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Protein

Alpha-amylase inhibitor HOE-467A

Gene
N/A
Organism
Streptomyces tendae
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits mammalian alpha-amylases specifically but has no action on plant and microbial alpha-amylases. Forms a tight stoichiometric 1:1 complex with alpha-amylase.

GO - Molecular functioni

Keywordsi

Molecular functionAlpha-amylase inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-amylase inhibitor HOE-467A
Alternative name(s):
Tendamistat
OrganismiStreptomyces tendae
Taxonomic identifieri1932 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 301 PublicationAdd BLAST30
ChainiPRO_000001434331 – 104Alpha-amylase inhibitor HOE-467AAdd BLAST74

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi41 ↔ 571 Publication
Disulfide bondi75 ↔ 1031 Publication

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

MINTiMINT-1510723.

Structurei

Secondary structure

1104
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi35 – 37Combined sources3
Beta strandi42 – 46Combined sources5
Beta strandi48 – 55Combined sources8
Beta strandi57 – 59Combined sources3
Beta strandi61 – 67Combined sources7
Beta strandi76 – 78Combined sources3
Beta strandi83 – 88Combined sources6
Beta strandi90 – 94Combined sources5
Beta strandi96 – 102Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BVNX-ray2.50T31-104[»]
1HOEX-ray2.00A31-104[»]
1OK0X-ray0.93A31-104[»]
2AITNMR-A31-104[»]
3AITNMR-A31-104[»]
4AITNMR-A31-104[»]
ProteinModelPortaliP01092.
SMRiP01092.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01092.

Family & Domainsi

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR000833. A-amylase_inhib.
PfamiView protein in Pfam
PF01356. A_amylase_inhib. 1 hit.
PIRSFiPIRSF001658. Amylase_inhib. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD009058. A-amylase_inhib. 1 hit.
SMARTiView protein in SMART
SM00783. A_amylase_inhib. 1 hit.
SUPFAMiSSF49498. SSF49498. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01092-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVRALRLAA LVGAGAALAL SPLAAGPASA DTTVSEPAPS CVTLYQSWRY
60 70 80 90 100
SQADNGCAQT VTVKVVYEDD TEGLCYAVAP GQITTVGDGY IGSHGHARYL

ARCL
Length:104
Mass (Da):10,759
Last modified:November 1, 1990 - v2
Checksum:i8C58DEF975EA01AE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti59Q → E AA sequence (PubMed:6605909).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28478 Genomic DNA. Translation: AAA26686.1.
PIRiA33961. WISMAT.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28478 Genomic DNA. Translation: AAA26686.1.
PIRiA33961. WISMAT.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BVNX-ray2.50T31-104[»]
1HOEX-ray2.00A31-104[»]
1OK0X-ray0.93A31-104[»]
2AITNMR-A31-104[»]
3AITNMR-A31-104[»]
4AITNMR-A31-104[»]
ProteinModelPortaliP01092.
SMRiP01092.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1510723.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP01092.

Family and domain databases

InterProiView protein in InterPro
IPR000833. A-amylase_inhib.
PfamiView protein in Pfam
PF01356. A_amylase_inhib. 1 hit.
PIRSFiPIRSF001658. Amylase_inhib. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD009058. A-amylase_inhib. 1 hit.
SMARTiView protein in SMART
SM00783. A_amylase_inhib. 1 hit.
SUPFAMiSSF49498. SSF49498. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiIAA_STRTE
AccessioniPrimary (citable) accession number: P01092
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: November 1, 1990
Last modified: May 10, 2017
This is version 85 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.