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P01019

- ANGT_HUMAN

UniProt

P01019 - ANGT_HUMAN

Protein

Angiotensinogen

Gene

AGT

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 178 (01 Oct 2014)
      Sequence version 1 (21 Jul 1986)
      Previous versions | rss
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    Functioni

    Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.
    Angiotensin-2: acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone.
    Angiotensin-3: stimulates aldosterone release.
    Angiotensin 1-7: is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets.By similarity

    GO - Molecular functioni

    1. growth factor activity Source: BHF-UCL
    2. hormone activity Source: BHF-UCL
    3. protein binding Source: IntAct
    4. serine-type endopeptidase inhibitor activity Source: RefGenome
    5. type 1 angiotensin receptor binding Source: BHF-UCL
    6. type 2 angiotensin receptor binding Source: BHF-UCL

    GO - Biological processi

    1. activation of NF-kappaB-inducing kinase activity Source: Ensembl
    2. activation of phospholipase C activity Source: Ensembl
    3. aging Source: Ensembl
    4. angiotensin maturation Source: Reactome
    5. angiotensin-mediated drinking behavior Source: Ensembl
    6. angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure Source: Ensembl
    7. artery smooth muscle contraction Source: Ensembl
    8. astrocyte activation Source: Ensembl
    9. blood vessel development Source: Ensembl
    10. blood vessel remodeling Source: BHF-UCL
    11. branching involved in ureteric bud morphogenesis Source: Ensembl
    12. catenin import into nucleus Source: Ensembl
    13. cell-cell signaling Source: ProtInc
    14. cell growth involved in cardiac muscle cell development Source: Ensembl
    15. cell-matrix adhesion Source: Ensembl
    16. cellular lipid metabolic process Source: Reactome
    17. cellular protein metabolic process Source: Reactome
    18. cellular response to mechanical stimulus Source: Ensembl
    19. cellular sodium ion homeostasis Source: Ensembl
    20. cytokine secretion Source: Ensembl
    21. ERK1 and ERK2 cascade Source: Ensembl
    22. establishment of blood-nerve barrier Source: Ensembl
    23. excretion Source: Ensembl
    24. extracellular matrix organization Source: Ensembl
    25. fibroblast proliferation Source: Ensembl
    26. G-protein coupled receptor signaling pathway Source: BHF-UCL
    27. G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger Source: BHF-UCL
    28. kidney development Source: BHF-UCL
    29. low-density lipoprotein particle remodeling Source: BHF-UCL
    30. negative regulation of angiogenesis Source: Ensembl
    31. negative regulation of cell growth Source: Ensembl
    32. negative regulation of cell proliferation Source: Ensembl
    33. negative regulation of endopeptidase activity Source: RefGenome
    34. negative regulation of neuron apoptotic process Source: Ensembl
    35. negative regulation of neurotrophin TRK receptor signaling pathway Source: BHF-UCL
    36. negative regulation of tissue remodeling Source: Ensembl
    37. nitric oxide mediated signal transduction Source: BHF-UCL
    38. ovarian follicle rupture Source: Ensembl
    39. peristalsis Source: Ensembl
    40. phospholipase C-activating G-protein coupled receptor signaling pathway Source: BHF-UCL
    41. positive regulation of activation of JAK2 kinase activity Source: UniProtKB
    42. positive regulation of branching involved in ureteric bud morphogenesis Source: UniProtKB
    43. positive regulation of cardiac muscle hypertrophy Source: BHF-UCL
    44. positive regulation of cellular protein metabolic process Source: BHF-UCL
    45. positive regulation of cholesterol esterification Source: BHF-UCL
    46. positive regulation of cytokine production Source: BHF-UCL
    47. positive regulation of endothelial cell migration Source: BHF-UCL
    48. positive regulation of epidermal growth factor receptor signaling pathway Source: BHF-UCL
    49. positive regulation of extracellular matrix constituent secretion Source: Ensembl
    50. positive regulation of extrinsic apoptotic signaling pathway Source: BHF-UCL
    51. positive regulation of fatty acid biosynthetic process Source: Ensembl
    52. positive regulation of fibroblast proliferation Source: BHF-UCL
    53. positive regulation of inflammatory response Source: BHF-UCL
    54. positive regulation of macrophage derived foam cell differentiation Source: BHF-UCL
    55. positive regulation of MAPK cascade Source: Ensembl
    56. positive regulation of multicellular organism growth Source: Ensembl
    57. positive regulation of NAD(P)H oxidase activity Source: BHF-UCL
    58. positive regulation of NF-kappaB transcription factor activity Source: BHF-UCL
    59. positive regulation of organ growth Source: Ensembl
    60. positive regulation of peptidyl-tyrosine phosphorylation Source: BHF-UCL
    61. positive regulation of phosphatidylinositol 3-kinase signaling Source: BHF-UCL
    62. positive regulation of protein tyrosine kinase activity Source: UniProtKB
    63. positive regulation of reactive oxygen species metabolic process Source: BHF-UCL
    64. positive regulation of renal sodium excretion Source: Ensembl
    65. positive regulation of superoxide anion generation Source: Ensembl
    66. positive regulation of transcription, DNA-templated Source: UniProtKB
    67. regulation of blood vessel size by renin-angiotensin Source: BHF-UCL
    68. regulation of blood volume by renin-angiotensin Source: BHF-UCL
    69. regulation of calcium ion transport Source: Ensembl
    70. regulation of cell growth Source: BHF-UCL
    71. regulation of cell proliferation Source: BHF-UCL
    72. regulation of long-term neuronal synaptic plasticity Source: Ensembl
    73. regulation of norepinephrine secretion Source: Ensembl
    74. regulation of proteolysis Source: RefGenome
    75. regulation of renal output by angiotensin Source: BHF-UCL
    76. regulation of renal sodium excretion Source: BHF-UCL
    77. regulation of vasoconstriction Source: BHF-UCL
    78. renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure Source: Ensembl
    79. renal system process Source: UniProt
    80. renin-angiotensin regulation of aldosterone production Source: BHF-UCL
    81. response to cold Source: Ensembl
    82. response to muscle activity involved in regulation of muscle adaptation Source: BHF-UCL
    83. response to salt stress Source: Ensembl
    84. small molecule metabolic process Source: Reactome
    85. smooth muscle cell differentiation Source: Ensembl
    86. smooth muscle cell proliferation Source: Ensembl
    87. stress-activated MAPK cascade Source: Ensembl
    88. uterine smooth muscle contraction Source: Ensembl
    89. vasodilation Source: Ensembl

