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Protein

ATPase inhibitor, mitochondrial

Gene

INH1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Forms a one-to-one complex with ATPase to inhibit the enzyme activity completely.

Miscellaneous

Present with 981 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • ATPase inhibitor activity Source: SGD
  • enzyme inhibitor activity Source: SGD

GO - Biological processi

  • negative regulation of ATPase activity Source: SGD

Enzyme and pathway databases

BioCyciYEAST:G3O-29568-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
ATPase inhibitor, mitochondrial
Gene namesi
Name:INH1
Ordered Locus Names:YDL181W
ORF Names:D1305
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDL181W
SGDiS000002340 INH1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi41K → Q or E: No loss of inhibitory activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 22Mitochondrion2 PublicationsAdd BLAST22
ChainiPRO_000000255423 – 85ATPase inhibitor, mitochondrialAdd BLAST63

Proteomic databases

MaxQBiP01097
PaxDbiP01097
PRIDEiP01097

Interactioni

Protein-protein interaction databases

BioGridi31863, 94 interactors
DIPiDIP-2985N
IntActiP01097, 6 interactors
MINTiP01097
STRINGi4932.YDL181W

Structurei

Secondary structure

185
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni24 – 28Combined sources5
Helixi38 – 57Combined sources20

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ZIAX-ray2.50J/T23-85[»]
DisProtiDP00995
ProteinModelPortaliP01097
SMRiP01097
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili41 – 84Sequence analysisAdd BLAST44

Sequence similaritiesi

Belongs to the ATPase inhibitor family.Curated

Keywords - Domaini

Coiled coil, Transit peptide

Phylogenomic databases

HOGENOMiHOG000183772
InParanoidiP01097
KOiK22255
OMAiPRVMTEG
OrthoDBiEOG092C607C

Family and domain databases

InterProiView protein in InterPro
IPR007648 ATPase_inhibitor_mt
PfamiView protein in Pfam
PF04568 IATP, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01097-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPRSALARS LQLQRGVAAR FYSEGSTGTP RGSGSEDSFV KRERATEDFF
60 70 80
VRQREKEQLR HLKEQLEKQR KKIDSLENKI DSMTK
Length:85
Mass (Da):9,870
Last modified:August 1, 1990 - v2
Checksum:iE1AF73A47F63CE58
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00443 Genomic DNA Translation: BAA00344.1
X83276 Genomic DNA Translation: CAA58265.1
Z74229 Genomic DNA Translation: CAA98755.1
AY558374 Genomic DNA Translation: AAS56700.1
BK006938 Genomic DNA Translation: DAA11681.1
PIRiA35231 IWBY
RefSeqiNP_010100.1, NM_001180241.1

Genome annotation databases

EnsemblFungiiYDL181W; YDL181W; YDL181W
GeneIDi851347
KEGGisce:YDL181W

Similar proteinsi

Entry informationi

Entry nameiATIF_YEAST
AccessioniPrimary (citable) accession number: P01097
Secondary accession number(s): D6VRH1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 1, 1990
Last modified: May 23, 2018
This is version 159 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names
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Main funding by: National Institutes of Health