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Protein

Angiotensinogen

Gene

AGT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.
Angiotensin-2: acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone.
Angiotensin-3: stimulates aldosterone release.
Angiotensin 1-7: is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets.By similarity3 Publications

GO - Molecular functioni

  • growth factor activity Source: BHF-UCL
  • hormone activity Source: BHF-UCL
  • receptor agonist activity Source: BHF-UCL
  • serine-type endopeptidase inhibitor activity Source: ProtInc
  • sodium channel regulator activity Source: BHF-UCL
  • superoxide-generating NADPH oxidase activator activity Source: BHF-UCL
  • type 1 angiotensin receptor binding Source: BHF-UCL
  • type 2 angiotensin receptor binding Source: BHF-UCL

GO - Biological processi

  • activation of phospholipase C activity Source: Ensembl
  • aging Source: Ensembl
  • angiotensin-activated signaling pathway Source: BHF-UCL
  • angiotensin maturation Source: Reactome
  • angiotensin-mediated drinking behavior Source: Ensembl
  • artery smooth muscle contraction Source: Ensembl
  • blood vessel remodeling Source: BHF-UCL
  • catenin import into nucleus Source: Ensembl
  • cell-cell signaling Source: ProtInc
  • cell growth involved in cardiac muscle cell development Source: Ensembl
  • cell surface receptor signaling pathway Source: Ensembl
  • cellular response to mechanical stimulus Source: Ensembl
  • cellular sodium ion homeostasis Source: Ensembl
  • cytokine secretion Source: Ensembl
  • ERK1 and ERK2 cascade Source: Ensembl
  • female pregnancy Source: Ensembl
  • fibroblast proliferation Source: Ensembl
  • G-protein coupled receptor signaling pathway Source: BHF-UCL
  • G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger Source: BHF-UCL
  • kidney development Source: BHF-UCL
  • low-density lipoprotein particle remodeling Source: BHF-UCL
  • negative regulation of angiogenesis Source: Ensembl
  • negative regulation of cell growth Source: Ensembl
  • negative regulation of gene expression Source: BHF-UCL
  • negative regulation of neurotrophin TRK receptor signaling pathway Source: BHF-UCL
  • negative regulation of sodium ion transmembrane transporter activity Source: BHF-UCL
  • negative regulation of tissue remodeling Source: Ensembl
  • nitric oxide mediated signal transduction Source: BHF-UCL
  • phospholipase C-activating G-protein coupled receptor signaling pathway Source: BHF-UCL
  • positive regulation of activation of JAK2 kinase activity Source: UniProtKB
  • positive regulation of blood pressure Source: Ensembl
  • positive regulation of branching involved in ureteric bud morphogenesis Source: UniProtKB
  • positive regulation of cardiac muscle cell apoptotic process Source: Ensembl
  • positive regulation of cardiac muscle hypertrophy Source: BHF-UCL
  • positive regulation of cellular protein metabolic process Source: BHF-UCL
  • positive regulation of cholesterol esterification Source: BHF-UCL
  • positive regulation of cytokine production Source: BHF-UCL
  • positive regulation of cytosolic calcium ion concentration Source: Ensembl
