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Protein

Alpha-amylase inhibitor 0.19

Gene
N/A
Organism
Triticum aestivum (Wheat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Alpha-amylase inhibitor.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Alpha-amylase inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-amylase inhibitor 0.19
Alternative name(s):
0.19 alpha-AI
Short name:
0.19 AI
Allergen: Tri a 28
OrganismiTriticum aestivum (Wheat)
Taxonomic identifieri4565 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladePooideaeTriticodaeTriticeaeTriticinaeTriticum
Proteomesi
  • UP000019116 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Binds to IgE.1 Publication

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei8186. Tri a 28.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000704841 – 124Alpha-amylase inhibitor 0.19Add BLAST124

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi6 ↔ 52Combined sources1 Publication
Disulfide bondi20 ↔ 41Combined sources1 Publication
Disulfide bondi28 ↔ 83Combined sources1 Publication
Disulfide bondi42 ↔ 99Combined sources1 Publication
Disulfide bondi54 ↔ 115Combined sources1 Publication

Post-translational modificationi

The disulfide bonds are essential for the inhibitor activity.

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP01085.

Expressioni

Tissue specificityi

Endosperm.

Interactioni

Subunit structurei

Homodimer.

Structurei

Secondary structure

1124
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni8 – 10Combined sources3
Helixi20 – 27Combined sources8
Turni28 – 30Combined sources3
Helixi35 – 46Combined sources12
Turni50 – 52Combined sources3
Helixi53 – 67Combined sources15
Helixi85 – 92Combined sources8
Helixi95 – 98Combined sources4
Beta strandi111 – 114Combined sources4
Helixi116 – 119Combined sources4
Turni120 – 123Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HSSX-ray2.06A/B/C/D1-124[»]
ProteinModelPortaliP01085.
SMRiP01085.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01085.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di1.10.120.10. 1 hit.
InterProiIPR016309. A-amylase_inhib/allergen.
IPR006106. Allergen/soft/tryp_amyl_inhib.
IPR006105. Allergen/tryp_amyl_inhib_CS.
IPR016140. Bifunc_inhib/LTP/seed_store.
IPR013771. Trypsin/amylase_inhib.
[Graphical view]
PfamiPF00234. Tryp_alpha_amyl. 1 hit.
[Graphical view]
PIRSFiPIRSF001657. Allergen/amylase_inhib. 1 hit.
PRINTSiPR00808. AMLASEINHBTR.
SMARTiSM00499. AAI. 1 hit.
[Graphical view]
SUPFAMiSSF47699. SSF47699. 1 hit.
PROSITEiPS00426. CEREAL_TRYP_AMYL_INH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P01085-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
SGPWMCYPGQ AFQVPALPAC RPLLRLQCNG SQVPEAVLRD CCQQLAHISE
60 70 80 90 100
WCRCGALYSM LDSMYKEHGA QEGQAGTGAF PRCRREVVKL TAASITAVCR
110 120
LPIVVDASGD GAYVCKDVAA YPDA
Length:124
Mass (Da):13,337
Last modified:July 21, 1986 - v1
Checksum:i97A8FB07D5A7788B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB003682 mRNA. Translation: BAA20139.1.
PIRiA01324. WIWTA1.
UniGeneiTa.24102.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB003682 mRNA. Translation: BAA20139.1.
PIRiA01324. WIWTA1.
UniGeneiTa.24102.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HSSX-ray2.06A/B/C/D1-124[»]
ProteinModelPortaliP01085.
SMRiP01085.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei8186. Tri a 28.

Proteomic databases

PRIDEiP01085.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP01085.

Family and domain databases

Gene3Di1.10.120.10. 1 hit.
InterProiIPR016309. A-amylase_inhib/allergen.
IPR006106. Allergen/soft/tryp_amyl_inhib.
IPR006105. Allergen/tryp_amyl_inhib_CS.
IPR016140. Bifunc_inhib/LTP/seed_store.
IPR013771. Trypsin/amylase_inhib.
[Graphical view]
PfamiPF00234. Tryp_alpha_amyl. 1 hit.
[Graphical view]
PIRSFiPIRSF001657. Allergen/amylase_inhib. 1 hit.
PRINTSiPR00808. AMLASEINHBTR.
SMARTiSM00499. AAI. 1 hit.
[Graphical view]
SUPFAMiSSF47699. SSF47699. 1 hit.
PROSITEiPS00426. CEREAL_TRYP_AMYL_INH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIAA1_WHEAT
AccessioniPrimary (citable) accession number: P01085
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 2, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.