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P01111

- RASN_HUMAN

UniProt

P01111 - RASN_HUMAN

Protein

GTPase NRas

Gene

NRAS

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.

    Enzyme regulationi

    Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 178GTP
    Nucleotide bindingi57 – 615GTP
    Nucleotide bindingi116 – 1194GTP

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-KW
    2. protein complex binding Source: MGI

    GO - Biological processi

    1. actin cytoskeleton organization Source: Ensembl
    2. activation of MAPKK activity Source: Reactome
    3. axon guidance Source: Reactome
    4. blood coagulation Source: Reactome
    5. epidermal growth factor receptor signaling pathway Source: Reactome
    6. Fc-epsilon receptor signaling pathway Source: Reactome
    7. fibroblast growth factor receptor signaling pathway Source: Reactome
    8. GTP catabolic process Source: InterPro
    9. innate immune response Source: Reactome
    10. insulin receptor signaling pathway Source: Reactome
    11. leukocyte migration Source: Reactome
    12. MAPK cascade Source: Reactome
    13. negative regulation of neuron apoptotic process Source: Ensembl
    14. neurotrophin TRK receptor signaling pathway Source: Reactome
    15. positive regulation of cell proliferation Source: Ensembl
    16. positive regulation of Rac protein signal transduction Source: Ensembl
    17. Ras protein signal transduction Source: Reactome
    18. regulation of long-term neuronal synaptic plasticity Source: Ensembl
    19. regulation of synaptic transmission, GABAergic Source: Ensembl
    20. small GTPase mediated signal transduction Source: Reactome
    21. striated muscle cell differentiation Source: Ensembl
    22. visual learning Source: Ensembl

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_111040. Signaling by SCF-KIT.
    REACT_115852. Signaling by constitutively active EGFR.
    REACT_115854. GRB2 events in ERBB2 signaling.
    REACT_115993. SHC1 events in ERBB2 signaling.
    REACT_116005. SHC1 events in ERBB4 signaling.
    REACT_118778. Activation of RAS in B cells.
    REACT_12033. Signalling to RAS.
    REACT_12065. p38MAPK events.
    REACT_121096. EGFR Transactivation by Gastrin.
    REACT_121398. Signaling by FGFR mutants.
    REACT_12579. SHC1 events in EGFR signaling.
    REACT_12606. GRB2 events in EGFR signaling.
    REACT_12621. Tie2 Signaling.
    REACT_147814. DAP12 signaling.
    REACT_163701. FCERI mediated MAPK activation.
    REACT_17025. Downstream signal transduction.
    REACT_18334. NCAM signaling for neurite out-growth.
    REACT_2077. RAF activation.
    REACT_21247. FRS2-mediated cascade.
    REACT_21374. SHC-mediated cascade.
    REACT_524. SOS-mediated signalling.
    REACT_614. RAF phosphorylates MEK.
    REACT_661. SHC-mediated signalling.
    REACT_962. MEK activation.
    SignaLinkiP01111.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTPase NRas
    Alternative name(s):
    Transforming protein N-Ras
    Gene namesi
    Name:NRAS
    Synonyms:HRAS1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:7989. NRAS.

    Subcellular locationi

    Cell membrane 1 Publication; Lipid-anchor 1 Publication; Cytoplasmic side 1 Publication. Golgi apparatus membrane 1 Publication; Lipid-anchor 1 Publication
    Note: Shuttles between the plasma membrane and the Golgi apparatus.

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. Golgi membrane Source: UniProtKB-SubCell
    3. membrane Source: UniProtKB
    4. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Golgi apparatus, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Leukemia, juvenile myelomonocytic (JMML) [MIM:607785]: An aggressive pediatric myelodysplastic syndrome/myeloproliferative disorder characterized by malignant transformation in the hematopoietic stem cell compartment with proliferation of differentiated progeny. Patients have splenomegaly, enlarged lymph nodes, rashes, and hemorrhages.
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Noonan syndrome 6 (NS6) [MIM:613224]: A form of Noonan syndrome, a disease characterized by short stature, facial dysmorphic features such as hypertelorism, a downward eyeslant and low-set posteriorly rotated ears, and a high incidence of congenital heart defects and hypertrophic cardiomyopathy. Other features can include a short neck with webbing or redundancy of skin, deafness, motor delay, variable intellectual deficits, multiple skeletal defects, cryptorchidism, and bleeding diathesis. Individuals with Noonan syndrome are at risk of juvenile myelomonocytic leukemia, a myeloproliferative disorder characterized by excessive production of myelomonocytic cells.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti50 – 501T → I in NS6; hypermorphic mutation. 1 Publication
    VAR_063085
    Natural varianti60 – 601G → E in NS6; hypermorphic mutation. 1 Publication
    VAR_063086
    Autoimmune lymphoproliferative syndrome 4 (ALPS4) [MIM:614470]: A disorder of apoptosis, characterized by chronic accumulation of non-malignant lymphocytes, defective lymphocyte apoptosis, and an increased risk for the development of hematologic malignancies.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti13 – 131G → D in ALPS4. 1 Publication
    VAR_063084
    Melanocytic nevus syndrome, congenital (CMNS) [MIM:137550]: A syndrome characterized by congenital pigmentary skin lesions which can occur at any site and can cover most of the body surface. These lesions may or may not be hairy. Congenital melanocytic nevi are associated with neuromelanosis (the presence of melanin-producing cells within the brain parenchyma or leptomeninges). Less commonly they are associated with malignant melanoma in childhood, both in the skin and the central nervous system. CMNS patients also tend to have a characteristic facial appearance, including wide or prominent forehead, periorbital fullness, small short nose with narrow nasal bridge, round face, full cheeks, prominent premaxilla, and everted lower lip.2 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti13 – 131G → R in CMNS and colorectal cancer; somatic mutation. 2 Publications
    VAR_006845
    Natural varianti61 – 611Q → K in CMNS and NCMS; somatic mutation. 1 Publication
    VAR_006846
    Natural varianti61 – 611Q → R in CMNS, NCMS and KNEN; also found in lung carcinoma cell and melanoma. 4 Publications
    Corresponds to variant rs11554290 [ dbSNP | Ensembl ].
    VAR_006847
    Melanosis, neurocutaneous (NCMS) [MIM:249400]: A rare congenital disease characterized by the presence of giant or multiple melanocytic nevi on the skin, foci of melanin-producing cells within the brain parenchyma, and infiltration of leptomeninges by abnormal melanin deposits. Neurologic abnormalities include seizures, hydrocephalus, arachnoid cysts, tumors, and syringomyelia. Some patients may develop malignant melanoma.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti61 – 611Q → K in CMNS and NCMS; somatic mutation. 1 Publication
    VAR_006846
    Natural varianti61 – 611Q → R in CMNS, NCMS and KNEN; also found in lung carcinoma cell and melanoma. 4 Publications
    Corresponds to variant rs11554290 [ dbSNP | Ensembl ].
    VAR_006847
    Keratinocytic non-epidermolytic nevus (KNEN) [MIM:162900]: Epidermal nevi of the common, non-organoid and non-epidermolytic type are benign skin lesions and may vary in their extent from a single (usually linear) lesion to widespread and systematized involvement. They may be present at birth or develop early during childhood.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti12 – 121G → D in KNEN. 1 Publication
    VAR_071129
    Natural varianti34 – 341P → L in KNEN. 1 Publication
    VAR_071130
    Natural varianti61 – 611Q → R in CMNS, NCMS and KNEN; also found in lung carcinoma cell and melanoma. 4 Publications
    Corresponds to variant rs11554290 [ dbSNP | Ensembl ].
    VAR_006847

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi164 – 1641R → A: Loss of GTP-binding activity.

    Keywords - Diseasei

    Disease mutation, Proto-oncogene

    Organism-specific databases

    MIMi137550. phenotype.
    162900. phenotype.
    249400. phenotype.
    607785. phenotype.
    613224. phenotype.
    614470. phenotype.
    Orphaneti3261. Autoimmune lymphoproliferative syndrome.
    86834. Juvenile myelomonocytic leukemia.
    626. Large congenital melanocytic nevus.
    648. Noonan syndrome.
    PharmGKBiPA31768.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 186186GTPase NRasPRO_0000043006Add
    BLAST
    Propeptidei187 – 1893Removed in mature formBy similarityPRO_0000043007