  • positive regulation of endothelial cell migration Source: BHF-UCL
  • positive regulation of epidermal growth factor receptor signaling pathway Source: BHF-UCL
  • positive regulation of extracellular matrix constituent secretion Source: Ensembl
  • positive regulation of extrinsic apoptotic signaling pathway Source: BHF-UCL
  • positive regulation of fibroblast proliferation Source: BHF-UCL
  • positive regulation of gap junction assembly Source: BHF-UCL
  • positive regulation of glucose import in response to insulin stimulus Source: Ensembl
  • positive regulation of inflammatory response Source: BHF-UCL
  • positive regulation of L-arginine import into cell Source: Ensembl
  • positive regulation of L-lysine import into cell Source: Ensembl
  • positive regulation of macrophage derived foam cell differentiation Source: BHF-UCL
  • positive regulation of membrane hyperpolarization Source: BHF-UCL
  • positive regulation of NAD(P)H oxidase activity Source: BHF-UCL
  • positive regulation of NF-kappaB transcription factor activity Source: BHF-UCL
  • positive regulation of nitric oxide biosynthetic process Source: Ensembl
  • positive regulation of peptidyl-tyrosine phosphorylation Source: BHF-UCL
  • positive regulation of phosphatidylinositol 3-kinase signaling Source: BHF-UCL
  • positive regulation of protein tyrosine kinase activity Source: UniProtKB
  • positive regulation of reactive oxygen species metabolic process Source: BHF-UCL
  • positive regulation of renal sodium excretion Source: Ensembl
  • positive regulation of superoxide anion generation Source: Ensembl
  • positive regulation of transcription, DNA-templated Source: BHF-UCL
  • positive regulation of vascular associated smooth muscle cell migration Source: Ensembl
  • positive regulation of vascular smooth muscle cell proliferation Source: Ensembl
  • positive regulation of vasodilation Source: Ensembl
  • regulation of blood pressure Source: BHF-UCL
  • regulation of blood vessel size by renin-angiotensin Source: BHF-UCL
  • regulation of blood volume by renin-angiotensin Source: BHF-UCL
  • regulation of calcium ion transport Source: Ensembl
  • regulation of cardiac conduction Source: BHF-UCL
  • regulation of cell growth Source: BHF-UCL
  • regulation of cell proliferation Source: BHF-UCL
  • regulation of extracellular matrix assembly Source: BHF-UCL
  • regulation of heart rate Source: Ensembl
  • regulation of long-term neuronal synaptic plasticity Source: Ensembl
  • regulation of norepinephrine secretion Source: Ensembl
  • regulation of renal output by angiotensin Source: BHF-UCL
  • regulation of renal sodium excretion Source: BHF-UCL
  • regulation of transmission of nerve impulse Source: Ensembl
  • regulation of vasoconstriction Source: BHF-UCL
  • renal system process Source: UniProtKB
  • renin-angiotensin regulation of aldosterone production Source: BHF-UCL
  • response to muscle activity involved in regulation of muscle adaptation Source: BHF-UCL
  • smooth muscle cell proliferation Source: Ensembl
  • stress-activated MAPK cascade Source: Ensembl
  • uterine smooth muscle contraction Source: Ensembl
  • vasodilation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Vasoactive, Vasoconstrictor

