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Protein

Complement C5a anaphylatoxin

Gene

C5

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.By similarity

GO - Biological processi

Keywordsi

Biological processComplement alternate pathway, Complement pathway, Immunity, Inflammatory response, Innate immunity

Protein family/group databases

MEROPSiI39.952.

Names & Taxonomyi

Protein namesi
Recommended name:
Complement C5a anaphylatoxin
Gene namesi
Name:C5
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000485211 – 74Complement C5a anaphylatoxinAdd BLAST74

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi21 ↔ 47
Disulfide bondi22 ↔ 54
Disulfide bondi34 ↔ 55

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP01032.
PeptideAtlasiP01032.
PRIDEiP01032.

Interactioni

Subunit structurei

The C5a anaphylatoxin interacts with C5AR1.By similarity

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000005908.

Structurei

Secondary structure

174
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi2 – 11Combined sources10
Helixi16 – 26Combined sources11
Helixi34 – 40Combined sources7
Helixi45 – 62Combined sources18

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1C5ANMR-A1-73[»]
ProteinModelPortaliP01032.
SMRiP01032.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01032.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 55Anaphylatoxin-likePROSITE-ProRule annotationAdd BLAST35

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni15 – 44Involved in C5AR1 bindingBy similarityAdd BLAST30
Regioni72 – 74Required for 90% of C5a activity; although Arg-74 is not essential3

Phylogenomic databases

eggNOGiKOG1366. Eukaryota.
ENOG410XRED. LUCA.
HOVERGENiHBG051050.
InParanoidiP01032.

Family and domain databases

Gene3Di1.20.91.20. 1 hit.
InterProiView protein in InterPro
IPR000020. Anaphylatoxin/fibulin.
IPR018081. Anaphylatoxin_comp_syst.
IPR001840. Anaphylatoxn_comp_syst_dom.
PfamiView protein in Pfam
PF01821. ANATO. 1 hit.
PRINTSiPR00004. ANAPHYLATOXN.
SMARTiView protein in SMART
SM00104. ANATO. 1 hit.
SUPFAMiSSF47686. SSF47686. 1 hit.
PROSITEiView protein in PROSITE
PS01177. ANAPHYLATOXIN_1. 1 hit.
PS01178. ANAPHYLATOXIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P01032-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQKKIEEEA AKYKYAMLKK CCYDGAYRND DETCEERAAR IKIGPKCVKA
60 70
FKDCCYIANQ VRAEQSHKNI QLGR
Length:74
Mass (Da):8,609
Last modified:July 21, 1986 - v1
Checksum:i11AAF2E94A026EB3
GO

Sequence databases

PIRiA01268.
UniGeneiSsc.21108.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCO5_PIG
AccessioniPrimary (citable) accession number: P01032
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: March 15, 2017
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references