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Protein

Trypsin inhibitor A

Gene

KTI3

Organism
Glycine max (Soybean) (Glycine hispida)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibition of trypsin.

Miscellaneous

The sequence of variant A is shown.
Electrophoresis identifies three genetically distinct variants, A, B, and C, that are inherited as codominant alleles.

Caution

PubMed:8318586 sequence was originally thought to be rat caltrin. A number of peptide fragments were derived from a trypsin digest of caltrin and soybean trypsin inhibitor was used to stop the digestion. It appears that some of the inhibitor was also digested and sequenced.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei87 – 88Reactive bond for trypsin2

GO - Molecular functioni

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI03.001

Names & Taxonomyi

Protein namesi
Recommended name:
Trypsin inhibitor A
Alternative name(s):
Kunitz-type trypsin inhibitor A
Gene namesi
Name:KTI3
OrganismiGlycine max (Soybean) (Glycine hispida)
Taxonomic identifieri3847 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaePhaseoleaeGlycineSoja
Proteomesi
  • UP000008827 Componenti: Unplaced

Pathology & Biotechi

Protein family/group databases

Allergomei1144 Gly m TI

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 243 PublicationsAdd BLAST24
ChainiPRO_000001688925 – 205Trypsin inhibitor AAdd BLAST181
PropeptideiPRO_0000016890206 – 216Add BLAST11

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi63 ↔ 1101 Publication
Disulfide bondi160 ↔ 1691 Publication

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

DIPiDIP-6101N
MINTiP01070
STRINGi3847.GLYMA08G45531.1

Structurei

Secondary structure

1216
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni30 – 32Combined sources3
Beta strandi39 – 47Combined sources9
Beta strandi53 – 56Combined sources4
Beta strandi66 – 69Combined sources4
Beta strandi80 – 83Combined sources4
Beta strandi85 – 87Combined sources3
Beta strandi97 – 101Combined sources5
Helixi108 – 110Combined sources3
Beta strandi118 – 120Combined sources3
Beta strandi126 – 130Combined sources5
Beta strandi135 – 137Combined sources3
Beta strandi140 – 146Combined sources7
Beta strandi148 – 152Combined sources5
Beta strandi155 – 161Combined sources7
Beta strandi170 – 176Combined sources7
Turni178 – 180Combined sources3
Beta strandi183 – 187Combined sources5
Beta strandi189 – 191Combined sources3
Beta strandi194 – 199Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AVUX-ray2.30A25-205[»]
1AVWX-ray1.75B25-201[»]
1AVXX-ray1.90B25-201[»]
1BA7X-ray2.50A/B25-205[»]
ProteinModelPortaliP01070
SMRiP01070
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01070

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

InParanoidiP01070

Family and domain databases

CDDicd00178 STI, 1 hit
InterProiView protein in InterPro
IPR011065 Kunitz_inhibitor_STI-like_sf
IPR002160 Prot_inh_Kunz-lg
PANTHERiPTHR33107 PTHR33107, 1 hit
PfamiView protein in Pfam
PF00197 Kunitz_legume, 1 hit
PRINTSiPR00291 KUNITZINHBTR
SMARTiView protein in SMART
SM00452 STI, 1 hit
SUPFAMiSSF50386 SSF50386, 1 hit
PROSITEiView protein in PROSITE
PS00283 SOYBEAN_KUNITZ, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01070-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSTIFFLFL FCAFTTSYLP SAIADFVLDN EGNPLENGGT YYILSDITAF
60 70 80 90 100
GGIRAAPTGN ERCPLTVVQS RNELDKGIGT IISSPYRIRF IAEGHPLSLK
110 120 130 140 150
FDSFAVIMLC VGIPTEWSVV EDLPEGPAVK IGENKDAMDG WFRLERVSDD
160 170 180 190 200
EFNNYKLVFC PQQAEDDKCG DIGISIDHDD GTRRLVVSKN KPLVVQFQKL
210
DKESLAKKNH GLSRSE
Length:216
Mass (Da):24,005
Last modified:May 1, 1992 - v2
Checksum:i1251FE0DE46CCA96
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25D → S AA sequence (PubMed:8318586).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti79G → E in variant C. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S45092 mRNA Translation: AAB23464.1
PIRiJQ0968
RefSeqiNP_001238611.1, NM_001251682.1
UniGeneiGma.29257
Gma.37001
Gma.37101
Gma.51651

Genome annotation databases

GeneIDi547831
KEGGigmx:547831

Similar proteinsi

Entry informationi

Entry nameiITRA_SOYBN
AccessioniPrimary (citable) accession number: P01070
Secondary accession number(s): Q9QV66
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: May 1, 1992
Last modified: May 23, 2018
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health