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Protein

Eglin C

Gene
N/A
Organism
Hirudo medicinalis (Medicinal leech)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits both elastase and cathepsin G.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei45 – 462Reactive bond

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI13.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Eglin C
OrganismiHirudo medicinalis (Medicinal leech)
Taxonomic identifieri6421 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaAnnelidaClitellataHirudinidaHirudineaArhynchobdellidaHirudiniformesHirudinidaeHirudo

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7070Eglin CPRO_0000217645Add
BLAST

Interactioni

Protein-protein interaction databases

DIPiDIP-6069N.
MINTiMINT-1345724.

Structurei

Secondary structure

1
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi11 – 133Combined sources
Helixi18 – 2811Combined sources
Beta strandi32 – 387Combined sources
Beta strandi42 – 443Combined sources
Beta strandi48 – 5710Combined sources
Turni58 – 614Combined sources
Beta strandi68 – 703Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ACBX-ray2.00I1-70[»]
1CSEX-ray1.20I1-70[»]
1EGLNMR-A1-70[»]
1EGPX-ray2.00A1-45[»]
B46-70[»]
1MEEX-ray2.00I7-70[»]
1SBNX-ray2.10I1-70[»]
1SIBX-ray2.40I1-70[»]
1TECX-ray2.20I1-70[»]
2SECX-ray1.80I1-70[»]
2TECX-ray1.98I1-70[»]
3TECX-ray2.00I1-70[»]
4B1TX-ray1.78B/D1-70[»]
4B2AX-ray1.89B/D5-70[»]
4B2BX-ray1.36B/D1-70[»]
4B2CX-ray1.43B/D1-70[»]
4H4FX-ray1.90B8-70[»]
ProteinModelPortaliP01051.
SMRiP01051. Positions 1-70.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01051.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR000864. Prot_inh_pot1.
[Graphical view]
PfamiPF00280. potato_inhibit. 1 hit.
[Graphical view]
PRINTSiPR00292. POTATOINHBTR.
ProDomiPD002604. Prot_inh_pot1. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF54654. SSF54654. 1 hit.
PROSITEiPS00285. POTATO_INHIBITOR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P01051-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
TEFGSELKSF PEVVGKTVDQ AREYFTLHYP QYDVYFLPEG SPVTLDLRYN
60 70
RVRVFYNPGT NVVNHVPHVG
Length:70
Mass (Da):8,091
Last modified:July 21, 1986 - v1
Checksum:i7E5C5BBD39DC3C11
GO

Sequence databases

PIRiA94592. EILXCH.

Cross-referencesi

Sequence databases

PIRiA94592. EILXCH.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ACBX-ray2.00I1-70[»]
1CSEX-ray1.20I1-70[»]
1EGLNMR-A1-70[»]
1EGPX-ray2.00A1-45[»]
B46-70[»]
1MEEX-ray2.00I7-70[»]
1SBNX-ray2.10I1-70[»]
1SIBX-ray2.40I1-70[»]
1TECX-ray2.20I1-70[»]
2SECX-ray1.80I1-70[»]
2TECX-ray1.98I1-70[»]
3TECX-ray2.00I1-70[»]
4B1TX-ray1.78B/D1-70[»]
4B2AX-ray1.89B/D5-70[»]
4B2BX-ray1.36B/D1-70[»]
4B2CX-ray1.43B/D1-70[»]
4H4FX-ray1.90B8-70[»]
ProteinModelPortaliP01051.
SMRiP01051. Positions 1-70.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-6069N.
MINTiMINT-1345724.

Protein family/group databases

MEROPSiI13.001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP01051.

Family and domain databases

InterProiIPR000864. Prot_inh_pot1.
[Graphical view]
PfamiPF00280. potato_inhibit. 1 hit.
[Graphical view]
PRINTSiPR00292. POTATOINHBTR.
ProDomiPD002604. Prot_inh_pot1. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF54654. SSF54654. 1 hit.
PROSITEiPS00285. POTATO_INHIBITOR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiICIC_HIRME
AccessioniPrimary (citable) accession number: P01051
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: May 11, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.