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P01051

- ICIC_HIRME

UniProt

P01051 - ICIC_HIRME

Protein

Eglin C

Gene
N/A
Organism
Hirudo medicinalis (Medicinal leech)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Inhibits both elastase and cathepsin G.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei45 – 462Reactive bond

    GO - Molecular functioni

    1. serine-type endopeptidase inhibitor activity Source: UniProtKB-KW

    GO - Biological processi

    1. response to wounding Source: InterPro

    Keywords - Molecular functioni

    Protease inhibitor, Serine protease inhibitor

    Protein family/group databases

    MEROPSiI13.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Eglin C
    OrganismiHirudo medicinalis (Medicinal leech)
    Taxonomic identifieri6421 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaLophotrochozoaAnnelidaClitellataHirudinidaHirudineaArhynchobdellidaHirudiniformesHirudinidaeHirudo

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 7070Eglin CPRO_0000217645Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-6069N.
    MINTiMINT-1345724.

    Structurei

    Secondary structure

    1
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi11 – 133
    Helixi18 – 2811
    Beta strandi32 – 387
    Beta strandi42 – 443
    Beta strandi48 – 5710
    Turni58 – 614
    Beta strandi68 – 703

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1ACBX-ray2.00I1-70[»]
    1CSEX-ray1.20I1-70[»]
    1EGLNMR-A1-70[»]
    1EGPX-ray2.00A1-45[»]
    B46-70[»]
    1MEEX-ray2.00I7-70[»]
    1SBNX-ray2.10I1-70[»]
    1SIBX-ray2.40I1-70[»]
    1TECX-ray2.20I1-70[»]
    2SECX-ray1.80I1-70[»]
    2TECX-ray1.98I1-70[»]
    3TECX-ray2.00I1-70[»]
    4B1TX-ray1.78B/D1-70[»]
    4B2AX-ray1.89B/D5-70[»]
    4B2BX-ray1.36B/D1-70[»]
    4B2CX-ray1.43B/D1-70[»]
    4H4FX-ray1.90B8-70[»]
    ProteinModelPortaliP01051.
    SMRiP01051. Positions 1-70.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP01051.

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    InterProiIPR000864. Prot_inh_pot1.
    [Graphical view]
    PfamiPF00280. potato_inhibit. 1 hit.
    [Graphical view]
    PRINTSiPR00292. POTATOINHBTR.
    ProDomiPD002604. Prot_inh_pot1. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF54654. SSF54654. 1 hit.
    PROSITEiPS00285. POTATO_INHIBITOR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P01051-1 [UniParc]FASTAAdd to Basket

    « Hide

    TEFGSELKSF PEVVGKTVDQ AREYFTLHYP QYDVYFLPEG SPVTLDLRYN   50
    RVRVFYNPGT NVVNHVPHVG 70
    Length:70
    Mass (Da):8,091
    Last modified:July 21, 1986 - v1
    Checksum:i7E5C5BBD39DC3C11
    GO

    Sequence databases

    PIRiA94592. EILXCH.

    Cross-referencesi

    Sequence databases

    PIRi A94592. EILXCH.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1ACB X-ray 2.00 I 1-70 [» ]
    1CSE X-ray 1.20 I 1-70 [» ]
    1EGL NMR - A 1-70 [» ]
    1EGP X-ray 2.00 A 1-45 [» ]
    B 46-70 [» ]
    1MEE X-ray 2.00 I 7-70 [» ]
    1SBN X-ray 2.10 I 1-70 [» ]
    1SIB X-ray 2.40 I 1-70 [» ]
    1TEC X-ray 2.20 I 1-70 [» ]
    2SEC X-ray 1.80 I 1-70 [» ]
    2TEC X-ray 1.98 I 1-70 [» ]
    3TEC X-ray 2.00 I 1-70 [» ]
    4B1T X-ray 1.78 B/D 1-70 [» ]
    4B2A X-ray 1.89 B/D 5-70 [» ]
    4B2B X-ray 1.36 B/D 1-70 [» ]
    4B2C X-ray 1.43 B/D 1-70 [» ]
    4H4F X-ray 1.90 B 8-70 [» ]
    ProteinModelPortali P01051.
    SMRi P01051. Positions 1-70.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-6069N.
    MINTi MINT-1345724.

    Protein family/group databases

    MEROPSi I13.001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei P01051.

    Family and domain databases

    InterProi IPR000864. Prot_inh_pot1.
    [Graphical view ]
    Pfami PF00280. potato_inhibit. 1 hit.
    [Graphical view ]
    PRINTSi PR00292. POTATOINHBTR.
    ProDomi PD002604. Prot_inh_pot1. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF54654. SSF54654. 1 hit.
    PROSITEi PS00285. POTATO_INHIBITOR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure of the elastase-cathepsin G inhibitor of the leech Hirudo medicinalis."
      Seemueller U., Eulitz M., Fritz H., Strobl A.
      Hoppe-Seyler's Z. Physiol. Chem. 361:1841-1846(1980) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE.
    2. Fritz H., Seemuller U.
      Submitted (MAR-1982) to the PIR data bank
      Cited for: SEQUENCE REVISION TO 33.
    3. "Refined 1.2 A crystal structure of the complex formed between subtilisin Carlsberg and the inhibitor eglin c. Molecular structure of eglin and its detailed interaction with subtilisin."
      Bode W., Papamokos E., Musil D., Seemueller U., Fritz H.
      EMBO J. 5:813-818(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.2 ANGSTROMS) IN COMPLEX WITH SUBTILISIN.
    4. "Sequence-specific 1H NMR assignments and secondary structure of eglin c."
      Hyberts S.G., Wagner G.
      Biochemistry 29:1465-1474(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR.
    5. "X-ray crystal structure of the serine proteinase inhibitor eglin c at 1.95-A resolution."
      Hipler K., Priestle J.P., Rahuel J., Gruetter M.G.
      FEBS Lett. 309:139-145(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS).
    6. "Structure of the proteinase inhibitor eglin c with hydrolysed reactive centre at 2.0-A resolution."
      Betzel C., Dauter Z., Genov N., Lamzin V., Navaza J., Schnebli H.P., Visanji M., Wilson K.S.
      FEBS Lett. 317:185-188(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).
    7. "Long-range electrostatic complementarity governs substrate recognition by human chymotrypsin C, a key regulator of digestive enzyme activation."
      Batra J., Szabo A., Caulfield T.R., Soares A.S., Sahin-Toth M., Radisky E.S.
      J. Biol. Chem. 288:9848-9859(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 4-70 IN COMPLEX WITH HUMAN CTRC.

    Entry informationi

    Entry nameiICIC_HIRME
    AccessioniPrimary (citable) accession number: P01051
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3