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P01015

- ANGT_RAT

UniProt

P01015 - ANGT_RAT

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Protein

Angiotensinogen

Gene

Agt

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.By similarity
Angiotensin-2: acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone.By similarity
Angiotensin-3: stimulates aldosterone release.By similarity
Angiotensin 1-7: is a ligand for the G-protein coupled receptor MAS1 (By similarity). Has vasodilator and antidiuretic effects (By similarity). Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets.By similarity1 Publication

GO - Molecular functioni

  1. angiotensin receptor binding Source: RGD
  2. hormone activity Source: BHF-UCL
  3. serine-type endopeptidase inhibitor activity Source: RefGenome
  4. type 1 angiotensin receptor binding Source: RGD
  5. type 2 angiotensin receptor binding Source: RGD

GO - Biological processi

  1. activation of NF-kappaB-inducing kinase activity Source: Ensembl
  2. activation of phospholipase C activity Source: RGD
  3. aging Source: RGD
  4. angiotensin-mediated drinking behavior Source: RGD
  5. angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure Source: Ensembl
  6. artery smooth muscle contraction Source: RGD
  7. astrocyte activation Source: Ensembl
  8. blood vessel development Source: Ensembl
  9. branching involved in ureteric bud morphogenesis Source: Ensembl
  10. catenin import into nucleus Source: RGD
  11. cell growth involved in cardiac muscle cell development Source: RGD
  12. cell-matrix adhesion Source: Ensembl
  13. cell surface receptor signaling pathway Source: RGD
  14. cellular response to mechanical stimulus Source: RGD
  15. cellular sodium ion homeostasis Source: RGD
  16. cytokine secretion Source: RGD
  17. ERK1 and ERK2 cascade Source: RGD
  18. establishment of blood-nerve barrier Source: Ensembl
  19. excretion Source: Ensembl
  20. extracellular matrix organization Source: Ensembl
  21. female pregnancy Source: RGD
  22. fibroblast proliferation Source: RGD
  23. G-protein coupled receptor signaling pathway Source: RGD
  24. hormone metabolic process Source: Ensembl
  25. negative regulation of angiogenesis Source: RGD
  26. negative regulation of cell growth Source: RGD
  27. negative regulation of cell proliferation Source: Ensembl
  28. negative regulation of endopeptidase activity Source: RefGenome
  29. negative regulation of neuron apoptotic process Source: Ensembl
  30. negative regulation of neurotrophin TRK receptor signaling pathway Source: Ensembl
  31. negative regulation of tissue remodeling Source: RGD
  32. ovarian follicle rupture Source: Ensembl
  33. peristalsis Source: Ensembl
  34. positive regulation of activation of JAK2 kinase activity Source: Ensembl
  35. positive regulation of blood pressure Source: RGD
  36. positive regulation of branching involved in ureteric bud morphogenesis Source: Ensembl
  37. positive regulation of cardiac muscle hypertrophy Source: BHF-UCL
  38. positive regulation of catalytic activity Source: RGD
  39. positive regulation of cell proliferation Source: RGD
  40. positive regulation of cholesterol esterification Source: Ensembl
  41. positive regulation of endothelial cell migration Source: Ensembl
  42. positive regulation of epidermal growth factor receptor signaling pathway Source: Ensembl
  43. positive regulation of extracellular matrix constituent secretion Source: RGD
  44. positive regulation of extrinsic apoptotic signaling pathway Source: Ensembl
  45. positive regulation of fatty acid biosynthetic process Source: Ensembl
  46. positive regulation of fibroblast proliferation Source: BHF-UCL
  47. positive regulation of MAPK cascade Source: Ensembl
  48. positive regulation of multicellular organism growth Source: Ensembl
  49. positive regulation of nitric oxide biosynthetic process Source: RGD
  50. positive regulation of organ growth Source: Ensembl
  51. positive regulation of phosphatidylinositol 3-kinase signaling Source: Ensembl
  52. positive regulation of protein tyrosine kinase activity Source: Ensembl
  53. positive regulation of renal sodium excretion Source: RGD
  54. positive regulation of superoxide anion generation Source: RGD
  55. positive regulation of transcription, DNA-templated Source: Ensembl
  56. positive regulation of vasodilation Source: RGD
  57. regulation of calcium ion transport Source: RGD
  58. regulation of inflammatory response Source: Ensembl
  59. regulation of long-term neuronal synaptic plasticity Source: RGD
  60. regulation of norepinephrine secretion Source: RGD
  61. regulation of proteolysis Source: RefGenome
  62. regulation of renal output by angiotensin Source: Ensembl
  63. regulation of renal sodium excretion Source: RGD
  64. regulation of transmission of nerve impulse Source: RGD
  65. renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure Source: Ensembl
  66. renin-angiotensin regulation of aldosterone production Source: RGD
  67. response to cold Source: Ensembl
  68. response to muscle activity involved in regulation of muscle adaptation Source: BHF-UCL
  69. response to salt stress Source: Ensembl
  70. smooth muscle cell differentiation Source: Ensembl
  71. smooth muscle cell proliferation Source: RGD
  72. stress-activated MAPK cascade Source: RGD
  73. uterine smooth muscle contraction Source: RGD
  74. vasoconstriction Source: RGD
  75. vasodilation Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Vasoactive, Vasoconstrictor

Enzyme and pathway databases

ReactomeiREACT_196408. PPARA activates gene expression.
REACT_198807. Metabolism of Angiotensinogen to Angiotensins.
REACT_233455. G alpha (i) signalling events.
REACT_250028. Peptide ligand-binding receptors.
REACT_263374. G alpha (q) signalling events.

Protein family/group databases

MEROPSiI04.953.

Names & Taxonomyi

Protein namesi
Recommended name:
Angiotensinogen
Alternative name(s):
Serpin A8
Cleaved into the following 8 chains:
Alternative name(s):
Angiotensin 1-10
Angiotensin I
Short name:
Ang I
Alternative name(s):
Angiotensin 1-8
Angiotensin II
Short name:
Ang II
Alternative name(s):
Angiotensin 2-8
Angiotensin III
Short name:
Ang III
Des-Asp[1]-angiotensin II
Alternative name(s):
Angiotensin 3-8
Angiotensin IV
Short name:
Ang IV
Gene namesi
Name:Agt
Synonyms:Serpina8
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 19

Organism-specific databases

RGDi2069. Agt.

Subcellular locationi

GO - Cellular componenti

  1. blood microparticle Source: Ensembl
  2. cytoplasm Source: RGD
  3. extracellular space Source: BHF-UCL
  4. extracellular vesicular exosome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 24241 PublicationAdd
BLAST
Chaini25 – 477453AngiotensinogenPRO_0000032468Add
BLAST
Peptidei25 – 3410Angiotensin-1PRO_0000032469
Peptidei25 – 339Angiotensin 1-9PRO_0000420674
Peptidei25 – 328Angiotensin-2PRO_0000032470
Peptidei25 – 317Angiotensin 1-7PRO_0000420675
Peptidei25 – 295Angiotensin 1-5PRO_0000420676
Peptidei25 – 284Angiotensin 1-4PRO_0000420677
Peptidei26 – 327Angiotensin-3PRO_0000032471
Peptidei27 – 326Angiotensin-4PRO_0000420678

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi42 ↔ 1611 Publication
Glycosylationi295 – 2951N-linked (GlcNAc...)Sequence Analysis
Glycosylationi319 – 3191N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

In response to low blood pressure, the enzyme renin/REN cleaves angiotensinogen to produce angiotensin-1. Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2. Angiotensin-1 and angiotensin-2 can be further processed to generate angiotensin-3, angiotensin-4 (By similarity). Angiotensin 1-9 is cleaved from angiotensin-1 by ACE2 and can be further processed by ACE to produce angiotensin 1-7, angiotensin 1-5 and angiotensin 1-4. Angiotensin 1-7 has also been proposed to be cleaved from angiotensin-2 by ACE2 or from angiotensin-1 by MME (neprilysin) (By similarity).By similarity
The disulfide bond is labile. Angiotensinogen is present in the circulation in a near 40:60 ratio with the oxidized disulfide-bonded form, which preferentially interacts with receptor-bound renin.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP01015.
PRIDEiP01015.

