Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P01029 (CO4B_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 146. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Complement C4-B
Gene names
Name:C4b
Synonyms:C4
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1738 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. Catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens By similarity.

Subunit structure

Circulates in blood as a disulfide-linked trimer of an alpha, beta and gamma chain.

Subcellular location

Secreted.

Post-translational modification

Prior to secretion, the single-chain precursor is enzymatically cleaved to yield non-identical chains alpha, beta and gamma. During activation, the alpha chain is cleaved by C1 into C4a and C4b, and C4b stays linked to the beta and gamma chains. Further degradation of C4b by C1 into the inactive fragments C4c and C4d blocks the generation of C3 convertase.

Miscellaneous

C4 is a major histocompatibility complex class-III protein.

Sequence similarities

Contains 1 anaphylatoxin-like domain.

Contains 1 NTR domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919
Chain20 – 673654Complement C4 beta chain
PRO_0000005973
Propeptide674 – 6774
PRO_0000005974
Chain678 – 1443766Complement C4 alpha chain
PRO_0000005975
Chain678 – 75376C4a anaphylatoxin
PRO_0000005976
Propeptide1444 – 14474
PRO_0000005977
Chain1448 – 1738291Complement C4 gamma chain
PRO_0000005978

Regions

Domain700 – 73435Anaphylatoxin-like
Domain1589 – 1736148NTR

Amino acid modifications

Modified residue14131Sulfotyrosine By similarity
Modified residue14161Sulfotyrosine By similarity
Modified residue14171Sulfotyrosine By similarity
Glycosylation2241N-linked (GlcNAc...) Potential
Glycosylation7431N-linked (GlcNAc...)
Glycosylation13241N-linked (GlcNAc...) Ref.17
Glycosylation13871N-linked (GlcNAc...) Potential
Disulfide bond700 ↔ 726 By similarity
Disulfide bond701 ↔ 733 By similarity
Disulfide bond714 ↔ 734 By similarity
Disulfide bond1589 ↔ 1667 By similarity
Disulfide bond1612 ↔ 1736 By similarity
Cross-link1006 ↔ 1009Isoglutamyl cysteine thioester (Cys-Gln) By similarity

Experimental info

Sequence conflict1321F → Y in AAA39557. Ref.1
Sequence conflict1771E → G in BAE34429. Ref.4
Sequence conflict2831A → V in BAE34429. Ref.4
Sequence conflict3271G → E in AAA39557. Ref.1
Sequence conflict4401E → K in AAH67394. Ref.7
Sequence conflict4401E → K in AAH67409. Ref.7
Sequence conflict5701Q → E in AAA39557. Ref.1
Sequence conflict5701Q → E in BAE34280. Ref.4
Sequence conflict6041M → T in AAA39557. Ref.1
Sequence conflict6041M → T in AAA39506. Ref.2
Sequence conflict6041M → T in AAA39561. Ref.3
Sequence conflict6041M → T in BAE34280. Ref.4
Sequence conflict6041M → T in BAE34429. Ref.4
Sequence conflict6041M → T in AAH67394. Ref.7
Sequence conflict6041M → T in AAH67409. Ref.7
Sequence conflict6391D → G in BAE34429. Ref.4
Sequence conflict7581M → I in BAE34280. Ref.4
Sequence conflict8381P → R in AAA39557. Ref.1
Sequence conflict9161V → I in BAE34280. Ref.4
Sequence conflict10771F → S in AAH67394. Ref.7
Sequence conflict10771F → S in AAH67409. Ref.7
Sequence conflict11191V → A in AAC42021. Ref.14
Sequence conflict11901A → T in AAC42021. Ref.14
Sequence conflict12061R → Q in BAE34280. Ref.4
Sequence conflict12061R → Q in BAE34429. Ref.4
Sequence conflict12061R → Q in AAH67394. Ref.7
Sequence conflict12061R → Q in AAH67409. Ref.7
Sequence conflict12061R → Q in AAA40487. Ref.12
Sequence conflict12901S → N in AAC42022. Ref.15
Sequence conflict13241N → K in AAA39506. Ref.2
Sequence conflict13241N → K in AAA39561. Ref.3
Sequence conflict13241N → K in AAC42021. Ref.14
Sequence conflict13651K → E in BAE34429. Ref.4
Sequence conflict14011G → S in AAA39554. Ref.16
Sequence conflict14421R → K in AAA39557. Ref.1
Sequence conflict14531V → A in AAA39506. Ref.2
Sequence conflict14531V → A in AAA39561. Ref.3
Sequence conflict14531V → A in BAE34429. Ref.4
Sequence conflict14531V → A in AAA39554. Ref.16
Sequence conflict14561Q → R in BAE34429. Ref.4
Sequence conflict15861E → Q in CAA28936. Ref.10
Sequence conflict16111A → T in AAC05279. Ref.5

Sequences

Sequence LengthMass (Da)Tools
P01029 [UniParc].

