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P01029

- CO4B_MOUSE

UniProt

P01029 - CO4B_MOUSE

Protein

Complement C4-B

Gene

C4b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 148 (01 Oct 2014)
      Sequence version 3 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. Catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens By similarity.By similarity

    GO - Molecular functioni

    1. endopeptidase inhibitor activity Source: InterPro

    GO - Biological processi

    1. complement activation, classical pathway Source: UniProtKB-KW
    2. inflammatory response Source: UniProtKB-KW
    3. innate immune response Source: UniProtKB-KW

    Keywords - Biological processi

    Complement pathway, Immunity, Inflammatory response, Innate immunity

    Enzyme and pathway databases

    ReactomeiREACT_198562. Regulation of Complement cascade.
    REACT_202834. Initial triggering of complement.
    REACT_213087. Activation of C3 and C5.

    Protein family/group databases

    MEROPSiI39.951.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Complement C4-B
    Cleaved into the following 4 chains:
    Gene namesi
    Name:C4b
    Synonyms:C4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:88228. C4b.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: InterPro

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Add
    BLAST
    Chaini20 – 673654Complement C4 beta chainPRO_0000005973Add
    BLAST
    Propeptidei674 – 6774PRO_0000005974
    Chaini678 – 1443766Complement C4 alpha chainPRO_0000005975Add
    BLAST
    Chaini678 – 75376C4a anaphylatoxinPRO_0000005976Add
    BLAST
    Propeptidei1444 – 14474PRO_0000005977
    Chaini1448 – 1738291Complement C4 gamma chainPRO_0000005978Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi224 – 2241N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi700 ↔ 726By similarity
    Disulfide bondi701 ↔ 733By similarity
    Disulfide bondi714 ↔ 734By similarity
    Glycosylationi743 – 7431N-linked (GlcNAc...)
    Cross-linki1006 ↔ 1009Isoglutamyl cysteine thioester (Cys-Gln)By similarity
    Glycosylationi1324 – 13241N-linked (GlcNAc...)1 Publication
    Glycosylationi1387 – 13871N-linked (GlcNAc...)Sequence Analysis
    Modified residuei1413 – 14131SulfotyrosineBy similarity
    Modified residuei1416 – 14161SulfotyrosineBy similarity
    Modified residuei1417 – 14171SulfotyrosineBy similarity
    Disulfide bondi1589 ↔ 1667By similarity
    Disulfide bondi1612 ↔ 1736By similarity

    Post-translational modificationi

    Prior to secretion, the single-chain precursor is enzymatically cleaved to yield non-identical chains alpha, beta and gamma. During activation, the alpha chain is cleaved by C1 into C4a and C4b, and C4b stays linked to the beta and gamma chains. Further degradation of C4b by C1 into the inactive fragments C4c and C4d blocks the generation of C3 convertase.

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Sulfation, Thioester bond

    Proteomic databases

    MaxQBiP01029.
    PaxDbiP01029.
    PRIDEiP01029.

    PTM databases

    PhosphoSiteiP01029.

    Expressioni

    Gene expression databases

    ArrayExpressiP01029.
    BgeeiP01029.
    CleanExiMM_C4B.
    GenevestigatoriP01029.

    Interactioni

    Subunit structurei

    Circulates in blood as a disulfide-linked trimer of an alpha, beta and gamma chain.

    Protein-protein interaction databases

    IntActiP01029. 2 interactions.
    MINTiMINT-1857263.

    Structurei

    3D structure databases

    ProteinModelPortaliP01029.
    SMRiP01029. Positions 679-1416, 1449-1738.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini700 – 73435Anaphylatoxin-likePROSITE-ProRule annotationAdd
    BLAST
    Domaini1589 – 1736148NTRPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 anaphylatoxin-like domain.PROSITE-ProRule annotation
    Contains 1 NTR domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG2373.
    GeneTreeiENSGT00560000077078.
    HOVERGENiHBG107123.
    InParanoidiP01029.
    KOiK03989.
    OMAiTAYFKDE.
    OrthoDBiEOG77HDCX.
    TreeFamiTF313285.

