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P01111

- RASN_HUMAN

UniProt

P01111 - RASN_HUMAN

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Protein

GTPase NRas

Gene

NRAS

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.

Enzyme regulationi

Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 178GTP
Nucleotide bindingi57 – 615GTP
Nucleotide bindingi116 – 1194GTP

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. protein complex binding Source: MGI

GO - Biological processi

  1. actin cytoskeleton organization Source: Ensembl
  2. activation of MAPKK activity Source: Reactome
  3. axon guidance Source: Reactome
  4. blood coagulation Source: Reactome
  5. epidermal growth factor receptor signaling pathway Source: Reactome
  6. epithelial tube branching involved in lung morphogenesis Source: Ensembl
  7. Fc-epsilon receptor signaling pathway Source: Reactome
  8. fibroblast growth factor receptor signaling pathway Source: Reactome
  9. GTP catabolic process Source: InterPro
  10. innate immune response Source: Reactome
  11. insulin receptor signaling pathway Source: Reactome
  12. leukocyte migration Source: Reactome
  13. MAPK cascade Source: Reactome
  14. negative regulation of cell differentiation Source: Ensembl
  15. negative regulation of neuron apoptotic process Source: Ensembl
  16. negative regulation of skeletal muscle tissue development Source: Ensembl
  17. neurotrophin TRK receptor signaling pathway Source: Reactome
  18. positive regulation of cell proliferation Source: Ensembl
  19. positive regulation of Rac protein signal transduction Source: Ensembl
  20. Ras protein signal transduction Source: Reactome
  21. regulation of long-term neuronal synaptic plasticity Source: Ensembl
  22. regulation of synaptic transmission, GABAergic Source: Ensembl
  23. small GTPase mediated signal transduction Source: Reactome
  24. striated muscle cell differentiation Source: Ensembl
  25. visual learning Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_111040. Signaling by SCF-KIT.
REACT_115852. Signaling by constitutively active EGFR.
REACT_115854. GRB2 events in ERBB2 signaling.
REACT_115993. SHC1 events in ERBB2 signaling.
REACT_116005. SHC1 events in ERBB4 signaling.
REACT_118778. Activation of RAS in B cells.
REACT_12033. Signalling to RAS.
REACT_12065. p38MAPK events.
REACT_121096. EGFR Transactivation by Gastrin.
REACT_121398. Signaling by FGFR mutants.
REACT_12579. SHC1 events in EGFR signaling.
REACT_12606. GRB2 events in EGFR signaling.
REACT_12621. Tie2 Signaling.
REACT_147814. DAP12 signaling.
REACT_163701. FCERI mediated MAPK activation.
REACT_17025. Downstream signal transduction.
REACT_18334. NCAM signaling for neurite out-growth.
REACT_2077. RAF activation.
REACT_21247. FRS2-mediated cascade.
REACT_21374. SHC-mediated cascade.
REACT_228024. VEGFR2 mediated cell proliferation.
REACT_524. SOS-mediated signalling.
REACT_614. RAF phosphorylates MEK.
REACT_661. SHC-mediated signalling.
REACT_962. MEK activation.
SignaLinkiP01111.

Names & Taxonomyi

Protein namesi
Recommended name:
GTPase NRas
Alternative name(s):
Transforming protein N-Ras
Gene namesi
Name:NRAS
Synonyms:HRAS1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:7989. NRAS.

Subcellular locationi

Cell membrane 1 Publication; Lipid-anchor 1 Publication; Cytoplasmic side 1 Publication. Golgi apparatus membrane 1 Publication; Lipid-anchor 1 Publication
Note: Shuttles between the plasma membrane and the Golgi apparatus.