Enzyme and pathway databases

BioCyciZFISH:ENSG00000135744-MONOMER.
ReactomeiR-HSA-1989781. PPARA activates gene expression.
R-HSA-2022377. Metabolism of Angiotensinogen to Angiotensins.
R-HSA-375276. Peptide ligand-binding receptors.
R-HSA-416476. G alpha (q) signalling events.
R-HSA-418594. G alpha (i) signalling events.
SIGNORiP01019.

Protein family/group databases

MEROPSiI04.953.

Names & Taxonomyi

Protein namesi
Recommended name:
Angiotensinogen
Alternative name(s):
Serpin A8
Cleaved into the following 8 chains:
Alternative name(s):
Angiotensin 1-10
Angiotensin I
Short name:
Ang I
Alternative name(s):
Angiotensin 1-8
Angiotensin II
Short name:
Ang II
Alternative name(s):
Angiotensin 2-8
Angiotensin III
Short name:
Ang III
Des-Asp[1]-angiotensin II
Alternative name(s):
Angiotensin 3-8
Angiotensin IV
Short name:
Ang IV
Gene namesi
Name:AGT
Synonyms:SERPINA8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:333. AGT.

Subcellular locationi

GO - Cellular componenti

  • blood microparticle Source: UniProtKB
  • cytoplasm Source: Ensembl
  • extracellular exosome Source: UniProtKB
  • extracellular region Source: UniProtKB
  • extracellular space Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Essential hypertension (EHT)2 Publications
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA condition in which blood pressure is consistently higher than normal with no identifiable cause.
See also OMIM:145500
Renal tubular dysgenesis (RTD)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAutosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).
See also OMIM:267430
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035433375R → Q in RTD. 1 PublicationCorresponds to variant rs74315283dbSNPEnsembl.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi183.
MalaCardsiAGT.
MIMi145500. phenotype.
267430. phenotype.
OpenTargetsiENSG00000135744.
Orphaneti243761. Essential hypertension.
97369. Renal tubular dysgenesis of genetic origin.
PharmGKBiPA42.

Chemistry databases

ChEMBLiCHEMBL3596085.

Polymorphism and mutation databases

BioMutaiAGT.
DMDMi113880.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 333 PublicationsAdd BLAST33
ChainiPRO_000003245634 – 485AngiotensinogenAdd BLAST452
PeptideiPRO_000003245734 – 43Angiotensin-110
PeptideiPRO_000042065934 – 42Angiotensin 1-99
PeptideiPRO_000003245834 – 41Angiotensin-28
PeptideiPRO_000042066034 – 40Angiotensin 1-77
PeptideiPRO_000042066134 – 38Angiotensin 1-55
PeptideiPRO_000042066234 – 37Angiotensin 1-44
PeptideiPRO_000003245935 – 41Angiotensin-37
PeptideiPRO_000042066336 – 41Angiotensin-46

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei34Beta-decarboxylated aspartate; in form angiotensin-A1 Publication1
Glycosylationi47N-linked (GlcNAc...)3 Publications1
Disulfide bondi51 ↔ 1711 Publication
Glycosylationi170N-linked (GlcNAc...)1 Publication1
Glycosylationi304N-linked (GlcNAc...)1 Publication1
Glycosylationi328N-linked (GlcNAc...)1 Publication1

Post-translational modificationi

Beta-decarboxylation of Asp-34 in angiotensin-2, by mononuclear leukocytes produces alanine. The resulting peptide form, angiotensin-A, has the same affinity for the AT1 receptor as angiotensin-2, but a higher affinity for the AT2 receptor.1 Publication
In response to low blood pressure, the enzyme renin/REN cleaves angiotensinogen to produce angiotensin-1. Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2. Angiotensin-1 and angiotensin-2 can be further processed to generate angiotensin-3, angiotensin-4. Angiotensin 1-9 is cleaved from angiotensin-1 by ACE2 and can be further processed by ACE to produce angiotensin 1-7, angiotensin 1-5 and angiotensin 1-4. Angiotensin 1-7 has also been proposed to be cleaved from angiotensin-2 by ACE2 or from angiotensin-1 by MME (neprilysin).2 Publications
The disulfide bond is labile. Angiotensinogen is present in the circulation in a near 40:60 ratio with the oxidized disulfide-bonded form, which preferentially interacts with receptor-bound renin.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP01019.
MaxQBiP01019.
PaxDbiP01019.
PeptideAtlasiP01019.
PRIDEiP01019.

2D gel databases

SWISS-2DPAGEP01019.

PTM databases

iPTMnetiP01019.
PhosphoSitePlusiP01019.

Miscellaneous databases

PMAP-CutDBP01019.

Expressioni

Tissue specificityi

Expressed by the liver and secreted in plasma.

Gene expression databases

BgeeiENSG00000135744.
CleanExiHS_AGT.
ExpressionAtlasiP01019. baseline and differential.
GenevisibleiP01019. HS.

Organism-specific databases

HPAiHPA001557.

Interactioni

Subunit structurei

During pregnancy, exists as a disulfide-linked 2:2 heterotetramer with the proform of PRG2 and as a complex (probably a 2:2:2 heterohexamer) with pro-PRG2 and C3dg.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
AGTR1P305562EBI-6622938,EBI-6623016
Agtr1P2509510EBI-751728,EBI-764979From a different organism.
AGTR2P500522EBI-2927577,EBI-1748067
AnceQ107142EBI-751728,EBI-115736From a different organism.

GO - Molecular functioni

  • growth factor activity Source: BHF-UCL
  • hormone activity Source: BHF-UCL
  • receptor agonist activity Source: BHF-UCL
  • type 1 angiotensin receptor binding Source: BHF-UCL
  • type 2 angiotensin receptor binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi106690. 15 interactors.
DIPiDIP-309N.
IntActiP01019. 9 interactors.
MINTiMINT-1472115.
STRINGi9606.ENSP00000355627.

Structurei

Secondary structure

1485
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni42 – 44Combined sources3
Helixi48 – 57Combined sources10
Beta strandi59 – 62Combined sources4
Helixi81 – 93Combined sources13
Helixi97 – 117Combined sources21
Helixi118 – 120Combined sources3
Turni124 – 126Combined sources3
Beta strandi129 – 134Combined sources6
Helixi136 – 148Combined sources13
Helixi154 – 162Combined sources9
Turni171 – 173Combined sources3
Helixi177 – 191Combined sources15
Turni195 – 197Combined sources3
Beta strandi203 – 212Combined sources10
Helixi221 – 230Combined sources10
Beta strandi234 – 236Combined sources3
Helixi244 – 259Combined sources16
Beta strandi277 – 288Combined sources12
Beta strandi291 – 293Combined sources3
Beta strandi302 – 305Combined sources4
Beta strandi313 – 322Combined sources10
Turni325 – 328Combined sources4
Beta strandi329 – 333Combined sources5
Turni337 – 339Combined sources3
Beta strandi340 – 349Combined sources10
Helixi353 – 358Combined sources6
Helixi365 – 368Combined sources4
Beta strandi374 – 381Combined sources8
Beta strandi385 – 391Combined sources7
Helixi392 – 395Combined sources4
Helixi402 – 406Combined sources5
Beta strandi407 – 409Combined sources3
Beta strandi425 – 434Combined sources10
Beta strandi452 – 455Combined sources4
Beta strandi460 – 466Combined sources7
Turni467 – 470Combined sources4
Beta strandi475 – 479Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1N9UNMR-A34-43[»]
1N9VNMR-A34-41[»]
2JP8NMR-P34-40[»]
2WXWX-ray3.30A34-485[»]
2X0BX-ray4.33B/D/F/H34-485[»]
3CK0X-ray3.00P34-41[»]
3WOOX-ray1.80C/D36-41[»]
3WORX-ray2.10C/D34-41[»]
4AA1X-ray1.99P34-41[»]
4APHX-ray1.99P34-41[»]
4FYSX-ray2.01C36-41[»]
5E2QX-ray2.40B34-41[»]
ProteinModelPortaliP01019.
SMRiP01019.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01019.

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2392. Eukaryota.
COG4826. LUCA.
GeneTreeiENSGT00850000132337.
HOVERGENiHBG004233.
InParanoidiP01019.
KOiK09821.
OMAiRFMQAVT.
OrthoDBiEOG091G077M.
PhylomeDBiP01019.
TreeFamiTF343201.