PTM databases

PhosphoSiteiP01015.

Expressioni

Tissue specificityi

Expressed by the liver and secreted in plasma.

Gene expression databases

GenevestigatoriP01015.

Interactioni

Protein-protein interaction databases

MINTiMINT-1522474.
STRINGi10116.ENSRNOP00000024917.

Structurei

Secondary structure

1
477
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni33 – 353Combined sources
Helixi39 – 435Combined sources
Helixi72 – 8413Combined sources
Helixi88 – 11528Combined sources
Beta strandi120 – 1245Combined sources
Helixi126 – 13813Combined sources
Helixi142 – 15110Combined sources
Helixi167 – 18115Combined sources
Beta strandi193 – 20311Combined sources
Helixi211 – 2166Combined sources
Turni217 – 2204Combined sources
Beta strandi224 – 2285Combined sources
Beta strandi231 – 2333Combined sources
Helixi235 – 25016Combined sources
Beta strandi267 – 27913Combined sources
Beta strandi282 – 2843Combined sources
Beta strandi289 – 2946Combined sources
Beta strandi297 – 3015Combined sources
Beta strandi303 – 31513Combined sources
Turni316 – 3194Combined sources
Beta strandi320 – 34021Combined sources
Helixi341 – 3433Combined sources
Helixi344 – 3518Combined sources
Beta strandi353 – 3553Combined sources
Beta strandi366 – 3738Combined sources
Beta strandi375 – 3828Combined sources
Helixi383 – 3897Combined sources
Turni393 – 3964Combined sources
Helixi403 – 4053Combined sources
Beta strandi406 – 4083Combined sources
Beta strandi416 – 42510Combined sources
Beta strandi452 – 4587Combined sources
Turni459 – 4624Combined sources
Beta strandi463 – 4719Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1SMRX-ray2.00B/D/F/H30-33[»]
2WXZX-ray2.80A/C25-477[»]
2WY1X-ray3.15A/B25-477[»]
ProteinModelPortaliP01015.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01015.

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG4826.
GeneTreeiENSGT00750000117773.
HOGENOMiHOG000033941.
HOVERGENiHBG004233.
InParanoidiP01015.
KOiK09821.
OMAiRFMQAVT.
OrthoDBiEOG7QK0BN.
PhylomeDBiP01015.
TreeFamiTF343201.

Family and domain databases

InterProiIPR000227. Angiotensinogen.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
PRINTSiPR00654. ANGIOTENSNGN.
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01015-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTPTGAGLKA TIFCILTWVS LTAGDRVYIH PFHLLYYSKS TCAQLENPSV
60 70 80 90 100
ETLPEPTFEP VPIQAKTSPV DEKTLRDKLV LATEKLEAED RQRAAQVAMI
110 120 130 140 150
ANFMGFRMYK MLSEARGVAS GAVLSPPALF GTLVSFYLGS LDPTASQLQV
160 170 180 190 200
LLGVPVKEGD CTSRLDGHKV LTALQAVQGL LVTQGGSSSQ TPLLQSTVVG
210 220 230 240 250
LFTAPGLRLK QPFVESLGPF TPAIFPRSLD LSTDPVLAAQ KINRFVQAVT
260 270 280 290 300
GWKMNLPLEG VSTDSTLFFN TYVHFQGKMR GFSQLTGLHE FWVDNSTSVS
310 320 330 340 350
VPMLSGTGNF QHWSDAQNNF SVTRVPLGES VTLLLIQPQC ASDLDRVEVL
360 370 380 390 400
VFQHDFLTWI KNPPPRAIRL TLPQLEIRGS YNLQDLLAQA KLSTLLGAEA
410 420 430 440 450
NLGKMGDTNP RVGEVLNSIL LELQAGEEEQ PTESAQQPGS PEVLDVTLSS
460 470
PFLFAIYERD SGALHFLGRV DNPQNVV
Length:477
Mass (Da):51,982
Last modified:July 21, 1986 - v1
Checksum:i689051A5788D693D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L00094
, L00091, L00092, L00093 Genomic DNA. Translation: AAA98779.1.
BC078741 mRNA. Translation: AAH78741.1.
BC087679 mRNA. Translation: AAH87679.1.
PIRiA93945. ANRT.
RefSeqiNP_602308.1. NM_134432.2.
XP_008770819.1. XM_008772597.1.
UniGeneiRn.6319.

Genome annotation databases

EnsembliENSRNOT00000024917; ENSRNOP00000024917; ENSRNOG00000018445.
GeneIDi24179.
KEGGirno:24179.
UCSCiRGD:2069. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L00094
, L00091 , L00092 , L00093 Genomic DNA. Translation: AAA98779.1 .
BC078741 mRNA. Translation: AAH78741.1 .
BC087679 mRNA. Translation: AAH87679.1 .
PIRi A93945. ANRT.
RefSeqi NP_602308.1. NM_134432.2.
XP_008770819.1. XM_008772597.1.
UniGenei Rn.6319.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1SMR X-ray 2.00 B/D/F/H 30-33 [» ]
2WXZ X-ray 2.80 A/C 25-477 [» ]
2WY1 X-ray 3.15 A/B 25-477 [» ]
ProteinModelPortali P01015.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-1522474.
STRINGi 10116.ENSRNOP00000024917.

Chemistry

BindingDBi P01015.

Protein family/group databases

MEROPSi I04.953.

PTM databases

PhosphoSitei P01015.

Proteomic databases

PaxDbi P01015.
PRIDEi P01015.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000024917 ; ENSRNOP00000024917 ; ENSRNOG00000018445 .
GeneIDi 24179.
KEGGi rno:24179.
UCSCi RGD:2069. rat.

Organism-specific databases

CTDi 183.
RGDi 2069. Agt.

Phylogenomic databases

eggNOGi COG4826.
GeneTreei ENSGT00750000117773.
HOGENOMi HOG000033941.
HOVERGENi HBG004233.
InParanoidi P01015.
KOi K09821.
OMAi RFMQAVT.
OrthoDBi EOG7QK0BN.
PhylomeDBi P01015.
TreeFami TF343201.

Enzyme and pathway databases

Reactomei REACT_196408. PPARA activates gene expression.
REACT_198807. Metabolism of Angiotensinogen to Angiotensins.
REACT_233455. G alpha (i) signalling events.
REACT_250028. Peptide ligand-binding receptors.
REACT_263374. G alpha (q) signalling events.

Miscellaneous databases

EvolutionaryTracei P01015.
NextBioi 602521.
PROi P01015.

Gene expression databases

Genevestigatori P01015.

Family and domain databases

InterProi IPR000227. Angiotensinogen.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view ]
PANTHERi PTHR11461. PTHR11461. 1 hit.
Pfami PF00079. Serpin. 1 hit.
[Graphical view ]
PRINTSi PR00654. ANGIOTENSNGN.
SMARTi SM00093. SERPIN. 1 hit.
[Graphical view ]
SUPFAMi SSF56574. SSF56574. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
  2. "Common structural organization of the angiotensinogen and the alpha 1-antitrypsin genes."
    Tanaka T., Ohkubo H., Nakanishi S.
    J. Biol. Chem. 259:8063-8065(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Kidney.
  4. "Comparative studies on angiotensins. II. Structure of rat angiotensin and its identification by DNS-method."
    Nakayama T., Nakajima T., Sokabe H.
    Chem. Pharm. Bull. 20:1579-1581(1972) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 25-34.
  5. "The antithrombotic effect of angiotensin-(1-7) involves mas-mediated NO release from platelets."
    Fraga-Silva R.A., Pinheiro S.V.B., Goncalves A.C., Alenina N., Bader M., Santos R.A.S.
    Mol. Med. 14:28-35(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION OF ANGIOTENSIN 1-7.
  6. Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 25-477, DISULFIDE BOND.

Entry informationi

Entry nameiANGT_RAT
AccessioniPrimary (citable) accession number: P01015
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 26, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3