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Protein

Protein phosphatase 1 regulatory subunit 1A

Gene

PPP1R1A

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protein phosphatase inhibitor

Keywords - Biological processi

Carbohydrate metabolism, Glycogen metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 1A
Alternative name(s):
Protein phosphatase inhibitor 1
Short name:
I-1
Short name:
IPP-1
Gene namesi
Name:PPP1R1A
Synonyms:IPP1
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 166166Protein phosphatase 1 regulatory subunit 1APRO_0000071479Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication
Modified residuei35 – 351Phosphothreonine; by PKA1 Publication
Modified residuei43 – 431PhosphoserineBy similarity
Modified residuei46 – 461PhosphoserineBy similarity
Modified residuei47 – 471PhosphoserineBy similarity
Modified residuei67 – 671Phosphoserine1 Publication

Post-translational modificationi

Phosphorylation of Thr-35 is required for activity.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

PTM databases

iPTMnetiP01099.

Interactioni

Subunit structurei

Interacts with PPP1R15A.By similarity

Protein-protein interaction databases

IntActiP01099. 1 interaction.
MINTiMINT-8146709.
STRINGi9986.ENSOCUP00000011659.

Structurei

3D structure databases

DisProtiDP00325.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni9 – 124Essential for activity
Regioni42 – 5413Essential for activityCuratedAdd
BLAST
Regioni143 – 16624Interaction with PPP1R15ABy similarityAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410J0ZP. Eukaryota.
ENOG41125ZM. LUCA.
HOGENOMiHOG000115665.
HOVERGENiHBG096069.
InParanoidiP01099.

Family and domain databases

InterProiIPR008466. PPP1R1A/B/C.
[Graphical view]
PANTHERiPTHR15417. PTHR15417. 1 hit.
PfamiPF05395. DARPP-32. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P01099-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQDNSPRKI QFTVPLLEPH LDPEAAEQIR RRRPTPATLV LTSDQSSPEV
60 70 80 90 100
DEDRIPNPLL KPSLAMSPRQ RKKMTRTTPT MKELQMMVEH HLGQQEQGEE
110 120 130 140 150
PEGAAEGTGA QESQPPGTPG TGAESRLGPS ATAQKPAQPS PRAQERRGEE
160
PSTAKTSQDS QGASAV
Length:166
Mass (Da):18,032
Last modified:November 1, 1988 - v1
Checksum:i0D26A5FE0C617C88
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti164 – 1663Missing in 40% of the molecules.

Sequence databases

PIRiA91120. PZRB1.

Cross-referencesi

Sequence databases

PIRiA91120. PZRB1.

3D structure databases

DisProtiDP00325.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP01099. 1 interaction.
MINTiMINT-8146709.
STRINGi9986.ENSOCUP00000011659.

PTM databases

iPTMnetiP01099.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410J0ZP. Eukaryota.
ENOG41125ZM. LUCA.
HOGENOMiHOG000115665.
HOVERGENiHBG096069.
InParanoidiP01099.

Family and domain databases

InterProiIPR008466. PPP1R1A/B/C.
[Graphical view]
PANTHERiPTHR15417. PTHR15417. 1 hit.
PfamiPF05395. DARPP-32. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPPR1A_RABIT
AccessioniPrimary (citable) accession number: P01099
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: November 1, 1988
Last modified: June 8, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.