Family and domain databases

CDDicd02054. angiotensinogen. 1 hit.
InterProiIPR000227. Angiotensinogen.
IPR033834. Angiotensinogen_serpin.
IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 2 hits.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
PRINTSiPR00654. ANGIOTENSNGN.
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01019-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKRAPQSEM APAGVSLRAT ILCLLAWAGL AAGDRVYIHP FHLVIHNEST
60 70 80 90 100
CEQLAKANAG KPKDPTFIPA PIQAKTSPVD EKALQDQLVL VAAKLDTEDK
110 120 130 140 150
LRAAMVGMLA NFLGFRIYGM HSELWGVVHG ATVLSPTAVF GTLASLYLGA
160 170 180 190 200
LDHTADRLQA ILGVPWKDKN CTSRLDAHKV LSALQAVQGL LVAQGRADSQ
210 220 230 240 250
AQLLLSTVVG VFTAPGLHLK QPFVQGLALY TPVVLPRSLD FTELDVAAEK
260 270 280 290 300
IDRFMQAVTG WKTGCSLMGA SVDSTLAFNT YVHFQGKMKG FSLLAEPQEF
310 320 330 340 350
WVDNSTSVSV PMLSGMGTFQ HWSDIQDNFS VTQVPFTESA CLLLIQPHYA
360 370 380 390 400
SDLDKVEGLT FQQNSLNWMK KLSPRTIHLT MPQLVLQGSY DLQDLLAQAE
410 420 430 440 450
LPAILHTELN LQKLSNDRIR VGEVLNSIFF ELEADEREPT ESTQQLNKPE
460 470 480
VLEVTLNRPF LFAVYDQSAT ALHFLGRVAN PLSTA
Length:485
Mass (Da):53,154
Last modified:July 21, 1986 - v1
Checksum:i5026C2DFB2DD236E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti51C → S AA sequence (PubMed:7259779).Curated1
Sequence conflicti58N → D AA sequence (PubMed:7259779).Curated1
Sequence conflicti333Q → E in AAA51679 (PubMed:2924688).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02293343L → F Associated with susceptibility to pre-eclampsia; alters the reactions with renin and angiotensin-converting enzyme. 1 PublicationCorresponds to variant rs41271499dbSNPEnsembl.1
Natural variantiVAR_02916698E → K.Corresponds to variant rs11568032dbSNPEnsembl.1
Natural variantiVAR_051939114G → C.Corresponds to variant rs2229389dbSNPEnsembl.1
Natural variantiVAR_035431137T → M.Corresponds to variant rs34829218dbSNPEnsembl.1
Natural variantiVAR_007093207T → M Associated with hypertension. 1 PublicationCorresponds to variant rs4762dbSNPEnsembl.1
Natural variantiVAR_007094242T → I Associated with susceptibility to hypertension. 1 PublicationCorresponds to variant rs765678426dbSNPEnsembl.1
Natural variantiVAR_007095244L → R Associated with susceptibility to hypertension. 1 PublicationCorresponds to variant rs5041dbSNPEnsembl.1
Natural variantiVAR_029167268M → I.Corresponds to variant rs11568053dbSNPEnsembl.1
Natural variantiVAR_007096268M → T Associated with essential hypertension and pre-eclampsia. 2 PublicationsCorresponds to variant rs699dbSNPEnsembl.1
Natural variantiVAR_007097281Y → C Associated with susceptibility to hypertension; alters the structure, glycosylation and secretion of angiotensinogen. 3 PublicationsCorresponds to variant rs56073403dbSNPEnsembl.1
Natural variantiVAR_035432335P → S.1 PublicationCorresponds to variant rs17856352dbSNPEnsembl.1
Natural variantiVAR_035433375R → Q in RTD. 1 PublicationCorresponds to variant rs74315283dbSNPEnsembl.1
Natural variantiVAR_014573392L → M.Corresponds to variant rs1805090dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02215 mRNA. Translation: AAA51731.1.
M24689
, M24686, M24687, M24688 Genomic DNA. Translation: AAA51679.1.
X15324
, X15325, X15326, X15327 Genomic DNA. Translation: CAA33385.1.
BC011519 mRNA. Translation: AAH11519.1.
M69110 mRNA. Translation: AAA52282.1.
S78529 Genomic DNA. Translation: AAD14287.1.
S78530 Genomic DNA. Translation: AAD14288.1.
CCDSiCCDS1585.1.
PIRiA35203. ANHU.
RefSeqiNP_000020.1. NM_000029.3.
UniGeneiHs.19383.