Last modified July 27, 2011. Version 3.
Checksum: FCC7580209029E88

FASTA1,738192,915
        10         20         30         40         50         60 
MRLLWGLAWV FSFCASSLQK PRLLLFSPSV VNLGTPLSVG VQLLDAPPGQ EVKGSVFLRN 

        70         80         90        100        110        120 
PKGGSCSPKK DFKLSSGDDF VLLSLEVPLE DVRSCGLFDL RRAPHIQLVA QSPWLRNTAF 

       130        140        150        160        170        180 
KATETQGVNL LFSSRRGHIF VQTDQPIYNP GQRVRYRVFA LDQKMRPSTD FLTITVENSH 

       190        200        210        220        230        240 
GLRVLKKEIF TSTSIFQDAF TIPDISEPGT WKISARFSDG LESNRSTHFE VKKYVLPNFE 

       250        260        270        280        290        300 
VKITPWKPYI LMVPSNSDEI QLDIQARYIY GKPVQGVAYT RFALMDEQGK RTFLRGLETQ 

       310        320        330        340        350        360 
AKLVEGRTHI SISKDQFQAA LDKINIGVRD LEGLRLYAAT AVIESPGGEM EEAELTSWRF 

       370        380        390        400        410        420 
VSSAFSLDLS RTKRHLVPGA HFLLQALVQE MSGSEASNVP VKVSATLVSG SDSQVLDIQQ 

       430        440        450        460        470        480 
STNGIGQVSI SFPIPPTVTE LRLLVSAGSL YPAIARLTVQ APPSRGTGFL SIEPLDPRSP 

       490        500        510        520        530        540 
SVGDTFILNL QPVGIPAPTF SHYYYMIISR GQIMAMGREP RKTVTSVSVL VDHQLAPSFY 

       550        560        570        580        590        600 
FVAYFYHQGH PVANSLLINI QSRDCEGKLQ LKVDGAKEYR NADMMKLRIQ TDSKALVALG 

       610        620        630        640        650        660 
AVDMALYAVG GRSHKPLDMS KVFEVINSYN VGCGPGGGDD ALQVFQDAGL AFSDGDRLTQ 

       670        680        690        700        710        720 
TREDLSCPKE KKSRQKRNVN FQKAVSEKLG QYSSPDAKRC CQDGMTKLPM KRTCEQRAAR 

       730        740        750        760        770        780 
VPQQACREPF LSCCKFAEDL RRNQTRSQAH LARNNHNMLQ EEDLIDEDDI LVRTSFPENW 

       790        800        810        820        830        840 
LWRVEPVDSS KLLTVWLPDS MTTWEIHGVS LSKSKGLCVA KPTRVRVFRK FHLHLRLPIS 

       850        860        870        880        890        900 
IRRFEQFELR PVLYNYLNDD VAVSVHVTPV EGLCLAGGGM MAQQVTVPAG SARPVAFSVV 

       910        920        930        940        950        960 
PTAAANVPLK VVARGVFDLG DAVSKILQIE KEGAIHREEL VYNLDPLNNL GRTLEIPGSS 

       970        980        990       1000       1010       1020 
DPNIVPDGDF SSLVRVTASE PLETMGSEGA LSPGGVASLL RLPQGCAEQT MIYLAPTLTA 

      1030       1040       1050       1060       1070       1080 
SNYLDRTEQW SKLSPETKDH AVDLIQKGYM RIQQFRKNDG SFGAWLHRDS STWLTAFVLK 

      1090       1100       1110       1120       1130       1140 
ILSLAQEQVG NSPEKLQETA SWLLAQQLGD GSFHDPCPVI HRAMQGGLVG SDETVALTAF 

      1150       1160       1170       1180       1190       1200 
VVIALHHGLD VFQDDDAKQL KNRVEASITK ANSFLGQKAS AGLLGAHAAA ITAYALTLTK 

      1210       1220       1230       1240       1250       1260 
ASEDLRNVAH NSLMAMAEET GEHLYWGLVL GSQDKVVLRP TAPRSPTEPV PQAPALWIET 

      1270       1280       1290       1300       1310       1320 
TAYALLHLLL REGKGKMADK AASWLTHQGS FHGAFRSTQD TVVTLDALSA YWIASHTTEE 

      1330       1340       1350       1360       1370       1380 
KALNVTLSSM GRNGLKTHGL HLNNHQVKGL EEELKFSLGS TISVKVEGNS KGTLKILRTY 

      1390       1400       1410       1420       1430       1440 
NVLDMKNTTC QDLQIEVKVT GAVEYAWDAN EDYEDYYDMP AADDPSVPLQ PVTPLQLFEG 

      1450       1460       1470       1480       1490       1500 
RRSRRRREAP KVVEEQESRV QYTVCIWRNG KLGLSGMAIA DITLLSGFHA LRADLEKLTS 

      1510       1520       1530       1540       1550       1560 
LSDRYVSHFE TDGPHVLLYF DSVPTTRECV GFGASQEVVV GLVQPSSAVL YDYYSPDHKC 

      1570       1580       1590       1600       1610       1620 
SVFYAAPTKS QLLATLCSGD VCQCAEGKCP RLLRSLERRV EDKDGYRMRF ACYYPRVEYG 

      1630       1640       1650       1660       1670       1680 
FTVKVLREDG RAAFRLFESK ITQVLHFRKD TMASIGQTRN FLSRASCRLR LEPNKEYLIM 

      1690       1700       1710       1720       1730 
GMDGETSDNK GDPQYLLDSN TWIEEMPSEQ MCKSTRHRAA CFQLKDFLME FSSRGCQV 

« Hide

References

« Hide 'large scale' references
[1]"Complete nucleotide and derived amino acid sequences of the fourth component of mouse complement (C4). Evolutionary aspects."
Nonaka M., Nakayama K., Yeul Y.D., Takahashi M.
J. Biol. Chem. 260:10936-10943(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: FM.
[2]"Complete cDNA sequence of the fourth component of murine complement."
Sepich D.S., Noonan D.J., Ogata R.T.
Proc. Natl. Acad. Sci. U.S.A. 82:5895-5899(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: B10.WR.
[3]"Sequence of the gene for murine complement component C4."
Ogata R.T., Rosa P.A., Zepf N.E.
J. Biol. Chem. 264:16565-16572(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: B10.WR.
[4]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Inner ear.
[5]"Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L.
Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 129.
[6]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J and CD-1.
Tissue: Germ cell and Neural stem cell.
[8]"Molecular cloning and characterization of complementary and genomic DNA clones for mouse C4 and Slp."
Nonaka M., Nakayama K., Yeul Y.D., Shimizu A., Takahashi M.
Immunol. Rev. 87:81-99(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-128.
Strain: FM.
[9]"Identification of the 5'-flanking regulatory region responsible for the difference in transcriptional control between mouse complement C4 and Slp genes."
Nonaka M., Kimura H., Yeul Y.D., Yokoyama S., Nakayama K., Takahashi M.
Proc. Natl. Acad. Sci. U.S.A. 83:7883-7887(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-21.
[10]"Sequence comparison of alleles of the fourth component of complement (C4) and sex-limited protein (Slp)."
Hemenway C., Kalff M., Stavenhagen J., Walthall D., Robins D.
Nucleic Acids Res. 14:2539-2554(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 591-1738.
Strain: C57BL/10 X DBA/2.
[11]"Isolation of cDNA clones specifying the fourth component of mouse complement and its isotype, sex-limited protein."
Nonaka M., Takahashi M., Natsuume-Sakai S., Nonaka M., Tanaka S., Shimizu A., Honjo T.
Proc. Natl. Acad. Sci. U.S.A. 81:6822-6826(1984) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 651-810 AND 924-1083.
[12]"Structural basis for the C4d.1/C4d.2 serologic allotypes of murine complement component C4."
Taillon-Miller P.A., Shreffler D.C.
J. Immunol. 141:2382-2387(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 961-1290.
[13]"C4 from C4-high and C4-low mouse strains have identical sequences in the region corresponding to the isotype-specific segment of human C4."
Ogata R.T., Zepf N.E.
Eur. J. Immunol. 20:1607-1610(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1099-1142.
Strain: B10.BR, B10.WR, C3H/He, C57BL/6, CBA/J and DBA/2.
[14]"Multiple duplications of complement C4 gene correlate with H-2-controlled testosterone-independent expression of its sex-limited isoform, C4-Slp."
Levi-Strauss M., Tosi M., Steinmetz M., Klein J., Meo T.
Proc. Natl. Acad. Sci. U.S.A. 82:1746-1750(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1105-1449.
[15]"Sequence heterogeneity of murine complementary DNA clones related to the C4 and C4-Slp isoforms of the fourth complement component."
Tosi M., Levi-Strauss M., Duponchel C., Meo T.
Philos. Trans. R. Soc. Lond., B, Biol. Sci. 306:389-394(1984) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1257-1376.
[16]"cDNA clone spanning the alpha-gamma subunit junction in the precursor of the murine fourth complement component (C4)."
Ogata R.T., Shreffler D.C., Sepich D.S., Lilly S.P.
Proc. Natl. Acad. Sci. U.S.A. 80:5061-5065(1983) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1360-1511.
[17]"Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides."
Bernhard O.K., Kapp E.A., Simpson R.J.
J. Proteome Res. 6:987-995(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1324.
Strain: C57BL/6.
Tissue: Plasma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M11789 Genomic DNA. Translation: AAA39557.1.
M11729 mRNA. Translation: AAA39506.1.
M17440 Genomic DNA. Translation: AAA39561.1.
AK157954 mRNA. Translation: BAE34280.1.
AK158256 mRNA. Translation: BAE34429.1.
AF049850 Genomic DNA. Translation: AAC05279.1.
CT573030 Genomic DNA. No translation available.
BC067394 mRNA. Translation: AAH67394.1.
BC067409 mRNA. Translation: AAH67409.1.
M12968 Genomic DNA. Translation: AAA39558.1.
M12969 Genomic DNA. Translation: AAA39559.1.
M14225 Genomic DNA. Translation: AAA39563.1.
X05314 mRNA. Translation: CAA28936.1.
M12970 mRNA. Translation: AAA39555.1.
M12972 mRNA. Translation: AAA39556.1.
M23186 Genomic DNA. Translation: AAA40487.1.
X55493 Genomic DNA. Translation: CAA39112.1.
X55495 Genomic DNA. Translation: CAA39114.1.
K02798 mRNA. Translation: AAC42021.1.
K02799 mRNA. Translation: AAC42022.1.
K00019 mRNA. Translation: AAA39554.1.
CCDSCCDS28657.1.
PIRA24558.
A29176.
RefSeqNP_033910.2. NM_009780.2.
XP_006544540.1. XM_006544477.1.
UniGeneMm.439678.
Mm.477109.