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi181 – 1811S-palmitoyl cysteine3 Publications
    Modified residuei186 – 1861Cysteine methyl esterBy similarity
    Lipidationi186 – 1861S-farnesyl cysteine1 Publication

    Post-translational modificationi

    Palmitoylated by the ZDHHC9-GOLGA7 complex. A continuous cycle of de- and re-palmitoylation regulates rapid exchange between plasma membrane and Golgi.3 Publications
    Acetylation at Lys-104 prevents interaction with guanine nucleotide exchange factors (GEFs).By similarity

    Keywords - PTMi

    Acetylation, Lipoprotein, Methylation, Palmitate, Prenylation

    Proteomic databases

    MaxQBiP01111.
    PaxDbiP01111.
    PeptideAtlasiP01111.
    PRIDEiP01111.

    2D gel databases

    OGPiP01111.

    PTM databases

    PhosphoSiteiP01111.

    Expressioni

    Gene expression databases

    ArrayExpressiP01111.
    BgeeiP01111.
    CleanExiHS_NRAS.
    GenevestigatoriP01111.

    Organism-specific databases

    HPAiCAB010157.
    HPA049830.

    Interactioni

    Subunit structurei

    Interacts (active GTP-bound form preferentially) with RGS14 By similarity. Interacts (active GTP-bound form) with RASSF7.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi110952. 19 interactions.
    DIPiDIP-1058N.
    IntActiP01111. 7 interactions.
    MINTiMINT-131535.
    STRINGi9606.ENSP00000358548.

    Structurei

    Secondary structure

    1
    189
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi2 – 98
    Helixi16 – 2510
    Beta strandi38 – 469
    Beta strandi49 – 579
    Beta strandi76 – 838
    Helixi87 – 10418
    Beta strandi111 – 1166
    Helixi127 – 13711
    Beta strandi141 – 1433
    Turni146 – 1483
    Helixi152 – 16615

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3CONX-ray1.65A1-172[»]
    ProteinModelPortaliP01111.
    SMRiP01111. Positions 1-167.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP01111.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni166 – 18520Hypervariable regionAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi32 – 409Effector region

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Ras family.Curated

    Phylogenomic databases

    eggNOGiCOG1100.
    HOGENOMiHOG000233973.
    HOVERGENiHBG009351.
    InParanoidiP01111.
    KOiK07828.
    OMAiSNEDGNQ.
    OrthoDBiEOG7QVM41.
    PhylomeDBiP01111.
    TreeFamiTF312796.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR020849. Small_GTPase_Ras.
    [Graphical view]
    PANTHERiPTHR24070. PTHR24070. 1 hit.
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SMARTiSM00173. RAS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51421. RAS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P01111-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTEYKLVVVG AGGVGKSALT IQLIQNHFVD EYDPTIEDSY RKQVVIDGET    50
    CLLDILDTAG QEEYSAMRDQ YMRTGEGFLC VFAINNSKSF ADINLYREQI 100
    KRVKDSDDVP MVLVGNKCDL PTRTVDTKQA HELAKSYGIP FIETSAKTRQ 150
    GVEDAFYTLV REIRQYRMKK LNSSDDGTQG CMGLPCVVM 189
    Length:189
    Mass (Da):21,229
    Last modified:July 21, 1986 - v1
    Checksum:i6898D3F6815B1EC7
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti12 – 121G → C in leukemia. 1 Publication
    VAR_021194
    Natural varianti12 – 121G → D in KNEN. 1 Publication
    VAR_071129
    Natural varianti13 – 131G → D in ALPS4. 1 Publication
    VAR_063084
    Natural varianti13 – 131G → R in CMNS and colorectal cancer; somatic mutation. 2 Publications
    VAR_006845
    Natural varianti34 – 341P → L in KNEN. 1 Publication
    VAR_071130
    Natural varianti50 – 501T → I in NS6; hypermorphic mutation. 1 Publication
    VAR_063085
    Natural varianti60 – 601G → E in NS6; hypermorphic mutation. 1 Publication
    VAR_063086
    Natural varianti61 – 611Q → K in CMNS and NCMS; somatic mutation. 1 Publication
    VAR_006846
    Natural varianti61 – 611Q → R in CMNS, NCMS and KNEN; also found in lung carcinoma cell and melanoma. 4 Publications
    Corresponds to variant rs11554290 [ dbSNP | Ensembl ].
    VAR_006847