    Family and domain databases

    Gene3Di1.20.91.20. 1 hit.
    1.50.10.20. 1 hit.
    2.60.40.690. 1 hit.
    InterProiIPR009048. A-macroglobulin_rcpt-bd.
    IPR011626. A2M_comp.
    IPR002890. A2M_N.
    IPR011625. A2M_N_2.
    IPR000020. Anaphylatoxin/fibulin.
    IPR018081. Anaphylatoxin_comp_syst.
    IPR001840. Anaphylatoxn_comp_syst_dom.
    IPR001599. Macroglobln_a2.
    IPR019742. MacrogloblnA2_CS.
    IPR019565. MacrogloblnA2_thiol-ester-bond.
    IPR001134. Netrin_domain.
    IPR018933. Netrin_module_non-TIMP.
    IPR008930. Terpenoid_cyclase/PrenylTrfase.
    IPR008993. TIMP-like_OB-fold.
    [Graphical view]
    PfamiPF00207. A2M. 1 hit.
    PF07678. A2M_comp. 1 hit.
    PF01835. A2M_N. 1 hit.
    PF07703. A2M_N_2. 1 hit.
    PF07677. A2M_recep. 1 hit.
    PF01821. ANATO. 1 hit.
    PF01759. NTR. 1 hit.
    PF10569. Thiol-ester_cl. 1 hit.
    [Graphical view]
    PRINTSiPR00004. ANAPHYLATOXN.
    SMARTiSM00104. ANATO. 1 hit.
    SM00643. C345C. 1 hit.
    [Graphical view]
    SUPFAMiSSF47686. SSF47686. 1 hit.
    SSF48239. SSF48239. 1 hit.
    SSF49410. SSF49410. 1 hit.
    SSF50242. SSF50242. 1 hit.
    PROSITEiPS00477. ALPHA_2_MACROGLOBULIN. 1 hit.
    PS01177. ANAPHYLATOXIN_1. 1 hit.
    PS01178. ANAPHYLATOXIN_2. 1 hit.
    PS50189. NTR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P01029-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRLLWGLAWV FSFCASSLQK PRLLLFSPSV VNLGTPLSVG VQLLDAPPGQ     50
    EVKGSVFLRN PKGGSCSPKK DFKLSSGDDF VLLSLEVPLE DVRSCGLFDL 100
    RRAPHIQLVA QSPWLRNTAF KATETQGVNL LFSSRRGHIF VQTDQPIYNP 150
    GQRVRYRVFA LDQKMRPSTD FLTITVENSH GLRVLKKEIF TSTSIFQDAF 200
    TIPDISEPGT WKISARFSDG LESNRSTHFE VKKYVLPNFE VKITPWKPYI 250
    LMVPSNSDEI QLDIQARYIY GKPVQGVAYT RFALMDEQGK RTFLRGLETQ 300
    AKLVEGRTHI SISKDQFQAA LDKINIGVRD LEGLRLYAAT AVIESPGGEM 350
    EEAELTSWRF VSSAFSLDLS RTKRHLVPGA HFLLQALVQE MSGSEASNVP 400
    VKVSATLVSG SDSQVLDIQQ STNGIGQVSI SFPIPPTVTE LRLLVSAGSL 450
    YPAIARLTVQ APPSRGTGFL SIEPLDPRSP SVGDTFILNL QPVGIPAPTF 500
    SHYYYMIISR GQIMAMGREP RKTVTSVSVL VDHQLAPSFY FVAYFYHQGH 550
    PVANSLLINI QSRDCEGKLQ LKVDGAKEYR NADMMKLRIQ TDSKALVALG 600
    AVDMALYAVG GRSHKPLDMS KVFEVINSYN VGCGPGGGDD ALQVFQDAGL 650
    AFSDGDRLTQ TREDLSCPKE KKSRQKRNVN FQKAVSEKLG QYSSPDAKRC 700
    CQDGMTKLPM KRTCEQRAAR VPQQACREPF LSCCKFAEDL RRNQTRSQAH 750
    LARNNHNMLQ EEDLIDEDDI LVRTSFPENW LWRVEPVDSS KLLTVWLPDS 800
    MTTWEIHGVS LSKSKGLCVA KPTRVRVFRK FHLHLRLPIS IRRFEQFELR 850
    PVLYNYLNDD VAVSVHVTPV EGLCLAGGGM MAQQVTVPAG SARPVAFSVV 900
    PTAAANVPLK VVARGVFDLG DAVSKILQIE KEGAIHREEL VYNLDPLNNL 950
    GRTLEIPGSS DPNIVPDGDF SSLVRVTASE PLETMGSEGA LSPGGVASLL 1000
    RLPQGCAEQT MIYLAPTLTA SNYLDRTEQW SKLSPETKDH AVDLIQKGYM 1050
    RIQQFRKNDG SFGAWLHRDS STWLTAFVLK ILSLAQEQVG NSPEKLQETA 1100
    SWLLAQQLGD GSFHDPCPVI HRAMQGGLVG SDETVALTAF VVIALHHGLD 1150
    VFQDDDAKQL KNRVEASITK ANSFLGQKAS AGLLGAHAAA ITAYALTLTK 1200
    ASEDLRNVAH NSLMAMAEET GEHLYWGLVL GSQDKVVLRP TAPRSPTEPV 1250
    PQAPALWIET TAYALLHLLL REGKGKMADK AASWLTHQGS FHGAFRSTQD 1300
    TVVTLDALSA YWIASHTTEE KALNVTLSSM GRNGLKTHGL HLNNHQVKGL 1350
    EEELKFSLGS TISVKVEGNS KGTLKILRTY NVLDMKNTTC QDLQIEVKVT 1400
    GAVEYAWDAN EDYEDYYDMP AADDPSVPLQ PVTPLQLFEG RRSRRRREAP 1450
    KVVEEQESRV QYTVCIWRNG KLGLSGMAIA DITLLSGFHA LRADLEKLTS 1500
    LSDRYVSHFE TDGPHVLLYF DSVPTTRECV GFGASQEVVV GLVQPSSAVL 1550
    YDYYSPDHKC SVFYAAPTKS QLLATLCSGD VCQCAEGKCP RLLRSLERRV 1600
    EDKDGYRMRF ACYYPRVEYG FTVKVLREDG RAAFRLFESK ITQVLHFRKD 1650
    TMASIGQTRN FLSRASCRLR LEPNKEYLIM GMDGETSDNK GDPQYLLDSN 1700
    TWIEEMPSEQ MCKSTRHRAA CFQLKDFLME FSSRGCQV 1738
    Length:1,738
    Mass (Da):192,915
    Last modified:July 27, 2011 - v3
    Checksum:iFCC7580209029E88
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti132 – 1321F → Y in AAA39557. (PubMed:2993295)Curated
    Sequence conflicti177 – 1771E → G in BAE34429. (PubMed:16141072)Curated
    Sequence conflicti283 – 2831A → V in BAE34429. (PubMed:16141072)Curated
    Sequence conflicti327 – 3271G → E in AAA39557. (PubMed:2993295)Curated
    Sequence conflicti440 – 4401E → K in AAH67394. (PubMed:15489334)Curated
    Sequence conflicti440 – 4401E → K in AAH67409. (PubMed:15489334)Curated
    Sequence conflicti570 – 5701Q → E in AAA39557. (PubMed:2993295)Curated
    Sequence conflicti570 – 5701Q → E in BAE34280. (PubMed:16141072)Curated
    Sequence conflicti604 – 6041M → T in AAA39557. (PubMed:2993295)Curated
    Sequence conflicti604 – 6041M → T in AAA39506. (PubMed:3862104)Curated
    Sequence conflicti604 – 6041M → T in AAA39561. (PubMed:2777798)Curated
    Sequence conflicti604 – 6041M → T in BAE34280. (PubMed:16141072)Curated
    Sequence conflicti604 – 6041M → T in BAE34429. (PubMed:16141072)Curated
    Sequence conflicti604 – 6041M → T in AAH67394. (PubMed:15489334)Curated
    Sequence conflicti604 – 6041M → T in AAH67409. (PubMed:15489334)Curated
    Sequence conflicti639 – 6391D → G in BAE34429. (PubMed:16141072)Curated
    Sequence conflicti758 – 7581M → I in BAE34280. (PubMed:16141072)Curated
    Sequence conflicti838 – 8381P → R in AAA39557. (PubMed:2993295)Curated
    Sequence conflicti916 – 9161V → I in BAE34280. (PubMed:16141072)Curated
    Sequence conflicti1077 – 10771F → S in AAH67394. (PubMed:15489334)Curated
    Sequence conflicti1077 – 10771F → S in AAH67409. (PubMed:15489334)Curated
    Sequence conflicti1119 – 11191V → A in AAC42021. (PubMed:3856857)Curated
