Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P01019

- ANGT_HUMAN

UniProt

P01019 - ANGT_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Angiotensinogen

Gene

AGT

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.
Angiotensin-2: acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone.
Angiotensin-3: stimulates aldosterone release.
Angiotensin 1-7: is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets.By similarity

GO - Molecular functioni

  1. growth factor activity Source: BHF-UCL
  2. hormone activity Source: BHF-UCL
  3. serine-type endopeptidase inhibitor activity Source: RefGenome
  4. superoxide-generating NADPH oxidase activator activity Source: BHF-UCL
  5. type 1 angiotensin receptor binding Source: BHF-UCL
  6. type 2 angiotensin receptor binding Source: BHF-UCL

GO - Biological processi

  1. activation of NF-kappaB-inducing kinase activity Source: Ensembl
  2. activation of phospholipase C activity Source: Ensembl
  3. aging Source: Ensembl
  4. angiotensin maturation Source: Reactome
  5. angiotensin-mediated drinking behavior Source: Ensembl
  6. angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure Source: Ensembl
  7. artery smooth muscle contraction Source: Ensembl
  8. astrocyte activation Source: Ensembl
  9. blood vessel development Source: Ensembl
  10. blood vessel remodeling Source: BHF-UCL
  11. branching involved in ureteric bud morphogenesis Source: Ensembl
  12. catenin import into nucleus Source: Ensembl
  13. cell-cell signaling Source: ProtInc
  14. cell growth involved in cardiac muscle cell development Source: Ensembl
  15. cell-matrix adhesion Source: Ensembl
  16. cellular lipid metabolic process Source: Reactome
  17. cellular protein metabolic process Source: Reactome
  18. cellular response to mechanical stimulus Source: Ensembl
  19. cellular sodium ion homeostasis Source: Ensembl
  20. cytokine secretion Source: Ensembl
  21. ERK1 and ERK2 cascade Source: Ensembl
  22. establishment of blood-nerve barrier Source: Ensembl
  23. excretion Source: Ensembl
  24. extracellular matrix organization Source: Ensembl
  25. fibroblast proliferation Source: Ensembl
  26. G-protein coupled receptor signaling pathway Source: BHF-UCL
  27. G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger Source: BHF-UCL
  28. kidney development Source: BHF-UCL
  29. low-density lipoprotein particle remodeling Source: BHF-UCL
  30. negative regulation of angiogenesis Source: Ensembl
  31. negative regulation of cell growth Source: Ensembl
  32. negative regulation of cell proliferation Source: Ensembl
  33. negative regulation of endopeptidase activity Source: RefGenome
  34. negative regulation of neuron apoptotic process Source: Ensembl
  35. negative regulation of neurotrophin TRK receptor signaling pathway Source: BHF-UCL
  36. negative regulation of sodium ion transmembrane transporter activity Source: BHF-UCL
  37. negative regulation of tissue remodeling Source: Ensembl
  38. nitric oxide mediated signal transduction Source: BHF-UCL
  39. ovarian follicle rupture Source: Ensembl
  40. peristalsis Source: Ensembl
  41. phospholipase C-activating G-protein coupled receptor signaling pathway Source: BHF-UCL
  42. positive regulation of activation of JAK2 kinase activity Source: UniProtKB
  43. positive regulation of branching involved in ureteric bud morphogenesis Source: UniProtKB
  44. positive regulation of cardiac muscle hypertrophy Source: BHF-UCL
  45. positive regulation of cellular protein metabolic process Source: BHF-UCL
  46. positive regulation of cholesterol esterification Source: BHF-UCL
  47. positive regulation of cytokine production Source: BHF-UCL
  48. positive regulation of endothelial cell migration Source: BHF-UCL
  49. positive regulation of epidermal growth factor receptor signaling pathway Source: BHF-UCL
  50. positive regulation of extracellular matrix constituent secretion Source: Ensembl
  51. positive regulation of extrinsic apoptotic signaling pathway Source: BHF-UCL
  52. positive regulation of fatty acid biosynthetic process Source: Ensembl
  53. positive regulation of fibroblast proliferation Source: BHF-UCL
  54. positive regulation of inflammatory response Source: BHF-UCL
  55. positive regulation of macrophage derived foam cell differentiation Source: BHF-UCL
  56. positive regulation of MAPK cascade Source: Ensembl
  57. positive regulation of multicellular organism growth Source: Ensembl
  58. positive regulation of NAD(P)H oxidase activity Source: BHF-UCL
  59. positive regulation of NF-kappaB transcription factor activity Source: BHF-UCL
  60. positive regulation of organ growth Source: Ensembl
  61. positive regulation of peptidyl-tyrosine phosphorylation Source: BHF-UCL
  62. positive regulation of phosphatidylinositol 3-kinase signaling Source: BHF-UCL
  63. positive regulation of protein tyrosine kinase activity Source: UniProtKB
  64. positive regulation of reactive oxygen species metabolic process Source: BHF-UCL
  65. positive regulation of renal sodium excretion Source: Ensembl
  66. positive regulation of superoxide anion generation Source: Ensembl
  67. positive regulation of transcription, DNA-templated Source: UniProtKB
  68. regulation of blood vessel size by renin-angiotensin Source: BHF-UCL
  69. regulation of blood volume by renin-angiotensin Source: BHF-UCL
  70. regulation of calcium ion transport Source: Ensembl
  71. regulation of cell growth Source: BHF-UCL
  72. regulation of cell proliferation Source: BHF-UCL
  73. regulation of long-term neuronal synaptic plasticity Source: Ensembl
  74. regulation of norepinephrine secretion Source: Ensembl
  75. regulation of proteolysis Source: RefGenome
  76. regulation of renal output by angiotensin Source: BHF-UCL
  77. regulation of renal sodium excretion Source: BHF-UCL
  78. regulation of vasoconstriction Source: BHF-UCL
  79. renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure Source: Ensembl
  80. renal system process Source: UniProt
  81. renin-angiotensin regulation of aldosterone production Source: BHF-UCL
  82. response to cold Source: Ensembl
  83. response to muscle activity involved in regulation of muscle adaptation Source: BHF-UCL
  84. response to salt stress Source: Ensembl
  85. small molecule metabolic process Source: Reactome
  86. smooth muscle cell differentiation Source: Ensembl
  87. smooth muscle cell proliferation Source: Ensembl
  88. stress-activated MAPK cascade Source: Ensembl
  89. uterine smooth muscle contraction Source: Ensembl
  90. vasodilation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Vasoactive, Vasoconstrictor

Enzyme and pathway databases

ReactomeiREACT_116145. PPARA activates gene expression.
REACT_147707. Metabolism of Angiotensinogen to Angiotensins.
REACT_14819. Peptide ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.
REACT_19231. G alpha (i) signalling events.

Protein family/group databases

MEROPSiI04.953.

Names & Taxonomyi

Protein namesi
Recommended name:
Angiotensinogen
Alternative name(s):
Serpin A8
Cleaved into the following 8 chains:
Alternative name(s):
Angiotensin 1-10
Angiotensin I
Short name:
Ang I
Alternative name(s):
Angiotensin 1-8
Angiotensin II
Short name:
Ang II
Alternative name(s):
Angiotensin 2-8
Angiotensin III
Short name:
Ang III
Des-Asp[1]-angiotensin II
Alternative name(s):
Angiotensin 3-8
Angiotensin IV
Short name:
Ang IV
Gene namesi
Name:AGT
Synonyms:SERPINA8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:333. AGT.

Subcellular locationi

GO - Cellular componenti

  1. blood microparticle Source: UniProt
  2. extracellular region Source: UniProtKB
  3. extracellular space Source: BHF-UCL
  4. extracellular vesicular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Essential hypertension (EHT) [MIM:145500]: A condition in which blood pressure is consistently higher than normal with no identifiable cause.
Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.
Renal tubular dysgenesis (RTD) [MIM:267430]: Autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti375 – 3751R → Q in RTD. 1 Publication
VAR_035433

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi145500. phenotype.
267430. phenotype.
Orphaneti243761. Essential hypertension.
97369. Renal tubular dysgenesis of genetic origin.
PharmGKBiPA42.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 33333 PublicationsAdd
BLAST
Chaini34 – 485452AngiotensinogenPRO_0000032456Add
BLAST
Peptidei34 – 4310Angiotensin-1PRO_0000032457
Peptidei34 – 429Angiotensin 1-9PRO_0000420659
Peptidei34 – 418Angiotensin-2PRO_0000032458
Peptidei34 – 407Angiotensin 1-7PRO_0000420660
Peptidei34 – 385Angiotensin 1-5PRO_0000420661
Peptidei34 – 374Angiotensin 1-4PRO_0000420662
Peptidei35 – 417Angiotensin-3PRO_0000032459
Peptidei36 – 416Angiotensin-4PRO_0000420663

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei34 – 341Beta-decarboxylated aspartate; in form angiotensin-A1 Publication
Glycosylationi47 – 471N-linked (GlcNAc...)3 Publications
Disulfide bondi51 ↔ 1711 Publication
Glycosylationi170 – 1701N-linked (GlcNAc...)1 Publication
Glycosylationi304 – 3041N-linked (GlcNAc...)1 Publication
Glycosylationi328 – 3281N-linked (GlcNAc...)1 Publication

Post-translational modificationi

Beta-decarboxylation of Asp-34 in angiotensin-2, by mononuclear leukocytes produces alanine. The resulting peptide form, angiotensin-A, has the same affinity for the AT1 receptor as angiotensin-2, but a higher affinity for the AT2 receptor.1 Publication
In response to low blood pressure, the enzyme renin/REN cleaves angiotensinogen to produce angiotensin-1. Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2. Angiotensin-1 and angiotensin-2 can be further processed to generate angiotensin-3, angiotensin-4. Angiotensin 1-9 is cleaved from angiotensin-1 by ACE2 and can be further processed by ACE to produce angiotensin 1-7, angiotensin 1-5 and angiotensin 1-4. Angiotensin 1-7 has also been proposed to be cleaved from angiotensin-2 by ACE2 or from angiotensin-1 by MME (neprilysin).2 Publications
The disulfide bond is labile. Angiotensinogen is present in the circulation in a near 40:60 ratio with the oxidized disulfide-bonded form, which preferentially interacts with receptor-bound renin.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP01019.
PaxDbiP01019.
PeptideAtlasiP01019.
PRIDEiP01019.

2D gel databases

SWISS-2DPAGEP01019.

PTM databases

PhosphoSiteiP01019.

Miscellaneous databases

PMAP-CutDBP01019.

Expressioni

Tissue specificityi

Expressed by the liver and secreted in plasma.

Gene expression databases

BgeeiP01019.
CleanExiHS_AGT.
ExpressionAtlasiP01019. baseline and differential.
GenevestigatoriP01019.

Organism-specific databases

HPAiHPA001557.

Interactioni

Subunit structurei

During pregnancy, exists as a disulfide-linked 2:2 heterotetramer with the proform of PRG2 and as a complex (probably a 2:2:2 heterohexamer) with pro-PRG2 and C3dg.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
AGTR1P305562EBI-6622938,EBI-6623016
Agtr1P2509510EBI-751728,EBI-764979From a different organism.
AGTR2P500522EBI-2927577,EBI-1748067
AnceQ107142EBI-751728,EBI-115736From a different organism.

Protein-protein interaction databases

BioGridi106690. 11 interactions.
DIPiDIP-309N.
IntActiP01019. 8 interactions.
MINTiMINT-1472115.
STRINGi9606.ENSP00000355627.

Structurei

Secondary structure

1
485
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni42 – 443Combined sources
Helixi48 – 5710Combined sources
Beta strandi59 – 624Combined sources
Helixi81 – 9313Combined sources
Helixi97 – 11721Combined sources
Helixi118 – 1203Combined sources
Turni124 – 1263Combined sources
Beta strandi129 – 1346Combined sources
Helixi136 – 14813Combined sources
Helixi154 – 1629Combined sources
Turni171 – 1733Combined sources
Helixi177 – 19115Combined sources
Turni195 – 1973Combined sources
Beta strandi203 – 21210Combined sources
Helixi221 – 23010Combined sources
Beta strandi234 – 2363Combined sources
Helixi244 – 25916Combined sources
Beta strandi277 – 28812Combined sources
Beta strandi291 – 2933Combined sources
Beta strandi302 – 3054Combined sources
Beta strandi313 – 32210Combined sources
Turni325 – 3284Combined sources
Beta strandi329 – 3335Combined sources
Turni337 – 3393Combined sources
Beta strandi340 – 34910Combined sources
Helixi353 – 3586Combined sources
Helixi365 – 3684Combined sources
Beta strandi374 – 3818Combined sources
Beta strandi385 – 3917Combined sources
Helixi392 – 3954Combined sources
Helixi402 – 4065Combined sources
Beta strandi407 – 4093Combined sources
Beta strandi425 – 43410Combined sources
Beta strandi452 – 4554Combined sources
Beta strandi460 – 4667Combined sources
Turni467 – 4704Combined sources
Beta strandi475 – 4795Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1N9UNMR-A34-43[»]
1N9VNMR-A34-41[»]
2JP8NMR-P34-40[»]
2WXWX-ray3.30A34-485[»]
2X0BX-ray4.33B/D/F/H34-485[»]
3CK0X-ray3.00P34-41[»]
3WOOX-ray1.80C/D36-41[»]
3WORX-ray2.10C/D34-41[»]
4AA1X-ray1.99P34-41[»]
4APHX-ray1.99P34-41[»]
4FYSX-ray2.01C36-41[»]
ProteinModelPortaliP01019.
SMRiP01019. Positions 34-482.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01019.

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG314543.
GeneTreeiENSGT00750000117773.
HOVERGENiHBG004233.
InParanoidiP01019.
KOiK09821.
OMAiRFMQAVT.
OrthoDBiEOG7QK0BN.
PhylomeDBiP01019.
TreeFamiTF343201.

Family and domain databases

InterProiIPR000227. Angiotensinogen.
IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
PRINTSiPR00654. ANGIOTENSNGN.
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01019-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRKRAPQSEM APAGVSLRAT ILCLLAWAGL AAGDRVYIHP FHLVIHNEST
60 70 80 90 100
CEQLAKANAG KPKDPTFIPA PIQAKTSPVD EKALQDQLVL VAAKLDTEDK
110 120 130 140 150
LRAAMVGMLA NFLGFRIYGM HSELWGVVHG ATVLSPTAVF GTLASLYLGA
160 170 180 190 200
LDHTADRLQA ILGVPWKDKN CTSRLDAHKV LSALQAVQGL LVAQGRADSQ
210 220 230 240 250
AQLLLSTVVG VFTAPGLHLK QPFVQGLALY TPVVLPRSLD FTELDVAAEK
260 270 280 290 300
IDRFMQAVTG WKTGCSLMGA SVDSTLAFNT YVHFQGKMKG FSLLAEPQEF
310 320 330 340 350
WVDNSTSVSV PMLSGMGTFQ HWSDIQDNFS VTQVPFTESA CLLLIQPHYA
360 370 380 390 400
SDLDKVEGLT FQQNSLNWMK KLSPRTIHLT MPQLVLQGSY DLQDLLAQAE
410 420 430 440 450
LPAILHTELN LQKLSNDRIR VGEVLNSIFF ELEADEREPT ESTQQLNKPE
460 470 480
VLEVTLNRPF LFAVYDQSAT ALHFLGRVAN PLSTA
Length:485
Mass (Da):53,154
Last modified:July 21, 1986 - v1
Checksum:i5026C2DFB2DD236E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti51 – 511C → S AA sequence (PubMed:7259779)Curated
Sequence conflicti58 – 581N → D AA sequence (PubMed:7259779)Curated
Sequence conflicti333 – 3331Q → E in AAA51679. (PubMed:2924688)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti43 – 431L → F Associated with susceptibility to pre-eclampsia; alters the reactions with renin and angiotensin-converting enzyme. 1 Publication
Corresponds to variant rs41271499 [ dbSNP | Ensembl ].
VAR_022933
Natural varianti98 – 981E → K.
Corresponds to variant rs11568032 [ dbSNP | Ensembl ].
VAR_029166
Natural varianti114 – 1141G → C.
Corresponds to variant rs2229389 [ dbSNP | Ensembl ].
VAR_051939
Natural varianti137 – 1371T → M.
Corresponds to variant rs34829218 [ dbSNP | Ensembl ].
VAR_035431
Natural varianti207 – 2071T → M Associated with hypertension. 1 Publication
Corresponds to variant rs4762 [ dbSNP | Ensembl ].
VAR_007093
Natural varianti242 – 2421T → I Associated with susceptibility to hypertension. 1 Publication
VAR_007094
Natural varianti244 – 2441L → R Associated with susceptibility to hypertension. 1 Publication
Corresponds to variant rs5041 [ dbSNP | Ensembl ].
VAR_007095
Natural varianti268 – 2681M → I.
Corresponds to variant rs11568053 [ dbSNP | Ensembl ].
VAR_029167
Natural varianti268 – 2681M → T Associated with essential hypertension and pre-eclampsia. 2 Publications
Corresponds to variant rs699 [ dbSNP | Ensembl ].
VAR_007096
Natural varianti281 – 2811Y → C Associated with susceptibility to hypertension; alters the structure, glycosylation and secretion of angiotensinogen. 2 Publications
Corresponds to variant rs56073403 [ dbSNP | Ensembl ].
VAR_007097
Natural varianti335 – 3351P → S.1 Publication
Corresponds to variant rs17856352 [ dbSNP | Ensembl ].
VAR_035432
Natural varianti375 – 3751R → Q in RTD. 1 Publication
VAR_035433
Natural varianti392 – 3921L → M.
Corresponds to variant rs1805090 [ dbSNP | Ensembl ].
VAR_014573

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02215 mRNA. Translation: AAA51731.1.
M24689
, M24686, M24687, M24688 Genomic DNA. Translation: AAA51679.1.
X15324
, X15325, X15326, X15327 Genomic DNA. Translation: CAA33385.1.
BC011519 mRNA. Translation: AAH11519.1.
M69110 mRNA. Translation: AAA52282.1.
S78529 Genomic DNA. Translation: AAD14287.1.
S78530 Genomic DNA. Translation: AAD14288.1.
CCDSiCCDS1585.1.
PIRiA35203. ANHU.
RefSeqiNP_000020.1. NM_000029.3.
UniGeneiHs.19383.

Genome annotation databases

EnsembliENST00000366667; ENSP00000355627; ENSG00000135744.
GeneIDi183.
KEGGihsa:183.
UCSCiuc001hty.4. human.

Polymorphism databases

DMDMi113880.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

SHMPD

The Singapore human mutation and polymorphism database

Wikipedia

Angiotensin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02215 mRNA. Translation: AAA51731.1 .
M24689
, M24686 , M24687 , M24688 Genomic DNA. Translation: AAA51679.1 .
X15324
, X15325 , X15326 , X15327 Genomic DNA. Translation: CAA33385.1 .
BC011519 mRNA. Translation: AAH11519.1 .
M69110 mRNA. Translation: AAA52282.1 .
S78529 Genomic DNA. Translation: AAD14287.1 .
S78530 Genomic DNA. Translation: AAD14288.1 .
CCDSi CCDS1585.1.
PIRi A35203. ANHU.
RefSeqi NP_000020.1. NM_000029.3.
UniGenei Hs.19383.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1N9U NMR - A 34-43 [» ]
1N9V NMR - A 34-41 [» ]
2JP8 NMR - P 34-40 [» ]
2WXW X-ray 3.30 A 34-485 [» ]
2X0B X-ray 4.33 B/D/F/H 34-485 [» ]
3CK0 X-ray 3.00 P 34-41 [» ]
3WOO X-ray 1.80 C/D 36-41 [» ]
3WOR X-ray 2.10 C/D 34-41 [» ]
4AA1 X-ray 1.99 P 34-41 [» ]
4APH X-ray 1.99 P 34-41 [» ]
4FYS X-ray 2.01 C 36-41 [» ]
ProteinModelPortali P01019.
SMRi P01019. Positions 34-482.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 106690. 11 interactions.
DIPi DIP-309N.
IntActi P01019. 8 interactions.
MINTi MINT-1472115.
STRINGi 9606.ENSP00000355627.

Protein family/group databases

MEROPSi I04.953.

PTM databases

PhosphoSitei P01019.

Polymorphism databases

DMDMi 113880.

2D gel databases

SWISS-2DPAGE P01019.

Proteomic databases

MaxQBi P01019.
PaxDbi P01019.
PeptideAtlasi P01019.
PRIDEi P01019.

Protocols and materials databases

DNASUi 183.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000366667 ; ENSP00000355627 ; ENSG00000135744 .
GeneIDi 183.
KEGGi hsa:183.
UCSCi uc001hty.4. human.

Organism-specific databases

CTDi 183.
GeneCardsi GC01M230838.
HGNCi HGNC:333. AGT.
HPAi HPA001557.
MIMi 106150. gene.
145500. phenotype.
267430. phenotype.
neXtProti NX_P01019.
Orphaneti 243761. Essential hypertension.
97369. Renal tubular dysgenesis of genetic origin.
PharmGKBi PA42.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG314543.
GeneTreei ENSGT00750000117773.
HOVERGENi HBG004233.
InParanoidi P01019.
KOi K09821.
OMAi RFMQAVT.
OrthoDBi EOG7QK0BN.
PhylomeDBi P01019.
TreeFami TF343201.

Enzyme and pathway databases

Reactomei REACT_116145. PPARA activates gene expression.
REACT_147707. Metabolism of Angiotensinogen to Angiotensins.
REACT_14819. Peptide ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

ChiTaRSi AGT. human.
EvolutionaryTracei P01019.
GeneWikii Angiotensin.
GenomeRNAii 183.
NextBioi 748.
PMAP-CutDB P01019.
PROi P01019.
SOURCEi Search...

Gene expression databases

Bgeei P01019.
CleanExi HS_AGT.
ExpressionAtlasi P01019. baseline and differential.
Genevestigatori P01019.

