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P01008

- ANT3_HUMAN

UniProt

P01008 - ANT3_HUMAN

Protein

Antithrombin-III

Gene

SERPINC1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 194 (01 Oct 2014)
      Sequence version 1 (21 Jul 1986)
      Previous versions | rss
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    Functioni

    Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei81 – 811Heparin
    Binding sitei161 – 1611Heparin
    Binding sitei177 – 1771Heparin
    Sitei425 – 4262Reactive bond

    GO - Molecular functioni

    1. heparin binding Source: UniProtKB-KW
    2. protease binding Source: UniProtKB
    3. protein binding Source: UniProtKB
    4. serine-type endopeptidase inhibitor activity Source: UniProtKB

    GO - Biological processi

    1. blood coagulation Source: Reactome
    2. negative regulation of endopeptidase activity Source: RefGenome
    3. negative regulation of inflammatory response Source: Ensembl
    4. regulation of blood coagulation, intrinsic pathway Source: InterPro
    5. regulation of proteolysis Source: RefGenome
    6. response to nutrient Source: Ensembl

    Keywords - Molecular functioni

    Protease inhibitor, Serine protease inhibitor

    Keywords - Biological processi

    Blood coagulation, Hemostasis

    Keywords - Ligandi

    Heparin-binding

    Enzyme and pathway databases

    ReactomeiREACT_1439. Common Pathway.

    Protein family/group databases

    MEROPSiI04.018.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Antithrombin-III
    Short name:
    ATIII
    Alternative name(s):
    Serpin C1
    Gene namesi
    Name:SERPINC1
    Synonyms:AT3
    ORF Names:PRO0309
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:775. SERPINC1.

    Subcellular locationi

    GO - Cellular componenti

    1. blood microparticle Source: UniProt
    2. extracellular region Source: UniProtKB
    3. extracellular space Source: BHF-UCL
    4. extracellular vesicular exosome Source: UniProt
    5. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Involvement in diseasei