    Keywords - Molecular functioni

    Vasoactive, Vasoconstrictor

    Enzyme and pathway databases

    ReactomeiREACT_116145. PPARA activates gene expression.
    REACT_147707. Metabolism of Angiotensinogen to Angiotensins.
    REACT_14819. Peptide ligand-binding receptors.
    REACT_18283. G alpha (q) signalling events.
    REACT_19231. G alpha (i) signalling events.

    Protein family/group databases

    MEROPSiI04.953.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Angiotensinogen
    Alternative name(s):
    Serpin A8
    Cleaved into the following 8 chains:
    Alternative name(s):
    Angiotensin 1-10
    Angiotensin I
    Short name:
    Ang I
    Alternative name(s):
    Angiotensin 1-8
    Angiotensin II
    Short name:
    Ang II
    Alternative name(s):
    Angiotensin 2-8
    Angiotensin III
    Short name:
    Ang III
    Des-Asp[1]-angiotensin II
    Alternative name(s):
    Angiotensin 3-8
    Angiotensin IV
    Short name:
    Ang IV
    Gene namesi
    Name:AGT
    Synonyms:SERPINA8
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:333. AGT.

    Subcellular locationi

    GO - Cellular componenti

    1. blood microparticle Source: UniProt
    2. extracellular region Source: UniProtKB
    3. extracellular space Source: BHF-UCL
    4. extracellular vesicular exosome Source: UniProt

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Involvement in diseasei

    Essential hypertension (EHT) [MIM:145500]: A condition in which blood pressure is consistently higher than normal with no identifiable cause.
    Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.
    Renal tubular dysgenesis (RTD) [MIM:267430]: Autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti375 – 3751R → Q in RTD. 1 Publication
    VAR_035433

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi145500. phenotype.
    267430. phenotype.
    Orphaneti243761. Essential hypertension.
    97369. Renal tubular dysgenesis of genetic origin.
    PharmGKBiPA42.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 33333 PublicationsAdd
    BLAST
    Chaini34 – 485452AngiotensinogenPRO_0000032456Add
    BLAST
    Peptidei34 – 4310Angiotensin-1PRO_0000032457
    Peptidei34 – 429Angiotensin 1-9PRO_0000420659
    Peptidei34 – 418Angiotensin-2PRO_0000032458
    Peptidei34 – 407Angiotensin 1-7PRO_0000420660
    Peptidei34 – 385Angiotensin 1-5PRO_0000420661
    Peptidei34 – 374Angiotensin 1-4PRO_0000420662
    Peptidei35 – 417Angiotensin-3PRO_0000032459
    Peptidei36 – 416Angiotensin-4PRO_0000420663

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei34 – 341Beta-decarboxylated aspartate; in form angiotensin-A1 Publication
    Glycosylationi47 – 471N-linked (GlcNAc...)3 Publications
    Disulfide bondi51 ↔ 1711 Publication
    Glycosylationi170 – 1701N-linked (GlcNAc...)1 Publication
    Glycosylationi304 – 3041N-linked (GlcNAc...)1 Publication
    Glycosylationi328 – 3281N-linked (GlcNAc...)1 Publication

    Post-translational modificationi

    Beta-decarboxylation of Asp-34 in angiotensin-2, by mononuclear leukocytes produces alanine. The resulting peptide form, angiotensin-A, has the same affinity for the AT1 receptor as angiotensin-2, but a higher affinity for the AT2 receptor.1 Publication
    In response to low blood pressure, the enzyme renin/REN cleaves angiotensinogen to produce angiotensin-1. Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2. Angiotensin-1 and angiotensin-2 can be further processed to generate angiotensin-3, angiotensin-4. Angiotensin 1-9 is cleaved from angiotensin-1 by ACE2 and can be further processed by ACE to produce angiotensin 1-7, angiotensin 1-5 and angiotensin 1-4. Angiotensin 1-7 has also been proposed to be cleaved from angiotensin-2 by ACE2 or from angiotensin-1 by MME (neprilysin).2 Publications
    The disulfide bond is labile. Angiotensinogen is present in the circulation in a near 40:60 ratio with the oxidized disulfide-bonded form, which preferentially interacts with receptor-bound renin.

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiP01019.
    PaxDbiP01019.
    PeptideAtlasiP01019.
    PRIDEiP01019.

    2D gel databases

    SWISS-2DPAGEP01019.

    PTM databases

    PhosphoSiteiP01019.

    Miscellaneous databases

    PMAP-CutDBP01019.

    Expressioni

    Tissue specificityi

    Expressed by the liver and secreted in plasma.

    Gene expression databases

    ArrayExpressiP01019.
    BgeeiP01019.
    CleanExiHS_AGT.
    GenevestigatoriP01019.

    Organism-specific databases

    HPAiHPA001557.

    Interactioni

    Subunit structurei

    During pregnancy, exists as a disulfide-linked 2:2 heterotetramer with the proform of PRG2 and as a complex (probably a 2:2:2 heterohexamer) with pro-PRG2 and C3dg.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    AGTR1P305562EBI-6622938,EBI-6623016
    Agtr1P2509510EBI-751728,EBI-764979From a different organism.
    AGTR2P500522EBI-2927577,EBI-1748067
    AnceQ107142EBI-751728,EBI-115736From a different organism.

    Protein-protein interaction databases

    BioGridi106690. 11 interactions.
    DIPiDIP-309N.
    IntActiP01019. 8 interactions.
    MINTiMINT-1472115.
    STRINGi9606.ENSP00000355627.

    Structurei

    Secondary structure

    1
    485
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni42 – 443
    Helixi48 – 5710
    Beta strandi59 – 624
    Helixi81 – 9313
    Helixi97 – 11721
    Helixi118 – 1203
    Turni124 – 1263
    Beta strandi129 – 1346
    Helixi136 – 14813
    Helixi154 – 1629
    Turni171 – 1733
    Helixi177 – 19115
    Turni195 – 1973
    Beta strandi203 – 21210
    Helixi221 – 23010
    Beta strandi234 – 2363
    Helixi244 – 25916
    Beta strandi277 – 28812
    Beta strandi291 – 2933
    Beta strandi302 – 3054
    Beta strandi313 – 32210
    Turni325 – 3284
    Beta strandi329 – 3335
    Turni337 – 3393
    Beta strandi340 – 34910
    Helixi353 – 3586
    Helixi365 – 3684
    Beta strandi374 – 3818
    Beta strandi385 – 3917
    Helixi392 – 3954
    Helixi402 – 4065
    Beta strandi407 – 4093
    Beta strandi425 – 43410
    Beta strandi452 – 4554
    Beta strandi460 – 4667
    Turni467 – 4704
    Beta strandi475 – 4795

