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Protein

Cystatin

Gene
N/A
Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein binds tightly to and inhibits a variety of thiol proteases including ficin, papain, and cathepsins B, C, H, and L. Although isolated from egg white, it is also present in serum.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei32Reactive site1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionProtease inhibitor, Thiol protease inhibitor

Enzyme and pathway databases

ReactomeiR-GGA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-GGA-6798695 Neutrophil degranulation
R-GGA-8957275 Post-translational protein phosphorylation

Protein family/group databases

MEROPSiI25.011

Names & Taxonomyi

Protein namesi
Recommended name:
Cystatin
Alternative name(s):
Egg-white cystatin
Ovocystatin
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 232 PublicationsAdd BLAST23
ChainiPRO_000000666324 – 139CystatinAdd BLAST116

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi94 ↔ 1041 Publication
Modified residuei103Phosphoserine1 Publication1
Disulfide bondi118 ↔ 1381 Publication

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiP01038

PTM databases

iPTMnetiP01038

Expressioni

Gene expression databases

BgeeiENSGALG00000028520
ExpressionAtlasiP01038 baseline and differential

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Q9N6S82EBI-15593412,EBI-15593394From Plasmodium falciparum.

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-61237N
IntActiP01038, 1 interactor
STRINGi9031.ENSGALP00000014093

Structurei

Secondary structure

1139
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi42 – 51Combined sources10
Helixi53 – 56Combined sources4
Beta strandi62 – 95Combined sources34
Beta strandi96 – 99Combined sources4
Helixi101 – 108Combined sources8
Beta strandi115 – 125Combined sources11
Turni126 – 129Combined sources4
Beta strandi130 – 138Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A67NMR-A32-139[»]
1A90NMR-A32-139[»]
1CEWX-ray2.00I32-139[»]
1YVBX-ray2.70I29-139[»]
ProteinModelPortaliP01038
SMRiP01038
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01038

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi76 – 80Secondary area of contact5

Sequence similaritiesi

Belongs to the cystatin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZZH Eukaryota
ENOG4112CFJ LUCA
HOGENOMiHOG000231754
HOVERGENiHBG009556
InParanoidiP01038
KOiK13899
OrthoDBiEOG091G0TP1
PhylomeDBiP01038

Family and domain databases

CDDicd00042 CY, 1 hit
InterProiView protein in InterPro
IPR027214 Cystatin
IPR000010 Cystatin_dom
IPR018073 Prot_inh_cystat_CS
PANTHERiPTHR11413 PTHR11413, 1 hit
PfamiView protein in Pfam
PF00031 Cystatin, 1 hit
SMARTiView protein in SMART
SM00043 CY, 1 hit
PROSITEiView protein in PROSITE
PS00287 CYSTATIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01038-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGARGCVVL LAAALMLVGA VLGSEDRSRL LGAPVPVDEN DEGLQRALQF
60 70 80 90 100
AMAEYNRASN DKYSSRVVRV ISAKRQLVSG IKYILQVEIG RTTCPKSSGD
110 120 130
LQSCEFHDEP EMAKYTTCTF VVYSIPWLNQ IKLLESKCQ
Length:139
Mass (Da):15,287
Last modified:October 1, 1989 - v2
Checksum:iD92D1131C4D37891
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05077 mRNA Translation: AAA48744.1
PIRiA34456 UDCH
RefSeqiNP_990831.2, NM_205500.2
UniGeneiGga.5058

Genome annotation databases

EnsembliENSGALT00000045265; ENSGALP00000043172; ENSGALG00000028520
GeneIDi396497
KEGGigga:396497

Similar proteinsi

Entry informationi

Entry nameiCYT_CHICK
AccessioniPrimary (citable) accession number: P01038
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 1, 1989
Last modified: May 23, 2018
This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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