    Antithrombin III deficiency (AT3D) [MIM:613118]: An important risk factor for hereditary thrombophilia, a hemostatic disorder characterized by a tendency to recurrent thrombosis. Antithrombin-III deficiency is classified into 4 types. Type I: characterized by a 50% decrease in antigenic and functional levels. Type II: has defects affecting the thrombin-binding domain. Type III: alteration of the heparin-binding domain. Plasma AT-III antigen levels are normal in type II and III. Type IV: consists of miscellaneous group of unclassifiable mutations.36 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti17 – 171Y → S in AT3D; type-I. 1 Publication
    VAR_027450
    Natural varianti23 – 231L → P in AT3D; type-I; does not undergo post-translational glycosylation. 2 Publications
    VAR_012748
    Natural varianti32 – 321C → R in AT3D; type-I. 1 Publication
    VAR_027451
    Natural varianti39 – 391I → N in AT3D; type-II; Rouen-3; lack of heparin-binding properties. 1 Publication
    Corresponds to variant rs28929468 [ dbSNP | Ensembl ].
    VAR_007033
    Natural varianti56 – 561R → C in AT3D; type-II; Rouen-4; lack of heparin-binding properties. 2 Publications
    Corresponds to variant rs28929469 [ dbSNP | Ensembl ].
    VAR_007035
    Natural varianti73 – 731P → L in AT3D; type-II; Basel/Franconville/Clichy-1/Clichy-2/Dublin-2; lacks heparin-binding ability. 3 Publications
    Corresponds to variant rs121909551 [ dbSNP | Ensembl ].
    VAR_007036
    Natural varianti79 – 791R → C in AT3D; Tours/Alger/Amiens/Toyama/Paris-1/Paris-2/Padua-2/Barcelona-2/Kumamoto/Omura/Sasebo; lacks heparin-binding ability. 3 Publications
    VAR_007037
    Natural varianti79 – 791R → H in AT3D; type-II; Rouen-1/Padua-1/Bligny/Budapest-2; lack of heparin-binding properties. 2 Publications
    Corresponds to variant rs121909552 [ dbSNP | Ensembl ].
    VAR_007038
    Natural varianti79 – 791R → S in AT3D; type-II; Rouen-2; lack of heparin-binding properties. 1 Publication
    VAR_007039
    Natural varianti87 – 871Missing in AT3D; type-I. 1 Publication
    VAR_007040
    Natural varianti89 – 891R → C in AT3D; type-I. 1 Publication
    Corresponds to variant rs147266200 [ dbSNP | Ensembl ].
    VAR_007041
    Natural varianti90 – 901F → L in AT3D; type-I; Budapest-6. 1 Publication
    VAR_007042
    Natural varianti95 – 951Y → C in AT3D; type-I. 1 Publication
    VAR_027452
    Natural varianti95 – 951Y → S in AT3D; type-I. 2 Publications
    VAR_012316
    Natural varianti98 – 981L → P in AT3D; type-I. 1 Publication
    VAR_027453
    Natural varianti108 – 1092Missing in AT3D; type-I.
    VAR_007043
    Natural varianti112 – 1121P → T in AT3D; type-I. 2 Publications
    VAR_007044
    Natural varianti121 – 1211M → K in AT3D; type-I. 1 Publication
    VAR_027454
    Natural varianti127 – 1271C → R in AT3D; type-I. 1 Publication
    VAR_027455
    Natural varianti131 – 1311L → F in AT3D; type-II; Budapest-3/Budapest-7. 2 Publications
    VAR_007045
    Natural varianti131 – 1311L → V in AT3D; type-II; Southport. 2 Publications
    VAR_007046
    Natural varianti133 – 1331Q → K in AT3D; type I. 1 Publication
    VAR_007047
    Natural varianti138 – 1392Missing in AT3D; type-I. 1 Publication
    VAR_007048
    Natural varianti146 – 1461K → E in AT3D; Dreux; complete loss af heparin binding. 1 Publication
    VAR_027456
    Natural varianti148 – 1481S → P in AT3D; type-II; Nagasaki; defective heparin binding associated with thrombosis. 2 Publications
    VAR_007049
    Natural varianti150 – 1501Q → P in AT3D; type-II; Vienna. 2 Publications
    VAR_007050
    Natural varianti152 – 1543Missing in AT3D; type-I. 1 Publication
    VAR_012749
    Natural varianti152 – 1521H → Y in AT3D; type-I. 1 Publication
    VAR_007051
    Natural varianti153 – 1531Missing in AT3D; type-I.
    VAR_007052
    Natural varianti158 – 1581L → P in AT3D; type-I. 1 Publication
    VAR_007053
    Natural varianti160 – 1601C → Y in AT3D; type-I. 2 Publications
    VAR_027457
    Natural varianti161 – 1611R → Q in AT3D; type-II; Geneva. 2 Publications
    VAR_007054
    Natural varianti178 – 1781L → H in AT3D; type-I. 1 Publication
    VAR_027458
    Natural varianti179 – 1791F → L in AT3D; type-I. 1 Publication
    VAR_027459
    Natural varianti198 – 1981Y → C in AT3D; type-I and -II; Whitechapel. 1 Publication
    VAR_007056
    Natural varianti198 – 1981Y → H in AT3D; type-I. 2 Publications
    VAR_027460
    Natural varianti214 – 2141S → F in AT3D; type-I. 1 Publication
    VAR_027461
    Natural varianti214 – 2141S → Y in AT3D; type-I.
    VAR_007057
    Natural varianti218 – 2181Missing in AT3D; type-I. 1 Publication
    VAR_027462
    Natural varianti219 – 2191N → D in AT3D; type-II; Rouen-6; increases affinity for heparin. 2 Publications
    VAR_007059
    Natural varianti219 – 2191N → K in AT3D; type-II; Glasgow-3. 1 Publication
    VAR_007058
    Natural varianti223 – 2231S → P in AT3D; type-I. 2 Publications
    VAR_027463
    Natural varianti243 – 2431T → I in AT3D; type-I. 1 Publication
    VAR_027464
    Natural varianti251 – 2511I → T in AT3D; type-I. 1 Publication
    VAR_027465
    Natural varianti257 – 2571W → R in AT3D; type-I. 2 Publications
    VAR_027466
    Natural varianti261 – 2611F → L in AT3D. 1 Publication
    VAR_027467
    Natural varianti269 – 2691E → K in AT3D; type-II; Truro, increases affinity for heparin. 1 Publication
    VAR_007060
    Natural varianti273 – 30735Missing in AT3D; type-I. 1 Publication
    VAR_007061Add
    BLAST
    Natural varianti283 – 2831M → I in AT3D; type-II. 2 Publications
    VAR_007062
    Natural varianti283 – 2831M → V in AT3D; type-II. 1 Publication
    VAR_027468
    Natural varianti302 – 3021L → P in AT3D; type-I.
    VAR_007063
    Natural varianti316 – 3161I → N in AT3D; type-II; Haslar/Whitechapel. 1 Publication
    VAR_007064
    Natural varianti323 – 3231S → P in AT3D.
    VAR_027469
    Natural varianti334 – 3341E → K in AT3D; type-II. 1 Publication
    VAR_007065
    Natural varianti344 – 3441Missing in AT3D; type-I.
    VAR_007066
    Natural varianti381 – 3811S → P in AT3D; type-I.
    VAR_007067
    Natural varianti397 – 3971S → P in AT3D; type-I. 1 Publication
    VAR_027470
    Natural varianti398 – 3981D → H in AT3D; type-I. 1 Publication
    VAR_027471
    Natural varianti412 – 4121S → R in AT3D; type-I. 2 Publications
    VAR_027472
    Natural varianti414 – 4141A → T in AT3D; type-II; Hamilton/Glasgow-2; reduces interaction with thrombin by 90%. 3 Publications
    VAR_007069
    Natural varianti416 – 4161A → P in AT3D; type-II; Charleville/Sudbury/Vicenza/Cambridge-1. 1 Publication
    Corresponds to variant rs28930978 [ dbSNP | Ensembl ].
    VAR_007070
    Natural varianti416 – 4161A → S in AT3D; type-II; Cambridge-2. 2 Publications
    Corresponds to variant rs121909548 [ dbSNP | Ensembl ].
    VAR_007071
    Natural varianti419 – 4191A → V in AT3D; type-I. 1 Publication
    VAR_007072
    Natural varianti424 – 4241G → D in AT3D; type-II; Stockholm. 2 Publications
    VAR_007073
    Natural varianti425 – 4251R → C in AT3D; type-II; Northwick-Park/Milano-1/Frankfurt-1; deprived of inhibitory activity. 4 Publications
    Corresponds to variant rs121909554 [ dbSNP | Ensembl ].
    VAR_007075
    Natural varianti425 – 4251R → H in AT3D; type-II; Glasgow/Sheffield/Chicago/Avranches/Kumamoto-2; increases affinity for heparin; deprived of inhibitory activity. 5 Publications
    VAR_007074
    Natural varianti425 – 4251R → P in AT3D; type-II; Pescara; deprived of inhibitory of activity. 1 Publication
    VAR_007076
    Natural varianti426 – 4261S → L in AT3D; type-II; Denver/Milano-2; deprived of inhibitory activity. 3 Publications
    VAR_007077
    Natural varianti434 – 4341F → C in AT3D; type-II; Rosny. 1 Publication
    VAR_007078
    Natural varianti434 – 4341F → L in AT3D; type-II; Maisons-Laffite. 1 Publication
    VAR_007080
    Natural varianti434 – 4341F → S in AT3D; type-II; Torino. 1 Publication
    VAR_007079
    Natural varianti436 – 4361A → T in AT3D; type-II; Oslo/Paris-3. 1 Publication
    VAR_007081
    Natural varianti437 – 4371N → K in AT3D; type-II; La Rochelle. 1 Publication
    VAR_007082
    Natural varianti438 – 4381R → G in AT3D; type-II. 1 Publication
    VAR_009258
    Natural varianti438 – 4381R → M in AT3D; type-II; Kyoto. 2 Publications
    VAR_007083
    Natural varianti439 – 4391P → L in AT3D; type-II; Utah; deprived of inhibitory activity. 2 Publications
    VAR_007084
    Natural varianti439 – 4391P → T in AT3D; type-II; Budapest-5. 1 Publication
    VAR_007085
    Natural varianti441 – 4411L → P in AT3D; type-II. 1 Publication
    VAR_027473
    Natural varianti453 – 4531I → T in AT3D; type-I. 2 Publications
    VAR_007086
    Natural varianti456 – 4561G → R in AT3D; type-I. 2 Publications
    VAR_007087
    Natural varianti457 – 4571R → T in AT3D; type-II. 1 Publication
    VAR_007088
    Natural varianti459 – 4613Missing in AT3D; type-I.
    VAR_007089
    Natural varianti459 – 4591A → D in AT3D; type-I. 1 Publication
    VAR_007090
    Natural varianti461 – 4611P → L in AT3D; type-II; Budapest. 1 Publication
    VAR_007091
    Natural varianti462 – 4621C → F in AT3D; type-I. 2 Publications
    VAR_007092

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi414 – 4141A → K: Reduces interaction with thrombin by 99%. 1 Publication
    Mutagenesisi414 – 4141A → Q: Reduces interaction with thrombin by 80%. 1 Publication

    Keywords - Diseasei

    Disease mutation, Thrombophilia

    Organism-specific databases

    MIMi613118. phenotype.
    Orphaneti82. Hereditary thrombophilia due to congenital antithrombin deficiency.
    PharmGKBiPA35026.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 32321 PublicationAdd
    BLAST
    Chaini33 – 464432Antithrombin-IIIPRO_0000032489Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi40 ↔ 1601 Publication
    Disulfide bondi53 ↔ 1271 Publication
    Glycosylationi128 – 1281N-linked (GlcNAc...)4 Publications
    Glycosylationi167 – 1671N-linked (GlcNAc...)1 Publication
    Glycosylationi187 – 1871N-linked (GlcNAc...) (complex)6 Publications
    Glycosylationi224 – 2241N-linked (GlcNAc...)3 Publications
    Disulfide bondi279 ↔ 4621 Publication

    Post-translational modificationi

    Phosphorylation sites are present in the extracellular medium.

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiP01008.
    PaxDbiP01008.
    PRIDEiP01008.

    2D gel databases

    DOSAC-COBS-2DPAGEP01008.
    REPRODUCTION-2DPAGEP01008.
    SWISS-2DPAGEP01008.

    PTM databases

    PhosphoSiteiP01008.

    Miscellaneous databases

    PMAP-CutDBP01008.

    Expressioni

    Tissue specificityi

    Found in plasma.

    Gene expression databases

    ArrayExpressiP01008.
    BgeeiP01008.
    CleanExiHS_SERPINC1.
    GenevestigatoriP01008.

    Organism-specific databases

    HPAiCAB016790.
    HPA001816.
    HPA024007.

    Interactioni

    Subunit structurei

    Forms protease inhibiting heterodimer with TMPRSS7.

    Protein-protein interaction databases

    BioGridi106953. 1 interaction.
    DIPiDIP-38009N.
    IntActiP01008. 3 interactions.

    Structurei

    Secondary structure

    1
    464
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi39 – 413
    Turni44 – 463
    Beta strandi51 – 533
    Helixi78 – 10124
    Beta strandi104 – 1063
    Beta strandi108 – 1103
    Helixi112 – 12312
    Helixi128 – 13710
    Helixi140 – 1423
    Helixi145 – 1495
    Helixi151 – 16616
    Turni167 – 1693
    Beta strandi170 – 18112
    Beta strandi184 – 1863
    Helixi188 – 19811
    Beta strandi203 – 2053
    Helixi207 – 22519
    Turni226 – 2283
    Beta strandi236 – 2394
    Beta strandi240 – 2423
    Beta strandi245 – 25511
    Beta strandi257 – 2593
    Helixi263 – 2653
    Beta strandi267 – 2726
    Beta strandi274 – 2763
    Beta strandi278 – 29417
    Helixi296 – 2983
    Beta strandi300 – 3067
    Beta strandi309 – 3179
    Beta strandi320 – 3223
    Helixi324 – 3296
    Helixi333 – 34210
    Beta strandi344 – 35310
    Beta strandi355 – 3628
    Helixi364 – 3696
    Helixi374 – 3763
    Turni378 – 3803
    Turni384 – 3863
    Beta strandi389 – 3924
    Beta strandi398 – 40710
    Beta strandi409 – 4135
    Beta strandi419 – 4224
    Beta strandi423 – 4264
    Beta strandi432 – 4354
    Beta strandi440 – 4467
    Turni447 – 4504
    Beta strandi451 – 4599

