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Protein

Transcriptional activator Myb

Gene

MYB

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi63 – 8624H-T-H motifPROSITE-ProRule annotationAdd
BLAST
DNA bindingi115 – 13824H-T-H motifPROSITE-ProRule annotationAdd
BLAST
DNA bindingi166 – 18924H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional activator Myb
Alternative name(s):
Proto-oncogene c-Myb
Gene namesi
Name:MYB
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

Chemistry

ChEMBLiCHEMBL2380186.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 641641Transcriptional activator MybPRO_0000197050Add
BLAST

Proteomic databases

PaxDbiP01103.
PRIDEiP01103.

PTM databases

iPTMnetiP01103.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PPIDQ087522EBI-6502562,EBI-716596From a different organism.

Protein-protein interaction databases

BioGridi676504. 1 interaction.
IntActiP01103. 1 interaction.
STRINGi9031.ENSGALP00000022584.

Chemistry

BindingDBiP01103.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1POMmodel-A142-192[»]
ProteinModelPortaliP01103.
SMRiP01103. Positions 38-193.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 8652HTH myb-type 1PROSITE-ProRule annotationAdd
BLAST
Domaini87 – 14256HTH myb-type 2PROSITE-ProRule annotationAdd
BLAST
Domaini143 – 19351HTH myb-type 3PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni275 – 32753Transcriptional activation domainBy similarityAdd
BLAST
Regioni328 – 465138Negative regulatory domainBy similarityAdd
BLAST
Regioni376 – 39722Leucine-zipperAdd
BLAST

Domaini

Comprised of 3 domains; an N-terminal DNA-binding domain, a centrally located transcriptional activation domain and a C-terminal domain involved in transcriptional repression.
Truncation of either the N- or C-terminal of C-Myb leads to increased transformation and transactivation potential.

Sequence similaritiesi

Contains 3 HTH myb-type DNA-binding domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0048. Eukaryota.
COG5147. LUCA.
HOGENOMiHOG000231021.
HOVERGENiHBG007964.
InParanoidiP01103.
KOiK09420.
PhylomeDBiP01103.

Family and domain databases

Gene3Di1.10.10.60. 3 hits.
InterProiIPR015395. C-myb_C.
IPR009057. Homeodomain-like.
IPR017930. Myb_dom.
IPR001005. SANT/Myb.
IPR012642. Tscrpt_reg_Wos2-domain.
[Graphical view]
PfamiPF09316. Cmyb_C. 1 hit.
PF07988. LMSTEN. 1 hit.
PF00249. Myb_DNA-binding. 3 hits.
[Graphical view]
SMARTiSM00717. SANT. 3 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS51294. HTH_MYB. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P01103-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARRPRHSIY SSDDDEEDVE MYDHDYDGLL PKAGKRHLGK TRWTREEDEK
60 70 80 90 100
LKKLVEQNGT EDWKVIASFL PNRTDVQCQH RWQKVLNPEL IKGPWTKEED
110 120 130 140 150
QRVIELVQKY GPKRWSVIAK HLKGRIGKQC RERWHNHLNP EVKKTSWTEE
160 170 180 190 200
EDRIIYQAHK RLGNRWAEIA KLLPGRTDNA IKNHWNSTMR RKVEQEGYLQ
210 220 230 240 250
ESSKAGLPSA TTGFQKSSHL MAFAHNPPAG PLPGAGQAPL GSDYPYYHIA
260 270 280 290 300
EPQNVPGQIP YPVALHVNIV NVPQPAAAAI QRHYNDEDPE KEKRIKELEL
310 320 330 340 350
LLMSTENELK GQQALPTQNH TANYPGWHST TVADNTRTSG DNAPVSCLGE
360 370 380 390 400
HHHCTPSPPV DHGCLPEESA SPARCMIVHQ SNILDNVKNL LEFAETLQLI
410 420 430 440 450
DSFLNTSSNH ENLNLDNPAL TSTPVCGHKM SVTTPFHRDQ PFKTQKENHV
460 470 480 490 500
FRTPAIKRSI LESSPRTPTP FKNALAAQEI KYGPLKMLPQ TPTHLVEDLQ
510 520 530 540 550
DVIKQESEES AIVAGLHESG PPLLKKIKQE VESPTDKAGN FFCSNHWEGE
560 570 580 590 600
NLNTQLFTHA STMEDVPNLL TSSILKMPVS EEEGSFHKAF AVPRNRPLAS
610 620 630 640
PMQHLNNAWE SASCGKTEDQ MALTDQARKY MAAFPTRTLV M
Length:641
Mass (Da):72,467
Last modified:April 1, 1988 - v1
Checksum:iDDDD62BFD3B29187
GO
Isoform 2 (identifier: P01103-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     402-402: S → SDPSSWGDLS...VKSLPFSPSQ

Show »
Length:761
Mass (Da):84,626
Checksum:i903FD864B9E6C464
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei402 – 4021S → SDPSSWGDLSSFEFFEDTDI LAGKATSGTAVQLQHGGASA CRPPGLPISNLSKTMSSQSP PGSPKSLSASQGSVAPWVLR KRRGHASPLASGPSSTLGLA DGSSSTSKHSPVKSLPFSPS Q in isoform 2. CuratedVSP_010978

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14129 mRNA. Translation: AAA48962.1.
X03477 mRNA. Translation: CAA27197.1. Sequence problems.
X14612 Genomic DNA. Translation: CAA32767.1.
X12495 Genomic DNA. Translation: CAA31015.1.
M24373 Genomic DNA. Translation: AAA48697.1.
M35509
, M35506, M35507, M35508 Genomic DNA. Translation: AAA48698.1.
M35509, M35507, M35508 Genomic DNA. Translation: AAA48699.1.
X73660 mRNA. No translation available.
PIRiA25075. TVCHM.
RefSeqiNP_990637.1. NM_205306.1.
UniGeneiGga.721.

