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Protein

Cystatin-C

Gene

CST3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This is a thiol proteinase inhibitor.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei40 – 401Reactive site

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Thiol protease inhibitor

Protein family/group databases

MEROPSiI25.004.

Names & Taxonomyi

Protein namesi
Recommended name:
Cystatin-C
Alternative name(s):
Colostrum thiol proteinase inhibitor
Cystatin-3
Gene namesi
Name:CST3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 13

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030CuratedAdd
BLAST
Chaini31 – 148118Cystatin-CPRO_0000006638Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei31 – 311Pyrrolidone carboxylic acidCurated
Disulfide bondi102 ↔ 112By similarity
Disulfide bondi126 ↔ 146By similarity

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP01035.
PeptideAtlasiP01035.
PRIDEiP01035.

Expressioni

Gene expression databases

BgeeiENSBTAG00000000598.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000000790.

Structurei

3D structure databases

ProteinModelPortaliP01035.
SMRiP01035. Positions 37-148.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi84 – 885Secondary area of contact

Sequence similaritiesi

Belongs to the cystatin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZZH. Eukaryota.
ENOG4112CFJ. LUCA.
GeneTreeiENSGT00840000129787.
HOGENOMiHOG000231754.
HOVERGENiHBG009556.
InParanoidiP01035.
KOiK13899.
OMAiYTVPWLG.
OrthoDBiEOG091G0TP1.

Family and domain databases

InterProiIPR027214. Cystatin.
IPR000010. Cystatin_dom.
IPR018073. Prot_inh_cystat_CS.
[Graphical view]
PANTHERiPTHR11413. PTHR11413. 1 hit.
PfamiPF00031. Cystatin. 1 hit.
[Graphical view]
SMARTiSM00043. CY. 1 hit.
[Graphical view]
PROSITEiPS00287. CYSTATIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01035-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGSPRAPLL LLASLIVALA LALAVSPAAA QGPRKGRLLG GLMEADVNEE
60 70 80 90 100
GVQEALSFAV SEFNKRSNDA YQSRVVRVVR ARKQVVSGMN YFLDVELGRT
110 120 130 140
TCTKSQANLD SCPFHNQPHL KREKLCSFQV YVVPWMNTIN LVKFSCQD
Length:148
Mass (Da):16,265
Last modified:July 15, 1999 - v2
Checksum:iEE740FE37CFB9F0E
GO

Mass spectrometryi

Molecular mass is 13420 Da from positions 31 - 148. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10811 mRNA. Translation: CAA71771.1.
AB098964 mRNA. Translation: BAC56454.1.
AB099041 mRNA. Translation: BAC56531.1.
BC109629 mRNA. Translation: AAI09630.1.
PIRiA01271. UDBO.
S62326.
RefSeqiNP_776454.1. NM_174029.1.
UniGeneiBt.1855.

Genome annotation databases

EnsembliENSBTAT00000000790; ENSBTAP00000000790; ENSBTAG00000000598.
GeneIDi281102.
KEGGibta:281102.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10811 mRNA. Translation: CAA71771.1.
AB098964 mRNA. Translation: BAC56454.1.
AB099041 mRNA. Translation: BAC56531.1.
BC109629 mRNA. Translation: AAI09630.1.
PIRiA01271. UDBO.
S62326.
RefSeqiNP_776454.1. NM_174029.1.
UniGeneiBt.1855.

3D structure databases

ProteinModelPortaliP01035.
SMRiP01035. Positions 37-148.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000000790.

Protein family/group databases

MEROPSiI25.004.

Proteomic databases

PaxDbiP01035.
PeptideAtlasiP01035.
PRIDEiP01035.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000000790; ENSBTAP00000000790; ENSBTAG00000000598.
GeneIDi281102.
KEGGibta:281102.

Organism-specific databases

CTDi1471.

Phylogenomic databases

eggNOGiENOG410IZZH. Eukaryota.
ENOG4112CFJ. LUCA.
GeneTreeiENSGT00840000129787.
HOGENOMiHOG000231754.
HOVERGENiHBG009556.
InParanoidiP01035.
KOiK13899.
OMAiYTVPWLG.
OrthoDBiEOG091G0TP1.

Gene expression databases

BgeeiENSBTAG00000000598.

Family and domain databases

InterProiIPR027214. Cystatin.
IPR000010. Cystatin_dom.
IPR018073. Prot_inh_cystat_CS.
[Graphical view]
PANTHERiPTHR11413. PTHR11413. 1 hit.
PfamiPF00031. Cystatin. 1 hit.
[Graphical view]
SMARTiSM00043. CY. 1 hit.
[Graphical view]
PROSITEiPS00287. CYSTATIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCYTC_BOVIN
AccessioniPrimary (citable) accession number: P01035
Secondary accession number(s): Q54A26
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 15, 1999
Last modified: September 7, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.