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P01065 (IBB_VICSN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bowman-Birk type proteinase inhibitor
Alternative name(s):
VAI
OrganismVicia sativa subsp. nigra (Common vetch) (Vicia angustifolia)
Taxonomic identifier3909 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaeFabeaeVicia

Protein attributes

Sequence length72 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This inhibitor has two domains, each with separate antiprotease activity. 1 mole of inhibitor inhibits either 1 mole of trypsin or 2 moles of chymotrypsin, stoichiometrically.

Sequence similarities

Belongs to the Bowman-Birk serine protease inhibitor family.

Ontologies

Keywords
   Molecular functionProtease inhibitor
Serine protease inhibitor
   PTMDisulfide bond
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: InterPro

   Molecular_functionserine-type endopeptidase inhibitor activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 7272Bowman-Birk type proteinase inhibitor
PRO_0000105854

Sites

Site16 – 172Reactive bond for trypsin
Site42 – 432Reactive bond for chymotrypsin

Amino acid modifications

Disulfide bond8 ↔ 61 By similarity
Disulfide bond9 ↔ 24 By similarity
Disulfide bond12 ↔ 57 By similarity
Disulfide bond14 ↔ 22 By similarity
Disulfide bond31 ↔ 38 By similarity
Disulfide bond35 ↔ 50 By similarity
Disulfide bond40 ↔ 48 By similarity

Sequences

Sequence LengthMass (Da)Tools
P01065 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: 21AADB275DE33D83

FASTA728,038
        10         20         30         40         50         60 
GDDVKSACCD TCLCTRSQPP TCRCVDVGER CHSACNHCVC NYSNPPQCQC FDTHKFCYKA 

        70 
CHSSEKEEVI KN 

« Hide

References

[1]"The complete amino acid sequence of Vicia angustifolia proteinase inhibitor."
Shimokawa Y., Kuromizu K., Araki T., Ohata J., Abe O.
Nat. Cult. 10:69-73(1983)
Cited for: PROTEIN SEQUENCE.
Strain: cv. Segetalis.

Cross-references

Sequence databases

PIRTIVTOA. A01304.

3D structure databases

ProteinModelPortalP01065.
SMRP01065. Positions 1-67.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.10.69.10. 1 hit.
InterProIPR000877. Prot_inh_BBI.
[Graphical view]
PfamPF00228. Bowman-Birk_leg. 2 hits.
[Graphical view]
SMARTSM00269. BowB. 1 hit.
[Graphical view]
SUPFAMSSF57247. SSF57247. 1 hit.
PROSITEPS00281. BOWMAN_BIRK. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIBB_VICSN
AccessionPrimary (citable) accession number: P01065
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: April 16, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families