Genome annotation databases

GeneIDi396244.
KEGGigga:396244.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14129 mRNA. Translation: AAA48962.1.
X03477 mRNA. Translation: CAA27197.1. Sequence problems.
X14612 Genomic DNA. Translation: CAA32767.1.
X12495 Genomic DNA. Translation: CAA31015.1.
M24373 Genomic DNA. Translation: AAA48697.1.
M35509
, M35506, M35507, M35508 Genomic DNA. Translation: AAA48698.1.
M35509, M35507, M35508 Genomic DNA. Translation: AAA48699.1.
X73660 mRNA. No translation available.
PIRiA25075. TVCHM.
RefSeqiNP_990637.1. NM_205306.1.
UniGeneiGga.721.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1POMmodel-A142-192[»]
ProteinModelPortaliP01103.
SMRiP01103. Positions 38-193.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi676504. 1 interaction.
IntActiP01103. 1 interaction.
STRINGi9031.ENSGALP00000022584.

Chemistry

BindingDBiP01103.
ChEMBLiCHEMBL2380186.

PTM databases

iPTMnetiP01103.

Proteomic databases

PaxDbiP01103.
PRIDEiP01103.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396244.
KEGGigga:396244.

Organism-specific databases

CTDi4602.

Phylogenomic databases

eggNOGiKOG0048. Eukaryota.
COG5147. LUCA.
HOGENOMiHOG000231021.
HOVERGENiHBG007964.
InParanoidiP01103.
KOiK09420.
PhylomeDBiP01103.

Miscellaneous databases

NextBioi20816296.
PROiP01103.

Family and domain databases

Gene3Di1.10.10.60. 3 hits.
InterProiIPR015395. C-myb_C.
IPR009057. Homeodomain-like.
IPR017930. Myb_dom.
IPR001005. SANT/Myb.
IPR012642. Tscrpt_reg_Wos2-domain.
[Graphical view]
PfamiPF09316. Cmyb_C. 1 hit.
PF07988. LMSTEN. 1 hit.
PF00249. Myb_DNA-binding. 3 hits.
[Graphical view]
SMARTiSM00717. SANT. 3 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS51294. HTH_MYB. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Structure of the protein encoded by the chicken proto-oncogene c-myb."
    Gerondakis S., Bishop J.M.
    Mol. Cell. Biol. 6:3677-3684(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Nucleotide sequence of chicken c-myb complementary DNA and implications for myb oncogene activation."
    Rosson D., Reddy P.
    Nature 319:604-606(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Transcription of the chicken myb proto-oncogene starts within a CpG island."
    Dvorak M., Urbanek P., Bartunek P., Paces V., Vlach J., Pecenka V., Arnold L., Travnicek M.
    Nucleic Acids Res. 17:5651-5664(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-176.
    Strain: Brown leghorn.
    Tissue: Thymus.
  4. "Nucleotide sequence of chicken myb proto-oncogene promoter region: detection of an evolutionarily conserved element."
    Urbanek P., Dvorak P., Bartunek M., Vlach P., Pecenka J., Paces V., Travnicek M.
    Nucleic Acids Res. 16:11521-11530(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-7.
  5. "Structural organization of upstream exons and distribution of transcription start sites in the chicken c-myb gene."
    Hahn S.L., Hahn M., Hayward W.S.
    Mol. Cell. Biol. 9:837-843(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-7.
  6. "Organization of 5'-proximal c-myb exons in chicken DNA. Implications for c-myb tissue-specific transcription."
    Soret J., Vellard M., Martinerie C., Perbal B.
    FEBS Lett. 232:227-234(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 21-79 AND 73-79.
    Tissue: Thymus.
  7. "Alternative splicing of the chicken c-myb exon 9A."
    Schuur E.R., Dasgupta P., Reddy E.P., Rabinovich J.M., Baluda M.A.
    Oncogene 8:1839-1847(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING.
  8. "Protein truncation is required for the activation of the c-myb proto-oncogene."
    Graesser F.A., Graf T., Lipsick J.S.
    Mol. Cell. Biol. 11:3987-3996(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: TRUNCATION MUTATIONS.
  9. "Proposed structure for the DNA-binding domain of the Myb oncoprotein based on model building and mutational analysis."
    Frampton J., Gibson T.J., Ness S.A., Doederlein G., Graf T.
    Protein Eng. 4:891-901(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING OF 142-192.

Entry informationi

Entry nameiMYB_CHICK
AccessioniPrimary (citable) accession number: P01103
Secondary accession number(s): P87467, Q788R2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: April 1, 1988
Last modified: January 20, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.