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Protein

ATPase inhibitor, mitochondrial

Gene

INH1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Forms a one-to-one complex with ATPase to inhibit the enzyme activity completely.

GO - Molecular functioni

  • ATPase binding Source: GO_Central
  • ATPase inhibitor activity Source: SGD
  • enzyme inhibitor activity Source: SGD

GO - Biological processi

  • heme biosynthetic process Source: GO_Central
  • negative regulation of ATPase activity Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-29568-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ATPase inhibitor, mitochondrial
Gene namesi
Name:INH1
Ordered Locus Names:YDL181W
ORF Names:D1305
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDL181W.
SGDiS000002340. INH1.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi41 – 411K → Q or E: No loss of inhibitory activity. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2222Mitochondrion2 PublicationsAdd
BLAST
Chaini23 – 8563ATPase inhibitor, mitochondrialPRO_0000002554Add
BLAST

Proteomic databases

MaxQBiP01097.
PRIDEiP01097.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi31863. 50 interactions.
DIPiDIP-2985N.
IntActiP01097. 5 interactions.
MINTiMINT-434735.

Structurei

Secondary structure

1
85
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni24 – 285Combined sources
Helixi38 – 5720Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ZIAX-ray2.50J/T23-85[»]
ProteinModelPortaliP01097.
SMRiP01097. Positions 23-58.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili41 – 8444Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the ATPase inhibitor family.Curated

Keywords - Domaini

Coiled coil, Transit peptide

Phylogenomic databases

HOGENOMiHOG000183772.
InParanoidiP01097.
OMAiEQGGEQN.
OrthoDBiEOG092C607C.

Family and domain databases

InterProiIPR007648. ATPase_inhibitor_mt.
[Graphical view]
PfamiPF04568. IATP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01097-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPRSALARS LQLQRGVAAR FYSEGSTGTP RGSGSEDSFV KRERATEDFF
60 70 80
VRQREKEQLR HLKEQLEKQR KKIDSLENKI DSMTK
Length:85
Mass (Da):9,870
Last modified:August 1, 1990 - v2
Checksum:iE1AF73A47F63CE58
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00443 Genomic DNA. Translation: BAA00344.1.
X83276 Genomic DNA. Translation: CAA58265.1.
Z74229 Genomic DNA. Translation: CAA98755.1.
AY558374 Genomic DNA. Translation: AAS56700.1.
BK006938 Genomic DNA. Translation: DAA11681.1.
PIRiA35231. IWBY.
RefSeqiNP_010100.1. NM_001180241.1.

Genome annotation databases

EnsemblFungiiYDL181W; YDL181W; YDL181W.
GeneIDi851347.
KEGGisce:YDL181W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00443 Genomic DNA. Translation: BAA00344.1.
X83276 Genomic DNA. Translation: CAA58265.1.
Z74229 Genomic DNA. Translation: CAA98755.1.
AY558374 Genomic DNA. Translation: AAS56700.1.
BK006938 Genomic DNA. Translation: DAA11681.1.
PIRiA35231. IWBY.
RefSeqiNP_010100.1. NM_001180241.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ZIAX-ray2.50J/T23-85[»]
ProteinModelPortaliP01097.
SMRiP01097. Positions 23-58.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31863. 50 interactions.
DIPiDIP-2985N.
IntActiP01097. 5 interactions.
MINTiMINT-434735.

Proteomic databases

MaxQBiP01097.
PRIDEiP01097.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDL181W; YDL181W; YDL181W.
GeneIDi851347.
KEGGisce:YDL181W.

Organism-specific databases

EuPathDBiFungiDB:YDL181W.
SGDiS000002340. INH1.

Phylogenomic databases

HOGENOMiHOG000183772.
InParanoidiP01097.
OMAiEQGGEQN.
OrthoDBiEOG092C607C.

Enzyme and pathway databases

BioCyciYEAST:G3O-29568-MONOMER.

Miscellaneous databases

PROiP01097.

Family and domain databases

InterProiIPR007648. ATPase_inhibitor_mt.
[Graphical view]
PfamiPF04568. IATP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATIF_YEAST
AccessioniPrimary (citable) accession number: P01097
Secondary accession number(s): D6VRH1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 1, 1990
Last modified: September 7, 2016
This is version 148 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 981 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.