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1ANTX-ray3.00I/L33-464[»]
    1ATHX-ray3.20A/B33-464[»]
    1AZXX-ray2.90I/L33-464[»]
    1BR8X-ray2.90I/L33-464[»]
    1DZGX-ray2.80I/L33-464[»]
    1DZHX-ray2.85I/L33-464[»]
    1E03X-ray2.90I/L33-464[»]
    1E04X-ray2.60I/L33-464[»]
    1E05X-ray2.62I/L33-464[»]
    1JVQX-ray2.60I/L33-464[»]
    1LK6X-ray2.80I/L33-464[»]
    1NQ9X-ray2.60I/L33-464[»]
    1OYHX-ray2.62I/L33-464[»]
    1R1LX-ray2.70I/L33-464[»]
    1SR5X-ray3.10A33-464[»]
    1T1FX-ray2.75A/B/C33-464[»]
    1TB6X-ray2.50I33-464[»]
    2ANTX-ray2.60I/L33-464[»]
    2B4XX-ray2.80I/L37-463[»]
    2B5TX-ray2.10I33-464[»]
    2BEHX-ray2.70I/L33-464[»]
    2GD4X-ray3.30C/I22-464[»]
    2HIJX-ray2.90I/L33-464[»]
    2ZNHX-ray2.80A/B33-464[»]
    3EVJX-ray3.00I/L33-464[»]
    3KCGX-ray1.70I33-464[»]
    4EB1X-ray2.80I/L33-464[»]
    ProteinModelPortaliP01008.
    SMRiP01008. Positions 37-463.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP01008.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the serpin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG4826.
    HOVERGENiHBG005957.
    InParanoidiP01008.
    KOiK03911.
    OMAiKADGESC.
    OrthoDBiEOG7327PB.
    PhylomeDBiP01008.
    TreeFamiTF343094.

    Family and domain databases

    InterProiIPR015555. AT-III.
    IPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view]
    PANTHERiPTHR11461. PTHR11461. 1 hit.
    PTHR11461:SF53. PTHR11461:SF53. 1 hit.
    PfamiPF00079. Serpin. 1 hit.
    [Graphical view]
    SMARTiSM00093. SERPIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF56574. SSF56574. 1 hit.
    PROSITEiPS00284. SERPIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P01008-1 [UniParc]FASTAAdd to Basket

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    MYSNVIGTVT SGKRKVYLLS LLLIGFWDCV TCHGSPVDIC TAKPRDIPMN    50
    PMCIYRSPEK KATEDEGSEQ KIPEATNRRV WELSKANSRF ATTFYQHLAD 100
    SKNDNDNIFL SPLSISTAFA MTKLGACNDT LQQLMEVFKF DTISEKTSDQ 150
    IHFFFAKLNC RLYRKANKSS KLVSANRLFG DKSLTFNETY QDISELVYGA 200
    KLQPLDFKEN AEQSRAAINK WVSNKTEGRI TDVIPSEAIN ELTVLVLVNT 250
    IYFKGLWKSK FSPENTRKEL FYKADGESCS ASMMYQEGKF RYRRVAEGTQ 300
    VLELPFKGDD ITMVLILPKP EKSLAKVEKE LTPEVLQEWL DELEEMMLVV 350
    HMPRFRIEDG FSLKEQLQDM GLVDLFSPEK SKLPGIVAEG RDDLYVSDAF 400
    HKAFLEVNEE GSEAAASTAV VIAGRSLNPN RVTFKANRPF LVFIREVPLN 450
    TIIFMGRVAN PCVK 464
    Length:464
    Mass (Da):52,602
    Last modified:July 21, 1986 - v1
    Checksum:i9A4E324F00683D9D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti69 – 702EQ → QE AA sequence 1 PublicationCurated
    Sequence conflicti77 – 771N → NN in BAA06212. 1 PublicationCurated
    Sequence conflicti97 – 971H → R in AAG35525. 1 PublicationCurated
    Sequence conflicti120 – 1201A → T in BAG35537. (PubMed:14702039)Curated
    Sequence conflicti226 – 2261T → A in BAG35537. (PubMed:14702039)Curated
    Sequence conflicti247 – 2493Missing AA sequence 1 PublicationCurated
    Sequence conflicti388 – 3881Missing AA sequence (PubMed:7734359)Curated
    Sequence conflicti395 – 3951Y → YA AA sequence (PubMed:7734359)Curated

    Mass spectrometryi

    Molecular mass is 57863 Da from positions 33 - 464. Determined by ESI. 1 Publication
    Molecular mass is 57911 Da from positions 33 - 464. Determined by ESI. Variant Thr-414.1 Publication

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti17 – 171Y → S in AT3D; type-I. 1 Publication
    VAR_027450
    Natural varianti23 – 231L → P in AT3D; type-I; does not undergo post-translational glycosylation. 2 Publications
    VAR_012748
    Natural varianti30 – 301V → E in Dublin. 3 Publications
    Corresponds to variant rs2227624 [ dbSNP | Ensembl ].
    VAR_007032
    Natural varianti32 – 321C → R in AT3D; type-I. 1 Publication
    VAR_027451
    Natural varianti39 – 391I → N in AT3D; type-II; Rouen-3; lack of heparin-binding properties. 1 Publication
    Corresponds to variant rs28929468 [ dbSNP | Ensembl ].
    VAR_007033
    Natural varianti52 – 521M → T Previously Whitechapel. 1 Publication
    VAR_007034
    Natural varianti56 – 561R → C in AT3D; type-II; Rouen-4; lack of heparin-binding properties. 2 Publications
    Corresponds to variant rs28929469 [ dbSNP | Ensembl ].
    VAR_007035
    Natural varianti73 – 731P → L in AT3D; type-II; Basel/Franconville/Clichy-1/Clichy-2/Dublin-2; lacks heparin-binding ability. 3 Publications
    Corresponds to variant rs121909551 [ dbSNP | Ensembl ].
    VAR_007036
    Natural varianti79 – 791R → C in AT3D; Tours/Alger/Amiens/Toyama/Paris-1/Paris-2/Padua-2/Barcelona-2/Kumamoto/Omura/Sasebo; lacks heparin-binding ability. 3 Publications
    VAR_007037
    Natural varianti79 – 791R → H in AT3D; type-II; Rouen-1/Padua-1/Bligny/Budapest-2; lack of heparin-binding properties. 2 Publications
    Corresponds to variant rs121909552 [ dbSNP | Ensembl ].
    VAR_007038
    Natural varianti79 – 791R → S in AT3D; type-II; Rouen-2; lack of heparin-binding properties. 1 Publication
    VAR_007039
    Natural varianti87 – 871Missing in AT3D; type-I. 1 Publication
    VAR_007040
    Natural varianti89 – 891R → C in AT3D; type-I. 1 Publication
    Corresponds to variant rs147266200 [ dbSNP | Ensembl ].
    VAR_007041
    Natural varianti90 – 901F → L in AT3D; type-I; Budapest-6. 1 Publication
    VAR_007042
    Natural varianti95 – 951Y → C in AT3D; type-I. 1 Publication
    VAR_027452
    Natural varianti95 – 951Y → S in AT3D; type-I. 2 Publications
    VAR_012316
    Natural varianti98 – 981L → P in AT3D; type-I. 1 Publication
    VAR_027453
    Natural varianti108 – 1092Missing in AT3D; type-I.
    VAR_007043
    Natural varianti112 – 1121P → T in AT3D; type-I. 2 Publications
    VAR_007044
    Natural varianti121 – 1211M → K in AT3D; type-I. 1 Publication
    VAR_027454
    Natural varianti127 – 1271C → R in AT3D; type-I. 1 Publication
    VAR_027455
    Natural varianti131 – 1311L → F in AT3D; type-II; Budapest-3/Budapest-7. 2 Publications
    VAR_007045
    Natural varianti131 – 1311L → V in AT3D; type-II; Southport. 2 Publications
    VAR_007046
    Natural varianti133 – 1331Q → K in AT3D; type I. 1 Publication
    VAR_007047
    Natural varianti138 – 1392Missing in AT3D; type-I. 1 Publication
    VAR_007048
