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Protein

Cystatin-SN

Gene

CST1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Human saliva appears to contain several cysteine proteinase inhibitors that are immunologically related to cystatin S but that differ in their specificity due to amino acid sequence differences. Cystatin SN, with a pI of 7.5, is a much better inhibitor of papain and dipeptidyl peptidase I than is cystatin S, although both inhibit ficin equally well.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei32Reactive site1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionProtease inhibitor, Thiol protease inhibitor

Protein family/group databases

MEROPSiI25.010.

Names & Taxonomyi

Protein namesi
Recommended name:
Cystatin-SN
Alternative name(s):
Cystain-SA-I
Cystatin-1
Salivary cystatin-SA-1
Gene namesi
Name:CST1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000170373.8.
HGNCiHGNC:2473. CST1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi1469.
OpenTargetsiENSG00000170373.
PharmGKBiPA26972.

Polymorphism and mutation databases

BioMutaiCST1.
DMDMi311033460.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 203 PublicationsAdd BLAST20
ChainiPRO_000000664921 – 141Cystatin-SNAdd BLAST121

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi94 ↔ 1041 Publication
Disulfide bondi118 ↔ 1381 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiP01037.
MaxQBiP01037.
PaxDbiP01037.
PeptideAtlasiP01037.
PRIDEiP01037.
TopDownProteomicsiP01037.

PTM databases

iPTMnetiP01037.

Expressioni

Tissue specificityi

Expressed in submandibular and sublingual saliva but not in parotid saliva (at protein level). Expressed in saliva, tears, urine and seminal fluid.1 Publication

Gene expression databases

BgeeiENSG00000170373.
CleanExiHS_CST1.
GenevisibleiP01037. HS.

Organism-specific databases

HPAiCAB026769.
HPA043706.
HPA044763.

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107851. 38 interactors.
IntActiP01037. 4 interactors.
STRINGi9606.ENSP00000305731.

Structurei

3D structure databases

ProteinModelPortaliP01037.
SMRiP01037.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi76 – 80Secondary area of contact5

Sequence similaritiesi

Belongs to the cystatin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZZH. Eukaryota.
ENOG4112CFJ. LUCA.
GeneTreeiENSGT00890000139386.
HOGENOMiHOG000231754.
HOVERGENiHBG009556.
InParanoidiP01037.
KOiK13897.
OMAiEYNKATK.
OrthoDBiEOG091G0TP1.
PhylomeDBiP01037.

Family and domain databases

CDDicd00042. CY. 1 hit.
InterProiView protein in InterPro
IPR027214. Cystatin.
IPR000010. Cystatin_dom.
IPR018073. Prot_inh_cystat_CS.
PANTHERiPTHR11413. PTHR11413. 1 hit.
PfamiView protein in Pfam
PF00031. Cystatin. 1 hit.
SMARTiView protein in SMART
SM00043. CY. 1 hit.
PROSITEiView protein in PROSITE
PS00287. CYSTATIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01037-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQYLSTLLL LLATLAVALA WSPKEEDRII PGGIYNADLN DEWVQRALHF
60 70 80 90 100
AISEYNKATK DDYYRRPLRV LRARQQTVGG VNYFFDVEVG RTICTKSQPN
110 120 130 140
LDTCAFHEQP ELQKKQLCSF EIYEVPWENR RSLVKSRCQE S
Length:141
Mass (Da):16,388
Last modified:November 2, 2010 - v3
Checksum:i9F9934704D6C077D
GO

Mass spectrometryi

Molecular mass is 14303.1553±0.0675 Da from positions 21 - 141. Determined by ESI. 1 Publication
Molecular mass is 14319.171±0.0523 Da from positions 21 - 141. Determined by ESI. Variant Leu-31.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0289324Y → H2 PublicationsCorresponds to variant dbSNP:rs6076122Ensembl.1
Natural variantiVAR_02893331P → L. Corresponds to variant dbSNP:rs2070856Ensembl.1
Natural variantiVAR_028934129N → D. Corresponds to variant dbSNP:rs3188319Ensembl.1
Natural variantiVAR_028935131R → M. Corresponds to variant dbSNP:rs3188320Ensembl.1
Natural variantiVAR_028936135K → N. Corresponds to variant dbSNP:rs3188322Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19169 Genomic DNA. Translation: AAA36115.1.
J03870 mRNA. Translation: AAA60299.1.
AL591074 Genomic DNA. No translation available.
BC021225 mRNA. Translation: AAH21225.1.
CCDSiCCDS13160.1.
PIRiA28110. UDHUP2.
RefSeqiNP_001889.2. NM_001898.2.
UniGeneiHs.123114.

Genome annotation databases

EnsembliENST00000304749; ENSP00000305731; ENSG00000170373.
ENST00000398402; ENSP00000381439; ENSG00000170373.
GeneIDi1469.
KEGGihsa:1469.
UCSCiuc002wtp.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCYTN_HUMAN
AccessioniPrimary (citable) accession number: P01037
Secondary accession number(s): Q96LE6, Q9UCQ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: November 2, 2010
Last modified: September 27, 2017
This is version 174 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families