true1986-07-212024-01-24212CYTS_HUMANHuman salivary cystatin S. Cloning, sequence analysis, hybridization in situ and immunocytochemistry.Bobek L.A.Aguirre A.Levine M.J.doi:10.1042/bj27806271991Biochem. J.278627-635NUCLEOTIDE SEQUENCE [MRNA]Submandibular glandCharacterization of two members (CST4 and CST5) of the cystatin gene family and molecular evolution of cystatin genes.Saitoh E.Isemura S.Sanada K.Ohnishi K.doi:10.1007/978-3-0348-7321-5_431992Agents Actions38340-348NUCLEOTIDE SEQUENCE [GENOMIC DNA]Acquisition of complex patterns of differential expression in epithelial cell populations during the evolution of type 2 cystatin genes.Dickinson D.P.Hewett-Emmett D.Thiesse M.2000-11EMBL/GenBank/DDBJNUCLEOTIDE SEQUENCE [GENOMIC DNA]The DNA sequence and comparative analysis of human chromosome 20.Deloukas P.Matthews L.H.Ashurst J.L.Burton J.Gilbert J.G.R.Jones M.Stavrides G.Almeida J.P.Babbage A.K.Bagguley C.L.Bailey J.Barlow K.F.Bates K.N.Beard L.M.Beare D.M.Beasley O.P.Bird C.P.Blakey S.E.Bridgeman A.M.Brown A.J.Buck D.Burrill W.D.Butler A.P.Carder C.Carter N.P.Chapman J.C.Clamp M.Clark G.Clark L.N.Clark S.Y.Clee C.M.Clegg S.Cobley V.E.Collier R.E.Connor R.E.Corby N.R.Coulson A.Coville G.J.Deadman R.Dhami P.D.Dunn M.Ellington A.G.Frankland J.A.Fraser A.French L.Garner P.Grafham D.V.Griffiths C.Griffiths M.N.D.Gwilliam R.Hall R.E.Hammond S.Harley J.L.Heath P.D.Ho S.Holden J.L.Howden P.J.Huckle E.Hunt A.R.Hunt S.E.Jekosch K.Johnson C.M.Johnson D.Kay M.P.Kimberley A.M.King A.Knights A.Laird G.K.Lawlor S.Lehvaeslaiho M.H.Leversha M.A.Lloyd C.Lloyd D.M.Lovell J.D.Marsh V.L.Martin S.L.McConnachie L.J.McLay K.McMurray A.A.Milne S.A.Mistry D.Moore M.J.F.Mullikin J.C.Nickerson T.Oliver K.Parker A.Patel R.Pearce T.A.V.Peck A.I.Phillimore B.J.C.T.Prathalingam S.R.Plumb R.W.Ramsay H.Rice C.M.Ross M.T.Scott C.E.Sehra H.K.Shownkeen R.Sims S.Skuce C.D.Smith M.L.Soderlund C.Steward C.A.Sulston J.E.Swann R.M.Sycamore N.Taylor R.Tee L.Thomas D.W.Thorpe A.Tracey A.Tromans A.C.Vaudin M.Wall M.Wallis J.M.Whitehead S.L.Whittaker P.Willey D.L.Williams L.Williams S.A.Wilming L.Wray P.W.Hubbard T.Durbin R.M.Bentley D.R.Beck S.Rogers J.doi:10.1038/414865a2001Nature414865-871NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).The MGC Project Teamdoi:10.1101/gr.25965042004Genome Res.142121-2127NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]ThyroidIdentification of a long form of cystatin from human saliva by rapid microbore HPLC mapping.Hawke D.H.Yuan P.M.Wilson K.J.Hunkapiller M.W.doi:10.1016/0006-291x(87)91571-31987Biochem. Biophys. Res. Commun.1451248-1253PROTEIN SEQUENCE OF 21-51Large-scale purification and characterization of the major phosphoproteins and mucins of human submandibular-sublingual saliva.Ramasubbu N.Reddy M.S.Bergey E.J.Haraszthy G.G.Soni S.-D.Levine M.J.doi:10.1042/bj28003411991Biochem. J.280341-352PROTEIN SEQUENCE OF 21-55PHOSPHORYLATION AT SER-23SalivaIdentification of full-sized forms of salivary (S-type) cystatins (cystatin SN, cystatin SA, cystatin S, and two phosphorylated forms of cystatin S) in human whole saliva and determination of phosphorylation sites of cystatin S.Isemura S.Saitoh E.Sanada K.Minakata K.doi:10.1093/oxfordjournals.jbchem.a1236341991J. Biochem.110648-654PROTEIN SEQUENCE OF 21-36PHOSPHORYLATION AT SER-21 AND SER-23The effects of human salivary cystatins and statherin on hydroxyapatite crystallization.Johnsson M.Richardson C.F.Bergey E.J.Levine