    Natural varianti146 – 1461K → E in AT3D; Dreux; complete loss af heparin binding. 1 Publication
    VAR_027456
    Natural varianti147 – 1471T → A.1 Publication
    Corresponds to variant rs2227606 [ dbSNP | Ensembl ].
    VAR_013085
    Natural varianti148 – 1481S → P in AT3D; type-II; Nagasaki; defective heparin binding associated with thrombosis. 2 Publications
    VAR_007049
    Natural varianti150 – 1501Q → P in AT3D; type-II; Vienna. 2 Publications
    VAR_007050
    Natural varianti152 – 1543Missing in AT3D; type-I. 1 Publication
    VAR_012749
    Natural varianti152 – 1521H → Y in AT3D; type-I. 1 Publication
    VAR_007051
    Natural varianti153 – 1531Missing in AT3D; type-I.
    VAR_007052
    Natural varianti158 – 1581L → P in AT3D; type-I. 1 Publication
    VAR_007053
    Natural varianti160 – 1601C → Y in AT3D; type-I. 2 Publications
    VAR_027457
    Natural varianti161 – 1611R → Q in AT3D; type-II; Geneva. 2 Publications
    VAR_007054
    Natural varianti167 – 1671N → T.1 Publication
    VAR_012750
    Natural varianti178 – 1781L → H in AT3D; type-I. 1 Publication
    VAR_027458
    Natural varianti179 – 1791F → L in AT3D; type-I. 1 Publication
    VAR_027459
    Natural varianti190 – 1901Y → C Polymorphism in population of Scandinavian origin. 2 Publications
    VAR_007055
    Natural varianti198 – 1981Y → C in AT3D; type-I and -II; Whitechapel. 1 Publication
    VAR_007056
    Natural varianti198 – 1981Y → H in AT3D; type-I. 2 Publications
    VAR_027460
    Natural varianti214 – 2141S → F in AT3D; type-I. 1 Publication
    VAR_027461
    Natural varianti214 – 2141S → Y in AT3D; type-I.
    VAR_007057
    Natural varianti218 – 2181Missing in AT3D; type-I. 1 Publication
    VAR_027462
    Natural varianti219 – 2191N → D in AT3D; type-II; Rouen-6; increases affinity for heparin. 2 Publications
    VAR_007059
    Natural varianti219 – 2191N → K in AT3D; type-II; Glasgow-3. 1 Publication
    VAR_007058
    Natural varianti223 – 2231S → P in AT3D; type-I. 2 Publications
    VAR_027463
    Natural varianti243 – 2431T → I in AT3D; type-I. 1 Publication
    VAR_027464
    Natural varianti251 – 2511I → T in AT3D; type-I. 1 Publication
    VAR_027465
    Natural varianti257 – 2571W → R in AT3D; type-I. 2 Publications
    VAR_027466
    Natural varianti261 – 2611F → L in AT3D. 1 Publication
    VAR_027467
    Natural varianti269 – 2691E → K in AT3D; type-II; Truro, increases affinity for heparin. 1 Publication
    VAR_007060
    Natural varianti273 – 30735Missing in AT3D; type-I. 1 Publication
    VAR_007061Add
    BLAST
    Natural varianti283 – 2831M → I in AT3D; type-II. 2 Publications
    VAR_007062
    Natural varianti283 – 2831M → V in AT3D; type-II. 1 Publication
    VAR_027468
    Natural varianti302 – 3021L → P in AT3D; type-I.
    VAR_007063
    Natural varianti316 – 3161I → N in AT3D; type-II; Haslar/Whitechapel. 1 Publication
    VAR_007064
    Natural varianti323 – 3231S → P in AT3D.
    VAR_027469
    Natural varianti334 – 3341E → K in AT3D; type-II. 1 Publication
    VAR_007065
    Natural varianti344 – 3441Missing in AT3D; type-I.
    VAR_007066
