Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Antithrombin-III

Gene

SERPINC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei81Heparin1
Binding sitei161Heparin1
Binding sitei177Heparin1
Sitei425 – 426Reactive bond2

GO - Molecular functioni

  • heparin binding Source: UniProtKB-KW
  • protease binding Source: UniProtKB
  • serine-type endopeptidase inhibitor activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Keywords - Biological processi

Blood coagulation, Hemostasis

Keywords - Ligandi

Heparin-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000117601-MONOMER.
ReactomeiR-HSA-140837. Intrinsic Pathway of Fibrin Clot Formation.
R-HSA-140875. Common Pathway of Fibrin Clot Formation.
SIGNORiP01008.

Protein family/group databases

MEROPSiI04.018.

Names & Taxonomyi

Protein namesi
Recommended name:
Antithrombin-III
Short name:
ATIII
Alternative name(s):
Serpin C1
Gene namesi
Name:SERPINC1
Synonyms:AT3
ORF Names:PRO0309
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:775. SERPINC1.

Subcellular locationi

GO - Cellular componenti

  • blood microparticle Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • extracellular region Source: UniProtKB
  • extracellular space Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Antithrombin III deficiency (AT3D)37 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn important risk factor for hereditary thrombophilia, a hemostatic disorder characterized by a tendency to recurrent thrombosis. Antithrombin-III deficiency is classified into 4 types. Type I: characterized by a 50% decrease in antigenic and functional levels. Type II: has defects affecting the thrombin-binding domain. Type III: alteration of the heparin-binding domain. Plasma AT-III antigen levels are normal in type II and III. Type IV: consists of miscellaneous group of unclassifiable mutations.
See also OMIM:613118
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02745017Y → S in AT3D; type-I. 1 Publication1
Natural variantiVAR_01274823L → P in AT3D; type-I; does not undergo post-translational glycosylation. 2 PublicationsCorresponds to variant rs387906575dbSNPEnsembl.1
Natural variantiVAR_02745132C → R in AT3D; type-I. 1 Publication1
Natural variantiVAR_00703339I → N in AT3D; type-II; Rouen-3; lack of heparin-binding properties. 1 PublicationCorresponds to variant rs28929468dbSNPEnsembl.1
Natural variantiVAR_07119953C → F in AT3D. 1 Publication1
Natural variantiVAR_00703556R → C in AT3D; type-II; Rouen-4; lack of heparin-binding properties. 2 PublicationsCorresponds to variant rs28929469dbSNPEnsembl.1
Natural variantiVAR_00703673P → L in AT3D; type-II; lacks heparin-binding ability. 4 PublicationsCorresponds to variant rs121909551dbSNPEnsembl.1
Natural variantiVAR_00703779R → C in AT3D; Tours/Alger/Amiens/Toyama/Paris-1/Paris-2/Padua-2/Barcelona-2/Kumamoto/Omura/Sasebo; lacks heparin-binding ability. 3 PublicationsCorresponds to variant rs121909547dbSNPEnsembl.1
Natural variantiVAR_00703879R → H in AT3D; type-II; Rouen-1/Padua-1/Bligny/Budapest-2; lack of heparin-binding properties. 2 PublicationsCorresponds to variant rs121909552dbSNPEnsembl.1
Natural variantiVAR_00703979R → S in AT3D; type-II; Rouen-2; lack of heparin-binding properties. 1 PublicationCorresponds to variant rs121909547dbSNPEnsembl.1
Natural variantiVAR_00704087Missing in AT3D; type-I. 1 Publication1
Natural variantiVAR_00704189R → C in AT3D; type-I. 1 PublicationCorresponds to variant rs147266200dbSNPEnsembl.1
Natural variantiVAR_00704290F → L in AT3D; type-I; Budapest-6. 1 Publication1
Natural variantiVAR_02745295Y → C in AT3D; type-I. 1 Publication1
Natural variantiVAR_01231695Y → S in AT3D; type-I. 2 Publications1
Natural variantiVAR_02745398L → P in AT3D; type-I. 1 Publication1
Natural variantiVAR_007043108 – 109Missing in AT3D; type-I. 2
Natural variantiVAR_007044112P → T in AT3D; type-I. 2 Publications1
Natural variantiVAR_027454121M → K in AT3D; type-I. 1 Publication1
Natural variantiVAR_071200125G → D in AT3D. 1 Publication1
Natural variantiVAR_027455127C → R in AT3D; type-I. 1 PublicationCorresponds to variant rs121909573dbSNPEnsembl.1
Natural variantiVAR_007045131L → F in AT3D; type-II; Budapest-3/Budapest-7. 2 PublicationsCorresponds to variant rs121909567dbSNPEnsembl.1
Natural variantiVAR_007046131L → V in AT3D; type-II; Southport. 2 Publications1
Natural variantiVAR_007047133Q → K in AT3D; type I. 1 Publication1
Natural variantiVAR_007048138 – 139Missing in AT3D; type-I. 1 Publication2
Natural variantiVAR_027456146K → E in AT3D; Dreux; complete loss af heparin binding. 1 Publication1
Natural variantiVAR_007049148S → P in AT3D; type-II; Nagasaki; defective heparin binding associated with thrombosis. 2 PublicationsCorresponds to variant rs121909569dbSNPEnsembl.1
Natural variantiVAR_007050150Q → P in AT3D; type-II; Vienna. 2 PublicationsCorresponds to variant rs765445413dbSNPEnsembl.1
Natural variantiVAR_012749152 – 154Missing in AT3D; type-I. 1 Publication3
Natural variantiVAR_007051152H → Y in AT3D; type-I. 1 Publication1
Natural variantiVAR_007052153Missing in AT3D; type-I. 1
Natural variantiVAR_007053158L → P in AT3D; type-I. 1 Publication1
Natural variantiVAR_027457160C → Y in AT3D; type-I. 2 Publications1
Natural variantiVAR_007054161R → Q in AT3D; type-II; Geneva. 2 PublicationsCorresponds to variant rs121909563dbSNPEnsembl.1
Natural variantiVAR_071201170S → P in AT3D. 1 Publication1
Natural variantiVAR_027458178L → H in AT3D; type-I. 1 Publication1
Natural variantiVAR_027459179F → L in AT3D; type-I. 1 Publication1
Natural variantiVAR_007056198Y → C in AT3D; type-I and -II; Whitechapel. 1 Publication1
Natural variantiVAR_027460198Y → H in AT3D; type-I. 2 Publications1
Natural variantiVAR_027461214S → F in AT3D; type-I. 1 Publication1
Natural variantiVAR_007057214S → Y in AT3D; type-I. Corresponds to variant rs483352854dbSNPEnsembl.1
Natural variantiVAR_071202218I → N in AT3D. 1 Publication1
Natural variantiVAR_027462218Missing in AT3D; type-I. 1 Publication1
Natural variantiVAR_007059219N → D in AT3D; type-II; Rouen-6; increases affinity for heparin. 2 PublicationsCorresponds to variant rs121909571dbSNPEnsembl.1
Natural variantiVAR_007058219N → K in AT3D; type-II; Glasgow-3. 1 Publication1
Natural variantiVAR_027463223S → P in AT3D; type-I. 2 PublicationsCorresponds to variant rs121909572dbSNPEnsembl.1
Natural variantiVAR_027464243T → I in AT3D; type-I. 1 Publication1
Natural variantiVAR_071203248V → G in AT3D. 1 Publication1
Natural variantiVAR_027465251I → T in AT3D; type-I. 1 Publication1
Natural variantiVAR_027466257W → R in AT3D; type-I. 2 Publications1
Natural variantiVAR_027467261F → L in AT3D. 1 Publication1
Natural variantiVAR_007060269E → K in AT3D; type-II; Truro; increases affinity for heparin. 1 PublicationCorresponds to variant rs758087836dbSNPEnsembl.1
Natural variantiVAR_007061273 – 307Missing in AT3D; type-I. 1 PublicationAdd BLAST35
Natural variantiVAR_007062283M → I in AT3D; type-II. 2 Publications1
Natural variantiVAR_027468283M → V in AT3D; type-II. 1 Publication1
Natural variantiVAR_071204293R → P in AT3D. 1 Publication1
Natural variantiVAR_007063302L → P in AT3D; type-I. 1
Natural variantiVAR_007064316I → N in AT3D; type-II; Haslar/Whitechapel. 1 Publication1
Natural variantiVAR_027469323S → P in AT3D. 1
Natural variantiVAR_007065334E → K in AT3D; type-II. 1 Publication1
Natural variantiVAR_007066344Missing in AT3D; type-I. 1
Natural variantiVAR_007067381S → P in AT3D; type-I. Corresponds to variant rs121909565dbSNPEnsembl.1
Natural variantiVAR_027470397S → P in AT3D; type-I. 1 Publication1
Natural variantiVAR_027471398D → H in AT3D; type-I. 1 Publication1
Natural variantiVAR_071205401H → R in AT3D. 1 Publication1
Natural variantiVAR_027472412S → R in AT3D; type-I. 2 Publications1
Natural variantiVAR_007069414A → T in AT3D; type-II; Hamilton/Glasgow-2; reduces interaction with thrombin by 90%. 4 PublicationsCorresponds to variant rs121909557dbSNPEnsembl.1
Natural variantiVAR_007070416A → P in AT3D; type-II; Charleville/Sudbury/Vicenza/Cambridge-1. 1 PublicationCorresponds to variant rs28930978dbSNPEnsembl.1
Natural variantiVAR_007071416A → S in AT3D; type-II; Cambridge-2. 2 PublicationsCorresponds to variant rs121909548dbSNPEnsembl.1
Natural variantiVAR_007072419A → V in AT3D; type-I. 1 PublicationCorresponds to variant rs121909568dbSNPEnsembl.1
Natural variantiVAR_007073424G → D in AT3D; type-II; Stockholm. 2 PublicationsCorresponds to variant rs121909566dbSNPEnsembl.1
Natural variantiVAR_007075425R → C in AT3D; type-II. 5 PublicationsCorresponds to variant rs121909554dbSNPEnsembl.1
Natural variantiVAR_007074425R → H in AT3D; type-II; Glasgow/Sheffield/Chicago/Avranches/Kumamoto-2; increases affinity for heparin; deprived of inhibitory activity. 5 PublicationsCorresponds to variant rs121909549dbSNPEnsembl.1
Natural variantiVAR_007076425R → P in AT3D; type-II; Pescara; deprived of inhibitory of activity. 1 PublicationCorresponds to variant rs121909549dbSNPEnsembl.1
Natural variantiVAR_007077426S → L in AT3D; type-II; Denver/Milano-2; deprived of inhibitory activity. 3 PublicationsCorresponds to variant rs121909550dbSNPEnsembl.1
Natural variantiVAR_007078434F → C in AT3D; type-II; Rosny. 1 Publication1
Natural variantiVAR_007080434F → L in AT3D; type-II; Maisons-Laffite. 1 Publication1
Natural variantiVAR_007079434F → S in AT3D; type-II; Torino. 1 Publication1
Natural variantiVAR_007081436A → T in AT3D; type-II; Oslo/Paris-3. 1 PublicationCorresponds to variant rs121909546dbSNPEnsembl.1
Natural variantiVAR_007082437N → K in AT3D; type-II; La Rochelle. 1 Publication1
Natural variantiVAR_009258438R → G in AT3D; type I and type-II. 2 Publications1
Natural variantiVAR_007083438R → M in AT3D; type-II; Kyoto. 2 Publications1
Natural variantiVAR_071206439P → A in AT3D. 1 Publication1
Natural variantiVAR_007084439P → L in AT3D; type-II; Utah; deprived of inhibitory activity. 2 PublicationsCorresponds to variant rs121909555dbSNPEnsembl.1
Natural variantiVAR_007085439P → T in AT3D; type-II; Budapest-5. 1 Publication1
Natural variantiVAR_027473441L → P in AT3D; type-II. 1 Publication1
Natural variantiVAR_007086453I → T in AT3D; type-I. 2 Publications1
Natural variantiVAR_007087456G → R in AT3D; type-I. 2 Publications1
Natural variantiVAR_007088457R → T in AT3D; type-II. 1 Publication1
Natural variantiVAR_007089459 – 461Missing in AT3D; type-I. 3
Natural variantiVAR_007090459A → D in AT3D; type-I. 1 Publication1
Natural variantiVAR_007091461P → L in AT3D; type-II; Budapest. 1 PublicationCorresponds to variant rs121909564dbSNPEnsembl.1
Natural variantiVAR_007092462C → F in AT3D; type-I. 2 Publications1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi414A → K: Reduces interaction with thrombin by 99%. 1 Publication1
Mutagenesisi414A → Q: Reduces interaction with thrombin by 80%. 1 Publication1

Keywords - Diseasei

Disease mutation, Thrombophilia

Organism-specific databases

DisGeNETi462.
MalaCardsiSERPINC1.
MIMi613118. phenotype.
OpenTargetsiENSG00000117601.
Orphaneti82. Hereditary thrombophilia due to congenital antithrombin deficiency.
PharmGKBiPA35026.

Chemistry databases

ChEMBLiCHEMBL1950.
DrugBankiDB00407. Ardeparin.
DB06779. Dalteparin.
DB01225. Enoxaparin.
DB00569. Fondaparinux sodium.
DB01109. Heparin.
DB08813. Nadroparin.
DB06271. Sulodexide.
DB06822. Tinzaparin.
GuidetoPHARMACOLOGYi2632.

Polymorphism and mutation databases

BioMutaiSERPINC1.
DMDMi113936.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 321 PublicationAdd BLAST32
ChainiPRO_000003248933 – 464Antithrombin-IIIAdd BLAST432

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi40 ↔ 1601 Publication
Disulfide bondi53 ↔ 1271 Publication
Modified residuei63Phosphothreonine; by FAM20C1 Publication1
Modified residuei68Phosphoserine; by FAM20CCombined sources1 Publication1
Glycosylationi128N-linked (GlcNAc...)4 Publications1
Glycosylationi167N-linked (GlcNAc...)1 Publication1
Glycosylationi187N-linked (GlcNAc...) (complex)6 Publications1
Glycosylationi224N-linked (GlcNAc...)3 Publications1
Disulfide bondi279 ↔ 4621 Publication

Post-translational modificationi

Phosphorylated by FAM20C in the extracellular medium.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP01008.
MaxQBiP01008.
PaxDbiP01008.
PeptideAtlasiP01008.
PRIDEiP01008.

2D gel databases

DOSAC-COBS-2DPAGEP01008.
REPRODUCTION-2DPAGEP01008.
SWISS-2DPAGEP01008.

PTM databases

iPTMnetiP01008.
PhosphoSitePlusiP01008.
UniCarbKBiP01008.

Miscellaneous databases

PMAP-CutDBP01008.

Expressioni

Tissue specificityi

Found in plasma.

Gene expression databases

BgeeiENSG00000117601.
CleanExiHS_SERPINC1.
ExpressionAtlasiP01008. baseline and differential.
GenevisibleiP01008. HS.

Organism-specific databases

HPAiCAB016790.
HPA001816.
HPA024007.

Interactioni

Subunit structurei

Forms protease inhibiting heterodimer with TMPRSS7.

GO - Molecular functioni

  • protease binding Source: UniProtKB

Protein-protein interaction databases

BioGridi106953. 11 interactors.
DIPiDIP-38009N.
IntActiP01008. 3 interactors.
STRINGi9606.ENSP00000356671.

Chemistry databases

BindingDBiP01008.

Structurei

Secondary structure

1464
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi39 – 41Combined sources3
Turni44 – 46Combined sources3
Beta strandi51 – 53Combined sources3
Helixi78 – 101Combined sources24
Beta strandi104 – 106Combined sources3
Beta strandi108 – 110Combined sources3
Helixi112 – 123Combined sources12
Helixi128 – 137Combined sources10
Helixi140 – 142Combined sources3
Helixi145 – 149Combined sources5
Helixi151 – 166Combined sources16
Turni167 – 169Combined sources3
Beta strandi170 – 181Combined sources12
Beta strandi184 – 186Combined sources3
Helixi188 – 198Combined sources11
Beta strandi203 – 205Combined sources3
Helixi207 – 225Combined sources19
Turni226 – 228Combined sources3
Beta strandi236 – 239Combined sources4
Beta strandi240 – 242Combined sources3
Beta strandi245 – 255Combined sources11
Beta strandi257 – 259Combined sources3
Helixi263 – 265Combined sources3
Beta strandi267 – 272Combined sources6
Beta strandi274 – 276Combined sources3
Beta strandi278 – 294Combined sources17
Helixi296 – 298Combined sources3
Beta strandi300 – 306Combined sources7
Beta strandi309 – 317Combined sources9
Beta strandi320 – 322Combined sources3
Helixi324 – 329Combined sources6
Helixi333 – 342Combined sources10
Beta strandi344 – 353Combined sources10
Beta strandi355 – 362Combined sources8
Helixi364 – 369Combined sources6
Helixi374 – 376Combined sources3
Turni378 – 380Combined sources3
Turni384 – 386Combined sources3
Beta strandi389 – 392Combined sources4
Beta strandi398 – 407Combined sources10
Beta strandi409 – 413Combined sources5
Beta strandi419 – 422Combined sources4
Beta strandi423 – 426Combined sources4
Beta strandi432 – 435Combined sources4
Beta strandi440 – 446Combined sources7
Turni447 – 450Combined sources4
Beta strandi451 – 459Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ANTX-ray3.00I/L33-464[»]
1ATHX-ray3.20A/B33-464[»]
1AZXX-ray2.90I/L33-464[»]
1BR8X-ray2.90I/L33-464[»]
1DZGX-ray2.80I/L33-464[»]
1DZHX-ray2.85I/L33-464[»]
1E03X-ray2.90I/L33-464[»]
1E04X-ray2.60I/L33-464[»]
1E05X-ray2.62I/L33-464[»]
1JVQX-ray2.60I/L33-464[»]
1LK6X-ray2.80I/L33-464[»]
1NQ9X-ray2.60I/L33-464[»]
1OYHX-ray2.62I/L33-464[»]
1R1LX-ray2.70I/L33-464[»]
1SR5X-ray3.10A33-464[»]
1T1FX-ray2.75A/B/C33-464[»]
1TB6X-ray2.50I33-464[»]
2ANTX-ray2.60I/L33-464[»]
2B4XX-ray2.80I/L37-463[»]
2B5TX-ray2.10I33-464[»]
2BEHX-ray2.70I/L33-464[»]
2GD4X-ray3.30C/I22-464[»]
2HIJX-ray2.90I/L33-464[»]
2ZNHX-ray2.80A/B33-464[»]
3EVJX-ray3.00I/L33-464[»]
3KCGX-ray1.70I33-464[»]
4EB1X-ray2.80I/L33-464[»]
ProteinModelPortaliP01008.
SMRiP01008.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01008.

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2392. Eukaryota.
COG4826. LUCA.
GeneTreeiENSGT00760000118789.
HOVERGENiHBG005957.
InParanoidiP01008.
KOiK03911.
OMAiACDNTLK.
OrthoDBiEOG091G0ION.
PhylomeDBiP01008.
TreeFamiTF343094.

Family and domain databases

CDDicd02045. antithrombin-III_like. 1 hit.
InterProiIPR033829. Antithrombin_domain.
IPR015555. AT-III.
IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PTHR11461:SF53. PTHR11461:SF53. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01008-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYSNVIGTVT SGKRKVYLLS LLLIGFWDCV TCHGSPVDIC TAKPRDIPMN
60 70 80 90 100
PMCIYRSPEK KATEDEGSEQ KIPEATNRRV WELSKANSRF ATTFYQHLAD
110 120 130 140 150
SKNDNDNIFL SPLSISTAFA MTKLGACNDT LQQLMEVFKF DTISEKTSDQ
160 170 180 190 200
IHFFFAKLNC RLYRKANKSS KLVSANRLFG DKSLTFNETY QDISELVYGA
210 220 230 240 250
KLQPLDFKEN AEQSRAAINK WVSNKTEGRI TDVIPSEAIN ELTVLVLVNT
260 270 280 290 300
IYFKGLWKSK FSPENTRKEL FYKADGESCS ASMMYQEGKF RYRRVAEGTQ
310 320 330 340 350
VLELPFKGDD ITMVLILPKP EKSLAKVEKE LTPEVLQEWL DELEEMMLVV
360 370 380 390 400
HMPRFRIEDG FSLKEQLQDM GLVDLFSPEK SKLPGIVAEG RDDLYVSDAF
410 420 430 440 450
HKAFLEVNEE GSEAAASTAV VIAGRSLNPN RVTFKANRPF LVFIREVPLN
460
TIIFMGRVAN PCVK
Length:464
Mass (Da):52,602
Last modified:July 21, 1986 - v1
Checksum:i9A4E324F00683D9D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti69 – 70EQ → QE AA sequence (Ref. 10) Curated2
Sequence conflicti77N → NN in BAA06212 (Ref. 3) Curated1
Sequence conflicti97H → R in AAG35525 (Ref. 5) Curated1
Sequence conflicti120A → T in BAG35537 (PubMed:14702039).Curated1
Sequence conflicti226T → A in BAG35537 (PubMed:14702039).Curated1
Sequence conflicti247 – 249Missing AA sequence (Ref. 10) Curated3
Sequence conflicti388Missing AA sequence (PubMed:7734359).Curated1
Sequence conflicti395Y → YA AA sequence (PubMed:7734359).Curated1