Family and domain databases

InterProi IPR000227. Angiotensinogen.
IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view ]
PANTHERi PTHR11461. PTHR11461. 1 hit.
Pfami PF00079. Serpin. 1 hit.
[Graphical view ]
PRINTSi PR00654. ANGIOTENSNGN.
SMARTi SM00093. SERPIN. 1 hit.
[Graphical view ]
SUPFAMi SSF56574. SSF56574. 1 hit.
PROSITEi PS00284. SERPIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Primary structure of human preangiotensinogen deduced from the cloned cDNA sequence."
    Kageyama R., Ohkubo H., Nakanishi S.
    Biochemistry 23:3603-3609(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Structure of human angiotensinogen gene."
    Gaillard I., Clauser E., Corvol P.
    DNA 8:87-99(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Structure and expression of the human angiotensinogen gene. Identification of a unique and highly active promoter."
    Fukamizu A., Takahashi S., Seo M.S., Tada M., Tanimoto K., Uehara S., Murakami K.
    J. Biol. Chem. 265:7576-7582(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-335.
    Tissue: Brain.
  5. "Molecular cloning of human angiotensinogen cDNA and evidence for the presence of its mRNA in rat heart."
    Kunapuli S.P., Kumar A.
    Circ. Res. 60:786-790(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-338.
  6. "Tissue specific hormonal regulation of the rat angiotensinogen gene expression."
    Kunapuli S.P., Benedict C.R., Kumar A.
    Arch. Biochem. Biophys. 254:642-646(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 32-184.
  7. "The amino terminal amino acid sequence of human angiotensinogen."
    Tewksbury D.A., Dart R.A., Travis J.
    Biochem. Biophys. Res. Commun. 99:1311-1315(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 34-58.
  8. "Identification of angiotensinogen and complement C3dg as novel proteins binding the proform of eosinophil major basic protein in human pregnancy serum and plasma."
    Oxvig C., Haaning J., Kristensen L., Wagner J.M., Rubin I., Stigbrand T., Gleich G.J., Sottrup-Jensen L.
    J. Biol. Chem. 270:13645-13651(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 34-45, SUBUNIT.
    Tissue: Serum.
  9. "Enzymatic degradation and electrophoresis of human angiotensin I."
    Arakawa K., Minohara A., Yamada J., Nakamura M.
    Biochim. Biophys. Acta 168:106-112(1968) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 34-43.
  10. "Processing of rat and human angiotensinogen precursors by microsomal membranes."
    Campbell D.J., Bouhnik J., Coezy E., Menard J., Corvol P.
    Mol. Cell. Endocrinol. 43:31-40(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION AT ASN-47; ASN-170; ASN-304 AND ASN-328.
  11. "Angiotensin III: (DES-Aspartic Acid-1)-Angiotensin II. Evidence and speculation for its role as an important agonist in the renin - angiotensin system."
    Goodfriend T.L., Peach M.J.
    Circ. Res. 36:38-48(1975) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION OF ANGIOTENSIN-3.
  12. "The renin-angiotensin-aldosterone system: a specific target for hypertension management."
    Weir M.R., Dzau V.J.
    Am. J. Hypertens. 12:205S-213S(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION OF ANGIOTENSIN-2.
  13. "A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9."
    Donoghue M., Hsieh F., Baronas E., Godbout K., Gosselin M., Stagliano N., Donovan M., Woolf B., Robison K., Jeyaseelan R., Breitbart R.E., Acton S.
    Circ. Res. 87:E1-E9(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: CLEAVAGE BY ACE AND ACE2.
  14. "Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase."
    Vickers C., Hales P., Kaushik V., Dick L., Gavin J., Tang J., Godbout K., Parsons T., Baronas E., Hsieh F., Acton S., Patane M.A., Nichols A., Tummino P.
    J. Biol. Chem. 277:14838-14843(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: CLEAVAGE OF ANGIOTENSIN-1 AND ANGIOTENSIN-2 BY ACE2.
  15. "Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism."
    Rice G.I., Thomas D.A., Grant P.J., Turner A.J., Hooper N.M.
    Biochem. J. 383:45-51(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: ANGIOTENSIN PEPTIDES METABOLISM.
  16. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-47.
    Tissue: Plasma.
  17. Cited for: DECARBOXYLATION AT ASP-34, FUNCTION, IDENTIFICATION BY MASS SPECTROMETRY.
  18. Cited for: REVIEW ON THE RENIN-ANGIOTENSIN SYSTEM.
  19. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-47.
    Tissue: Liver.
  20. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  21. "The octapeptide angiotensin II adopts a well-defined structure in a phospholipid environment."
    Carpenter K.A., Wilkes B.C., Schiller P.W.
    Eur. J. Biochem. 251:448-453(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF ANGIOTENSIN-2.
  22. "Comparison of the solution structures of angiotensin I & II. Implication for structure-function relationship."
    Spyroulias G.A., Nikolakopoulou P., Tzakos A., Gerothanassis I.P., Magafa V., Manessi-Zoupa E., Cordopatis P.
    Eur. J. Biochem. 270:2163-2173(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 34-43, STRUCTURE BY NMR OF 34-41.
  23. Cited for: X-RAY CRYSTALLOGRAPHY (4.33 ANGSTROMS) OF 34-485 IN COMPLEX WITH RENIN, DISULFIDE BOND.
  24. Cited for: VARIANTS MET-207; THR-268 AND CYS-281.
  25. Cited for: VARIANT THR-268.
  26. "Detection and characterization of new mutations in the human angiotensinogen gene (AGT)."
    Hixson J.E., Powers P.K.
    Hum. Genet. 96:110-112(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS ILE-242; ARG-244 AND CYS-281.
  27. "A mutation of angiotensinogen in a patient with preeclampsia leads to altered kinetics of the renin-angiotensin system."
    Inoue I., Rohrwasser A., Helin C., Jeunemaitre X., Crain P., Bohlender J., Lifton R.P., Corvol P., Ward K., Lalouel J.-M.
    J. Biol. Chem. 270:11430-11436(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT PHE-43.
  28. "The natural mutation Y248C of human angiotensinogen leads to abnormal glycosylation and altered immunological recognition of the protein."
    Gimenez-Roqueplo A.P., Leconte I., Cohen P., Simon D., Guyene T.T., Celerier J., Pau B., Corvol P., Clauser E., Jeunemaitre X.
    J. Biol. Chem. 271:9838-9844(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION OF VARIANT CYS-281.
  29. Cited for: VARIANT RTD GLN-375.

Entry informationi

Entry nameiANGT_HUMAN
AccessioniPrimary (citable) accession number: P01019
Secondary accession number(s): Q16358, Q16359, Q96F91
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 26, 2014
This is version 180 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-10 is the initiator.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3