    Natural varianti381 – 3811S → P in AT3D; type-I.
    VAR_007067
    Natural varianti391 – 3911R → Q.
    VAR_007068
    Natural varianti397 – 3971S → P in AT3D; type-I. 1 Publication
    VAR_027470
    Natural varianti398 – 3981D → H in AT3D; type-I. 1 Publication
    VAR_027471
    Natural varianti412 – 4121S → R in AT3D; type-I. 2 Publications
    VAR_027472
    Natural varianti414 – 4141A → T in AT3D; type-II; Hamilton/Glasgow-2; reduces interaction with thrombin by 90%. 3 Publications
    VAR_007069
    Natural varianti416 – 4161A → P in AT3D; type-II; Charleville/Sudbury/Vicenza/Cambridge-1. 1 Publication
    Corresponds to variant rs28930978 [ dbSNP | Ensembl ].
    VAR_007070
    Natural varianti416 – 4161A → S in AT3D; type-II; Cambridge-2. 2 Publications
    Corresponds to variant rs121909548 [ dbSNP | Ensembl ].
    VAR_007071
    Natural varianti419 – 4191A → V in AT3D; type-I. 1 Publication
    VAR_007072
    Natural varianti424 – 4241G → D in AT3D; type-II; Stockholm. 2 Publications
    VAR_007073
    Natural varianti425 – 4251R → C in AT3D; type-II; Northwick-Park/Milano-1/Frankfurt-1; deprived of inhibitory activity. 4 Publications
    Corresponds to variant rs121909554 [ dbSNP | Ensembl ].
    VAR_007075
    Natural varianti425 – 4251R → H in AT3D; type-II; Glasgow/Sheffield/Chicago/Avranches/Kumamoto-2; increases affinity for heparin; deprived of inhibitory activity. 5 Publications
    VAR_007074
    Natural varianti425 – 4251R → P in AT3D; type-II; Pescara; deprived of inhibitory of activity. 1 Publication
    VAR_007076
    Natural varianti426 – 4261S → L in AT3D; type-II; Denver/Milano-2; deprived of inhibitory activity. 3 Publications
    VAR_007077
    Natural varianti434 – 4341F → C in AT3D; type-II; Rosny. 1 Publication
    VAR_007078
    Natural varianti434 – 4341F → L in AT3D; type-II; Maisons-Laffite. 1 Publication
    VAR_007080
    Natural varianti434 – 4341F → S in AT3D; type-II; Torino. 1 Publication
    VAR_007079
    Natural varianti436 – 4361A → T in AT3D; type-II; Oslo/Paris-3. 1 Publication
    VAR_007081
    Natural varianti437 – 4371N → K in AT3D; type-II; La Rochelle. 1 Publication
    VAR_007082
    Natural varianti438 – 4381R → G in AT3D; type-II. 1 Publication
    VAR_009258
    Natural varianti438 – 4381R → M in AT3D; type-II; Kyoto. 2 Publications
    VAR_007083
    Natural varianti439 – 4391P → L in AT3D; type-II; Utah; deprived of inhibitory activity. 2 Publications
    VAR_007084
    Natural varianti439 – 4391P → T in AT3D; type-II; Budapest-5. 1 Publication
    VAR_007085
    Natural varianti441 – 4411L → P in AT3D; type-II. 1 Publication
    VAR_027473
    Natural varianti453 – 4531I → T in AT3D; type-I. 2 Publications
    VAR_007086
    Natural varianti456 – 4561G → R in AT3D; type-I. 2 Publications
    VAR_007087
    Natural varianti457 – 4571R → T in AT3D; type-II. 1 Publication
    VAR_007088
    Natural varianti459 – 4613Missing in AT3D; type-I.
    VAR_007089
    Natural varianti459 – 4591A → D in AT3D; type-I. 1 Publication
    VAR_007090
    Natural varianti461 – 4611P → L in AT3D; type-II; Budapest. 1 Publication