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P01027

- CO3_MOUSE

UniProt

P01027 - CO3_MOUSE

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Protein

Complement C3

Gene
C3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates.2 Publications
Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. The short isoform has B-cell stimulatory activity.2 Publications
Acylation stimulating protein: adipogenic hormone that stimulates triglyceride (TG) synthesis and glucose transport in adipocytes, regulating fat storage and playing a role in postprandial TG clearance. Appears to stimulate TG synthesis via activation of the PLC, MAPK and AKT signaling pathways. Ligand for C5AR2. Promotes the phosphorylation, ARRB2-mediated internalization and recycling of C5AR2.2 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei747 – 7482Cleavage; by carboxypeptidases By similarity
Sitei748 – 7492Cleavage; by C3 convertase
Sitei954 – 9552Cleavage; by factor I Reviewed prediction
Sitei1303 – 13042Cleavage; by factor I
Sitei1320 – 13212Cleavage; by factor I

GO - Molecular functioni

  1. C5L2 anaphylatoxin chemotactic receptor binding Source: UniProtKB
  2. endopeptidase inhibitor activity Source: InterPro
  3. protein binding Source: MGI

GO - Biological processi

  1. complement activation Source: MGI
  2. complement activation, alternative pathway Source: UniProtKB-KW
  3. complement activation, classical pathway Source: UniProtKB-KW
  4. fatty acid metabolic process Source: UniProtKB-KW
  5. inflammatory response Source: UniProtKB-KW
  6. positive regulation of activation of membrane attack complex Source: BHF-UCL
  7. positive regulation of angiogenesis Source: BHF-UCL
  8. positive regulation of glucose transport Source: UniProtKB
  9. positive regulation of G-protein coupled receptor protein signaling pathway Source: UniProtKB
  10. positive regulation of lipid storage Source: UniProtKB
  11. positive regulation of phagocytosis Source: MGI
  12. positive regulation of protein phosphorylation Source: UniProtKB
  13. positive regulation of type IIa hypersensitivity Source: MGI
  14. positive regulation vascular endothelial growth factor production Source: Ensembl
  15. regulation of triglyceride biosynthetic process Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Complement alternate pathway, Complement pathway, Fatty acid metabolism, Immunity, Inflammatory response, Innate immunity, Lipid metabolism

Enzyme and pathway databases

ReactomeiREACT_198562. Regulation of Complement cascade.
REACT_202937. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_213087. Activation of C3 and C5.
REACT_218037. Alternative complement activation.

Protein family/group databases

MEROPSiI39.950.

Names & Taxonomyi

Protein namesi
Gene namesi
Name:C3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:88227. C3.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: InterPro
  2. extracellular vesicular exosome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Disruption phenotypei

Null mice displayed altered lipid metabolism and morphological changes in adipocyte distribution. There is reduced adipsin/CFD expression, increased number of smaller fat cells, decreased DGAT1 expression and activity, and less triglyceride storage capacity associated with delayed postprandial clearance. Mice on a high-fat diet exihibited no diet-induced up-regulation of adipsin/CFD expression nor adipocyte differentiation.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 24242 PublicationsAdd
BLAST
Chaini25 – 16631639Complement C3PRO_0000005917Add
BLAST
Chaini25 – 666642Complement C3 beta chainPRO_0000005918Add
BLAST
Chaini671 – 1663993Complement C3 alpha chainPRO_0000005919Add
BLAST
Chaini671 – 74878C3a anaphylatoxinPRO_0000005920Add
BLAST
Chaini671 – 74777Acylation stimulating proteinPRO_0000419936Add
BLAST
Chaini749 – 1663915Complement C3b alpha' chainPRO_0000005921Add
BLAST
Chaini749 – 954206Complement C3c alpha' chain fragment 1PRO_0000005922Add
BLAST
Chaini955 – 1303349Complement C3dg fragmentPRO_0000005923Add
BLAST
Chaini955 – 100147Complement C3g fragmentPRO_0000005924Add
BLAST
Chaini1002 – 1303302Complement C3d fragmentPRO_0000005925Add
BLAST
Peptidei1304 – 132017Complement C3f fragmentPRO_0000005927Add
BLAST
Chaini1321 – 1663343Complement C3c alpha' chain fragment 2PRO_0000273949Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi559 ↔ 816Interchain (between beta and alpha chains) By similarity
Disulfide bondi626 ↔ 661 By similarity
Disulfide bondi693 ↔ 720 By similarity
Disulfide bondi694 ↔ 727 By similarity
Disulfide bondi707 ↔ 728 By similarity
Disulfide bondi873 ↔ 1513 By similarity
Glycosylationi939 – 9391N-linked (GlcNAc...)
Cross-linki1010 ↔ 1013Isoglutamyl cysteine thioester (Cys-Gln) By similarity
Disulfide bondi1101 ↔ 1158 By similarity
Disulfide bondi1358 ↔ 1489 By similarity
Disulfide bondi1389 ↔ 1458 By similarity
Disulfide bondi1506 ↔ 1511 By similarity
Disulfide bondi1518 ↔ 1590 By similarity
Disulfide bondi1537 ↔ 1661 By similarity
Glycosylationi1617 – 16171N-linked (GlcNAc...)
Disulfide bondi1637 ↔ 1646 By similarity