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. Golgi apparatus Source: UniProtKB-KW
  3. membrane Source: UniProtKB
  4. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

Pathology & Biotechi

Involvement in diseasei

Leukemia, juvenile myelomonocytic (JMML) [MIM:607785]: An aggressive pediatric myelodysplastic syndrome/myeloproliferative disorder characterized by malignant transformation in the hematopoietic stem cell compartment with proliferation of differentiated progeny. Patients have splenomegaly, enlarged lymph nodes, rashes, and hemorrhages.
Note: The disease is caused by mutations affecting the gene represented in this entry.
Noonan syndrome 6 (NS6) [MIM:613224]: A form of Noonan syndrome, a disease characterized by short stature, facial dysmorphic features such as hypertelorism, a downward eyeslant and low-set posteriorly rotated ears, and a high incidence of congenital heart defects and hypertrophic cardiomyopathy. Other features can include a short neck with webbing or redundancy of skin, deafness, motor delay, variable intellectual deficits, multiple skeletal defects, cryptorchidism, and bleeding diathesis. Individuals with Noonan syndrome are at risk of juvenile myelomonocytic leukemia, a myeloproliferative disorder characterized by excessive production of myelomonocytic cells.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti50 – 501T → I in NS6; hypermorphic mutation. 1 Publication
VAR_063085
Natural varianti60 – 601G → E in NS6; hypermorphic mutation. 1 Publication
VAR_063086
Autoimmune lymphoproliferative syndrome 4 (ALPS4) [MIM:614470]: A disorder of apoptosis, characterized by chronic accumulation of non-malignant lymphocytes, defective lymphocyte apoptosis, and an increased risk for the development of hematologic malignancies.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti13 – 131G → D in ALPS4. 1 Publication
VAR_063084
Melanocytic nevus syndrome, congenital (CMNS) [MIM:137550]: A syndrome characterized by congenital pigmentary skin lesions which can occur at any site and can cover most of the body surface. These lesions may or may not be hairy. Congenital melanocytic nevi are associated with neuromelanosis (the presence of melanin-producing cells within the brain parenchyma or leptomeninges). Less commonly they are associated with malignant melanoma in childhood, both in the skin and the central nervous system. CMNS patients also tend to have a characteristic facial appearance, including wide or prominent forehead, periorbital fullness, small short nose with narrow nasal bridge, round face, full cheeks, prominent premaxilla, and everted lower lip.2 Publications
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti13 – 131G → R in CMNS and colorectal cancer; somatic mutation. 2 Publications
VAR_006845
Natural varianti61 – 611Q → K in CMNS and NCMS; somatic mutation. 1 Publication
VAR_006846
Natural varianti61 – 611Q → R in CMNS, NCMS and KNEN; also found in lung carcinoma cell and melanoma. 4 Publications
Corresponds to variant rs11554290 [ dbSNP | Ensembl ].
VAR_006847
Melanosis, neurocutaneous (NCMS) [MIM:249400]: A rare congenital disease characterized by the presence of giant or multiple melanocytic nevi on the skin, foci of melanin-producing cells within the brain parenchyma, and infiltration of leptomeninges by abnormal melanin deposits. Neurologic abnormalities include seizures, hydrocephalus, arachnoid cysts, tumors, and syringomyelia. Some patients may develop malignant melanoma.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti61 – 611Q → K in CMNS and NCMS; somatic mutation. 1 Publication
VAR_006846
Natural varianti61 – 611Q → R in CMNS, NCMS and KNEN; also found in lung carcinoma cell and melanoma. 4 Publications
Corresponds to variant rs11554290 [ dbSNP | Ensembl ].
VAR_006847
Keratinocytic non-epidermolytic nevus (KNEN) [MIM:162900]: Epidermal nevi of the common, non-organoid and non-epidermolytic type are benign skin lesions and may vary in their extent from a single (usually linear) lesion to widespread and systematized involvement. They may be present at birth or develop early during childhood.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti12 – 121G → D in KNEN. 1 Publication
VAR_071129
Natural varianti34 – 341P → L in KNEN. 1 Publication
VAR_071130
Natural varianti61 – 611Q → R in CMNS, NCMS and KNEN; also found in lung carcinoma cell and melanoma. 4 Publications
Corresponds to variant rs11554290 [ dbSNP | Ensembl ].
VAR_006847

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi164 – 1641R → A: Loss of GTP-binding activity.

