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Protein

Metallocarboxypeptidase inhibitor

Gene
N/A
Organism
Solanum tuberosum (Potato)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play a defensive role against insect attacks.

GO - Molecular functioni

Keywordsi

Molecular functionMetalloenzyme inhibitor

Protein family/group databases

MEROPSiI37.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Metallocarboxypeptidase inhibitor
Short name:
Carboxypeptidase inhibitor
Short name:
MCPI
OrganismiSolanum tuberosum (Potato)
Taxonomic identifieri4113 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanum
Proteomesi
  • UP000011115 Componenti: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000963021 – 39Metallocarboxypeptidase inhibitorAdd BLAST39

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1Pyrrolidone carboxylic acid1 Publication1
Disulfide bondi8 ↔ 241 Publication
Disulfide bondi12 ↔ 271 Publication
Disulfide bondi18 ↔ 341 Publication

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid

Proteomic databases

PRIDEiP01075.

Expressioni

Tissue specificityi

Highly concentrated in tubers. Closely related but distinct forms of MCPI are present in leaves, stems and buds.

Inductioni

By wounding; in leaves.

Interactioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei38Interaction with carboxypeptidase1

Protein-protein interaction databases

MINTiMINT-1505095.

Structurei

Secondary structure

139
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni6 – 9Combined sources4
Beta strandi13 – 18Combined sources6
Beta strandi22 – 24Combined sources3
Turni29 – 31Combined sources3
Beta strandi33 – 35Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1H20NMR-A2-39[»]
4CPAX-ray2.50I/J3-38[»]
ProteinModelPortaliP01075.
SMRiP01075.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01075.

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.

Keywords - Domaini

Knottin

Family and domain databases

InterProiView protein in InterPro
IPR004231. COpept_A_inh-like.
IPR021142. MCPI.
IPR011052. Proteinase_amylase_inhib_sf.
PfamiView protein in Pfam
PF02977. CarbpepA_inh. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD884054. Prot_inh_carbpA. 1 hit.
SUPFAMiSSF57027. SSF57027. 1 hit.

Sequencei

Sequence statusi: Complete.

P01075-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
QQHADPICNK PCKTHDDCSG AWFCQACWNS ARTCGPYVG
Length:39
Mass (Da):4,300
Last modified:July 21, 1986 - v1
Checksum:i82EA0E0762237AFA
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti2Missing in 50% of the molecules. 1

Similar proteinsi

Entry informationi

Entry nameiMCPI_SOLTU
AccessioniPrimary (citable) accession number: P01075
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 22, 2017
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references