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1N9UNMR-A34-43[»]
    1N9VNMR-A34-41[»]
    2JP8NMR-P34-40[»]
    2WXWX-ray3.30A34-485[»]
    2X0BX-ray4.33B/D/F/H34-485[»]
    3CK0X-ray3.00P34-41[»]
    4AA1X-ray1.99P34-41[»]
    4APHX-ray1.99P34-41[»]
    4FYSX-ray2.01C36-41[»]
    ProteinModelPortaliP01019.
    SMRiP01019. Positions 34-482.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP01019.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the serpin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG314543.
    HOVERGENiHBG004233.
    InParanoidiP01019.
    KOiK09821.
    OMAiRFMQAVT.
    OrthoDBiEOG7QK0BN.
    PhylomeDBiP01019.
    TreeFamiTF343201.

    Family and domain databases

    InterProiIPR000227. Angiotensinogen.
    IPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view]
    PANTHERiPTHR11461. PTHR11461. 1 hit.
    PfamiPF00079. Serpin. 1 hit.
    [Graphical view]
    PRINTSiPR00654. ANGIOTENSNGN.
    SMARTiSM00093. SERPIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF56574. SSF56574. 1 hit.
    PROSITEiPS00284. SERPIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P01019-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRKRAPQSEM APAGVSLRAT ILCLLAWAGL AAGDRVYIHP FHLVIHNEST    50
    CEQLAKANAG KPKDPTFIPA PIQAKTSPVD EKALQDQLVL VAAKLDTEDK 100
    LRAAMVGMLA NFLGFRIYGM HSELWGVVHG ATVLSPTAVF GTLASLYLGA 150
    LDHTADRLQA ILGVPWKDKN CTSRLDAHKV LSALQAVQGL LVAQGRADSQ 200
    AQLLLSTVVG VFTAPGLHLK QPFVQGLALY TPVVLPRSLD FTELDVAAEK 250
    IDRFMQAVTG WKTGCSLMGA SVDSTLAFNT YVHFQGKMKG FSLLAEPQEF 300
    WVDNSTSVSV PMLSGMGTFQ HWSDIQDNFS VTQVPFTESA CLLLIQPHYA 350
    SDLDKVEGLT FQQNSLNWMK KLSPRTIHLT MPQLVLQGSY DLQDLLAQAE 400
    LPAILHTELN LQKLSNDRIR VGEVLNSIFF ELEADEREPT ESTQQLNKPE 450
    VLEVTLNRPF LFAVYDQSAT ALHFLGRVAN PLSTA 485
    Length:485
    Mass (Da):53,154
    Last modified:July 21, 1986 - v1
    Checksum:i5026C2DFB2DD236E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti51 – 511C → S AA sequence (PubMed:7259779)Curated
    Sequence conflicti58 – 581N → D AA sequence (PubMed:7259779)Curated
    Sequence conflicti333 – 3331Q → E in AAA51679. (PubMed:2924688)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti43 – 431L → F Associated with susceptibility to pre-eclampsia; alters the reactions with renin and angiotensin-converting enzyme. 1 Publication
    Corresponds to variant rs41271499 [ dbSNP | Ensembl ].
    VAR_022933
    Natural varianti98 – 981E → K.
    Corresponds to variant rs11568032 [ dbSNP | Ensembl ].
    VAR_029166
    Natural varianti114 – 1141G → C.
    Corresponds to variant rs2229389 [ dbSNP | Ensembl ].
    VAR_051939
    Natural varianti137 – 1371T → M.
    Corresponds to variant rs34829218 [ dbSNP | Ensembl ].
    VAR_035431
    Natural varianti207 – 2071T → M Associated with hypertension. 1 Publication
    Corresponds to variant rs4762 [ dbSNP | Ensembl ].
    VAR_007093
    Natural varianti242 – 2421T → I Associated with susceptibility to hypertension. 1 Publication
    VAR_007094
    Natural varianti244 – 2441L → R Associated with susceptibility to hypertension. 1 Publication
    Corresponds to variant rs5041 [ dbSNP | Ensembl ].
    VAR_007095
    Natural varianti268 – 2681M → I.
    Corresponds to variant rs11568053 [ dbSNP | Ensembl ].
    VAR_029167
    Natural varianti268 – 2681M → T Associated with essential hypertension and pre-eclampsia. 2 Publications
    Corresponds to variant rs699 [ dbSNP | Ensembl ].
    VAR_007096
    Natural varianti281 – 2811Y → C Associated with susceptibility to hypertension; alters the structure, glycosylation and secretion of angiotensinogen. 2 Publications
    Corresponds to variant rs56073403 [ dbSNP | Ensembl ].
    VAR_007097
    Natural varianti335 – 3351P → S.1 Publication
    Corresponds to variant rs17856352 [ dbSNP | Ensembl ].
    VAR_035432
    Natural varianti375 – 3751R → Q in RTD. 1 Publication
    VAR_035433
    Natural varianti392 – 3921L → M.
    Corresponds to variant rs1805090 [ dbSNP | Ensembl ].
    VAR_014573