3D structure databases

ProteinModelPortalP01029.
SMRP01029. Positions 679-1416, 1449-1738.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP01029. 2 interactions.
MINTMINT-1857263.

Protein family/group databases

MEROPSI39.951.

PTM databases

PhosphoSiteP01029.

Proteomic databases

MaxQBP01029.
PaxDbP01029.
PRIDEP01029.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000069507; ENSMUSP00000069418; ENSMUSG00000073418.
GeneID102643089.
12268.
KEGGmmu:102643089.
mmu:12268.
UCSCuc008cdk.2. mouse.

Organism-specific databases

CTD721.
MGIMGI:88228. C4b.

Phylogenomic databases

eggNOGCOG2373.
GeneTreeENSGT00560000077078.
HOVERGENHBG107123.
InParanoidP01029.
KOK03989.
OMATAYFKDE.
OrthoDBEOG77HDCX.
TreeFamTF313285.

Gene expression databases

ArrayExpressP01029.
BgeeP01029.
CleanExMM_C4B.
GenevestigatorP01029.

Family and domain databases

Gene3D1.20.91.20. 1 hit.
1.50.10.20. 1 hit.
2.60.40.690. 1 hit.
InterProIPR009048. A-macroglobulin_rcpt-bd.
IPR011626. A2M_comp.
IPR002890. A2M_N.
IPR011625. A2M_N_2.
IPR000020. Anaphylatoxin/fibulin.
IPR018081. Anaphylatoxin_comp_syst.
IPR001840. Anaphylatoxn_comp_syst_dom.
IPR001599. Macroglobln_a2.
IPR019742. MacrogloblnA2_CS.
IPR019565. MacrogloblnA2_thiol-ester-bond.
IPR001134. Netrin_domain.
IPR018933. Netrin_module_non-TIMP.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
IPR008993. TIMP-like_OB-fold.
[Graphical view]
PfamPF00207. A2M. 1 hit.
PF07678. A2M_comp. 1 hit.
PF01835. A2M_N. 1 hit.
PF07703. A2M_N_2. 1 hit.
PF07677. A2M_recep. 1 hit.
PF01821. ANATO. 1 hit.
PF01759. NTR. 1 hit.
PF10569. Thiol-ester_cl. 1 hit.
[Graphical view]
PRINTSPR00004. ANAPHYLATOXN.
SMARTSM00104. ANATO. 1 hit.
SM00643. C345C. 1 hit.
[Graphical view]
SUPFAMSSF47686. SSF47686. 1 hit.
SSF48239. SSF48239. 1 hit.
SSF49410. SSF49410. 1 hit.
SSF50242. SSF50242. 1 hit.
PROSITEPS00477. ALPHA_2_MACROGLOBULIN. 1 hit.
PS01177. ANAPHYLATOXIN_1. 1 hit.
PS01178. ANAPHYLATOXIN_2. 1 hit.
PS50189. NTR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio280722.
PROP01029.
SOURCESearch...

Entry information

Entry nameCO4B_MOUSE
AccessionPrimary (citable) accession number: P01029
Secondary accession number(s): E9QKK7 expand/collapse secondary AC list , O70346, Q31201, Q3TYY1, Q3TZC9, Q61372, Q61859, Q62353, Q6NWV8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 146 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot