P01102 (FOS_MSVFB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
p55-v-Fos-transforming protein

Gene names

Name:

V-FOS

Organism

FBJ murine osteosarcoma virus (FBJ-MSV) (Finkel-Biskis-Jinkins murine osteosarcoma virus)

Taxonomic identifier

11805 [NCBI]

Taxonomic lineage

Viruses › Retro-transcribing viruses › Retroviridae › Orthoretrovirinae › Gammaretrovirus › Mammalian virus group › Replication defective viruses › Moloney murine sarcoma virus

Virus host

Mus musculus (Mouse) [TaxID: 10090]

Protein attributes

Sequence length	381 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Subcellular location	Host nucleus Potential.
Sequence similarities	Belongs to the bZIP family. Fos subfamily. Contains 1 bZIP (basic-leucine zipper) domain.

Ontologies

Keywords
Cellular component	Host nucleus
Disease	Oncogene
Ligand	DNA-binding
PTM	Phosphoprotein
Gene Ontology (GO)
Cellular_component	host cell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 381	381	p55-v-Fos-transforming protein		PRO_0000076460
Regions
	Domain	137 – 200	64	bZIP
	Region	139 – 159	21	Basic motif By similarity
	Region	165 – 193	29	Leucine-zipper By similarity

Sequences

	Sequence		Length	Mass (Da)
	P01102 [UniParc]. Last modified July 21, 1986. Version 1. Checksum: D15FFDB258949A9D	FASTA	381	41,648
	10 20 30 40 50 60 MMFSGFNADY EASSFRCSSA SPAGDSLSYY HSPADSFSSM GSPVNTQDFC ADLSVSSANF 70 80 90 100 110 120 IPTVTATSTS PDLQWLVQPT LVSSVAPSQT RAPHPYGLPT QSAGAYARAE MVKTVSGGRA 130 140 150 160 170 180 QSIGRRGKVE QLSPEEEEKR RIRRERNKMA AAKCRNRRRE LTDTLQAETD QLEDKKSALQ 190 200 210 220 230 240 TEIANLLKEK EKLEFILAAH RPACKIPDDL GFPEEMSVAS LDLTGGLPEA STPESEEAFT 250 260 270 280 290 300 LPLLNDPEPK PSLEPVKSIS NVELKAEPFD DFLFPASSRP SGSETSRSVP NVDLSGSFYA 310 320 330 340 350 360 ADWEPLHSNS LGMGPMVTEL EPLCTPVVTC TPLLRLPELT HAAGPVSSQR RQGSRHPDVP 370 380 LPELVHYREE KHVFPQRFPS T

References

[1]

"Analysis of FBJ-MuSV provirus and c-fos (mouse) gene reveals that viral and cellular fos gene products have different carboxy termini." van Beveren C., van Straaten F., Curran T., Mueller R., Verma I.M. Cell 32:1241-1255(1983) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	V01184 Genomic DNA. Translation: CAA24505.1.
PIR	TVMVJ. A01344.
3D structure databases
ProteinModelPortal	P01102.
SMR	P01102. Positions 139-198.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR004827. bZIP. IPR000837. Leuzip_Fos. [Graphical view]
Pfam	PF00170. bZIP_1. 1 hit. [Graphical view]
PRINTS	PR00042. LEUZIPPRFOS.
SMART	SM00338. BRLZ. 1 hit. [Graphical view]
PROSITE	PS50217. BZIP. 1 hit. PS00036. BZIP_BASIC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FOS_MSVFB

Accession

Primary (citable) accession number: P01102

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	April 3, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program