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Protein

Myc proto-oncogene protein

Gene

MYC

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Seems to activate the transcription of growth-related genes.

GO - Molecular functioni

GO - Biological processi

  • epidermis morphogenesis Source: AgBase
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-GGA-5689880. Ub-specific processing proteases.
R-GGA-8866911. TFAP2 (AP-2) family regulates transcription of cell cycle factors.

Names & Taxonomyi

Protein namesi
Recommended name:
Myc proto-oncogene protein
Short name:
c-Myc
Gene namesi
Name:MYC
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

Chemistry databases

ChEMBLiCHEMBL1250349.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001273131 – 416Myc proto-oncogene proteinAdd BLAST416

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi61O-linked (GlcNAc)By similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP01109.

Expressioni

Gene expression databases

BgeeiENSGALG00000016308.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX.

Protein-protein interaction databases

BioGridi681305. 2 interactors.
MINTiMINT-1367509.
STRINGi9031.ENSGALP00000026259.

Structurei

3D structure databases

ProteinModelPortaliP01109.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini331 – 383bHLHPROSITE-ProRule annotationAdd BLAST53

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni390 – 411Leucine-zipperAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi26 – 30Poly-Glu5
Compositional biasi163 – 167Poly-Pro5
Compositional biasi183 – 186Poly-Ala4
Compositional biasi398 – 401Poly-Arg4

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IFSM. Eukaryota.
ENOG41124Q3. LUCA.
GeneTreeiENSGT00510000046414.
HOGENOMiHOG000043075.
HOVERGENiHBG000472.
InParanoidiP01109.
KOiK04377.
OMAiAAASECI.
OrthoDBiEOG091G0ZJQ.
PhylomeDBiP01109.
TreeFamiTF106001.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR003327. Myc-LZ.
IPR002418. Tscrpt_reg_Myc.
IPR012682. Tscrpt_reg_Myc_N.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
PF02344. Myc-LZ. 1 hit.
PF01056. Myc_N. 1 hit.
[Graphical view]
PRINTSiPR00044. LEUZIPPRMYC.
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P01109-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLSASLPSK NYDYDYDSVQ PYFYFEEEEE NFYLAAQQRG SELQPPAPSE
60 70 80 90 100
DIWKKFELLP TPPLSPSRRS SLAAASCFPS TADQLEMVTE LLGGDMVNQS
110 120 130 140 150
FICDPDDESF VKSIIIQDCM WSGFSAAAKL EKVVSEKLAT YQASRREGGP
160 170 180 190 200
AAASRPGPPP SGPPPPPAGP AASAGLYLHD LGAAAADCID PSVVFPYPLS
210 220 230 240 250
ERAPRAAPPG ANPAALLGVD TPPTTSSDSE EEQEEDEEID VVTLAEANES
260 270 280 290 300
ESSTESSTEA SEEHCKPHHS PLVLKRCHVN IHQHNYAAPP STKVEYPAAK
310 320 330 340 350
RLKLDSGRVL KQISNNRKCS SPRTSDSEEN DKRRTHNVLE RQRRNELKLS
360 370 380 390 400
FFALRDQIPE VANNEKAPKV VILKKATEYV LSIQSDEHRL IAEKEQLRRR
410
REQLKHKLEQ LRNSRA
Length:416
Mass (Da):46,040
Last modified:July 21, 1986 - v1
Checksum:i6B35E4BD3A1A5883
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00889 Genomic DNA. Translation: AAA48963.1.
M20006 Genomic DNA. Translation: AAA48700.1.
PIRiA93944. FOCH.
RefSeqiNP_001026123.1. NM_001030952.1.
XP_015138575.1. XM_015283089.1.
UniGeneiGga.1030.

Genome annotation databases

EnsembliENSGALT00000080250; ENSGALP00000054503; ENSGALG00000033631.
GeneIDi420332.
KEGGigga:420332.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00889 Genomic DNA. Translation: AAA48963.1.
M20006 Genomic DNA. Translation: AAA48700.1.
PIRiA93944. FOCH.
RefSeqiNP_001026123.1. NM_001030952.1.
XP_015138575.1. XM_015283089.1.
UniGeneiGga.1030.

3D structure databases

ProteinModelPortaliP01109.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi681305. 2 interactors.
MINTiMINT-1367509.
STRINGi9031.ENSGALP00000026259.

Chemistry databases

ChEMBLiCHEMBL1250349.

Proteomic databases

PaxDbiP01109.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000080250; ENSGALP00000054503; ENSGALG00000033631.
GeneIDi420332.
KEGGigga:420332.

Organism-specific databases

CTDi4609.

Phylogenomic databases

eggNOGiENOG410IFSM. Eukaryota.
ENOG41124Q3. LUCA.
GeneTreeiENSGT00510000046414.
HOGENOMiHOG000043075.
HOVERGENiHBG000472.
InParanoidiP01109.
KOiK04377.
OMAiAAASECI.
OrthoDBiEOG091G0ZJQ.
PhylomeDBiP01109.
TreeFamiTF106001.

Enzyme and pathway databases

ReactomeiR-GGA-5689880. Ub-specific processing proteases.
R-GGA-8866911. TFAP2 (AP-2) family regulates transcription of cell cycle factors.

Miscellaneous databases

PROiP01109.

Gene expression databases

BgeeiENSGALG00000016308.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR003327. Myc-LZ.
IPR002418. Tscrpt_reg_Myc.
IPR012682. Tscrpt_reg_Myc_N.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
PF02344. Myc-LZ. 1 hit.
PF01056. Myc_N. 1 hit.
[Graphical view]
PRINTSiPR00044. LEUZIPPRMYC.
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYC_CHICK
AccessioniPrimary (citable) accession number: P01109
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 30, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.