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Protein

Complement C5a anaphylatoxin

Gene

C5

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Complement alternate pathway, Complement pathway, Immunity, Inflammatory response, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Complement C5a anaphylatoxin
Gene namesi
Name:C5
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000485211 – 74Complement C5a anaphylatoxinAdd BLAST74

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi21 ↔ 47
Disulfide bondi22 ↔ 54
Disulfide bondi34 ↔ 55

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP01032.
PeptideAtlasiP01032.
PRIDEiP01032.

Interactioni

Subunit structurei

The C5a anaphylatoxin interacts with C5AR1.By similarity

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000005908.

Structurei

Secondary structure

174
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi2 – 11Combined sources10
Helixi16 – 26Combined sources11
Helixi34 – 40Combined sources7
Helixi45 – 62Combined sources18

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1C5ANMR-A1-73[»]
ProteinModelPortaliP01032.
SMRiP01032.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01032.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 55Anaphylatoxin-likePROSITE-ProRule annotationAdd BLAST35

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni15 – 44Involved in C5AR1 bindingBy similarityAdd BLAST30
Regioni72 – 74Required for 90% of C5a activity; although Arg-74 is not essential3

Sequence similaritiesi

Contains 1 anaphylatoxin-like domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1366. Eukaryota.
ENOG410XRED. LUCA.
HOVERGENiHBG051050.
InParanoidiP01032.

Family and domain databases

Gene3Di1.20.91.20. 1 hit.
InterProiIPR000020. Anaphylatoxin/fibulin.
IPR018081. Anaphylatoxin_comp_syst.
IPR001840. Anaphylatoxn_comp_syst_dom.
[Graphical view]
PfamiPF01821. ANATO. 1 hit.
[Graphical view]
PRINTSiPR00004. ANAPHYLATOXN.
SMARTiSM00104. ANATO. 1 hit.
[Graphical view]
SUPFAMiSSF47686. SSF47686. 1 hit.
PROSITEiPS01177. ANAPHYLATOXIN_1. 1 hit.
PS01178. ANAPHYLATOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P01032-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQKKIEEEA AKYKYAMLKK CCYDGAYRND DETCEERAAR IKIGPKCVKA
60 70
FKDCCYIANQ VRAEQSHKNI QLGR
Length:74
Mass (Da):8,609
Last modified:July 21, 1986 - v1
Checksum:i11AAF2E94A026EB3
GO

Sequence databases

PIRiA01268.
UniGeneiSsc.21108.

Cross-referencesi

Sequence databases

PIRiA01268.
UniGeneiSsc.21108.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1C5ANMR-A1-73[»]
ProteinModelPortaliP01032.
SMRiP01032.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000005908.

Proteomic databases

PaxDbiP01032.
PeptideAtlasiP01032.
PRIDEiP01032.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG1366. Eukaryota.
ENOG410XRED. LUCA.
HOVERGENiHBG051050.
InParanoidiP01032.

Miscellaneous databases

EvolutionaryTraceiP01032.

Family and domain databases

Gene3Di1.20.91.20. 1 hit.
InterProiIPR000020. Anaphylatoxin/fibulin.
IPR018081. Anaphylatoxin_comp_syst.
IPR001840. Anaphylatoxn_comp_syst_dom.
[Graphical view]
PfamiPF01821. ANATO. 1 hit.
[Graphical view]
PRINTSiPR00004. ANAPHYLATOXN.
SMARTiSM00104. ANATO. 1 hit.
[Graphical view]
SUPFAMiSSF47686. SSF47686. 1 hit.
PROSITEiPS01177. ANAPHYLATOXIN_1. 1 hit.
PS01178. ANAPHYLATOXIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCO5_PIG
AccessioniPrimary (citable) accession number: P01032
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 2, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.