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Protein

Trypsin/factor XIIA inhibitor

Gene
N/A
Organism
Zea mays (Maize)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Potent inhibitor of mammalian trypsin and a specific inhibitor of factor XIIa (activated hageman factor).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei62 – 6211 Publication

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI06.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Trypsin/factor XIIA inhibitor
Alternative name(s):
CHFI
Hageman factor inhibitor
OrganismiZea mays (Maize)
Taxonomic identifieri4577 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogonodaeAndropogoneaeTripsacinaeZea
Proteomesi
  • UP000007305 Componenti: Unplaced

Organism-specific databases

MaizeGDBi25928.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 28281 PublicationAdd
BLAST
Chaini29 – 138110Trypsin/factor XIIA inhibitorPRO_0000014357Add
BLAST
Propeptidei139 – 15517C-terminal peptidePRO_0000014358Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi34 ↔ 83Combined sources1 Publication
Disulfide bondi48 ↔ 72Combined sources1 Publication
Disulfide bondi57 ↔ 114Combined sources1 Publication
Disulfide bondi73 ↔ 132Combined sources1 Publication
Disulfide bondi85 ↔ 143Combined sources1 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP01088.

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

STRINGi4577.GRMZM2G304548_P01.

Structurei

Secondary structure

1
155
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni37 – 393Combined sources
Helixi46 – 5510Combined sources
Helixi65 – 7713Combined sources
Helixi81 – 833Combined sources
Helixi84 – 9310Combined sources
Beta strandi99 – 1013Combined sources
Helixi116 – 1238Combined sources
Turni124 – 1274Combined sources
Turni129 – 1324Combined sources
Beta strandi139 – 1413Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BEAX-ray1.95A29-155[»]
1BFAX-ray2.20A28-154[»]
ProteinModelPortaliP01088.
SMRiP01088. Positions 33-148.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01088.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JT1U. Eukaryota.
ENOG411089M. LUCA.

Family and domain databases

Gene3Di1.10.120.10. 1 hit.
InterProiIPR006106. Allergen/soft/tryp_amyl_inhib.
IPR006105. Allergen/tryp_amyl_inhib_CS.
IPR016140. Bifunc_inhib/LTP/seed_store.
IPR013771. Trypsin/amylase_inhib.
[Graphical view]
PfamiPF00234. Tryp_alpha_amyl. 1 hit.
[Graphical view]
PRINTSiPR00808. AMLASEINHBTR.
SMARTiSM00499. AAI. 1 hit.
[Graphical view]
SUPFAMiSSF47699. SSF47699. 1 hit.
PROSITEiPS00426. CEREAL_TRYP_AMYL_INH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01088-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSSSSSHR RLILAAAVLL SVLAAASASA GTSCVPGWAI PHNPLPSCRW
60 70 80 90 100
YVTSRTCGIG PRLPWPELKR RCCRELADIP AYCRCTALSI LMDGAIPPGP
110 120 130 140 150
DAQLEGRLED LPGCPREVQR GFAATLVTEA ECNLATISGV AECPWILGGG

TMPSK
Length:155
Mass (Da):16,302
Last modified:April 1, 1993 - v2
Checksum:iA31A8AA3BA19DE7A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti49 – 491R → C AA sequence (PubMed:6610678).Curated
Sequence conflicti56 – 561T → R AA sequence (PubMed:6610678).Curated
Sequence conflicti62 – 621R → RPR AA sequence (PubMed:6610678).Curated
Sequence conflicti107 – 1071R → A AA sequence (PubMed:6610678).Curated
Sequence conflicti116 – 1161R → A AA sequence (PubMed:6610678).Curated
Sequence conflicti120 – 1201R → Q AA sequence (PubMed:6610678).Curated
Sequence conflicti135 – 1351A → E AA sequence (PubMed:6610678).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti117 – 1171E → A.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54064 mRNA. Translation: CAA37998.1.
PIRiS20850. TIZM1.
UniGeneiZm.123129.
Zm.142423.
Zm.93810.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54064 mRNA. Translation: CAA37998.1.
PIRiS20850. TIZM1.
UniGeneiZm.123129.
Zm.142423.
Zm.93810.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BEAX-ray1.95A29-155[»]
1BFAX-ray2.20A28-154[»]
ProteinModelPortaliP01088.
SMRiP01088. Positions 33-148.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi4577.GRMZM2G304548_P01.

Protein family/group databases

MEROPSiI06.001.

Proteomic databases

PaxDbiP01088.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MaizeGDBi25928.

Phylogenomic databases

eggNOGiENOG410JT1U. Eukaryota.
ENOG411089M. LUCA.

Miscellaneous databases

EvolutionaryTraceiP01088.

Family and domain databases

Gene3Di1.10.120.10. 1 hit.
InterProiIPR006106. Allergen/soft/tryp_amyl_inhib.
IPR006105. Allergen/tryp_amyl_inhib_CS.
IPR016140. Bifunc_inhib/LTP/seed_store.
IPR013771. Trypsin/amylase_inhib.
[Graphical view]
PfamiPF00234. Tryp_alpha_amyl. 1 hit.
[Graphical view]
PRINTSiPR00808. AMLASEINHBTR.
SMARTiSM00499. AAI. 1 hit.
[Graphical view]
SUPFAMiSSF47699. SSF47699. 1 hit.
PROSITEiPS00426. CEREAL_TRYP_AMYL_INH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiITRF_MAIZE
AccessioniPrimary (citable) accession number: P01088
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: April 1, 1993
Last modified: June 8, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

The sequence heterogeneity suggests that 2 genes exist for this inhibitor. The genes may be alleles, or multiple loci could exist.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.