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    K02215 mRNA. Translation: AAA51731.1.
    M24689
    , M24686, M24687, M24688 Genomic DNA. Translation: AAA51679.1.
    X15324
    , X15325, X15326, X15327 Genomic DNA. Translation: CAA33385.1.
    BC011519 mRNA. Translation: AAH11519.1.
    M69110 mRNA. Translation: AAA52282.1.
    S78529 Genomic DNA. Translation: AAD14287.1.
    S78530 Genomic DNA. Translation: AAD14288.1.
    CCDSiCCDS1585.1.
    PIRiA35203. ANHU.
    RefSeqiNP_000020.1. NM_000029.3.
    UniGeneiHs.19383.

    Genome annotation databases

    EnsembliENST00000366667; ENSP00000355627; ENSG00000135744.
    GeneIDi183.
    KEGGihsa:183.
    UCSCiuc001hty.4. human.

    Polymorphism databases

    DMDMi113880.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    SHMPD

    The Singapore human mutation and polymorphism database

    Wikipedia

    Angiotensin entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    K02215 mRNA. Translation: AAA51731.1 .
    M24689
    , M24686 , M24687 , M24688 Genomic DNA. Translation: AAA51679.1 .
    X15324
    , X15325 , X15326 , X15327 Genomic DNA. Translation: CAA33385.1 .
    BC011519 mRNA. Translation: AAH11519.1 .
    M69110 mRNA. Translation: AAA52282.1 .
    S78529 Genomic DNA. Translation: AAD14287.1 .
    S78530 Genomic DNA. Translation: AAD14288.1 .
    CCDSi CCDS1585.1.
    PIRi A35203. ANHU.
    RefSeqi NP_000020.1. NM_000029.3.
    UniGenei Hs.19383.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1N9U NMR - A 34-43 [» ]
    1N9V NMR - A 34-41 [» ]
    2JP8 NMR - P 34-40 [» ]
    2WXW X-ray 3.30 A 34-485 [» ]
    2X0B X-ray 4.33 B/D/F/H 34-485 [» ]
    3CK0 X-ray 3.00 P 34-41 [» ]
    4AA1 X-ray 1.99 P 34-41 [» ]
    4APH X-ray 1.99 P 34-41 [» ]
    4FYS X-ray 2.01 C 36-41 [» ]
    ProteinModelPortali P01019.
    SMRi P01019. Positions 34-482.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 106690. 11 interactions.
    DIPi DIP-309N.
    IntActi P01019. 8 interactions.
    MINTi MINT-1472115.
    STRINGi 9606.ENSP00000355627.

    Chemistry

    DrugBanki DB01258. Aliskiren.
    DB01076. Atorvastatin.
    DB01340. Cilazapril.
    DB01029. Irbesartan.
    DB00722. Lisinopril.
    DB01092. Ouabain.
    DB00641. Simvastatin.

    Protein family/group databases

    MEROPSi I04.953.

    PTM databases

    PhosphoSitei P01019.

    Polymorphism databases

    DMDMi 113880.

