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Protein

Transforming protein Myb

Gene

V-MYB

Organism
Avian myeloblastosis virus
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

DNA-binding protein that specifically recognizes the sequence 5'-YAAC[GT]G-3'. The v-Myb oncogene transforms immature myelomonocytic avian cells in culture and induces myeloblastosis (myeloid leukemia) in chickens.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi44 – 67H-T-H motifPROSITE-ProRule annotationAdd BLAST24
DNA bindingi95 – 118H-T-H motifPROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transforming protein Myb
Gene namesi
Name:V-MYB
OrganismiAvian myeloblastosis virus
Taxonomic identifieri11866 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeAlpharetrovirus
Virus hostiGalliformes [TaxID: 8976]

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host nucleus

Pathology & Biotechi

Keywords - Diseasei

Oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001970531 – 382Transforming protein MybAdd BLAST382

Interactioni

Protein-protein interaction databases

IntActiP01104. 2 interactors.

Structurei

Secondary structure

1382
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi26 – 38Combined sources13
Helixi44 – 50Combined sources7
Beta strandi51 – 53Combined sources3
Helixi56 – 65Combined sources10
Beta strandi69 – 71Combined sources3
Helixi78 – 91Combined sources14
Helixi95 – 98Combined sources4
Helixi99 – 101Combined sources3
Helixi107 – 115Combined sources9
Turni116 – 119Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1H8AX-ray2.23C1-122[»]
ProteinModelPortaliP01104.
SMRiP01104.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01104.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 15Myb-likePROSITE-ProRule annotationAdd BLAST15
Domaini16 – 71HTH myb-type 1PROSITE-ProRule annotationAdd BLAST56
Domaini72 – 122HTH myb-type 2PROSITE-ProRule annotationAdd BLAST51

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni204 – 256Transcriptional activation domainBy similarityAdd BLAST53
Regioni257 – 376Negative regulatory domain (incomplete)By similarityAdd BLAST120
Regioni305 – 326Leucine-zipperAdd BLAST22

Domaini

The absence of the N- and/or C-terminal may prevent homodimer formation, leading to DNA-binding and its increased transactivation activity.

Sequence similaritiesi

Contains 2 HTH myb-type DNA-binding domains.PROSITE-ProRule annotation
Contains 1 Myb-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Family and domain databases

Gene3Di1.10.10.60. 3 hits.
InterProiIPR015395. C-myb_C.
IPR009057. Homeodomain-like.
IPR017877. Myb-like_dom.
IPR017930. Myb_dom.
IPR001005. SANT/Myb.
IPR012642. Tscrpt_reg_Wos2-domain.
[Graphical view]
PfamiPF09316. Cmyb_C. 1 hit.
PF07988. LMSTEN. 1 hit.
PF00249. Myb_DNA-binding. 2 hits.
[Graphical view]
SMARTiSM00717. SANT. 2 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS51294. HTH_MYB. 2 hits.
PS50090. MYB_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P01104-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
NRTDVQCQHR WQKVLNPELN KGPWTKEEDQ RVIEHVQKYG PKRWSDIAKH
60 70 80 90 100
LKGRIGKQCR ERWHNHLNPE VKKTSWTEEE DRIIYQAHKR LGNRWAEIAK
110 120 130 140 150
LLPGRTDNAV KNHWNSTMRR KVEQEGYPQE SSKAGPPSAT TGFQKSSHLM
160 170 180 190 200
AFAHNPPAGP LPGAGQAPLG SDYPYYHIAE PQNVPGQIPY PVALHINIIN
210 220 230 240 250
VPQPAAAAIQ RHYTDEDPEK EKRIKELELL LMSTENELKG QQALPTQNHT
260 270 280 290 300
ANYPGWHSTT VADNTRTSGD NAPVSCLGEH HHCTPSPPVD HGCLPEESAS
310 320 330 340 350
PARCMIVHQS NILDNVKNLL EFAETLQLID SFLNTSSNHE NLNLDNPALT
360 370 380
STPVCGHKMS VTTPFHKDQT FTEYRKMHGG AV
Length:382
Mass (Da):43,061
Last modified:July 1, 1989 - v2
Checksum:i1459BACAD29EC971
GO

Sequence cautioni

The sequence AAA42553 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAC15907 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02012 Genomic RNA. Translation: AAA42553.1. Different initiation.
S74099 Genomic RNA. Translation: AAB31930.2.
J02013 Genomic DNA. Translation: AAC15907.1. Different initiation.
PIRiA36314. QOYV.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02012 Genomic RNA. Translation: AAA42553.1. Different initiation.
S74099 Genomic RNA. Translation: AAB31930.2.
J02013 Genomic DNA. Translation: AAC15907.1. Different initiation.
PIRiA36314. QOYV.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1H8AX-ray2.23C1-122[»]
ProteinModelPortaliP01104.
SMRiP01104.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP01104. 2 interactors.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP01104.

Family and domain databases

Gene3Di1.10.10.60. 3 hits.
InterProiIPR015395. C-myb_C.
IPR009057. Homeodomain-like.
IPR017877. Myb-like_dom.
IPR017930. Myb_dom.
IPR001005. SANT/Myb.
IPR012642. Tscrpt_reg_Wos2-domain.
[Graphical view]
PfamiPF09316. Cmyb_C. 1 hit.
PF07988. LMSTEN. 1 hit.
PF00249. Myb_DNA-binding. 2 hits.
[Graphical view]
SMARTiSM00717. SANT. 2 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS51294. HTH_MYB. 2 hits.
PS50090. MYB_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYB_AVIMB
AccessioniPrimary (citable) accession number: P01104
Secondary accession number(s): Q83871, Q90954
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 1, 1989
Last modified: November 30, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.