Genome annotation databases

EnsembliENST00000366667; ENSP00000355627; ENSG00000135744.
GeneIDi183.
KEGGihsa:183.
UCSCiuc001hty.6. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

SHMPD

The Singapore human mutation and polymorphism database

Wikipedia

Angiotensin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02215 mRNA. Translation: AAA51731.1.
M24689
, M24686, M24687, M24688 Genomic DNA. Translation: AAA51679.1.
X15324
, X15325, X15326, X15327 Genomic DNA. Translation: CAA33385.1.
BC011519 mRNA. Translation: AAH11519.1.
M69110 mRNA. Translation: AAA52282.1.
S78529 Genomic DNA. Translation: AAD14287.1.
S78530 Genomic DNA. Translation: AAD14288.1.
CCDSiCCDS1585.1.
PIRiA35203. ANHU.
RefSeqiNP_000020.1. NM_000029.3.
UniGeneiHs.19383.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1N9UNMR-A34-43[»]
1N9VNMR-A34-41[»]
2JP8NMR-P34-40[»]
2WXWX-ray3.30A34-485[»]
2X0BX-ray4.33B/D/F/H34-485[»]
3CK0X-ray3.00P34-41[»]
3WOOX-ray1.80C/D36-41[»]
3WORX-ray2.10C/D34-41[»]
4AA1X-ray1.99P34-41[»]
4APHX-ray1.99P34-41[»]
4FYSX-ray2.01C36-41[»]
5E2QX-ray2.40B34-41[»]
ProteinModelPortaliP01019.
SMRiP01019.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106690. 15 interactors.
DIPiDIP-309N.
IntActiP01019. 9 interactors.
MINTiMINT-1472115.
STRINGi9606.ENSP00000355627.

Chemistry databases

ChEMBLiCHEMBL3596085.

Protein family/group databases

MEROPSiI04.953.

PTM databases

iPTMnetiP01019.
PhosphoSitePlusiP01019.

Polymorphism and mutation databases

BioMutaiAGT.
DMDMi113880.

2D gel databases

SWISS-2DPAGEP01019.

Proteomic databases

EPDiP01019.
MaxQBiP01019.
PaxDbiP01019.
PeptideAtlasiP01019.
PRIDEiP01019.

Protocols and materials databases

DNASUi183.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000366667; ENSP00000355627; ENSG00000135744.
GeneIDi183.
KEGGihsa:183.
UCSCiuc001hty.6. human.

Organism-specific databases

CTDi183.
DisGeNETi183.
GeneCardsiAGT.
HGNCiHGNC:333. AGT.
HPAiHPA001557.
MalaCardsiAGT.
MIMi106150. gene.
145500. phenotype.
267430. phenotype.
neXtProtiNX_P01019.
OpenTargetsiENSG00000135744.
Orphaneti243761. Essential hypertension.
97369. Renal tubular dysgenesis of genetic origin.
PharmGKBiPA42.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2392. Eukaryota.
COG4826. LUCA.
GeneTreeiENSGT00850000132337.
HOVERGENiHBG004233.
InParanoidiP01019.
KOiK09821.
OMAiRFMQAVT.
OrthoDBiEOG091G077M.
PhylomeDBiP01019.
TreeFamiTF343201.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000135744-MONOMER.
ReactomeiR-HSA-1989781. PPARA activates gene expression.
R-HSA-2022377. Metabolism of Angiotensinogen to Angiotensins.
R-HSA-375276. Peptide ligand-binding receptors.
R-HSA-416476. G alpha (q) signalling events.
R-HSA-418594. G alpha (i) signalling events.
SIGNORiP01019.

Miscellaneous databases

ChiTaRSiAGT. human.
EvolutionaryTraceiP01019.
GeneWikiiAngiotensin.
GenomeRNAii183.
PMAP-CutDBP01019.
PROiP01019.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000135744.
CleanExiHS_AGT.
ExpressionAtlasiP01019. baseline and differential.
GenevisibleiP01019. HS.

Family and domain databases

CDDicd02054. angiotensinogen. 1 hit.
InterProiIPR000227. Angiotensinogen.
IPR033834. Angiotensinogen_serpin.
IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 2 hits.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
PRINTSiPR00654. ANGIOTENSNGN.
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANGT_HUMAN
AccessioniPrimary (citable) accession number: P01019
Secondary accession number(s): Q16358, Q16359, Q96F91
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 30, 2016
This is version 201 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-10 is the initiator.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.