    2D gel databases

    SWISS-2DPAGE P01019.

    Proteomic databases

    MaxQBi P01019.
    PaxDbi P01019.
    PeptideAtlasi P01019.
    PRIDEi P01019.

    Protocols and materials databases

    DNASUi 183.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000366667 ; ENSP00000355627 ; ENSG00000135744 .
    GeneIDi 183.
    KEGGi hsa:183.
    UCSCi uc001hty.4. human.

    Organism-specific databases

    CTDi 183.
    GeneCardsi GC01M230838.
    HGNCi HGNC:333. AGT.
    HPAi HPA001557.
    MIMi 106150. gene.
    145500. phenotype.
    267430. phenotype.
    neXtProti NX_P01019.
    Orphaneti 243761. Essential hypertension.
    97369. Renal tubular dysgenesis of genetic origin.
    PharmGKBi PA42.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG314543.
    HOVERGENi HBG004233.
    InParanoidi P01019.
    KOi K09821.
    OMAi RFMQAVT.
    OrthoDBi EOG7QK0BN.
    PhylomeDBi P01019.
    TreeFami TF343201.

    Enzyme and pathway databases

    Reactomei REACT_116145. PPARA activates gene expression.
    REACT_147707. Metabolism of Angiotensinogen to Angiotensins.
    REACT_14819. Peptide ligand-binding receptors.
    REACT_18283. G alpha (q) signalling events.
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    ChiTaRSi AGT. human.
    EvolutionaryTracei P01019.
    GeneWikii Angiotensin.
    GenomeRNAii 183.
    NextBioi 748.
    PMAP-CutDB P01019.
    PROi P01019.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P01019.
    Bgeei P01019.
    CleanExi HS_AGT.
    Genevestigatori P01019.

