. 5 PublicationsCorresponds to variant rs11554290dbSNPEnsembl.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi164R → A: Loss of GTP-binding activity. 1

Keywords - Diseasei

Disease mutation, Proto-oncogene

Organism-specific databases

DisGeNETi4893.
MalaCardsiNRAS.
MIMi137550. phenotype.
162900. phenotype.
188470. phenotype.
249400. phenotype.
607785. phenotype.
613224. phenotype.
614470. phenotype.
OpenTargetsiENSG00000213281.
Orphaneti86834. Juvenile myelomonocytic leukemia.
626. Large congenital melanocytic nevus.
648. Noonan syndrome.
268114. RAS-associated autoimmune leukoproliferative disease.
PharmGKBiPA31768.

Chemistry databases

ChEMBLiCHEMBL2079845.
GuidetoPHARMACOLOGYi2823.

Polymorphism and mutation databases

BioMutaiNRAS.
DMDMi131883.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000430061 – 186GTPase NRasAdd BLAST186
PropeptideiPRO_0000043007187 – 189Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi181S-palmitoyl cysteine2 Publications1
Modified residuei186Cysteine methyl esterBy similarity1
Lipidationi186S-farnesyl cysteine1 Publication1

Post-translational modificationi

Palmitoylated by the ZDHHC9-GOLGA7 complex. A continuous cycle of de- and re-palmitoylation regulates rapid exchange between plasma membrane and Golgi.3 Publications
Acetylation at Lys-104 prevents interaction with guanine nucleotide exchange factors (GEFs).By similarity

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Palmitate, Prenylation

Proteomic databases

EPDiP01111.
PaxDbiP01111.
PeptideAtlasiP01111.
PRIDEiP01111.

2D gel databases

OGPiP01111.

PTM databases

iPTMnetiP01111.
PhosphoSitePlusiP01111.
SwissPalmiP01111.

Expressioni

Gene expression databases

BgeeiENSG00000213281.
CleanExiHS_NRAS.
ExpressionAtlasiP01111. baseline and differential.
GenevisibleiP01111. HS.

Organism-specific databases

HPAiCAB010157.
HPA049830.

Interactioni

Subunit structurei

Interacts (active GTP-bound form preferentially) with RGS14 (By similarity). Interacts (active GTP-bound form) with RASSF7.By similarity1 Publication

GO - Molecular functioni

  • protein complex binding Source: MGI

Protein-protein interaction databases

BioGridi110952. 33 interactors.
DIPiDIP-1058N.
IntActiP01111. 31 interactors.
MINTiMINT-131535.
STRINGi9606.ENSP00000358548.

Chemistry databases

BindingDBiP01111.

Structurei

Secondary structure

1189
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 9Combined sources8
Helixi16 – 25Combined sources10
Beta strandi38 – 46Combined sources9
Beta strandi49 – 57Combined sources9
Beta strandi76 – 83Combined sources8
Helixi87 – 104Combined sources18
Beta strandi111 – 116Combined sources6
Helixi127 – 137Combined sources11
Beta strandi141 – 143Combined sources3
Turni146 – 148Combined sources3
Helixi152 – 166Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2N9CNMR-A1-17[»]
3CONX-ray1.65A1-172[»]
ProteinModelPortaliP01111.
SMRiP01111.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01111.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni166 – 185Hypervariable regionAdd BLAST20

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi32 – 40Effector region9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ras family.Curated

