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Protein

Cystatin-B

Gene

Cstb

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This is an intracellular thiol proteinase inhibitor.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei4Reactive site1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionProtease inhibitor, Thiol protease inhibitor

Enzyme and pathway databases

ReactomeiR-RNO-6798695. Neutrophil degranulation.

Protein family/group databases

MEROPSiI25.003.

Names & Taxonomyi

Protein namesi
Recommended name:
Cystatin-B
Alternative name(s):
Cystatin-beta
Liver thiol proteinase inhibitor
Stefin-B
Gene namesi
Name:Cstb
Synonyms:Cst6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi2435. Cstb.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002071431 – 98Cystatin-BAdd BLAST98

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP01041.
PRIDEiP01041.

PTM databases

iPTMnetiP01041.
PhosphoSitePlusiP01041.

Expressioni

Gene expression databases

BgeeiENSRNOG00000001201.
GenevisibleiP01041. RN.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001593.

Structurei

3D structure databases

ProteinModelPortaliP01041.
SMRiP01041.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi46 – 50Secondary area of contact5

Sequence similaritiesi

Belongs to the cystatin family.Curated

Phylogenomic databases

eggNOGiENOG410IZK7. Eukaryota.
ENOG41121QW. LUCA.
GeneTreeiENSGT00390000015607.
HOGENOMiHOG000294175.
HOVERGENiHBG002292.
InParanoidiP01041.
KOiK13907.
OMAiSLPHEDK.
OrthoDBiEOG091G12NK.
PhylomeDBiP01041.
TreeFamiTF333174.

Family and domain databases

CDDicd00042. CY. 1 hit.
InterProiView protein in InterPro
IPR000010. Cystatin_dom.
IPR018073. Prot_inh_cystat_CS.
IPR001713. Prot_inh_stefinA.
PfamiView protein in Pfam
PF00031. Cystatin. 1 hit.
PRINTSiPR00295. STEFINA.
SMARTiView protein in SMART
SM00043. CY. 1 hit.
PROSITEiView protein in PROSITE
PS00287. CYSTATIN. 1 hit.

Sequencei

Sequence statusi: Complete.

P01041-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMCGAPSATM PATTETQEIA DKVKSQLEEK ANQKFDVFKA ISFRRQVVAG
60 70 80 90
TNFFIKVDVG EEKCVHLRVF EPLPHENKPL TLSSYQTDKE KHDELTYF
Length:98
Mass (Da):11,196
Last modified:July 21, 1986 - v1
Checksum:i191406A8A5B1A70C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54737 mRNA. Translation: CAA38534.1.
D10607 Genomic DNA. Translation: BAA01462.1.
BC084725 mRNA. Translation: AAH84725.1.
PIRiJC1128. UDRTS.
RefSeqiNP_036970.1. NM_012838.2.
UniGeneiRn.1233.

Genome annotation databases

EnsembliENSRNOT00000001593; ENSRNOP00000001593; ENSRNOG00000001201.
GeneIDi25308.
KEGGirno:25308.
UCSCiRGD:2435. rat.

Similar proteinsi

Entry informationi

Entry nameiCYTB_RAT
AccessioniPrimary (citable) accession number: P01041
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: August 30, 2017
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families