Post-translational modificationi

C3b is rapidly split in two positions by factor I and a cofactor to form iC3b (inactivated C3b) and C3f which is released. Then iC3b is slowly cleaved (possibly by factor I) to form C3c (beta chain + alpha' chain fragment 1 + alpha' chain fragment 2), C3dg and C3f. Other proteases produce other fragments such as C3d or C3g. C3a is further processed by carboxypeptidases to release the C-terminal arginine residue generating the acylation stimulating protein (ASP). Levels of ASP are increased in adipocytes in the postprandial period and by dietary chylomicrons.
Phosphorylation sites are present in the extracellular medium By similarity.

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Phosphoprotein, Thioester bond

Proteomic databases

MaxQBiP01027.
PaxDbiP01027.
PRIDEiP01027.

PTM databases

PhosphoSiteiP01027.

Miscellaneous databases

PMAP-CutDBQ80XP1.

Expressioni

Gene expression databases

ArrayExpressiP01027.
BgeeiP01027.
CleanExiMM_C3.
GenevestigatoriP01027.

Interactioni

Subunit structurei

C3 precursor is first processed by the removal of 4 Arg residues, forming two chains, beta and alpha, linked by a disulfide bond. C3 convertase activates C3 by cleaving the alpha chain, releasing C3a anaphylatoxin and generating C3b (beta chain + alpha' chain). C3dg interacts with CR2 (via the N-terminal Sushi domains 1 and 2). Interacts with VSIG4. Interacts (both C3a and ASP) with C5AR2; the interaction occurs with higher affinity for ASP, enhancing the phosphorylation and activation of C5AR2, recruitment of ARRB2 to the cell surface and endocytosis of GRP77 By similarity.

Protein-protein interaction databases

BioGridi198418. 1 interaction.
IntActiP01027. 5 interactions.
MINTiMINT-1858136.

Structurei

3D structure databases

ProteinModelPortaliP01027.
SMRiP01027. Positions 26-663, 672-1663.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini693 – 72836Anaphylatoxin-likeAdd
BLAST
Domaini1518 – 1661144NTRAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1424 – 145633Properdin-binding By similarityAdd
BLAST

Sequence similaritiesi

Contains 1 NTR domain.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG241555.
GeneTreeiENSGT00560000077078.
HOGENOMiHOG000286028.
HOVERGENiHBG005110.
InParanoidiQ80XP1.
KOiK03990.
OMAiPGMPFDL.
OrthoDBiEOG77HDCX.
TreeFamiTF313285.

Family and domain databases

Gene3Di1.20.91.20. 1 hit.
1.50.10.20. 1 hit.
2.60.40.690. 1 hit.
InterProiIPR009048. A-macroglobulin_rcpt-bd.
IPR011626. A2M_comp.
IPR002890. A2M_N.
IPR011625. A2M_N_2.
IPR000020. Anaphylatoxin/fibulin.
IPR018081. Anaphylatoxin_comp_syst.
IPR001840. Anaphylatoxn_comp_syst_dom.
IPR001599. Macroglobln_a2.
IPR019742. MacrogloblnA2_CS.
IPR019565. MacrogloblnA2_thiol-ester-bond.
IPR001134. Netrin_domain.
IPR018933. Netrin_module_non-TIMP.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
IPR008993. TIMP-like_OB-fold.
[Graphical view]
PfamiPF00207. A2M. 1 hit.
PF07678. A2M_comp. 1 hit.
PF01835. A2M_N. 1 hit.
PF07703. A2M_N_2. 1 hit.
PF07677. A2M_recep. 1 hit.
PF01821. ANATO. 1 hit.
PF01759. NTR. 1 hit.
PF10569. Thiol-ester_cl. 1 hit.
[Graphical view]
PRINTSiPR00004. ANAPHYLATOXN.
SMARTiSM00104. ANATO. 1 hit.
SM00643. C345C. 1 hit.
[Graphical view]
SUPFAMiSSF47686. SSF47686. 1 hit.
SSF48239. SSF48239. 1 hit.
SSF49410. SSF49410. 1 hit.
SSF50242. SSF50242. 1 hit.
PROSITEiPS00477. ALPHA_2_MACROGLOBULIN. 1 hit.
PS01177. ANAPHYLATOXIN_1. 1 hit.
PS01178. ANAPHYLATOXIN_2. 1 hit.
PS50189. NTR. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative initiation. Align

Isoform Long (identifier: P01027-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGPASGSQLL VLLLLLASSP LALGIPMYSI ITPNVLRLES EETIVLEAHD     50
AQGDIPVTVT VQDFLKRQVL TSEKTVLTGA SGHLRSVSIK IPASKEFNSD 100
KEGHKYVTVV ANFGETVVEK AVMVSFQSGY LFIQTDKTIY TPGSTVLYRI 150
FTVDNNLLPV GKTVVILIET PDGIPVKRDI LSSNNQHGIL PLSWNIPELV 200
NMGQWKIRAF YEHAPKQIFS AEFEVKEYVL PSFEVRVEPT ETFYYIDDPN 250
GLEVSIIAKF LYGKNVDGTA FVIFGVQDGD KKISLAHSLT RVVIEDGVGD 300
AVLTRKVLME GVRPSNADAL VGKSLYVSVT VILHSGSDMV EAERSGIPIV 350
TSPYQIHFTK TPKFFKPAMP FDLMVFVTNP DGSPASKVLV VTQGSNAKAL 400
TQDDGVAKLS INTPNSRQPL TITVRTKKDT LPESRQATKT MEAHPYSTMH 450
NSNNYLHLSV SRMELKPGDN LNVNFHLRTD PGHEAKIRYY TYLVMNKGKL 500
LKAGRQVREP GQDLVVLSLP ITPEFIPSFR LVAYYTLIGA SGQREVVADS 550
VWVDVKDSCI GTLVVKGDPR DNHLAPGQQT TLRIEGNQGA RVGLVAVDKG 600
VFVLNKKNKL TQSKIWDVVE KADIGCTPGS GKNYAGVFMD AGLAFKTSQG 650
LQTEQRADLE CTKPAARRRR SVQLMERRMD KAGQYTDKGL RKCCEDGMRD 700
IPMRYSCQRR ARLITQGENC IKAFIDCCNH ITKLREQHRR DHVLGLARSE 750
LEEDIIPEED IISRSHFPQS WLWTIEELKE PEKNGISTKV MNIFLKDSIT 800
TWEILAVSLS DKKGICVADP YEIRVMQDFF IDLRLPYSVV RNEQVEIRAV 850
LFNYREQEEL KVRVELLHNP AFCSMATAKN RYFQTIKIPP KSSVAVPYVI 900
VPLKIGQQEV EVKAAVFNHF ISDGVKKTLK VVPEGMRINK TVAIHTLDPE 950
KLGQGGVQKV DVPAADLSDQ VPDTDSETRI ILQGSPVVQM AEDAVDGERL 1000
KHLIVTPAGC GEQNMIGMTP TVIAVHYLDQ TEQWEKFGIE KRQEALELIK 1050
KGYTQQLAFK QPSSAYAAFN NRPPSTWLTA YVVKVFSLAA NLIAIDSHVL 1100
CGAVKWLILE KQKPDGVFQE DGPVIHQEMI GGFRNAKEAD VSLTAFVLIA 1150
LQEARDICEG QVNSLPGSIN KAGEYIEASY MNLQRPYTVA IAGYALALMN 1200
KLEEPYLGKF LNTAKDRNRW EEPDQQLYNV EATSYALLAL LLLKDFDSVP 1250
PVVRWLNEQR YYGGGYGSTQ ATFMVFQALA QYQTDVPDHK DLNMDVSFHL 1300
PSRSSATTFR LLWENGNLLR SEETKQNEAF SLTAKGKGRG TLSVVAVYHA 1350
KLKSKVTCKK FDLRVSIRPA PETAKKPEEA KNTMFLEICT KYLGDVDATM 1400
SILDISMMTG FAPDTKDLEL LASGVDRYIS KYEMNKAFSN KNTLIIYLEK 1450
ISHTEEDCLT FKVHQYFNVG LIQPGSVKVY SYYNLEESCT RFYHPEKDDG 1500
MLSKLCHSEM CRCAEENCFM QQSQEKINLN VRLDKACEPG VDYVYKTELT 1550
NIELLDDFDE YTMTIQQVIK SGSDEVQAGQ QRKFISHIKC RNALKLQKGK 1600
KYLMWGLSSD LWGEKPNTSY IIGKDTWVEH WPEAEECQDQ KYQKQCEELG 1650
AFTESMVVYG CPN 1663
Length:1,663
Mass (Da):186,484
Last modified:July 27, 2011 - v3
Checksum:i7E5546CC7C314779
GO
Isoform Short (identifier: P01027-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1128: Missing.

Show »
Length:535
Mass (Da):60,952
Checksum:i6F6187342DC868CD
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11281128Missing in isoform Short. VSP_018708Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti137 – 1371K → Q in AAA37339. 1 Publication
Sequence conflicti858 – 8581E → Q in AAC42013. 1 Publication
Sequence conflicti1553 – 15531E → K in AAC42013. 1 Publication
Sequence conflicti1553 – 15531E → K in AAA37336. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
K02782 mRNA. Translation: AAC42013.1.
BC043338 mRNA. Translation: AAH43338.1.
M35659 mRNA. Translation: AAA37339.1.
M33032 mRNA. Translation: AAA37378.1.
J00369, J00367 Genomic DNA. Translation: AAA37336.1.
Z37998 Genomic DNA. Translation: CAA86099.2.
CCDSiCCDS37670.1. [P01027-1]
PIRiA92459. C3MS.
I48284.
RefSeqiNP_033908.2. NM_009778.2. [P01027-1]
UniGeneiMm.19131.

Genome annotation databases

EnsembliENSMUST00000024988; ENSMUSP00000024988; ENSMUSG00000024164. [P01027-1]
GeneIDi12266.
KEGGimmu:12266.
UCSCiuc008deg.1. mouse. [P01027-1]

Keywords - Coding sequence diversityi

Alternative initiation

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
K02782 mRNA. Translation: AAC42013.1 .
BC043338 mRNA. Translation: AAH43338.1 .
M35659 mRNA. Translation: AAA37339.1 .
M33032 mRNA. Translation: AAA37378.1 .
J00369 , J00367 Genomic DNA. Translation: AAA37336.1 .
Z37998 Genomic DNA. Translation: CAA86099.2 .
CCDSi CCDS37670.1. [P01027-1 ]
PIRi A92459. C3MS.
I48284.
RefSeqi NP_033908.2. NM_009778.2. [P01027-1 ]
UniGenei Mm.19131.

3D structure databases

ProteinModelPortali P01027.
SMRi P01027. Positions 26-663, 672-1663.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 198418. 1 interaction.
IntActi P01027. 5 interactions.
MINTi MINT-1858136.

Protein family/group databases

MEROPSi I39.950.

PTM databases

PhosphoSitei P01027.

Proteomic databases

MaxQBi P01027.
PaxDbi P01027.
PRIDEi P01027.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000024988 ; ENSMUSP00000024988 ; ENSMUSG00000024164 . [P01027-1 ]
GeneIDi 12266.
KEGGi mmu:12266.
UCSCi uc008deg.1. mouse. [P01027-1 ]

Organism-specific databases

CTDi 718.
MGIi MGI:88227. C3.

Phylogenomic databases

eggNOGi NOG241555.
GeneTreei ENSGT00560000077078.
HOGENOMi HOG000286028.
HOVERGENi HBG005110.
InParanoidi Q80XP1.
KOi K03990.
OMAi PGMPFDL.
OrthoDBi EOG77HDCX.
TreeFami TF313285.

Enzyme and pathway databases

Reactomei REACT_198562. Regulation of Complement cascade.
REACT_202937. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_213087. Activation of C3 and C5.
REACT_218037. Alternative complement activation.

Miscellaneous databases

ChiTaRSi C3. mouse.
NextBioi 280714.
PMAP-CutDB Q80XP1.
PROi P01027.
SOURCEi Search...

Gene expression databases

ArrayExpressi P01027.
Bgeei P01027.
CleanExi MM_C3.
Genevestigatori P01027.

Family and domain databases

Gene3Di 1.20.91.20. 1 hit.
1.50.10.20. 1 hit.
2.60.40.690. 1 hit.
InterProi IPR009048. A-macroglobulin_rcpt-bd.
IPR011626. A2M_comp.
IPR002890. A2M_N.
IPR011625. A2M_N_2.
IPR000020. Anaphylatoxin/fibulin.
IPR018081. Anaphylatoxin_comp_syst.
IPR001840. Anaphylatoxn_comp_syst_dom.
IPR001599. Macroglobln_a2.
IPR019742. MacrogloblnA2_CS.
IPR019565. MacrogloblnA2_thiol-ester-bond.
IPR001134. Netrin_domain.
IPR018933. Netrin_module_non-TIMP.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
IPR008993. TIMP-like_OB-fold.
[Graphical view ]
Pfami PF00207. A2M. 1 hit.
PF07678. A2M_comp. 1 hit.
PF01835. A2M_N. 1 hit.
PF07703. A2M_N_2. 1 hit.
PF07677. A2M_recep. 1 hit.
PF01821. ANATO. 1 hit.
PF01759. NTR. 1 hit.
PF10569. Thiol-ester_cl. 1 hit.
[Graphical view ]
PRINTSi PR00004. ANAPHYLATOXN.
SMARTi SM00104. ANATO. 1 hit.
SM00643. C345C. 1 hit.
[Graphical view ]
SUPFAMi SSF47686. SSF47686. 1 hit.
SSF48239. SSF48239. 1 hit.
SSF49410. SSF49410. 1 hit.
SSF50242. SSF50242. 1 hit.
PROSITEi PS00477. ALPHA_2_MACROGLOBULIN. 1 hit.
PS01177. ANAPHYLATOXIN_1. 1 hit.
PS01178. ANAPHYLATOXIN_2. 1 hit.
PS50189. NTR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of complementary DNA and derived amino acid sequence of murine complement protein C3."
    Fey G.H., Lundwall A., Wetsel R.A., Tack B.F., de Bruijn M.H.L., Domdey H.
    Philos. Trans. R. Soc. Lond., B, Biol. Sci. 306:333-344(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG).
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver.
  3. "Structure of murine complement component C3. I. Nucleotide sequence of cloned complementary and genomic DNA coding for the beta chain."
    Lundwall A., Wetsel R.A., Domdey H., Tack B.F., Fey G.H.
    J. Biol. Chem. 259:13851-13856(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-724 (ISOFORM LONG).
  4. "Isolation and analysis of genomic DNA clones encoding the third component of mouse complement."
    Wiebauer K., Domdey H., Diggelmann H., Fey G.
    Proc. Natl. Acad. Sci. U.S.A. 79:7077-7081(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-34.
  5. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 25-1663 (ISOFORM LONG).
  6. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 25-240 (ISOFORM LONG).
  7. "A paracrine migration-stimulating factor for metastatic tumor cells secreted by mouse hepatic sinusoidal endothelial cells: identification as complement component C3b."
    Hamada J., Cavanaugh P.G., Miki K., Nicolson G.L.
    Cancer Res. 53:4418-4423(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 25-41 AND 749-760.
  8. "The specific production of the third component of complement by osteoblastic cells treated with 1 alpha,25-dihydroxyvitamin D3."
    Sato T., Hong M.H., Jin C.H., Ishimi Y., Udagawa N., Shinki T., Abe E., Suda T.
    FEBS Lett. 285:21-24(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 25-31 AND 671-680.
  9. "Amino acid sequences of mouse complement C3 derived from nucleotide sequences of cloned cDNA."
    Fey G.H., Wiebauer K., Domdey H.
    Ann. N. Y. Acad. Sci. 421:307-312(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 658-761.
  10. "Structure of murine complement component C3. II. Nucleotide sequence of cloned complementary DNA coding for the alpha chain."
    Wetsel R.A., Lundwall A., Davidson F., Gibson T., Tack B.F., Fey G.H.
    J. Biol. Chem. 259:13857-13862(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 671-1663 (ISOFORM LONG).
  11. "Characterization of the mRNA and cloned cDNA specifying the third component of mouse complement."
    Domdey H., Wiebauer K., Kazmaier M., Mueller V., Odink K., Fey G.H.
    Proc. Natl. Acad. Sci. U.S.A. 79:7619-7623(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 671-748.
  12. "The structure of an alternate form of complement C3 that displays costimulatory growth factor activity for B lymphocytes."
    Cahen-Kramer Y., Martensson I.L., Melchers F.
    J. Exp. Med. 180:2079-2088(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE INITIATION (ISOFORM SHORT).
  13. "Acylation-stimulating protein (ASP) deficiency induces obesity resistance and increased energy expenditure in ob/ob mice."
    Xia Z., Sniderman A.D., Cianflone K.
    J. Biol. Chem. 277:45874-45879(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  14. "Acylation-stimulating protein deficiency and altered adipose tissue in alternative complement pathway knockout mice."
    Paglialunga S., Fisette A., Yan Y., Deshaies Y., Brouillette J.F., Pekna M., Cianflone K.
    Am. J. Physiol. 294:E521-E529(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE, FUNCTION.

Entry informationi

Entry nameiCO3_MOUSE
AccessioniPrimary (citable) accession number: P01027
Secondary accession number(s): Q61370, Q80XP1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 149 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi