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P01097

- ATIF_YEAST

UniProt

P01097 - ATIF_YEAST

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Protein

ATPase inhibitor, mitochondrial

Gene

INH1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Forms a one-to-one complex with ATPase to inhibit the enzyme activity completely.

GO - Molecular functioni

  1. ATPase inhibitor activity Source: SGD
  2. enzyme inhibitor activity Source: SGD

GO - Biological processi

  1. negative regulation of ATPase activity Source: SGD
  2. negative regulation of nucleotide metabolic process Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-29568-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ATPase inhibitor, mitochondrial
Gene namesi
Name:INH1
Ordered Locus Names:YDL181W
ORF Names:D1305
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome IV

Organism-specific databases

CYGDiYDL181w.
SGDiS000002340. INH1.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi41 – 411K → Q or E: No loss of inhibitory activity. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2222Mitochondrion2 PublicationsAdd
BLAST
Chaini23 – 8563ATPase inhibitor, mitochondrialPRO_0000002554Add
BLAST

Proteomic databases

MaxQBiP01097.
PaxDbiP01097.
PeptideAtlasiP01097.
PRIDEiP01097.

Expressioni

Gene expression databases

GenevestigatoriP01097.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
YHR080CP388001EBI-8874,EBI-24597

Protein-protein interaction databases

BioGridi31863. 49 interactions.
DIPiDIP-2985N.
IntActiP01097. 5 interactions.
MINTiMINT-434735.
STRINGi4932.YDL181W.

Structurei

Secondary structure

1
85
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni24 – 285
Helixi38 – 5720

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ZIAX-ray2.50J/T23-85[»]
ProteinModelPortaliP01097.
SMRiP01097. Positions 23-58.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili41 – 8444Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the ATPase inhibitor family.Curated

Keywords - Domaini

Coiled coil, Transit peptide

Phylogenomic databases

eggNOGiNOG84090.
GeneTreeiENSGT00390000016182.
HOGENOMiHOG000183772.
InParanoidiP01097.
OMAiKRERATE.
OrthoDBiEOG7MSN2Q.

Family and domain databases

InterProiIPR007648. ATPase_inhibitor_IATP_mt.
[Graphical view]
PfamiPF04568. IATP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01097-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLPRSALARS LQLQRGVAAR FYSEGSTGTP RGSGSEDSFV KRERATEDFF
60 70 80
VRQREKEQLR HLKEQLEKQR KKIDSLENKI DSMTK
Length:85
Mass (Da):9,870
Last modified:August 1, 1990 - v2
Checksum:iE1AF73A47F63CE58
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D00443 Genomic DNA. Translation: BAA00344.1.
X83276 Genomic DNA. Translation: CAA58265.1.
Z74229 Genomic DNA. Translation: CAA98755.1.
AY558374 Genomic DNA. Translation: AAS56700.1.
BK006938 Genomic DNA. Translation: DAA11681.1.
PIRiA35231. IWBY.
RefSeqiNP_010100.1. NM_001180241.1.

Genome annotation databases

EnsemblFungiiYDL181W; YDL181W; YDL181W.
GeneIDi851347.
KEGGisce:YDL181W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D00443 Genomic DNA. Translation: BAA00344.1 .
X83276 Genomic DNA. Translation: CAA58265.1 .
Z74229 Genomic DNA. Translation: CAA98755.1 .
AY558374 Genomic DNA. Translation: AAS56700.1 .
BK006938 Genomic DNA. Translation: DAA11681.1 .
PIRi A35231. IWBY.
RefSeqi NP_010100.1. NM_001180241.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3ZIA X-ray 2.50 J/T 23-85 [» ]
ProteinModelPortali P01097.
SMRi P01097. Positions 23-58.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 31863. 49 interactions.
DIPi DIP-2985N.
IntActi P01097. 5 interactions.
MINTi MINT-434735.
STRINGi 4932.YDL181W.

Proteomic databases

MaxQBi P01097.
PaxDbi P01097.
PeptideAtlasi P01097.
PRIDEi P01097.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YDL181W ; YDL181W ; YDL181W .
GeneIDi 851347.
KEGGi sce:YDL181W.

Organism-specific databases

CYGDi YDL181w.
SGDi S000002340. INH1.

Phylogenomic databases

eggNOGi NOG84090.
GeneTreei ENSGT00390000016182.
HOGENOMi HOG000183772.
InParanoidi P01097.
OMAi KRERATE.
OrthoDBi EOG7MSN2Q.

Enzyme and pathway databases

BioCyci YEAST:G3O-29568-MONOMER.

Miscellaneous databases

NextBioi 968432.

Gene expression databases

Genevestigatori P01097.

Family and domain databases

InterProi IPR007648. ATPase_inhibitor_IATP_mt.
[Graphical view ]
Pfami PF04568. IATP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Activation of ATP hydrolysis by an uncoupler in mutant mitochondria lacking an intrinsic ATPase inhibitor in yeast."
    Ichikawa N., Yoshida Y., Hashimoto T., Ogasawara N., Yoshikawa H., Imamoto F., Tagawa K.
    J. Biol. Chem. 265:6274-6278(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "New open reading frames, one of which is similar to the nifV gene of Azotobacter vinelandii, found on a 12.5 kbp fragment of chromosome IV of Saccharomyces cerevisiae."
    Verhasselt P., Voet M., Volckaert G.
    Yeast 11:961-966(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 96604 / S288c / FY1679.
  3. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
    Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
    , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
    Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  6. "Amino acid sequence of an intrinsic inhibitor of mitochondrial ATPase from yeast."
    Matsubara H., Hase T., Hashimoto T., Tagawa K.
    J. Biochem. 90:1159-1165(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 23-85.
  7. "Partial amino terminal sequence of the precursor of mitochondrial ATPase inhibitor protein synthesized with mRNA partially purified by gel permeation chromatography."
    Yoshida Y., Hashimoto T., Hase T., Matsubara H., Tagawa K.
    J. Biochem. 94:291-297(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-28.
  8. "Requirement for lysine-19 of the yeast mitochondrial ATPase inhibitor for the stability of the inactivated inhibitor-F1Fo complex at higher pH."
    Ichikawa N., Fujisaka R., Kuribayashi R.
    Biosci. Biotechnol. Biochem. 64:89-95(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS OF LYS-41.
  9. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiATIF_YEAST
AccessioniPrimary (citable) accession number: P01097
Secondary accession number(s): D6VRH1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 1, 1990
Last modified: October 29, 2014
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 981 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

External Data

Dasty 3