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Protein

Trypsin inhibitor 1

Gene
N/A
Organism
Cucurbita maxima (Pumpkin) (Winter squash)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits trypsin.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei5 – 6Reactive bond2

GO - Molecular functioni

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI07.005

Names & Taxonomyi

Protein namesi
Recommended name:
Trypsin inhibitor 1
Alternative name(s):
CMTI-I
ITD-I
Trypsin inhibitor I
OrganismiCucurbita maxima (Pumpkin) (Winter squash)
Taxonomic identifieri3661 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsCucurbitalesCucurbitaceaeCucurbiteaeCucurbita

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000443761 – 29Trypsin inhibitor 1Add BLAST29

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi3 ↔ 201 Publication
Disulfide bondi10 ↔ 221 Publication
Disulfide bondi16 ↔ 281 Publication

Keywords - PTMi

Disulfide bond

Miscellaneous databases

PMAP-CutDBiP01074

Interactioni

Protein-protein interaction databases

MINTiP01074

Structurei

Secondary structure

129
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi13 – 15Combined sources3
Beta strandi21 – 23Combined sources3
Beta strandi26 – 28Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CTINMR-A1-29[»]
1LU0X-ray1.03A/B1-29[»]
1PPEX-ray2.00I1-29[»]
2CTINMR-A1-29[»]
2STAX-ray1.80I1-29[»]
2V1VNMR-A1-29[»]
3CTINMR-A1-29[»]
ProteinModelPortaliP01074
SMRiP01074
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01074

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.

Sequence similaritiesi

Keywords - Domaini

Knottin

Family and domain databases

CDDicd00150 PlantTI, 1 hit
InterProiView protein in InterPro
IPR000737 Prot_inh_squash
IPR011052 Proteinase_amylase_inhib_sf
PfamiView protein in Pfam
PF00299 Squash, 1 hit
PRINTSiPR00293 SQUASHINHBTR
SUPFAMiSSF57027 SSF57027, 1 hit
PROSITEiView protein in PROSITE
PS00286 SQUASH_INHIBITOR, 1 hit

Sequencei

Sequence statusi: Complete.

P01074-1 [UniParc]FASTAAdd to basket

« Hide

        10         20 
RVCPRILMEC KKDSDCLAEC VCLEHGYCG
Length:29
Mass (Da):3,275
Last modified:July 21, 1986 - v1
Checksum:iCD509120BA52C01F
GO

Sequence databases

PIRiA01313 TIPU

Similar proteinsi

Entry informationi

Entry nameiITR1_CUCMA
AccessioniPrimary (citable) accession number: P01074
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: May 23, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

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