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Protein

Cystatin-B

Gene

Cstb

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This is an intracellular thiol proteinase inhibitor.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei4Reactive site1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Thiol protease inhibitor

Enzyme and pathway databases

ReactomeiR-RNO-6798695. Neutrophil degranulation.

Protein family/group databases

MEROPSiI25.003.

Names & Taxonomyi

Protein namesi
Recommended name:
Cystatin-B
Alternative name(s):
Cystatin-beta
Liver thiol proteinase inhibitor
Stefin-B
Gene namesi
Name:Cstb
Synonyms:Cst6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi2435. Cstb.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002071431 – 98Cystatin-BAdd BLAST98

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP01041.
PRIDEiP01041.

PTM databases

iPTMnetiP01041.
PhosphoSitePlusiP01041.

Expressioni

Gene expression databases

BgeeiENSRNOG00000001201.
GenevisibleiP01041. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001593.

Structurei

3D structure databases

ProteinModelPortaliP01041.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi46 – 50Secondary area of contact5

Sequence similaritiesi

Belongs to the cystatin family.Curated

Phylogenomic databases

eggNOGiENOG410IZK7. Eukaryota.
ENOG41121QW. LUCA.
GeneTreeiENSGT00390000015607.
HOGENOMiHOG000294175.
HOVERGENiHBG002292.
InParanoidiP01041.
KOiK13907.
OMAiPHENRPL.
OrthoDBiEOG091G12NK.
PhylomeDBiP01041.
TreeFamiTF333174.

Family and domain databases

CDDicd00042. CY. 1 hit.
InterProiIPR000010. Cystatin_dom.
IPR018073. Prot_inh_cystat_CS.
IPR001713. Prot_inh_stefinA.
[Graphical view]
PfamiPF00031. Cystatin. 1 hit.
[Graphical view]
PRINTSiPR00295. STEFINA.
SMARTiSM00043. CY. 1 hit.
[Graphical view]
PROSITEiPS00287. CYSTATIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P01041-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMCGAPSATM PATTETQEIA DKVKSQLEEK ANQKFDVFKA ISFRRQVVAG
60 70 80 90
TNFFIKVDVG EEKCVHLRVF EPLPHENKPL TLSSYQTDKE KHDELTYF
Length:98
Mass (Da):11,196
Last modified:July 21, 1986 - v1
Checksum:i191406A8A5B1A70C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54737 mRNA. Translation: CAA38534.1.
D10607 Genomic DNA. Translation: BAA01462.1.
BC084725 mRNA. Translation: AAH84725.1.
PIRiJC1128. UDRTS.
RefSeqiNP_036970.1. NM_012838.2.
UniGeneiRn.1233.

Genome annotation databases

EnsembliENSRNOT00000001593; ENSRNOP00000001593; ENSRNOG00000001201.
GeneIDi25308.
KEGGirno:25308.
UCSCiRGD:2435. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54737 mRNA. Translation: CAA38534.1.
D10607 Genomic DNA. Translation: BAA01462.1.
BC084725 mRNA. Translation: AAH84725.1.
PIRiJC1128. UDRTS.
RefSeqiNP_036970.1. NM_012838.2.
UniGeneiRn.1233.

3D structure databases

ProteinModelPortaliP01041.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001593.

Protein family/group databases

MEROPSiI25.003.

PTM databases

iPTMnetiP01041.
PhosphoSitePlusiP01041.

Proteomic databases

PaxDbiP01041.
PRIDEiP01041.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000001593; ENSRNOP00000001593; ENSRNOG00000001201.
GeneIDi25308.
KEGGirno:25308.
UCSCiRGD:2435. rat.

Organism-specific databases

CTDi1476.
RGDi2435. Cstb.

Phylogenomic databases

eggNOGiENOG410IZK7. Eukaryota.
ENOG41121QW. LUCA.
GeneTreeiENSGT00390000015607.
HOGENOMiHOG000294175.
HOVERGENiHBG002292.
InParanoidiP01041.
KOiK13907.
OMAiPHENRPL.
OrthoDBiEOG091G12NK.
PhylomeDBiP01041.
TreeFamiTF333174.

Enzyme and pathway databases

ReactomeiR-RNO-6798695. Neutrophil degranulation.

Miscellaneous databases

PROiP01041.

Gene expression databases

BgeeiENSRNOG00000001201.
GenevisibleiP01041. RN.

Family and domain databases

CDDicd00042. CY. 1 hit.
InterProiIPR000010. Cystatin_dom.
IPR018073. Prot_inh_cystat_CS.
IPR001713. Prot_inh_stefinA.
[Graphical view]
PfamiPF00031. Cystatin. 1 hit.
[Graphical view]
PRINTSiPR00295. STEFINA.
SMARTiSM00043. CY. 1 hit.
[Graphical view]
PROSITEiPS00287. CYSTATIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCYTB_RAT
AccessioniPrimary (citable) accession number: P01041
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 30, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.