M.J.Nancollas G.H.doi:10.1016/0003-9969(91)90014-l1991Arch. Oral Biol.36631-636PROTEIN SEQUENCE OF 21-36PHOSPHORYLATION AT SER-23Isolation and amino acid sequence of SAP-1, an acidic protein of human whole saliva, and sequence homology with human gamma-trace.Isemura S.Saitoh E.Sanada K.doi:10.1093/oxfordjournals.jbchem.a1348611984J. Biochem.96489-498PROTEIN SEQUENCE OF 29-141Human basal tear peptidome characterization by CID, HCD, and ETD followed by in silico and in vitro analyses for antimicrobial peptide identification.Azkargorta M.Soria J.Ojeda C.Guzman F.Acera A.Iloro I.Suarez T.Elortza F.doi:10.1021/acs.jproteome.5b001792015J. Proteome Res.142649-2658PROTEIN SEQUENCE OF 85-141IDENTIFICATION BY MASS SPECTROMETRYTearCystatin S: a cysteine proteinase inhibitor of human saliva.Isemura S.Saitoh E.Ito S.Isemura M.Sanada K.doi:10.1093/oxfordjournals.jbchem.a1349521984J. Biochem.961311-1314INHIBITOR SPECIFICITYSalivary cystatin SA-III, a potential precursor of the acquired enamel pellicle, is phosphorylated at both its amino- and carboxyl-terminal regions.Lamkin M.S.Jensen J.L.Setayesh M.R.Troxler R.F.Oppenheim F.G.doi:10.1016/0003-9861(91)90249-i1991Arch. Biochem. Biophys.288664-670PHOSPHORYLATIONConfident assignment of intact mass tags to human salivary cystatins using top-down Fourier-transform ion cyclotron resonance mass spectrometry.Ryan C.M.Souda P.Halgand F.Wong D.T.Loo J.A.Faull K.F.Whitelegge J.P.doi:10.1016/j.jasms.2010.01.0252010J. Am. Soc. Mass Spectrom.21908-917PHOSPHORYLATION AT SER-21 AND SER-23DISULFIDE BONDSTISSUE SPECIFICITYSUBCELLULAR LOCATIONMASS SPECTROMETRYThe consensus coding sequences of human breast and colorectal cancers.Sjoeblom T.Jones S.Wood L.D.Parsons D.W.Lin J.Barber T.D.Mandelker D.Leary R.J.Ptak J.Silliman N.Szabo S.Buckhaults P.Farrell C.Meeh P.Markowitz S.D.Willis J.Dawson D.Willson J.K.V.Gazdar A.F.Hartigan J.Wu L.Liu C.Parmigiani G.Park B.H.Bachman K.E.Papadopoulos N.Vogelstein B.Kinzler K.W.Velculescu V.E.doi:10.1126/science.11334272006Science314268-274VARIANT [LARGE SCALE ANALYSIS] ASN-77UDHUP110934380 antibodies from 27 providershumanCST4Tissue enriched (salivary)geneEukaryota20 hits in 1112 CRISPR screenshumanTbioProteinExpressed in parotid gland and 57 other cell types or tissuesCYCystatin_domCystatin_sfProt_inh_cystat_CSCYSTATINCYSTATIN-S-RELATEDCystatinCYCystatin/monellinCYSTATINHSAA sequenceCystatin-SCystatin-4Cystatin-SA-IIISalivary acidic protein 1CST4This protein strongly inhibits papain and ficin, partially inhibits stem bromelain and bovine cathepsin C, but does not inhibit porcine cathepsin B or clostripain. Papain is inhibited non-competitively.Expressed in submandibular and sublingual saliva but not in parotid saliva (at protein level). Expressed in saliva, tears, urine and seminal fluid.Phosphorylated at both its N- and C-terminal regions.14175.8560.0564Monophosphorylated at Ser-23, also called form S1.14255.8560.0899Diphosphorylated at Ser-21 and Ser-23, also called form S2.14335.8110.0775Belongs to the cystatin family.120Cystatin-S1418921141Secondary area of contact7680Reactive site32PhosphoserinePhosphoserine2394104118138N36In a breast cancer sample; somatic mutation.N77D135false3UBQLN21993-07-013true16214f576b0bb1ab1ca34bff1f54274ebad5aMARPLCTLLLLMATLAGALASSSKEENRIIPGGIYDADLNDEWVQRALHFAISEYNKATEDEYYRRPLQVLRAREQTFGGVNYFFDVEVGRTICTKSQPNLDTCAFHEQPELQKKQLCSFEIYEVPWEDRMSLVNSRCQEAtruetruetruetruetruetruetruetruetruetruetruetrue