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Protein

Bowman-Birk type proteinase inhibitor

Gene
N/A
Organism
Phaseolus lunatus (Lima bean) (Phaseolus limensis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei26 – 27Reactive bond for trypsinBy similarity2
Sitei53 – 54Reactive bond for chymotrypsinBy similarity2

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI12.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Bowman-Birk type proteinase inhibitor
OrganismiPhaseolus lunatus (Lima bean) (Phaseolus limensis)
Taxonomic identifieri3884 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaePhaseoleaePhaseolus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001058501 – 83Bowman-Birk type proteinase inhibitorAdd BLAST83

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi18 ↔ 72Combined sources1 Publication
Disulfide bondi19 ↔ 34Combined sources1 Publication
Disulfide bondi22 ↔ 68Combined sources1 Publication
Disulfide bondi24 ↔ 32Combined sources1 Publication
Disulfide bondi42 ↔ 49Combined sources1 Publication
Disulfide bondi46 ↔ 61Combined sources1 Publication
Disulfide bondi51 ↔ 59Combined sources1 Publication

Keywords - PTMi

Disulfide bond

Structurei

Secondary structure

183
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi20 – 24Combined sources5
Beta strandi26 – 29Combined sources4
Beta strandi32 – 34Combined sources3
Beta strandi37 – 41Combined sources5
Beta strandi47 – 51Combined sources5
Beta strandi53 – 56Combined sources4
Beta strandi58 – 61Combined sources4
Beta strandi65 – 67Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1H34X-ray2.04A1-83[»]
SMRiP01056.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01056.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

CDDicd00023. BBI. 1 hit.
Gene3Di2.10.69.10. 1 hit.
InterProiIPR000877. Prot_inh_BBI.
[Graphical view]
PfamiPF00228. Bowman-Birk_leg. 2 hits.
[Graphical view]
SMARTiSM00269. BowB. 1 hit.
[Graphical view]
SUPFAMiSSF57247. SSF57247. 1 hit.
PROSITEiPS00281. BOWMAN_BIRK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P01056-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
SGHHEHSTDZ PSZSSKPCCB HCACTKSIPP QCRCTDLRLD SCHSACKSCI
60 70 80
CTLSIPAQCV CBBIBDFCYE PCKSSHSDDD NNN
Length:83
Mass (Da):9,079
Last modified:July 21, 1986 - v1
Checksum:i765DEEA0253F030D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23A → S (PubMed:12554963).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti23A → L.1
Natural varianti35T → S.1
Natural varianti37L → F.1
Natural varianti47K → Z.1
Natural varianti53L → F.1
Natural varianti62B → T.1
Natural varianti65B → T.1

Sequence databases

PIRiA01295. TILI.

Cross-referencesi

Sequence databases

PIRiA01295. TILI.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1H34X-ray2.04A1-83[»]
SMRiP01056.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiI12.001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP01056.

Family and domain databases

CDDicd00023. BBI. 1 hit.
Gene3Di2.10.69.10. 1 hit.
InterProiIPR000877. Prot_inh_BBI.
[Graphical view]
PfamiPF00228. Bowman-Birk_leg. 2 hits.
[Graphical view]
SMARTiSM00269. BowB. 1 hit.
[Graphical view]
SUPFAMiSSF57247. SSF57247. 1 hit.
PROSITEiPS00281. BOWMAN_BIRK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIBB_PHALU
AccessioniPrimary (citable) accession number: P01056
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 2, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

Several variants were isolated from a commercial Lima bean preparation. Some lacked 8, 12, or 14 N-terminal residues and 2 C-terminal residues.

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.