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Protein

Metallocarboxypeptidase inhibitor

Gene
N/A
Organism
Solanum tuberosum (Potato)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play a defensive role against insect attacks.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Metalloenzyme inhibitor

Protein family/group databases

MEROPSiI37.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Metallocarboxypeptidase inhibitor
Short name:
Carboxypeptidase inhibitor
Short name:
MCPI
OrganismiSolanum tuberosum (Potato)
Taxonomic identifieri4113 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanum
Proteomesi
  • UP000011115 Componenti: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3939Metallocarboxypeptidase inhibitorPRO_0000096302Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11Pyrrolidone carboxylic acid
Disulfide bondi8 ↔ 241 Publication
Disulfide bondi12 ↔ 271 Publication
Disulfide bondi18 ↔ 341 Publication

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid

Expressioni

Tissue specificityi

Highly concentrated in tubers. Closely related but distinct forms of MCPI are present in leaves, stems and buds.

Inductioni

By wounding; in leaves.

Interactioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei38 – 381Interaction with carboxypeptidase

Protein-protein interaction databases

MINTiMINT-1505095.

Structurei

Secondary structure

1
39
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni6 – 94Combined sources
Beta strandi13 – 186Combined sources
Beta strandi22 – 243Combined sources
Turni29 – 313Combined sources
Beta strandi33 – 353Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1H20NMR-A2-39[»]
4CPAX-ray2.50I/J3-38[»]
ProteinModelPortaliP01075.
SMRiP01075. Positions 3-38.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01075.

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.

Keywords - Domaini

Knottin

Family and domain databases

InterProiIPR004231. COpept_A_inh-like.
IPR021142. MCPI.
IPR011052. Proteinase_amylase_inhib_dom.
[Graphical view]
PfamiPF02977. CarbpepA_inh. 1 hit.
[Graphical view]
ProDomiPD884054. Prot_inh_carbpA. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF57027. SSF57027. 1 hit.

Sequencei

Sequence statusi: Complete.

P01075-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
QQHADPICNK PCKTHDDCSG AWFCQACWNS ARTCGPYVG
Length:39
Mass (Da):4,300
Last modified:July 21, 1986 - v1
Checksum:i82EA0E0762237AFA
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti2 – 21Missing in 50% of the molecules.

Cross-referencesi

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1H20NMR-A2-39[»]
4CPAX-ray2.50I/J3-38[»]
ProteinModelPortaliP01075.
SMRiP01075. Positions 3-38.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1505095.

Protein family/group databases

MEROPSiI37.001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP01075.

Family and domain databases

InterProiIPR004231. COpept_A_inh-like.
IPR021142. MCPI.
IPR011052. Proteinase_amylase_inhib_dom.
[Graphical view]
PfamiPF02977. CarbpepA_inh. 1 hit.
[Graphical view]
ProDomiPD884054. Prot_inh_carbpA. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF57027. SSF57027. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMCPI_SOLTU
AccessioniPrimary (citable) accession number: P01075
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: May 11, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.