Keywords - Diseasei

Disease mutation, Proto-oncogene

Organism-specific databases

MIMi137550. phenotype.
162900. phenotype.
249400. phenotype.
607785. phenotype.
613224. phenotype.
614470. phenotype.
Orphaneti86834. Juvenile myelomonocytic leukemia.
626. Large congenital melanocytic nevus.
648. Noonan syndrome.
268114. RAS-associated autoimmune leukoproliferative disease.
PharmGKBiPA31768.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 186186GTPase NRasPRO_0000043006Add
BLAST
Propeptidei187 – 1893Removed in mature formBy similarityPRO_0000043007

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi181 – 1811S-palmitoyl cysteine2 Publications
Modified residuei186 – 1861Cysteine methyl esterBy similarity
Lipidationi186 – 1861S-farnesyl cysteine1 Publication

Post-translational modificationi

Palmitoylated by the ZDHHC9-GOLGA7 complex. A continuous cycle of de- and re-palmitoylation regulates rapid exchange between plasma membrane and Golgi.3 Publications
Acetylation at Lys-104 prevents interaction with guanine nucleotide exchange factors (GEFs).By similarity

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Palmitate, Prenylation

Proteomic databases

MaxQBiP01111.
PaxDbiP01111.
PeptideAtlasiP01111.
PRIDEiP01111.

2D gel databases

OGPiP01111.

PTM databases

PhosphoSiteiP01111.

Expressioni

Gene expression databases

BgeeiP01111.
CleanExiHS_NRAS.
ExpressionAtlasiP01111. baseline and differential.
GenevestigatoriP01111.

Organism-specific databases

HPAiCAB010157.
HPA049830.

Interactioni

Subunit structurei

Interacts (active GTP-bound form preferentially) with RGS14 (By similarity). Interacts (active GTP-bound form) with RASSF7.By similarity1 Publication

Protein-protein interaction databases

BioGridi110952. 21 interactions.
DIPiDIP-1058N.
IntActiP01111. 7 interactions.
MINTiMINT-131535.
STRINGi9606.ENSP00000358548.

Structurei

Secondary structure

1
189
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 98Combined sources
Helixi16 – 2510Combined sources
Beta strandi38 – 469Combined sources
Beta strandi49 – 579Combined sources
Beta strandi76 – 838Combined sources
Helixi87 – 10418Combined sources
Beta strandi111 – 1166Combined sources
Helixi127 – 13711Combined sources
Beta strandi141 – 1433Combined sources
Turni146 – 1483Combined sources
Helixi152 – 16615Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3CONX-ray1.65A1-172[»]
ProteinModelPortaliP01111.
SMRiP01111. Positions 1-167.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01111.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni166 – 18520Hypervariable regionAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi32 – 409Effector region

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ras family.Curated

Phylogenomic databases

eggNOGiCOG1100.
HOGENOMiHOG000233973.
HOVERGENiHBG009351.
InParanoidiP01111.
KOiK07828.
OMAiSNEDGNQ.
OrthoDBiEOG7QVM41.
PhylomeDBiP01111.
TreeFamiTF312796.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00173. RAS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01111-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTEYKLVVVG AGGVGKSALT IQLIQNHFVD EYDPTIEDSY RKQVVIDGET
60 70 80 90 100
CLLDILDTAG QEEYSAMRDQ YMRTGEGFLC VFAINNSKSF ADINLYREQI
110 120 130 140 150
KRVKDSDDVP MVLVGNKCDL PTRTVDTKQA HELAKSYGIP FIETSAKTRQ
160 170 180
GVEDAFYTLV REIRQYRMKK LNSSDDGTQG CMGLPCVVM
Length:189
Mass (Da):21,229
Last modified:July 21, 1986 - v1
Checksum:i6898D3F6815B1EC7
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti12 – 121G → C in leukemia. 1 Publication
VAR_021194
Natural varianti12 – 121G → D in KNEN. 1 Publication
VAR_071129
Natural varianti13 – 131G → D in ALPS4. 1 Publication
VAR_063084
Natural varianti13 – 131G → R in CMNS and colorectal cancer; somatic mutation. 2 Publications
VAR_006845
Natural varianti34 – 341P → L in KNEN. 1 Publication
VAR_071130
Natural varianti50 – 501T → I in NS6; hypermorphic mutation. 1 Publication
VAR_063085
Natural varianti60 – 601G → E in NS6; hypermorphic mutation. 1 Publication
VAR_063086
Natural varianti61 – 611Q → K in CMNS and NCMS; somatic mutation. 1 Publication
VAR_006846
Natural varianti61 – 611Q → R in CMNS, NCMS and KNEN; also found in lung carcinoma cell and melanoma. 4 Publications
Corresponds to variant rs11554290 [ dbSNP | Ensembl ].
VAR_006847

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02751 mRNA. Translation: CAA26529.1.
X00642 Genomic DNA. Translation: CAA25269.1.
X00643 Genomic DNA. Translation: CAA25270.1.
X00644 Genomic DNA. Translation: CAA25271.1.
X00645 Genomic DNA. Translation: CAA25272.1.
L00043
, L00040, L00041, L00042 Genomic DNA. Translation: AAA60255.1.
AF493919 mRNA. Translation: AAM12633.1.
AY428630 Genomic DNA. Translation: AAQ94397.1.
BC005219 mRNA. Translation: AAH05219.1.
M25898 Genomic DNA. Translation: AAA36548.1.
X53291, X53292 Genomic DNA. Translation: CAA37384.1.
K03211, M10055 Genomic DNA. Translation: AAA36556.1.
X05565 Genomic DNA. Translation: CAA29079.1.
X07440 Genomic DNA. Translation: CAA30320.1.
CCDSiCCDS877.1.
PIRiA90839. TVHURA.
I38149.
RefSeqiNP_002515.1. NM_002524.4.
UniGeneiHs.486502.

Genome annotation databases

EnsembliENST00000369535; ENSP00000358548; ENSG00000213281.
GeneIDi4893.
KEGGihsa:4893.
UCSCiuc009wgu.3. human.

Polymorphism databases

DMDMi131883.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
NRASbase

NRAS mutation db

NIEHS-SNPs
Wikipedia

RAS proteins entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02751 mRNA. Translation: CAA26529.1 .
X00642 Genomic DNA. Translation: CAA25269.1 .
X00643 Genomic DNA. Translation: CAA25270.1 .
X00644 Genomic DNA. Translation: CAA25271.1 .
X00645 Genomic DNA. Translation: CAA25272.1 .
L00043
, L00040 , L00041 , L00042 Genomic DNA. Translation: AAA60255.1 .
AF493919 mRNA. Translation: AAM12633.1 .
AY428630 Genomic DNA. Translation: AAQ94397.1 .
BC005219 mRNA. Translation: AAH05219.1 .
M25898 Genomic DNA. Translation: AAA36548.1 .
X53291 , X53292 Genomic DNA. Translation: CAA37384.1 .
K03211 , M10055 Genomic DNA. Translation: AAA36556.1 .
X05565 Genomic DNA. Translation: CAA29079.1 .
X07440 Genomic DNA. Translation: CAA30320.1 .
CCDSi CCDS877.1.
PIRi A90839. TVHURA.
I38149.
RefSeqi NP_002515.1. NM_002524.4.
UniGenei Hs.486502.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3CON X-ray 1.65 A 1-172 [» ]
ProteinModelPortali P01111.
SMRi P01111. Positions 1-167.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110952. 21 interactions.
DIPi DIP-1058N.
IntActi P01111. 7 interactions.
MINTi MINT-131535.
STRINGi 9606.ENSP00000358548.

Chemistry

BindingDBi P01111.
ChEMBLi CHEMBL2079845.

PTM databases

PhosphoSitei P01111.

Polymorphism databases

DMDMi 131883.

2D gel databases

OGPi P01111.

Proteomic databases

MaxQBi P01111.
PaxDbi P01111.
PeptideAtlasi P01111.
PRIDEi P01111.

Protocols and materials databases

DNASUi 4893.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000369535 ; ENSP00000358548 ; ENSG00000213281 .
GeneIDi 4893.
KEGGi hsa:4893.
UCSCi uc009wgu.3. human.

Organism-specific databases

CTDi 4893.
GeneCardsi GC01M115247.
GeneReviewsi NRAS.
HGNCi HGNC:7989. NRAS.
HPAi CAB010157.
HPA049830.
MIMi 137550. phenotype.
162900. phenotype.
164790. gene.
249400. phenotype.
607785. phenotype.
613224. phenotype.
614470. phenotype.
neXtProti NX_P01111.
Orphaneti 86834. Juvenile myelomonocytic leukemia.
626. Large congenital melanocytic nevus.
648. Noonan syndrome.
268114. RAS-associated autoimmune leukoproliferative disease.
PharmGKBi PA31768.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1100.
HOGENOMi HOG000233973.
HOVERGENi HBG009351.
InParanoidi P01111.
KOi K07828.
OMAi SNEDGNQ.
OrthoDBi EOG7QVM41.
PhylomeDBi P01111.
TreeFami TF312796.

Enzyme and pathway databases

Reactomei REACT_111040. Signaling by SCF-KIT.
REACT_115852. Signaling by constitutively active EGFR.
REACT_115854. GRB2 events in ERBB2 signaling.
REACT_115993. SHC1 events in ERBB2 signaling.
REACT_116005. SHC1 events in ERBB4 signaling.
REACT_118778. Activation of RAS in B cells.
REACT_12033. Signalling to RAS.
REACT_12065. p38MAPK events.
REACT_121096. EGFR Transactivation by Gastrin.
REACT_121398. Signaling by FGFR mutants.
REACT_12579. SHC1 events in EGFR signaling.
REACT_12606. GRB2 events in EGFR signaling.
REACT_12621. Tie2 Signaling.
REACT_147814. DAP12 signaling.
REACT_163701. FCERI mediated MAPK activation.
REACT_17025. Downstream signal transduction.
REACT_18334. NCAM signaling for neurite out-growth.
REACT_2077. RAF activation.
REACT_21247. FRS2-mediated cascade.
REACT_21374. SHC-mediated cascade.
REACT_228024. VEGFR2 mediated cell proliferation.
REACT_524. SOS-mediated signalling.
REACT_614. RAF phosphorylates MEK.
REACT_661. SHC-mediated signalling.
REACT_962. MEK activation.
SignaLinki P01111.

Miscellaneous databases

ChiTaRSi NRAS. human.
EvolutionaryTracei P01111.
GeneWikii Neuroblastoma_RAS_viral_oncogene_homolog.
GenomeRNAii 4893.
NextBioi 18835.
PROi P01111.
SOURCEi Search...

