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Protein

Trypsin/factor XIIA inhibitor

Gene
N/A
Organism
Zea mays (Maize)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Potent inhibitor of mammalian trypsin and a specific inhibitor of factor XIIa (activated hageman factor).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei621 Publication1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI06.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Trypsin/factor XIIA inhibitor
Alternative name(s):
CHFI
Hageman factor inhibitor
OrganismiZea mays (Maize)
Taxonomic identifieri4577 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogonodaeAndropogoneaeTripsacinaeZea
Proteomesi
  • UP000007305 Componenti: Unplaced

Organism-specific databases

MaizeGDBi25928.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 281 PublicationAdd BLAST28
ChainiPRO_000001435729 – 138Trypsin/factor XIIA inhibitorAdd BLAST110
PropeptideiPRO_0000014358139 – 155C-terminal peptideAdd BLAST17

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 83Combined sources1 Publication
Disulfide bondi48 ↔ 72Combined sources1 Publication
Disulfide bondi57 ↔ 114Combined sources1 Publication
Disulfide bondi73 ↔ 132Combined sources1 Publication
Disulfide bondi85 ↔ 143Combined sources1 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP01088.

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

STRINGi4577.GRMZM2G304548_P01.

Structurei

Secondary structure

1155
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni37 – 39Combined sources3
Helixi46 – 55Combined sources10
Helixi65 – 77Combined sources13
Helixi81 – 83Combined sources3
Helixi84 – 93Combined sources10
Beta strandi99 – 101Combined sources3
Helixi116 – 123Combined sources8
Turni124 – 127Combined sources4
Turni129 – 132Combined sources4
Beta strandi139 – 141Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BEAX-ray1.95A29-155[»]
1BFAX-ray2.20A28-154[»]
ProteinModelPortaliP01088.
SMRiP01088.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01088.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JT1U. Eukaryota.
ENOG411089M. LUCA.

Family and domain databases

Gene3Di1.10.120.10. 1 hit.
InterProiIPR006106. Allergen/soft/tryp_amyl_inhib.
IPR006105. Allergen/tryp_amyl_inhib_CS.
IPR016140. Bifunc_inhib/LTP/seed_store.
IPR013771. Trypsin/amylase_inhib.
[Graphical view]
PfamiPF00234. Tryp_alpha_amyl. 1 hit.
[Graphical view]
PRINTSiPR00808. AMLASEINHBTR.
SMARTiSM00499. AAI. 1 hit.
[Graphical view]
SUPFAMiSSF47699. SSF47699. 1 hit.
PROSITEiPS00426. CEREAL_TRYP_AMYL_INH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01088-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSSSSSHR RLILAAAVLL SVLAAASASA GTSCVPGWAI PHNPLPSCRW
60 70 80 90 100
YVTSRTCGIG PRLPWPELKR RCCRELADIP AYCRCTALSI LMDGAIPPGP
110 120 130 140 150
DAQLEGRLED LPGCPREVQR GFAATLVTEA ECNLATISGV AECPWILGGG

TMPSK
Length:155
Mass (Da):16,302
Last modified:April 1, 1993 - v2
Checksum:iA31A8AA3BA19DE7A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti49R → C AA sequence (PubMed:6610678).Curated1
Sequence conflicti56T → R AA sequence (PubMed:6610678).Curated1
Sequence conflicti62R → RPR AA sequence (PubMed:6610678).Curated1
Sequence conflicti107R → A AA sequence (PubMed:6610678).Curated1
Sequence conflicti116R → A AA sequence (PubMed:6610678).Curated1
Sequence conflicti120R → Q AA sequence (PubMed:6610678).Curated1
Sequence conflicti135A → E AA sequence (PubMed:6610678).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti117E → A.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54064 mRNA. Translation: CAA37998.1.
PIRiS20850. TIZM1.
UniGeneiZm.123129.
Zm.142423.
Zm.93810.

Genome annotation databases

EnsemblPlantsiZm00001d005230_T001; Zm00001d005230_T001; Zm00001d005230.
GrameneiZm00001d005230_T001; Zm00001d005230_T001; Zm00001d005230.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54064 mRNA. Translation: CAA37998.1.
PIRiS20850. TIZM1.
UniGeneiZm.123129.
Zm.142423.
Zm.93810.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BEAX-ray1.95A29-155[»]
1BFAX-ray2.20A28-154[»]
ProteinModelPortaliP01088.
SMRiP01088.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi4577.GRMZM2G304548_P01.

Protein family/group databases

MEROPSiI06.001.

Proteomic databases

PaxDbiP01088.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiZm00001d005230_T001; Zm00001d005230_T001; Zm00001d005230.
GrameneiZm00001d005230_T001; Zm00001d005230_T001; Zm00001d005230.

Organism-specific databases

MaizeGDBi25928.

Phylogenomic databases

eggNOGiENOG410JT1U. Eukaryota.
ENOG411089M. LUCA.

Miscellaneous databases

EvolutionaryTraceiP01088.

Family and domain databases

Gene3Di1.10.120.10. 1 hit.
InterProiIPR006106. Allergen/soft/tryp_amyl_inhib.
IPR006105. Allergen/tryp_amyl_inhib_CS.
IPR016140. Bifunc_inhib/LTP/seed_store.
IPR013771. Trypsin/amylase_inhib.
[Graphical view]
PfamiPF00234. Tryp_alpha_amyl. 1 hit.
[Graphical view]
PRINTSiPR00808. AMLASEINHBTR.
SMARTiSM00499. AAI. 1 hit.
[Graphical view]
SUPFAMiSSF47699. SSF47699. 1 hit.
PROSITEiPS00426. CEREAL_TRYP_AMYL_INH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiITRF_MAIZE
AccessioniPrimary (citable) accession number: P01088
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: April 1, 1993
Last modified: November 30, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

The sequence heterogeneity suggests that 2 genes exist for this inhibitor. The genes may be alleles, or multiple loci could exist.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.