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P01065

- IBB_VICSN

UniProt

P01065 - IBB_VICSN

Protein

Bowman-Birk type proteinase inhibitor

Gene
N/A
Organism
Vicia sativa subsp. nigra (Common vetch) (Vicia angustifolia)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Functioni

    This inhibitor has two domains, each with separate antiprotease activity. 1 mole of inhibitor inhibits either 1 mole of trypsin or 2 moles of chymotrypsin, stoichiometrically.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei16 – 172Reactive bond for trypsin
    Sitei42 – 432Reactive bond for chymotrypsin

    GO - Molecular functioni

    1. serine-type endopeptidase inhibitor activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Protease inhibitor, Serine protease inhibitor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bowman-Birk type proteinase inhibitor
    Alternative name(s):
    VAI
    OrganismiVicia sativa subsp. nigra (Common vetch) (Vicia angustifolia)
    Taxonomic identifieri3909 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaeFabeaeVicia

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 7272Bowman-Birk type proteinase inhibitorPRO_0000105854Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi8 ↔ 61By similarity
    Disulfide bondi9 ↔ 24By similarity
    Disulfide bondi12 ↔ 57By similarity
    Disulfide bondi14 ↔ 22By similarity
    Disulfide bondi31 ↔ 38By similarity
    Disulfide bondi35 ↔ 50By similarity
    Disulfide bondi40 ↔ 48By similarity

    Keywords - PTMi

    Disulfide bond

    Structurei

    3D structure databases

    ProteinModelPortaliP01065.
    SMRiP01065. Positions 1-67.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    Gene3Di2.10.69.10. 1 hit.
    InterProiIPR000877. Prot_inh_BBI.
    [Graphical view]
    PfamiPF00228. Bowman-Birk_leg. 2 hits.
    [Graphical view]
    SMARTiSM00269. BowB. 1 hit.
    [Graphical view]
    SUPFAMiSSF57247. SSF57247. 1 hit.
    PROSITEiPS00281. BOWMAN_BIRK. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P01065-1 [UniParc]FASTAAdd to Basket

    « Hide

    GDDVKSACCD TCLCTRSQPP TCRCVDVGER CHSACNHCVC NYSNPPQCQC   50
    FDTHKFCYKA CHSSEKEEVI KN 72
    Length:72
    Mass (Da):8,038
    Last modified:July 21, 1986 - v1
    Checksum:i21AADB275DE33D83
    GO

    Sequence databases

    PIRiA01304. TIVTOA.

    Cross-referencesi

    Sequence databases

    PIRi A01304. TIVTOA.

    3D structure databases

    ProteinModelPortali P01065.
    SMRi P01065. Positions 1-67.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 2.10.69.10. 1 hit.
    InterProi IPR000877. Prot_inh_BBI.
    [Graphical view ]
    Pfami PF00228. Bowman-Birk_leg. 2 hits.
    [Graphical view ]
    SMARTi SM00269. BowB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57247. SSF57247. 1 hit.
    PROSITEi PS00281. BOWMAN_BIRK. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete amino acid sequence of Vicia angustifolia proteinase inhibitor."
      Shimokawa Y., Kuromizu K., Araki T., Ohata J., Abe O.
      Nat. Cult. 10:69-73(1983)
      Cited for: PROTEIN SEQUENCE.
      Strain: cv. Segetalis.

    Entry informationi

    Entry nameiIBB_VICSN
    AccessioniPrimary (citable) accession number: P01065
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3