Gene expression databases

Bgeei P01111.
CleanExi HS_NRAS.
ExpressionAtlasi P01111. baseline and differential.
Genevestigatori P01111.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view ]
PANTHERi PTHR24070. PTHR24070. 1 hit.
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SMARTi SM00173. RAS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51421. RAS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structure and activation of the human N-ras gene."
    Taparowsky E., Shimizu K., Goldfarb M., Wigler M.
    Cell 34:581-586(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Human N-ras: cDNA cloning and gene structure."
    Hall A., Brown R.
    Nucleic Acids Res. 13:5255-5268(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Mechanism of activation of an N-ras gene in the human fibrosarcoma cell line HT1080."
    Brown R., Marshall C.J., Pennie S.G., Hall A.
    EMBO J. 3:1321-1326(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Fibrosarcoma.
  4. "Mechanism of activation of an N-ras oncogene of SW-1271 human lung carcinoma cells."
    Yuasa Y., Gol R.A., Chang A., Chiu I.-M., Reddy E.P., Tronick S.R., Aaronson S.A.
    Proc. Natl. Acad. Sci. U.S.A. 81:3670-3674(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Lung carcinoma.
  5. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Puhl H.L. III, Ikeda S.R., Aronstam R.S.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  6. NIEHS SNPs program
    Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  8. "Transforming genes in human leukemia cells."
    Hirai H., Tanaka S., Azuma M., Anraku Y., Kobayashi Y., Fujisawa M., Okabe T., Urabe A., Takaku F.
    Blood 66:1371-1378(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 1-96, VARIANT CYS-12.
    Tissue: Leukemia.
  9. "Transforming genes from familial adenomatous polyposis patient cells detected by a tumorigenicity assay."
    Yuasa Y., Kamiyama T., Kato M., Iwama T., Ikeuchi T., Tonomura A.
    Oncogene 5:589-596(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 1-29 AND 43-78.
  10. "Activation of an N-ras gene in acute myeloblastic leukemia through somatic mutation in the first exon."
    Gambke C., Hall A., Moroni C.
    Proc. Natl. Acad. Sci. U.S.A. 82:879-882(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-96.
  11. "A point mutation at codon 13 of the N-ras oncogene in myelodysplastic syndrome."
    Hirai H., Kobayashi Y., Mano H., Hagiwara K., Maru Y., Omine M., Mizoguchi H., Nishida J., Takaku F.
    Nature 327:430-432(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-96.
    Tissue: Bone marrow.
  12. "Detection of a low frequency of activated ras genes in human melanomas using a tumorigenicity assay."
    Raybaud F., Noguchi T., Marics I., Adelaide J., Planche J., Batoz M., Aubet C., de Lapeyriere O., Birnbaum D.
    Cancer Res. 48:950-953(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 60-96, VARIANT ARG-61.
  13. "All ras proteins are polyisoprenylated but only some are palmitoylated."
    Hancock J.F., Magee A.I., Childs J.E., Marshall C.J.
    Cell 57:1167-1177(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PALMITOYLATION AT CYS-181, ISOPRENYLATION AT CYS-186.
  14. "DHHC9 and GCP16 constitute a human protein fatty acyltransferase with specificity for H- and N-Ras."
    Swarthout J.T., Lobo S., Farh L., Croke M.R., Greentree W.K., Deschenes R.J., Linder M.E.
    J. Biol. Chem. 280:31141-31148(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: PALMITOYLATION AT CYS-181.
  15. "An acylation cycle regulates localization and activity of palmitoylated Ras isoforms."
    Rocks O., Peyker A., Kahms M., Verveer P.J., Koerner C., Lumbierres M., Kuhlmann J., Waldmann H., Wittinghofer A., Bastiaens P.I.H.
    Science 307:1746-1752(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: PALMITOYLATION, SUBCELLULAR LOCATION.
  16. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  17. "RASSF7 negatively regulates pro-apoptotic JNK signaling by inhibiting the activity of phosphorylated-MKK7."
    Takahashi S., Ebihara A., Kajiho H., Kontani K., Nishina H., Katada T.
    Cell Death Differ. 18:645-655(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RASSF7.
  18. "Amino-acid substitution at codon 13 of the N-ras oncogene in rectal cancer in a Japanese patient."
    Nitta N., Ochiai M., Nagao M., Sugimura T.
    Jpn. J. Cancer Res. 78:21-26(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT COLORECTAL CANCER ARG-13.
  19. Cited for: VARIANT ALPS4 ASP-13.
  20. "Genotypic and gene expression studies in congenital melanocytic nevi: insight into initial steps of melanotumorigenesis."
    Dessars B., De Raeve L.E., Morandini R., Lefort A., El Housni H., Ghanem G.E., Van den Eynde B.J., Ma W., Roseeuw D., Vassart G., Libert F., Heimann P.
    J. Invest. Dermatol. 129:139-147(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS CMNS ARG-13 AND ARG-61.
  21. Cited for: VARIANTS NS6 ILE-50 AND GLU-60, CHARACTERIZATION OF VARIANTS NS6 ILE-50 AND GLU-60.
  22. Cited for: VARIANTS KNEN ASP-12; LEU-34 AND ARG-61.
  23. "Multiple congenital melanocytic nevi and neurocutaneous melanosis are caused by postzygotic mutations in codon 61 of NRAS."
    Kinsler V.A., Thomas A.C., Ishida M., Bulstrode N.W., Loughlin S., Hing S., Chalker J., McKenzie K., Abu-Amero S., Slater O., Chanudet E., Palmer R., Morrogh D., Stanier P., Healy E., Sebire N.J., Moore G.E.
    J. Invest. Dermatol. 133:2229-2236(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS CMNS ARG-61 AND LYS-61, VARIANTS NCMS ARG-61 AND LYS-61.

Entry informationi

Entry nameiRASN_HUMAN
AccessioniPrimary (citable) accession number: P01111
Secondary accession number(s): Q14971, Q15104, Q15282
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 26, 2014
This is version 174 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Mutations which change AA 12, 13 or 61 activate the potential of Ras to transform cultured cells and are implicated in a variety of human tumors.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3