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Protein

Trypsin inhibitor A

Gene

KTI3

Organism
Glycine max (Soybean) (Glycine hispida)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Inhibition of trypsin.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei87 – 88Reactive bond for trypsin2

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI03.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Trypsin inhibitor A
Alternative name(s):
Kunitz-type trypsin inhibitor A
Gene namesi
Name:KTI3
OrganismiGlycine max (Soybean) (Glycine hispida)
Taxonomic identifieri3847 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaePhaseoleaeGlycineSoja
Proteomesi
  • UP000008827 Componenti: Unplaced

Pathology & Biotechi

Protein family/group databases

Allergomei1144. Gly m TI.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 243 PublicationsAdd BLAST24
ChainiPRO_000001688925 – 205Trypsin inhibitor AAdd BLAST181
PropeptideiPRO_0000016890206 – 216Add BLAST11

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi63 ↔ 1101 Publication
Disulfide bondi160 ↔ 1691 Publication

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

DIPiDIP-6101N.
MINTiMINT-1531958.
STRINGi3847.GLYMA08G45531.1.

Structurei

Secondary structure

1216
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni30 – 32Combined sources3
Beta strandi39 – 47Combined sources9
Beta strandi53 – 56Combined sources4
Beta strandi66 – 69Combined sources4
Beta strandi80 – 83Combined sources4
Beta strandi85 – 87Combined sources3
Beta strandi97 – 101Combined sources5
Helixi108 – 110Combined sources3
Beta strandi118 – 120Combined sources3
Beta strandi126 – 130Combined sources5
Beta strandi135 – 137Combined sources3
Beta strandi140 – 146Combined sources7
Beta strandi148 – 152Combined sources5
Beta strandi155 – 161Combined sources7
Beta strandi170 – 176Combined sources7
Turni178 – 180Combined sources3
Beta strandi183 – 187Combined sources5
Beta strandi189 – 191Combined sources3
Beta strandi194 – 199Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AVUX-ray2.30A25-205[»]
1AVWX-ray1.75B25-201[»]
1AVXX-ray1.90B25-201[»]
1BA7X-ray2.50A/B25-205[»]
ProteinModelPortaliP01070.
SMRiP01070.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01070.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

InParanoidiP01070.

Family and domain databases

CDDicd00178. STI. 1 hit.
InterProiIPR011065. Kunitz_inhibitor_ST1-like.
IPR002160. Prot_inh_Kunz-lg.
[Graphical view]
PfamiPF00197. Kunitz_legume. 1 hit.
[Graphical view]
PRINTSiPR00291. KUNITZINHBTR.
SMARTiSM00452. STI. 1 hit.
[Graphical view]
SUPFAMiSSF50386. SSF50386. 1 hit.
PROSITEiPS00283. SOYBEAN_KUNITZ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01070-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSTIFFLFL FCAFTTSYLP SAIADFVLDN EGNPLENGGT YYILSDITAF
60 70 80 90 100
GGIRAAPTGN ERCPLTVVQS RNELDKGIGT IISSPYRIRF IAEGHPLSLK
110 120 130 140 150
FDSFAVIMLC VGIPTEWSVV EDLPEGPAVK IGENKDAMDG WFRLERVSDD
160 170 180 190 200
EFNNYKLVFC PQQAEDDKCG DIGISIDHDD GTRRLVVSKN KPLVVQFQKL
210
DKESLAKKNH GLSRSE
Length:216
Mass (Da):24,005
Last modified:May 1, 1992 - v2
Checksum:i1251FE0DE46CCA96
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25D → S AA sequence (PubMed:8318586).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti79G → E in variant C. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S45092 mRNA. Translation: AAB23464.1.
PIRiJQ0968.
RefSeqiNP_001238611.1. NM_001251682.1.
UniGeneiGma.29257.
Gma.37001.
Gma.37101.
Gma.51651.

Genome annotation databases

GeneIDi547831.
KEGGigmx:547831.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S45092 mRNA. Translation: AAB23464.1.
PIRiJQ0968.
RefSeqiNP_001238611.1. NM_001251682.1.
UniGeneiGma.29257.
Gma.37001.
Gma.37101.
Gma.51651.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AVUX-ray2.30A25-205[»]
1AVWX-ray1.75B25-201[»]
1AVXX-ray1.90B25-201[»]
1BA7X-ray2.50A/B25-205[»]
ProteinModelPortaliP01070.
SMRiP01070.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-6101N.
MINTiMINT-1531958.
STRINGi3847.GLYMA08G45531.1.

Protein family/group databases

Allergomei1144. Gly m TI.
MEROPSiI03.001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi547831.
KEGGigmx:547831.

Phylogenomic databases

InParanoidiP01070.

Miscellaneous databases

EvolutionaryTraceiP01070.

Family and domain databases

CDDicd00178. STI. 1 hit.
InterProiIPR011065. Kunitz_inhibitor_ST1-like.
IPR002160. Prot_inh_Kunz-lg.
[Graphical view]
PfamiPF00197. Kunitz_legume. 1 hit.
[Graphical view]
PRINTSiPR00291. KUNITZINHBTR.
SMARTiSM00452. STI. 1 hit.
[Graphical view]
SUPFAMiSSF50386. SSF50386. 1 hit.
PROSITEiPS00283. SOYBEAN_KUNITZ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiITRA_SOYBN
AccessioniPrimary (citable) accession number: P01070
Secondary accession number(s): Q9QV66
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: May 1, 1992
Last modified: November 2, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

The sequence of variant A is shown.
Electrophoresis identifies three genetically distinct variants, A, B, and C, that are inherited as codominant alleles.

Caution

PubMed:8318586 sequence was originally thought to be rat caltrin. A number of peptide fragments were derived from a trypsin digest of caltrin and soybean trypsin inhibitor was used to stop the digestion. It appears that some of the inhibitor was also digested and sequenced.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.