Mass spectrometryi

Molecular mass is 57863 Da from positions 33 - 464. Determined by ESI. 1 Publication
Molecular mass is 57911 Da from positions 33 - 464. Determined by ESI. Variant Thr-414.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02745017Y → S in AT3D; type-I. 1 Publication1
Natural variantiVAR_01274823L → P in AT3D; type-I; does not undergo post-translational glycosylation. 2 PublicationsCorresponds to variant rs387906575dbSNPEnsembl.1
Natural variantiVAR_00703230V → E in Dublin. 4 PublicationsCorresponds to variant rs2227624dbSNPEnsembl.1
Natural variantiVAR_02745132C → R in AT3D; type-I. 1 Publication1
Natural variantiVAR_00703339I → N in AT3D; type-II; Rouen-3; lack of heparin-binding properties. 1 PublicationCorresponds to variant rs28929468dbSNPEnsembl.1
Natural variantiVAR_00703452M → T Previously Whitechapel. 1 Publication1
Natural variantiVAR_07119953C → F in AT3D. 1 Publication1
Natural variantiVAR_00703556R → C in AT3D; type-II; Rouen-4; lack of heparin-binding properties. 2 PublicationsCorresponds to variant rs28929469dbSNPEnsembl.1
Natural variantiVAR_00703673P → L in AT3D; type-II; lacks heparin-binding ability. 4 PublicationsCorresponds to variant rs121909551dbSNPEnsembl.1
Natural variantiVAR_00703779R → C in AT3D; Tours/Alger/Amiens/Toyama/Paris-1/Paris-2/Padua-2/Barcelona-2/Kumamoto/Omura/Sasebo; lacks heparin-binding ability. 3 PublicationsCorresponds to variant rs121909547dbSNPEnsembl.1
Natural variantiVAR_00703879R → H in AT3D; type-II; Rouen-1/Padua-1/Bligny/Budapest-2; lack of heparin-binding properties. 2 PublicationsCorresponds to variant rs121909552dbSNPEnsembl.1
Natural variantiVAR_00703979R → S in AT3D; type-II; Rouen-2; lack of heparin-binding properties. 1 PublicationCorresponds to variant rs121909547dbSNPEnsembl.1
Natural variantiVAR_00704087Missing in AT3D; type-I. 1 Publication1
Natural variantiVAR_00704189R → C in AT3D; type-I. 1 PublicationCorresponds to variant rs147266200dbSNPEnsembl.1
Natural variantiVAR_00704290F → L in AT3D; type-I; Budapest-6. 1 Publication1
Natural variantiVAR_02745295Y → C in AT3D; type-I. 1 Publication1
Natural variantiVAR_01231695Y → S in AT3D; type-I. 2 Publications1
Natural variantiVAR_02745398L → P in AT3D; type-I. 1 Publication1
Natural variantiVAR_007043108 – 109Missing in AT3D; type-I. 2
Natural variantiVAR_007044112P → T in AT3D; type-I. 2 Publications1
Natural variantiVAR_027454121M → K in AT3D; type-I. 1 Publication1
Natural variantiVAR_071200125G → D in AT3D. 1 Publication1
Natural variantiVAR_027455127C → R in AT3D; type-I. 1 PublicationCorresponds to variant rs121909573dbSNPEnsembl.1
Natural variantiVAR_007045131L → F in AT3D; type-II; Budapest-3/Budapest-7. 2 PublicationsCorresponds to variant rs121909567dbSNPEnsembl.1
Natural variantiVAR_007046131L → V in AT3D; type-II; Southport. 2 Publications1
Natural variantiVAR_007047133Q → K in AT3D; type I. 1 Publication1
Natural variantiVAR_007048138 – 139Missing in AT3D; type-I. 1 Publication2
Natural variantiVAR_027456146K → E in AT3D; Dreux; complete loss af heparin binding. 1 Publication1
Natural variantiVAR_013085147T → A.1 PublicationCorresponds to variant rs2227606dbSNPEnsembl.1
Natural variantiVAR_007049148S → P in AT3D; type-II; Nagasaki; defective heparin binding associated with thrombosis. 2 PublicationsCorresponds to variant rs121909569dbSNPEnsembl.1
Natural variantiVAR_007050150Q → P in AT3D; type-II; Vienna. 2 PublicationsCorresponds to variant rs765445413dbSNPEnsembl.1