    Sequence conflicti1190 – 11901A → T in AAC42021. (PubMed:3856857)Curated
    Sequence conflicti1206 – 12061R → Q in BAE34280. (PubMed:16141072)Curated
    Sequence conflicti1206 – 12061R → Q in BAE34429. (PubMed:16141072)Curated
    Sequence conflicti1206 – 12061R → Q in AAH67394. (PubMed:15489334)Curated
    Sequence conflicti1206 – 12061R → Q in AAH67409. (PubMed:15489334)Curated
    Sequence conflicti1206 – 12061R → Q in AAA40487. (PubMed:2459207)Curated
    Sequence conflicti1290 – 12901S → N in AAC42022. (PubMed:6149581)Curated
    Sequence conflicti1324 – 13241N → K in AAA39506. (PubMed:3862104)Curated
    Sequence conflicti1324 – 13241N → K in AAA39561. (PubMed:2777798)Curated
    Sequence conflicti1324 – 13241N → K in AAC42021. (PubMed:3856857)Curated
    Sequence conflicti1365 – 13651K → E in BAE34429. (PubMed:16141072)Curated
    Sequence conflicti1401 – 14011G → S in AAA39554. (PubMed:6192448)Curated
    Sequence conflicti1442 – 14421R → K in AAA39557. (PubMed:2993295)Curated
    Sequence conflicti1453 – 14531V → A in AAA39506. (PubMed:3862104)Curated
    Sequence conflicti1453 – 14531V → A in AAA39561. (PubMed:2777798)Curated
    Sequence conflicti1453 – 14531V → A in BAE34429. (PubMed:16141072)Curated
    Sequence conflicti1453 – 14531V → A in AAA39554. (PubMed:6192448)Curated
    Sequence conflicti1456 – 14561Q → R in BAE34429. (PubMed:16141072)Curated
    Sequence conflicti1586 – 15861E → Q in CAA28936. (PubMed:3008092)Curated
    Sequence conflicti1611 – 16111A → T in AAC05279. (PubMed:14656967)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M11789 Genomic DNA. Translation: AAA39557.1.
    M11729 mRNA. Translation: AAA39506.1.
    M17440 Genomic DNA. Translation: AAA39561.1.
    AK157954 mRNA. Translation: BAE34280.1.
    AK158256 mRNA. Translation: BAE34429.1.
    AF049850 Genomic DNA. Translation: AAC05279.1.
    CT573030 Genomic DNA. No translation available.
    BC067394 mRNA. Translation: AAH67394.1.
    BC067409 mRNA. Translation: AAH67409.1.
    M12968 Genomic DNA. Translation: AAA39558.1.
    M12969 Genomic DNA. Translation: AAA39559.1.
    M14225 Genomic DNA. Translation: AAA39563.1.
    X05314 mRNA. Translation: CAA28936.1.
    M12970 mRNA. Translation: AAA39555.1.
    M12972 mRNA. Translation: AAA39556.1.
    M23186 Genomic DNA. Translation: AAA40487.1.
    X55493 Genomic DNA. Translation: CAA39112.1.
    X55495 Genomic DNA. Translation: CAA39114.1.
    K02798 mRNA. Translation: AAC42021.1.
    K02799 mRNA. Translation: AAC42022.1.
    K00019 mRNA. Translation: AAA39554.1.
    CCDSiCCDS28657.1.
    PIRiA24558.
    A29176.
    RefSeqiNP_033910.2. NM_009780.2.
    XP_006544540.1. XM_006544477.1.
    UniGeneiMm.439678.
    Mm.477109.

    Genome annotation databases

    EnsembliENSMUST00000069507; ENSMUSP00000069418; ENSMUSG00000073418.
    GeneIDi102643089.
    12268.
    KEGGimmu:102643089.
    mmu:12268.
    UCSCiuc008cdk.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M11789 Genomic DNA. Translation: AAA39557.1 .
    M11729 mRNA. Translation: AAA39506.1 .
    M17440 Genomic DNA. Translation: AAA39561.1 .
    AK157954 mRNA. Translation: BAE34280.1 .
    AK158256 mRNA. Translation: BAE34429.1 .
    AF049850 Genomic DNA. Translation: AAC05279.1 .
    CT573030 Genomic DNA. No translation available.
    BC067394 mRNA. Translation: AAH67394.1 .
    BC067409 mRNA. Translation: AAH67409.1 .
    M12968 Genomic DNA. Translation: AAA39558.1 .
    M12969 Genomic DNA. Translation: AAA39559.1 .
    M14225 Genomic DNA. Translation: AAA39563.1 .
    X05314 mRNA. Translation: CAA28936.1 .
    M12970 mRNA. Translation: AAA39555.1 .
    M12972 mRNA. Translation: AAA39556.1 .
    M23186 Genomic DNA. Translation: AAA40487.1 .
    X55493 Genomic DNA. Translation: CAA39112.1 .
    X55495 Genomic DNA. Translation: CAA39114.1 .
    K02798 mRNA. Translation: AAC42021.1 .
    K02799 mRNA. Translation: AAC42022.1 .
    K00019 mRNA. Translation: AAA39554.1 .
    CCDSi CCDS28657.1.
    PIRi A24558.
    A29176.
    RefSeqi NP_033910.2. NM_009780.2.
    XP_006544540.1. XM_006544477.1.
    UniGenei Mm.439678.
    Mm.477109.

    3D structure databases

    ProteinModelPortali P01029.
    SMRi P01029. Positions 679-1416, 1449-1738.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P01029. 2 interactions.
    MINTi MINT-1857263.

    Protein family/group databases

    MEROPSi I39.951.

    PTM databases

    PhosphoSitei P01029.

    Proteomic databases

    MaxQBi P01029.
    PaxDbi P01029.
    PRIDEi P01029.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000069507 ; ENSMUSP00000069418 ; ENSMUSG00000073418 .
    GeneIDi 102643089.
    12268.
    KEGGi mmu:102643089.
    mmu:12268.
    UCSCi uc008cdk.2. mouse.

    Organism-specific databases

    CTDi 721.
    MGIi MGI:88228. C4b.

    Phylogenomic databases

    eggNOGi COG2373.
    GeneTreei ENSGT00560000077078.
    HOVERGENi HBG107123.
    InParanoidi P01029.
    KOi K03989.
    OMAi TAYFKDE.
    OrthoDBi EOG77HDCX.
    TreeFami TF313285.

    Enzyme and pathway databases

    Reactomei REACT_198562. Regulation of Complement cascade.
    REACT_202834. Initial triggering of complement.
    REACT_213087. Activation of C3 and C5.

    Miscellaneous databases

    NextBioi 280722.
    PROi P01029.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P01029.
    Bgeei P01029.
    CleanExi MM_C4B.
    Genevestigatori P01029.

    Family and domain databases

    Gene3Di 1.20.91.20. 1 hit.
    1.50.10.20. 1 hit.
    2.60.40.690. 1 hit.
    InterProi IPR009048. A-macroglobulin_rcpt-bd.
    IPR011626. A2M_comp.
    IPR002890. A2M_N.
    IPR011625. A2M_N_2.
    IPR000020. Anaphylatoxin/fibulin.
    IPR018081. Anaphylatoxin_comp_syst.
    IPR001840. Anaphylatoxn_comp_syst_dom.
    IPR001599. Macroglobln_a2.
    IPR019742. MacrogloblnA2_CS.
    IPR019565. MacrogloblnA2_thiol-ester-bond.
    IPR001134. Netrin_domain.
    IPR018933. Netrin_module_non-TIMP.
    IPR008930. Terpenoid_cyclase/PrenylTrfase.
    IPR008993. TIMP-like_OB-fold.
    [Graphical view ]
    Pfami PF00207. A2M. 1 hit.
    PF07678. A2M_comp. 1 hit.
    PF01835. A2M_N. 1 hit.
    PF07703. A2M_N_2. 1 hit.
    PF07677. A2M_recep. 1 hit.
    PF01821. ANATO. 1 hit.
    PF01759. NTR. 1 hit.
    PF10569. Thiol-ester_cl. 1 hit.
    [Graphical view ]
    PRINTSi PR00004. ANAPHYLATOXN.
    SMARTi SM00104. ANATO. 1 hit.
    SM00643. C345C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47686. SSF47686. 1 hit.
    SSF48239. SSF48239. 1 hit.
    SSF49410. SSF49410. 1 hit.
    SSF50242. SSF50242. 1 hit.
    PROSITEi PS00477. ALPHA_2_MACROGLOBULIN. 1 hit.
    PS01177. ANAPHYLATOXIN_1. 1 hit.
    PS01178. ANAPHYLATOXIN_2. 1 hit.
    PS50189. NTR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete nucleotide and derived amino acid sequences of the fourth component of mouse complement (C4). Evolutionary aspects."
      Nonaka M., Nakayama K., Yeul Y.D., Takahashi M.
      J. Biol. Chem. 260:10936-10943(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: FM.
    2. "Complete cDNA sequence of the fourth component of murine complement."
      Sepich D.S., Noonan D.J., Ogata R.T.
      Proc. Natl. Acad. Sci. U.S.A. 82:5895-5899(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: B10.WR.
    3. "Sequence of the gene for murine complement component C4."
      Ogata R.T., Rosa P.A., Zepf N.E.
      J. Biol. Chem. 264:16565-16572(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: B10.WR.
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Inner ear.
    5. "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
      Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L.
      Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 129.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and CD-1.
      Tissue: Germ cell and Neural stem cell.
    8. "Molecular cloning and characterization of complementary and genomic DNA clones for mouse C4 and Slp."
      Nonaka M., Nakayama K., Yeul Y.D., Shimizu A., Takahashi M.
      Immunol. Rev. 87:81-99(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-128.
      Strain: FM.
    9. "Identification of the 5'-flanking regulatory region responsible for the difference in transcriptional control between mouse complement C4 and Slp genes."
      Nonaka M., Kimura H., Yeul Y.D., Yokoyama S., Nakayama K., Takahashi M.
      Proc. Natl. Acad. Sci. U.S.A. 83:7883-7887(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-21.
    10. "Sequence comparison of alleles of the fourth component of complement (C4) and sex-limited protein (Slp)."
      Hemenway C., Kalff M., Stavenhagen J., Walthall D., Robins D.
      Nucleic Acids Res. 14:2539-2554(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 591-1738.
      Strain: C57BL/10 X DBA/2.
    11. "Isolation of cDNA clones specifying the fourth component of mouse complement and its isotype, sex-limited protein."
      Nonaka M., Takahashi M., Natsuume-Sakai S., Nonaka M., Tanaka S., Shimizu A., Honjo T.
      Proc. Natl. Acad. Sci. U.S.A. 81:6822-6826(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 651-810 AND 924-1083.
    12. "Structural basis for the C4d.1/C4d.2 serologic allotypes of murine complement component C4."
      Taillon-Miller P.A., Shreffler D.C.
      J. Immunol. 141:2382-2387(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 961-1290.
    13. "C4 from C4-high and C4-low mouse strains have identical sequences in the region corresponding to the isotype-specific segment of human C4."
      Ogata R.T., Zepf N.E.
      Eur. J. Immunol. 20:1607-1610(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1099-1142.
      Strain: B10.BR, B10.WR, C3H/He, C57BL/6, CBA/J and DBA/2.
    14. "Multiple duplications of complement C4 gene correlate with H-2-controlled testosterone-independent expression of its sex-limited isoform, C4-Slp."
      Levi-Strauss M., Tosi M., Steinmetz M., Klein J., Meo T.
      Proc. Natl. Acad. Sci. U.S.A. 82:1746-1750(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1105-1449.
    15. "Sequence heterogeneity of murine complementary DNA clones related to the C4 and C4-Slp isoforms of the fourth complement component."
      Tosi M., Levi-Strauss M., Duponchel C., Meo T.
      Philos. Trans. R. Soc. Lond., B, Biol. Sci. 306:389-394(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1257-1376.
    16. "cDNA clone spanning the alpha-gamma subunit junction in the precursor of the murine fourth complement component (C4)."
      Ogata R.T., Shreffler D.C., Sepich D.S., Lilly S.P.
      Proc. Natl. Acad. Sci. U.S.A. 80:5061-5065(1983) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1360-1511.
    17. "Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides."
      Bernhard O.K., Kapp E.A., Simpson R.J.
      J. Proteome Res. 6:987-995(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1324.
      Strain: C57BL/6.
      Tissue: Plasma.

    Entry informationi

    Entry nameiCO4B_MOUSE
    AccessioniPrimary (citable) accession number: P01029
    Secondary accession number(s): E9QKK7
    , O70346, Q31201, Q3TYY1, Q3TZC9, Q61372, Q61859, Q62353, Q6NWV8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 148 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    C4 is a major histocompatibility complex class-III protein.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3