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00860000133672.
HOGENOMiHOG000233973.
HOVERGENiHBG009351.
InParanoidiP01111.
KOiK07828.
OMAiRSSYDEI.
OrthoDBiEOG091G0UAU.
PhylomeDBiP01111.
TreeFamiTF312796.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01111-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEYKLVVVG AGGVGKSALT IQLIQNHFVD EYDPTIEDSY RKQVVIDGET
60 70 80 90 100
CLLDILDTAG QEEYSAMRDQ YMRTGEGFLC VFAINNSKSF ADINLYREQI
110 120 130 140 150
KRVKDSDDVP MVLVGNKCDL PTRTVDTKQA HELAKSYGIP FIETSAKTRQ
160 170 180
GVEDAFYTLV REIRQYRMKK LNSSDDGTQG CMGLPCVVM
Length:189
Mass (Da):21,229
Last modified:July 21, 1986 - v1
Checksum:i6898D3F6815B1EC7
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02119412G → C in leukemia. 1 PublicationCorresponds to variant rs121913250dbSNPEnsembl.1
Natural variantiVAR_07112912G → D in KNEN and JMML. 2 PublicationsCorresponds to variant rs121913237dbSNPEnsembl.1
Natural variantiVAR_06308413G → D in RALD and JMML. 2 PublicationsCorresponds to variant rs121434596dbSNPEnsembl.1
Natural variantiVAR_00684513G → R in CMNS and colorectal cancer; somatic mutation. 2 PublicationsCorresponds to variant rs121434595dbSNPEnsembl.1
Natural variantiVAR_07113034P → L in KNEN. 1 PublicationCorresponds to variant rs397514553dbSNPEnsembl.1
Natural variantiVAR_06308550T → I in NS6; hypermorphic mutation. 1 PublicationCorresponds to variant rs267606921dbSNPEnsembl.1
Natural variantiVAR_06308660G → E in NS6; hypermorphic mutation. 1 PublicationCorresponds to variant rs267606920dbSNPEnsembl.1
Natural variantiVAR_00684661Q → K in CMNS and NCMS; somatic mutation. 1 PublicationCorresponds to variant rs121913254dbSNPEnsembl.1
Natural variantiVAR_00684761Q → R in CMNS, NCMS, KNEN and NMTC2; also found in lung carcinoma cell and melanoma. 5 PublicationsCorresponds to variant rs11554290dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02751 mRNA. Translation: CAA26529.1.
X00642 Genomic DNA. Translation: CAA25269.1.
X00643 Genomic DNA. Translation: CAA25270.1.
X00644 Genomic DNA. Translation: CAA25271.1.
X00645 Genomic DNA. Translation: CAA25272.1.
L00043
, L00040, L00041, L00042 Genomic DNA. Translation: AAA60255.1.
AF493919 mRNA. Translation: AAM12633.1.
AY428630 Genomic DNA. Translation: AAQ94397.1.
BC005219 mRNA. Translation: AAH05219.1.
M25898 Genomic DNA. Translation: AAA36548.1.
X53291, X53292 Genomic DNA. Translation: CAA37384.1.
K03211, M10055 Genomic DNA. Translation: AAA36556.1.
X05565 Genomic DNA. Translation: CAA29079.1.
X07440 Genomic DNA. Translation: CAA30320.1.
CCDSiCCDS877.1.
PIRiA90839. TVHURA.
I38149.
RefSeqiNP_002515.1. NM_002524.4.
UniGeneiHs.486502.

Genome annotation databases

EnsembliENST00000369535; ENSP00000358548; ENSG00000213281.
GeneIDi4893.
KEGGihsa:4893.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
NRASbase

NRAS mutation db

NIEHS-SNPs
Wikipedia

RAS proteins entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02751 mRNA. Translation: CAA26529.1.
X00642 Genomic DNA. Translation: CAA25269.1.
X00643 Genomic DNA. Translation: CAA25270.1.
X00644 Genomic DNA. Translation: CAA25271.1.
X00645 Genomic DNA. Translation: CAA25272.1.
L00043
, L00040, L00041, L00042 Genomic DNA. Translation: AAA60255.1.
AF493919 mRNA. Translation: AAM12633.1.
AY428630 Genomic DNA. Translation: AAQ94397.1.
BC005219 mRNA. Translation: AAH05219.1.
M25898 Genomic DNA. Translation: AAA36548.1.
X53291, X53292 Genomic DNA. Translation: CAA37384.1.
K03211, M10055 Genomic DNA. Translation: AAA36556.1.
X05565 Genomic DNA. Translation: CAA29079.1.
X07440 Genomic DNA. Translation: CAA30320.1.
CCDSiCCDS877.1.
PIRiA90839. TVHURA.
I38149.
RefSeqiNP_002515.1. NM_002524.4.
UniGeneiHs.486502.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2N9CNMR-A1-17[»]
3CONX-ray1.65A1-172[»]
ProteinModelPortaliP01111.
SMRiP01111.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110952. 33 interactors.
DIPiDIP-1058N.
IntActiP01111. 31 interactors.
MINTiMINT-131535.
STRINGi9606.ENSP00000358548.

Chemistry databases

BindingDBiP01111.
ChEMBLiCHEMBL2079845.
GuidetoPHARMACOLOGYi2823.

PTM databases

iPTMnetiP01111.
PhosphoSitePlusiP01111.
SwissPalmiP01111.

Polymorphism and mutation databases

BioMutaiNRAS.
DMDMi131883.

2D gel databases

OGPiP01111.

Proteomic databases

EPDiP01111.
PaxDbiP01111.
PeptideAtlasiP01111.
PRIDEiP01111.

Protocols and materials databases

DNASUi4893.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369535; ENSP00000358548; ENSG00000213281.
GeneIDi4893.
KEGGihsa:4893.