Natural variantiVAR_012749152 – 154Missing in AT3D; type-I. 1 Publication3
Natural variantiVAR_007051152H → Y in AT3D; type-I. 1 Publication1
Natural variantiVAR_007052153Missing in AT3D; type-I. 1
Natural variantiVAR_007053158L → P in AT3D; type-I. 1 Publication1
Natural variantiVAR_027457160C → Y in AT3D; type-I. 2 Publications1
Natural variantiVAR_007054161R → Q in AT3D; type-II; Geneva. 2 PublicationsCorresponds to variant rs121909563dbSNPEnsembl.1
Natural variantiVAR_012750167N → T.1 PublicationCorresponds to variant rs121909570dbSNPEnsembl.1
Natural variantiVAR_071201170S → P in AT3D. 1 Publication1
Natural variantiVAR_027458178L → H in AT3D; type-I. 1 Publication1
Natural variantiVAR_027459179F → L in AT3D; type-I. 1 Publication1
Natural variantiVAR_007055190Y → C Polymorphism in population of Scandinavian origin. 2 Publications1
Natural variantiVAR_007056198Y → C in AT3D; type-I and -II; Whitechapel. 1 Publication1
Natural variantiVAR_027460198Y → H in AT3D; type-I. 2 Publications1
Natural variantiVAR_027461214S → F in AT3D; type-I. 1 Publication1
Natural variantiVAR_007057214S → Y in AT3D; type-I. Corresponds to variant rs483352854dbSNPEnsembl.1
Natural variantiVAR_071202218I → N in AT3D. 1 Publication1
Natural variantiVAR_027462218Missing in AT3D; type-I. 1 Publication1
Natural variantiVAR_007059219N → D in AT3D; type-II; Rouen-6; increases affinity for heparin. 2 PublicationsCorresponds to variant rs121909571dbSNPEnsembl.1
Natural variantiVAR_007058219N → K in AT3D; type-II; Glasgow-3. 1 Publication1
Natural variantiVAR_027463223S → P in AT3D; type-I. 2 PublicationsCorresponds to variant rs121909572dbSNPEnsembl.1
Natural variantiVAR_027464243T → I in AT3D; type-I. 1 Publication1
Natural variantiVAR_071203248V → G in AT3D. 1 Publication1
Natural variantiVAR_027465251I → T in AT3D; type-I. 1 Publication1
Natural variantiVAR_027466257W → R in AT3D; type-I. 2 Publications1
Natural variantiVAR_027467261F → L in AT3D. 1 Publication1
Natural variantiVAR_007060269E → K in AT3D; type-II; Truro; increases affinity for heparin. 1 PublicationCorresponds to variant rs758087836dbSNPEnsembl.1
Natural variantiVAR_007061273 – 307Missing in AT3D; type-I. 1 PublicationAdd BLAST35
Natural variantiVAR_007062283M → I in AT3D; type-II. 2 Publications1
Natural variantiVAR_027468283M → V in AT3D; type-II. 1 Publication1
Natural variantiVAR_071204293R → P in AT3D. 1 Publication1
Natural variantiVAR_007063302L → P in AT3D; type-I. 1
Natural variantiVAR_007064316I → N in AT3D; type-II; Haslar/Whitechapel. 1 Publication1
Natural variantiVAR_027469323S → P in AT3D. 1
Natural variantiVAR_007065334E → K in AT3D; type-II. 1 Publication1
Natural variantiVAR_007066344Missing in AT3D; type-I. 1
Natural variantiVAR_007067381S → P in AT3D; type-I. Corresponds to variant rs121909565dbSNPEnsembl.1
Natural variantiVAR_007068391R → Q.Corresponds to variant rs201541724dbSNPEnsembl.1
Natural variantiVAR_027470397S → P in AT3D; type-I. 1 Publication1
Natural variantiVAR_027471398D → H in AT3D; type-I. 1 Publication1
Natural variantiVAR_071205401H → R in AT3D. 1 Publication1
Natural variantiVAR_027472412S → R in AT3D; type-I. 2 Publications1
Natural variantiVAR_007069414A → T in AT3D; type-II; Hamilton/Glasgow-2; reduces interaction with thrombin by 90%. 4 PublicationsCorresponds to variant rs121909557dbSNPEnsembl.1
Natural variantiVAR_007070416A → P in AT3D; type-II; Charleville/Sudbury/Vicenza/Cambridge-1. 1 Publication