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X02751 mRNA. Translation: CAA26529.1.
    X00642 Genomic DNA. Translation: CAA25269.1.
    X00643 Genomic DNA. Translation: CAA25270.1.
    X00644 Genomic DNA. Translation: CAA25271.1.
    X00645 Genomic DNA. Translation: CAA25272.1.
    L00043
    , L00040, L00041, L00042 Genomic DNA. Translation: AAA60255.1.
    AF493919 mRNA. Translation: AAM12633.1.
    AY428630 Genomic DNA. Translation: AAQ94397.1.
    BC005219 mRNA. Translation: AAH05219.1.
    M25898 Genomic DNA. Translation: AAA36548.1.
    X53291, X53292 Genomic DNA. Translation: CAA37384.1.
    K03211, M10055 Genomic DNA. Translation: AAA36556.1.
    X05565 Genomic DNA. Translation: CAA29079.1.
    X07440 Genomic DNA. Translation: CAA30320.1.
    CCDSiCCDS877.1.
    PIRiA90839. TVHURA.
    I38149.
    RefSeqiNP_002515.1. NM_002524.4.
    UniGeneiHs.486502.

    Genome annotation databases

    EnsembliENST00000369535; ENSP00000358548; ENSG00000213281.
    GeneIDi4893.
    KEGGihsa:4893.
    UCSCiuc009wgu.3. human.

    Polymorphism databases

    DMDMi131883.

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology
    NRASbase

    NRAS mutation db

    NIEHS-SNPs
    Wikipedia

    RAS proteins entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X02751 mRNA. Translation: CAA26529.1 .
    X00642 Genomic DNA. Translation: CAA25269.1 .
    X00643 Genomic DNA. Translation: CAA25270.1 .
    X00644 Genomic DNA. Translation: CAA25271.1 .
    X00645 Genomic DNA. Translation: CAA25272.1 .
    L00043
    , L00040 , L00041 , L00042 Genomic DNA. Translation: AAA60255.1 .
    AF493919 mRNA. Translation: AAM12633.1 .
    AY428630 Genomic DNA. Translation: AAQ94397.1 .
    BC005219 mRNA. Translation: AAH05219.1 .
    M25898 Genomic DNA. Translation: AAA36548.1 .
    X53291 , X53292 Genomic DNA. Translation: CAA37384.1 .
    K03211 , M10055 Genomic DNA. Translation: AAA36556.1 .
    X05565 Genomic DNA. Translation: CAA29079.1 .
    X07440 Genomic DNA. Translation: CAA30320.1 .
    CCDSi CCDS877.1.
    PIRi A90839. TVHURA.
    I38149.
    RefSeqi NP_002515.1. NM_002524.4.
    UniGenei Hs.486502.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3CON X-ray 1.65 A 1-172 [» ]
    ProteinModelPortali P01111.
    SMRi P01111. Positions 1-167.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110952. 19 interactions.
    DIPi DIP-1058N.
    IntActi P01111. 7 interactions.
    MINTi MINT-131535.
    STRINGi 9606.ENSP00000358548.

    Chemistry

    ChEMBLi CHEMBL2079845.

    PTM databases

    PhosphoSitei P01111.

    Polymorphism databases

    DMDMi 131883.

    2D gel databases

    OGPi P01111.

    Proteomic databases

    MaxQBi P01111.
    PaxDbi P01111.
    PeptideAtlasi P01111.
    PRIDEi P01111.

    Protocols and materials databases

    DNASUi 4893.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000369535 ; ENSP00000358548 ; ENSG00000213281 .
    GeneIDi 4893.
    KEGGi hsa:4893.
    UCSCi uc009wgu.3. human.

    Organism-specific databases

    CTDi 4893.
    GeneCardsi GC01M115247.
    GeneReviewsi NRAS.
    HGNCi HGNC:7989. NRAS.
    HPAi CAB010157.
    HPA049830.
    MIMi 137550. phenotype.
    162900. phenotype.
    164790. gene.
    249400. phenotype.
    607785. phenotype.
    613224. phenotype.
    614470. phenotype.
    neXtProti NX_P01111.
    Orphaneti 3261. Autoimmune lymphoproliferative syndrome.
    86834. Juvenile myelomonocytic leukemia.
    626. Large congenital melanocytic nevus.
    648. Noonan syndrome.
    PharmGKBi PA31768.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1100.
    HOGENOMi HOG000233973.
    HOVERGENi HBG009351.
    InParanoidi P01111.
    KOi K07828.
    OMAi SNEDGNQ.
    OrthoDBi EOG7QVM41.
    PhylomeDBi P01111.
    TreeFami TF312796.

    Enzyme and pathway databases

    Reactomei REACT_111040. Signaling by SCF-KIT.
    REACT_115852. Signaling by constitutively active EGFR.
    REACT_115854. GRB2 events in ERBB2 signaling.
    REACT_115993. SHC1 events in ERBB2 signaling.
    REACT_116005. SHC1 events in ERBB4 signaling.
    REACT_118778. Activation of RAS in B cells.
    REACT_12033. Signalling to RAS.
    REACT_12065. p38MAPK events.
    REACT_121096. EGFR Transactivation by Gastrin.
    REACT_121398. Signaling by FGFR mutants.
    REACT_12579. SHC1 events in EGFR signaling.
    REACT_12606. GRB2 events in EGFR signaling.
    REACT_12621. Tie2 Signaling.
    REACT_147814. DAP12 signaling.
    REACT_163701. FCERI mediated MAPK activation.
    REACT_17025. Downstream signal transduction.
    REACT_18334. NCAM signaling for neurite out-growth.
    REACT_2077. RAF activation.
    REACT_21247. FRS2-mediated cascade.
    REACT_21374. SHC-mediated cascade.
    REACT_524. SOS-mediated signalling.
    REACT_614. RAF phosphorylates MEK.
    REACT_661. SHC-mediated signalling.
    REACT_962. MEK activation.
    SignaLinki P01111.

    Miscellaneous databases

    ChiTaRSi NRAS. human.
    EvolutionaryTracei P01111.
    GeneWikii Neuroblastoma_RAS_viral_oncogene_homolog.
    GenomeRNAii 4893.
    NextBioi 18835.
    PROi P01111.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P01111.
    Bgeei P01111.
    CleanExi HS_NRAS.
    Genevestigatori P01111.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR020849. Small_GTPase_Ras.
    [Graphical view ]
    PANTHERi PTHR24070. PTHR24070. 1 hit.
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SMARTi SM00173. RAS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51421. RAS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure and activation of the human N-ras gene."
      Taparowsky E., Shimizu K., Goldfarb M., Wigler M.
      Cell 34:581-586(1983) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Human N-ras: cDNA cloning and gene structure."
      Hall A., Brown R.
      Nucleic Acids Res. 13:5255-5268(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Mechanism of activation of an N-ras gene in the human fibrosarcoma cell line HT1080."
      Brown R., Marshall C.J., Pennie S.G., Hall A.
      EMBO J. 3:1321-1326(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Fibrosarcoma.
    4. "Mechanism of activation of an N-ras oncogene of SW-1271 human lung carcinoma cells."
      Yuasa Y., Gol R.A., Chang A., Chiu I.-M., Reddy E.P., Tronick S.R., Aaronson S.A.
      Proc. Natl. Acad. Sci. U.S.A. 81:3670-3674(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Lung carcinoma.
    5. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Puhl H.L. III, Ikeda S.R., Aronstam R.S.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    6. NIEHS SNPs program
      Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.
    8. "Transforming genes in human leukemia cells."
      Hirai H., Tanaka S., Azuma M., Anraku Y., Kobayashi Y., Fujisawa M., Okabe T., Urabe A., Takaku F.
      Blood 66:1371-1378(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 1-96, VARIANT CYS-12.
      Tissue: Leukemia.
    9. "Transforming genes from familial adenomatous polyposis patient cells detected by a tumorigenicity assay."
      Yuasa Y., Kamiyama T., Kato M., Iwama T., Ikeuchi T., Tonomura A.
      Oncogene 5:589-596(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 1-29 AND 43-78.
    10. "Activation of an N-ras gene in acute myeloblastic leukemia through somatic mutation in the first exon."
      Gambke C., Hall A., Moroni C.
      Proc. Natl. Acad. Sci. U.S.A. 82:879-882(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-96.
    11. "A point mutation at codon 13 of the N-ras oncogene in myelodysplastic syndrome."
      Hirai H., Kobayashi Y., Mano H., Hagiwara K., Maru Y., Omine M., Mizoguchi H., Nishida J., Takaku F.
      Nature 327:430-432(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-96.
      Tissue: Bone marrow.
    12. "Detection of a low frequency of activated ras genes in human melanomas using a tumorigenicity assay."
      Raybaud F., Noguchi T., Marics I., Adelaide J., Planche J., Batoz M., Aubet C., de Lapeyriere O., Birnbaum D.
      Cancer Res. 48:950-953(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 60-96, VARIANT ARG-61.
    13. "All ras proteins are polyisoprenylated but only some are palmitoylated."
      Hancock J.F., Magee A.I., Childs J.E., Marshall C.J.
      Cell 57:1167-1177(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: PALMITOYLATION AT CYS-181, ISOPRENYLATION AT CYS-186.
    14. "DHHC9 and GCP16 constitute a human protein fatty acyltransferase with specificity for H- and N-Ras."
      Swarthout J.T., Lobo S., Farh L., Croke M.R., Greentree W.K., Deschenes R.J., Linder M.E.
      J. Biol. Chem. 280:31141-31148(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: PALMITOYLATION AT CYS-181.
    15. "An acylation cycle regulates localization and activity of palmitoylated Ras isoforms."
      Rocks O., Peyker A., Kahms M., Verveer P.J., Koerner C., Lumbierres M., Kuhlmann J., Waldmann H., Wittinghofer A., Bastiaens P.I.H.
      Science 307:1746-1752(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: PALMITOYLATION, SUBCELLULAR LOCATION.
    16. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    17. "RASSF7 negatively regulates pro-apoptotic JNK signaling by inhibiting the activity of phosphorylated-MKK7."
      Takahashi S., Ebihara A., Kajiho H., Kontani K., Nishina H., Katada T.
      Cell Death Differ. 18:645-655(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH RASSF7.
    18. "Amino-acid substitution at codon 13 of the N-ras oncogene in rectal cancer in a Japanese patient."
      Nitta N., Ochiai M., Nagao M., Sugimura T.
      Jpn. J. Cancer Res. 78:21-26(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT COLORECTAL CANCER ARG-13.
    19. Cited for: VARIANT ALPS4 ASP-13.
    20. "Genotypic and gene expression studies in congenital melanocytic nevi: insight into initial steps of melanotumorigenesis."
      Dessars B., De Raeve L.E., Morandini R., Lefort A., El Housni H., Ghanem G.E., Van den Eynde B.J., Ma W., Roseeuw D., Vassart G., Libert F., Heimann P.
      J. Invest. Dermatol. 129:139-147(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS CMNS ARG-13 AND ARG-61.
    21. Cited for: VARIANTS NS6 ILE-50 AND GLU-60, CHARACTERIZATION OF VARIANTS NS6 ILE-50 AND GLU-60.
    22. Cited for: VARIANTS KNEN ASP-12; LEU-34 AND ARG-61.
    23. "Multiple congenital melanocytic nevi and neurocutaneous melanosis are caused by postzygotic mutations in codon 61 of NRAS."
      Kinsler V.A., Thomas A.C., Ishida M., Bulstrode N.W., Loughlin S., Hing S., Chalker J., McKenzie K., Abu-Amero S., Slater O., Chanudet E., Palmer R., Morrogh D., Stanier P., Healy E., Sebire N.J., Moore G.E.
      J. Invest. Dermatol. 133:2229-2236(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS CMNS ARG-61 AND LYS-61, VARIANTS NCMS ARG-61 AND LYS-61.

    Entry informationi

    Entry nameiRASN_HUMAN
    AccessioniPrimary (citable) accession number: P01111
    Secondary accession number(s): Q14971, Q15104, Q15282
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 172 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Mutations which change AA 12, 13 or 61 activate the potential of Ras to transform cultured cells and are implicated in a variety of human tumors.

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3