Organism-specific databases

CTDi4893.
DisGeNETi4893.
GeneCardsiNRAS.
GeneReviewsiNRAS.
HGNCiHGNC:7989. NRAS.
HPAiCAB010157.
HPA049830.
MalaCardsiNRAS.
MIMi137550. phenotype.
162900. phenotype.
164790. gene.
188470. phenotype.
249400. phenotype.
607785. phenotype.
613224. phenotype.
614470. phenotype.
neXtProtiNX_P01111.
OpenTargetsiENSG00000213281.
Orphaneti86834. Juvenile myelomonocytic leukemia.
626. Large congenital melanocytic nevus.
648. Noonan syndrome.
268114. RAS-associated autoimmune leukoproliferative disease.
PharmGKBiPA31768.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00860000133672.
HOGENOMiHOG000233973.
HOVERGENiHBG009351.
InParanoidiP01111.
KOiK07828.
OMAiRSSYDEI.
OrthoDBiEOG091G0UAU.
PhylomeDBiP01111.
TreeFamiTF312796.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000168638-MONOMER.
ReactomeiR-HSA-112412. SOS-mediated signalling.
R-HSA-1169092. Activation of RAS in B cells.
R-HSA-1236382. Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants.
R-HSA-1250196. SHC1 events in ERBB2 signaling.
R-HSA-1250347. SHC1 events in ERBB4 signaling.
R-HSA-1433557. Signaling by SCF-KIT.
R-HSA-167044. Signalling to RAS.
R-HSA-171007. p38MAPK events.
R-HSA-179812. GRB2 events in EGFR signaling.
R-HSA-180336. SHC1 events in EGFR signaling.
R-HSA-186763. Downstream signal transduction.
R-HSA-1963640. GRB2 events in ERBB2 signaling.
R-HSA-210993. Tie2 Signaling.
R-HSA-2179392. EGFR Transactivation by Gastrin.
R-HSA-2424491. DAP12 signaling.
R-HSA-2428933. SHC-related events triggered by IGF1R.
R-HSA-2871796. FCERI mediated MAPK activation.
R-HSA-375165. NCAM signaling for neurite out-growth.
R-HSA-5218921. VEGFR2 mediated cell proliferation.
R-HSA-5621575. CD209 (DC-SIGN) signaling.
R-HSA-5637810. Constitutive Signaling by EGFRvIII.
R-HSA-5654688. SHC-mediated cascade:FGFR1.
R-HSA-5654693. FRS-mediated FGFR1 signaling.
R-HSA-5654699. SHC-mediated cascade:FGFR2.
R-HSA-5654700. FRS-mediated FGFR2 signaling.
R-HSA-5654704. SHC-mediated cascade:FGFR3.
R-HSA-5654706. FRS-mediated FGFR3 signaling.
R-HSA-5654712. FRS-mediated FGFR4 signaling.
R-HSA-5654719. SHC-mediated cascade:FGFR4.
R-HSA-5655253. Signaling by FGFR2 in disease.
R-HSA-5655291. Signaling by FGFR4 in disease.
R-HSA-5655302. Signaling by FGFR1 in disease.
R-HSA-5658442. Regulation of RAS by GAPs.
R-HSA-5673000. RAF activation.
R-HSA-5673001. RAF/MAP kinase cascade.
R-HSA-5674135. MAP2K and MAPK activation.
R-HSA-5675221. Negative regulation of MAPK pathway.
R-HSA-6798695. Neutrophil degranulation.
R-HSA-6802946. Signaling by moderate kinase activity BRAF mutants.
R-HSA-6802948. Signaling by high-kinase activity BRAF mutants.
R-HSA-6802949. Signaling by RAS mutants.
R-HSA-6802952. Signaling by BRAF and RAF fusions.
R-HSA-6802953. RAS signaling downstream of NF1 loss-of-function variants.
R-HSA-6802955. Paradoxical activation of RAF signaling by kinase inactive BRAF.
R-HSA-74751. Insulin receptor signalling cascade.
R-HSA-8849471. PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases.
R-HSA-8851805. MET activates RAS signaling.
R-HSA-8853334. Signaling by FGFR3 fusions in cancer.
R-HSA-8853338. Signaling by FGFR3 point mutants in cancer.
SignaLinkiP01111.
SIGNORiP01111.

Miscellaneous databases

ChiTaRSiNRAS. human.
EvolutionaryTraceiP01111.
GeneWikiiNeuroblastoma_RAS_viral_oncogene_homolog.
GenomeRNAii4893.
PROiP01111.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000213281.
CleanExiHS_NRAS.
ExpressionAtlasiP01111. baseline and differential.
GenevisibleiP01111. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRASN_HUMAN
AccessioniPrimary (citable) accession number: P01111
Secondary accession number(s): Q14971, Q15104, Q15282
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 30, 2016
This is version 197 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Mutations which change AA 12, 13 or 61 activate the potential of Ras to transform cultured cells and are implicated in a variety of human tumors.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.