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P01062 (IBB_VIGRR) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bowman-Birk type trypsin inhibitor
OrganismVigna radiata var. radiata (Mung bean) (Phaseolus aureus)
Taxonomic identifier3916 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaePhaseoleaeVigna

Protein attributes

Sequence length72 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Miscellaneous

Functionally this inhibitor is unusual in that it stoichiometrically inhibits trypsin in a molar ratio of 1:2.

The specificities and functions of this superfamily of inhibitors depend not only on the active sites within the domains, but also upon the amino acid composition, and resulting molecular conformation, surrounding these regions.

Three isoinhibitors are also found whose amino ends differ slightly from that shown.

Sequence similarities

Belongs to the Bowman-Birk serine protease inhibitor family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 7272Bowman-Birk type trypsin inhibitor
PRO_0000105849

Sites

Site20 – 212Reactive bond for trypsin
Site47 – 482Reactive bond for trypsin

Amino acid modifications

Disulfide bond12 ↔ 66 By similarity
Disulfide bond13 ↔ 28 By similarity
Disulfide bond16 ↔ 62 By similarity
Disulfide bond18 ↔ 26
Disulfide bond36 ↔ 43 By similarity
Disulfide bond40 ↔ 55 By similarity
Disulfide bond45 ↔ 53 By similarity

Natural variations

Natural variant1 – 22Missing in 2nd and 3rd isoinhibitor.
Natural variant21H → D in 1st isoinhibitor.
Natural variant31D → K in 3rd isoinhibitor.

Secondary structure

............. 72
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P01062 [UniParc].

Last modified February 1, 1995. Version 2.
Checksum: 8359DE1A8E61E4F8

FASTA727,959
        10         20         30         40         50         60 
SHDEPSESSE PCCDSCDCTK SIPPECHCAN IRLNSCHSAC KSCICTRSMP GKCRCLDTDD 

        70 
FCYKPCESMD KD 

« Hide

References

[1]"Complete amino acid sequence of mung bean trypsin inhibitor."
Zhang Y., Luo S., Tan F., Qi Z., Xu L., Zhang A.
Sci. Sin., Ser. B Chem. Biol. Agric. Med. Earth Sci. 25:268-277(1982) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE.
[2]"Studies on an artificial trypsin inhibitor peptide derived from the mung bean trypsin inhibitor: chemical synthesis, refolding, and crystallographic analysis of its complex with trypsin."
Li Y., Huang Q., Zhang S., Liu S., Qi C., Tang Y.
J. Biochem. 116:18-25(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 10-31, SEQUENCE REVISION.
+Additional computationally mapped references.

Cross-references

Sequence databases

PIRTIMB. A01301.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1G9IX-ray2.20I10-31[»]
1SBWX-ray1.80I8-69[»]
1SMFX-ray2.10I10-31[»]
3MYWX-ray2.50I1-72[»]
ProteinModelPortalP01062.
SMRP01062. Positions 1-71.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSI12.001.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.10.69.10. 1 hit.
InterProIPR000877. Prot_inh_BBI.
[Graphical view]
PfamPF00228. Bowman-Birk_leg. 2 hits.
[Graphical view]
SMARTSM00269. BowB. 1 hit.
[Graphical view]
SUPFAMSSF57247. SSF57247. 1 hit.
PROSITEPS00281. BOWMAN_BIRK. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP01062.

Entry information

Entry nameIBB_VIGRR
AccessionPrimary (citable) accession number: P01062
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: February 1, 1995
Last modified: July 9, 2014
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references