    Family and domain databases

    InterProi IPR000227. Angiotensinogen.
    IPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view ]
    PANTHERi PTHR11461. PTHR11461. 1 hit.
    Pfami PF00079. Serpin. 1 hit.
    [Graphical view ]
    PRINTSi PR00654. ANGIOTENSNGN.
    SMARTi SM00093. SERPIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56574. SSF56574. 1 hit.
    PROSITEi PS00284. SERPIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Primary structure of human preangiotensinogen deduced from the cloned cDNA sequence."
      Kageyama R., Ohkubo H., Nakanishi S.
      Biochemistry 23:3603-3609(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Structure of human angiotensinogen gene."
      Gaillard I., Clauser E., Corvol P.
      DNA 8:87-99(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Structure and expression of the human angiotensinogen gene. Identification of a unique and highly active promoter."
      Fukamizu A., Takahashi S., Seo M.S., Tada M., Tanimoto K., Uehara S., Murakami K.
      J. Biol. Chem. 265:7576-7582(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-335.
      Tissue: Brain.
    5. "Molecular cloning of human angiotensinogen cDNA and evidence for the presence of its mRNA in rat heart."
      Kunapuli S.P., Kumar A.
      Circ. Res. 60:786-790(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-338.
    6. "Tissue specific hormonal regulation of the rat angiotensinogen gene expression."
      Kunapuli S.P., Benedict C.R., Kumar A.
      Arch. Biochem. Biophys. 254:642-646(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 32-184.
    7. "The amino terminal amino acid sequence of human angiotensinogen."
      Tewksbury D.A., Dart R.A., Travis J.
      Biochem. Biophys. Res. Commun. 99:1311-1315(1981) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 34-58.
    8. "Identification of angiotensinogen and complement C3dg as novel proteins binding the proform of eosinophil major basic protein in human pregnancy serum and plasma."
      Oxvig C., Haaning J., Kristensen L., Wagner J.M., Rubin I., Stigbrand T., Gleich G.J., Sottrup-Jensen L.
      J. Biol. Chem. 270:13645-13651(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 34-45, SUBUNIT.
      Tissue: Serum.
    9. "Enzymatic degradation and electrophoresis of human angiotensin I."
      Arakawa K., Minohara A., Yamada J., Nakamura M.
      Biochim. Biophys. Acta 168:106-112(1968) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 34-43.
    10. "Processing of rat and human angiotensinogen precursors by microsomal membranes."
      Campbell D.J., Bouhnik J., Coezy E., Menard J., Corvol P.
      Mol. Cell. Endocrinol. 43:31-40(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION AT ASN-47; ASN-170; ASN-304 AND ASN-328.
    11. "Angiotensin III: (DES-Aspartic Acid-1)-Angiotensin II. Evidence and speculation for its role as an important agonist in the renin - angiotensin system."
      Goodfriend T.L., Peach M.J.
      Circ. Res. 36:38-48(1975) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION OF ANGIOTENSIN-3.
    12. "The renin-angiotensin-aldosterone system: a specific target for hypertension management."
      Weir M.R., Dzau V.J.
      Am. J. Hypertens. 12:205S-213S(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION OF ANGIOTENSIN-2.
    13. "A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9."
      Donoghue M., Hsieh F., Baronas E., Godbout K., Gosselin M., Stagliano N., Donovan M., Woolf B., Robison K., Jeyaseelan R., Breitbart R.E., Acton S.
      Circ. Res. 87:E1-E9(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: CLEAVAGE BY ACE AND ACE2.
    14. "Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase."
      Vickers C., Hales P., Kaushik V., Dick L., Gavin J., Tang J., Godbout K., Parsons T., Baronas E., Hsieh F., Acton S., Patane M.A., Nichols A., Tummino P.
      J. Biol. Chem. 277:14838-14843(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: CLEAVAGE OF ANGIOTENSIN-1 AND ANGIOTENSIN-2 BY ACE2.
    15. "Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism."
      Rice G.I., Thomas D.A., Grant P.J., Turner A.J., Hooper N.M.
      Biochem. J. 383:45-51(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: ANGIOTENSIN PEPTIDES METABOLISM.
    16. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
      J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-47.
      Tissue: Plasma.
    17. Cited for: DECARBOXYLATION AT ASP-34, FUNCTION, IDENTIFICATION BY MASS SPECTROMETRY.
    18. Cited for: REVIEW ON THE RENIN-ANGIOTENSIN SYSTEM.
    19. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-47.
      Tissue: Liver.
    20. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    21. "The octapeptide angiotensin II adopts a well-defined structure in a phospholipid environment."
      Carpenter K.A., Wilkes B.C., Schiller P.W.
      Eur. J. Biochem. 251:448-453(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF ANGIOTENSIN-2.
    22. "Comparison of the solution structures of angiotensin I & II. Implication for structure-function relationship."
      Spyroulias G.A., Nikolakopoulou P., Tzakos A., Gerothanassis I.P., Magafa V., Manessi-Zoupa E., Cordopatis P.
      Eur. J. Biochem. 270:2163-2173(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 34-43, STRUCTURE BY NMR OF 34-41.
    23. Cited for: X-RAY CRYSTALLOGRAPHY (4.33 ANGSTROMS) OF 34-485 IN COMPLEX WITH RENIN, DISULFIDE BOND.
    24. Cited for: VARIANTS MET-207; THR-268 AND CYS-281.
    25. Cited for: VARIANT THR-268.
    26. "Detection and characterization of new mutations in the human angiotensinogen gene (AGT)."
      Hixson J.E., Powers P.K.
      Hum. Genet. 96:110-112(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS ILE-242; ARG-244 AND CYS-281.
    27. "A mutation of angiotensinogen in a patient with preeclampsia leads to altered kinetics of the renin-angiotensin system."
      Inoue I., Rohrwasser A., Helin C., Jeunemaitre X., Crain P., Bohlender J., Lifton R.P., Corvol P., Ward K., Lalouel J.-M.
      J. Biol. Chem. 270:11430-11436(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT PHE-43.
    28. "The natural mutation Y248C of human angiotensinogen leads to abnormal glycosylation and altered immunological recognition of the protein."
      Gimenez-Roqueplo A.P., Leconte I., Cohen P., Simon D., Guyene T.T., Celerier J., Pau B., Corvol P., Clauser E., Jeunemaitre X.
      J. Biol. Chem. 271:9838-9844(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION OF VARIANT CYS-281.
    29. Cited for: VARIANT RTD GLN-375.

    Entry informationi

    Entry nameiANGT_HUMAN
    AccessioniPrimary (citable) accession number: P01019
    Secondary accession number(s): Q16358, Q16359, Q96F91
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 178 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    It is uncertain whether Met-1 or Met-10 is the initiator.Curated

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3