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Protein

Myc proto-oncogene protein

Gene

MYC

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.By similarity

GO - Molecular functioni

GO - Biological processi

  • epidermis morphogenesis Source: AgBase
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-GGA-5689880 Ub-specific processing proteases
R-GGA-8866911 TFAP2 (AP-2) family regulates transcription of cell cycle factors

Names & Taxonomyi

Protein namesi
Recommended name:
Myc proto-oncogene protein
Short name:
c-Myc
Gene namesi
Name:MYC
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

Chemistry databases

ChEMBLiCHEMBL1250349

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001273131 – 416Myc proto-oncogene proteinAdd BLAST416

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi61O-linked (GlcNAc) threonineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP01109
PRIDEiP01109

Expressioni

Gene expression databases

BgeeiENSGALG00000016308
ExpressionAtlasiP01109 baseline and differential

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi681305, 2 interactors
MINTiP01109
STRINGi9031.ENSGALP00000026259

Structurei

3D structure databases

ProteinModelPortaliP01109
SMRiP01109
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini331 – 383bHLHPROSITE-ProRule annotationAdd BLAST53

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni390 – 411Leucine-zipperAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi26 – 30Poly-Glu5
Compositional biasi163 – 167Poly-Pro5
Compositional biasi183 – 186Poly-Ala4
Compositional biasi398 – 401Poly-Arg4

Phylogenomic databases

eggNOGiENOG410IFSM Eukaryota
ENOG41124Q3 LUCA
GeneTreeiENSGT00510000046414
HOGENOMiHOG000043075
HOVERGENiHBG000472
InParanoidiP01109
KOiK04377
OMAiQPYFYCD
OrthoDBiEOG091G0ZJQ
PhylomeDBiP01109
TreeFamiTF106001

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR003327 Myc-LZ
IPR002418 Tscrpt_reg_Myc
IPR012682 Tscrpt_reg_Myc_N
PfamiView protein in Pfam
PF00010 HLH, 1 hit
PF02344 Myc-LZ, 1 hit
PF01056 Myc_N, 1 hit
PIRSFiPIRSF001705 Myc_protein, 1 hit
PRINTSiPR00044 LEUZIPPRMYC
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequencei

Sequence statusi: Complete.

P01109-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLSASLPSK NYDYDYDSVQ PYFYFEEEEE NFYLAAQQRG SELQPPAPSE
60 70 80 90 100
DIWKKFELLP TPPLSPSRRS SLAAASCFPS TADQLEMVTE LLGGDMVNQS
110 120 130 140 150
FICDPDDESF VKSIIIQDCM WSGFSAAAKL EKVVSEKLAT YQASRREGGP
160 170 180 190 200
AAASRPGPPP SGPPPPPAGP AASAGLYLHD LGAAAADCID PSVVFPYPLS
210 220 230 240 250
ERAPRAAPPG ANPAALLGVD TPPTTSSDSE EEQEEDEEID VVTLAEANES
260 270 280 290 300
ESSTESSTEA SEEHCKPHHS PLVLKRCHVN IHQHNYAAPP STKVEYPAAK
310 320 330 340 350
RLKLDSGRVL KQISNNRKCS SPRTSDSEEN DKRRTHNVLE RQRRNELKLS
360 370 380 390 400
FFALRDQIPE VANNEKAPKV VILKKATEYV LSIQSDEHRL IAEKEQLRRR
410
REQLKHKLEQ LRNSRA
Length:416
Mass (Da):46,040
Last modified:July 21, 1986 - v1
Checksum:i6B35E4BD3A1A5883
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00889 Genomic DNA Translation: AAA48963.1
M20006 Genomic DNA Translation: AAA48700.1
PIRiA93944 FOCH
RefSeqiNP_001026123.1, NM_001030952.1
XP_015138575.1, XM_015283089.1
UniGeneiGga.1030

Genome annotation databases

EnsembliENSGALT00000080250; ENSGALP00000054503; ENSGALG00000033631
GeneIDi420332
KEGGigga:420332

Similar proteinsi

Entry informationi

Entry nameiMYC_CHICK
AccessioniPrimary (citable) accession number: P01109
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: May 23, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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