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P01005

- IOVO_CHICK

UniProt

P01005 - IOVO_CHICK

Protein

Ovomucoid

Gene
N/A
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 1 (21 Jul 1986)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei48 – 492Reactive bond 1 for endoproteinase Lys-C
    Sitei113 – 1142Reactive bond 2 for trypsin
    Sitei172 – 1732Reactive bond 3

    GO - Molecular functioni

    1. IgE binding Source: AgBase
    2. IgG binding Source: AgBase
    3. serine-type endopeptidase inhibitor activity Source: AgBase

    GO - Biological processi

    1. negative regulation of endopeptidase activity Source: GOC

    Keywords - Molecular functioni

    Protease inhibitor, Serine protease inhibitor

    Protein family/group databases

    MEROPSiI01.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ovomucoid
    Alternative name(s):
    Allergen Gal d I
    Allergen: Gal d 1
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Chromosome 13

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell
    2. protein complex Source: AgBase

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Allergenic propertiesi

    Causes an allergic reaction in human.

    Keywords - Diseasei

    Allergen

    Protein family/group databases

    Allergomei3291. Gal d 1.0101.
    359. Gal d 1.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 24241 PublicationAdd
    BLAST
    Chaini25 – 210186OvomucoidPRO_0000016579Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi29 ↔ 68
    Glycosylationi34 – 341N-linked (GlcNAc...)
    Disulfide bondi46 ↔ 65
    Disulfide bondi54 ↔ 86
    Glycosylationi77 – 771N-linked (GlcNAc...)1 Publication
    Glycosylationi93 – 931N-linked (GlcNAc...)
    Disulfide bondi94 ↔ 133
    Glycosylationi99 – 991N-linked (GlcNAc...)
    Disulfide bondi111 ↔ 130
    Disulfide bondi119 ↔ 151
    Disulfide bondi162 ↔ 192
    Disulfide bondi170 ↔ 189
    Disulfide bondi178 ↔ 210
    Glycosylationi199 – 1991N-linked (GlcNAc...); partial1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP01005.
    PRIDEiP01005.

    PTM databases

    UniCarbKBiP01005.

    Expressioni

    Gene expression databases

    ArrayExpressiP01005.

    Structurei

    3D structure databases

    ProteinModelPortaliP01005.
    SMRiP01005. Positions 27-86.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini25 – 8864Kazal-like 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini89 – 15365Kazal-like 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini156 – 21055Kazal-like 3PROSITE-ProRule annotationAdd
    BLAST

    Domaini

    Avian ovomucoid consists of three homologous, tandem Kazal family inhibitory domains.

    Sequence similaritiesi

    Contains 3 Kazal-like domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG265458.
    GeneTreeiENSGT00510000048608.
    HOGENOMiHOG000113088.
    HOVERGENiHBG006172.
    InParanoidiP01005.
    OMAiCNFCNAV.
    PhylomeDBiP01005.
    TreeFamiTF352550.

    Family and domain databases

    InterProiIPR002350. Kazal_dom.
    [Graphical view]
    PfamiPF00050. Kazal_1. 3 hits.
    [Graphical view]
    SMARTiSM00280. KAZAL. 3 hits.
    [Graphical view]
    PROSITEiPS00282. KAZAL_1. 3 hits.
    PS51465. KAZAL_2. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P01005-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAMAGVFVLF SFVLCGFLPD AAFGAEVDCS RFPNATDKEG KDVLVCNKDL    50
    RPICGTDGVT YTNDCLLCAY SIEFGTNISK EHDGECKETV PMNCSSYANT 100
    TSEDGKVMVL CNRAFNPVCG TDGVTYDNEC LLCAHKVEQG ASVDKRHDGG 150
    CRKELAAVSV DCSEYPKPDC TAEDRPLCGS DNKTYGNKCN FCNAVVESNG 200
    TLTLSHFGKC 210
    Length:210
    Mass (Da):22,591
    Last modified:July 21, 1986 - v1
    Checksum:i8BE9516B6D38ACF9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti62 – 621T → N AA sequence (PubMed:3548816)Curated
    Sequence conflicti64 – 641D → E AA sequence (PubMed:3548816)Curated
    Sequence conflicti108 – 1081M → T AA sequence (PubMed:3548816)Curated
    Sequence conflicti150 – 1501G → E AA sequence (PubMed:3548816)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti158 – 1592Missing Due to an ambiguous intron excision.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J00902 mRNA. No translation available.
    PIRiA92754. TICHM.
    UniGeneiGga.5085.
    Gga.51528.

    Genome annotation databases

    EnsembliENSGALT00000005554; ENSGALP00000005544; ENSGALG00000003512.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J00902 mRNA. No translation available.
    PIRi A92754. TICHM.
    UniGenei Gga.5085.
    Gga.51528.

    3D structure databases

    ProteinModelPortali P01005.
    SMRi P01005. Positions 27-86.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    Allergomei 3291. Gal d 1.0101.
    359. Gal d 1.
    MEROPSi I01.001.

    PTM databases

    UniCarbKBi P01005.

    Proteomic databases

    PaxDbi P01005.
    PRIDEi P01005.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSGALT00000005554 ; ENSGALP00000005544 ; ENSGALG00000003512 .

    Phylogenomic databases

    eggNOGi NOG265458.
    GeneTreei ENSGT00510000048608.
    HOGENOMi HOG000113088.
    HOVERGENi HBG006172.
    InParanoidi P01005.
    OMAi CNFCNAV.
    PhylomeDBi P01005.
    TreeFami TF352550.

    Gene expression databases

    ArrayExpressi P01005.

    Family and domain databases

    InterProi IPR002350. Kazal_dom.
    [Graphical view ]
    Pfami PF00050. Kazal_1. 3 hits.
    [Graphical view ]
    SMARTi SM00280. KAZAL. 3 hits.
    [Graphical view ]
    PROSITEi PS00282. KAZAL_1. 3 hits.
    PS51465. KAZAL_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Primary sequence of ovomucoid messenger RNA as determined from cloned complementary DNA."
      Catterall J.F., Stein J.P., Kristo P., Means A.R., O'Malley B.W.
      J. Cell Biol. 87:480-487(1980) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Chicken ovomucoid: determination of its amino acid sequence, determination of the trypsin reactive site, and preparation of all three of its domains."
      Kato I., Schrode J., Kohr W.J., Laskowski M. Jr.
      Biochemistry 26:193-201(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 25-210.
    3. "Precursor of egg white ovomucoid. Amino acid sequence of an NH2-terminal extension."
      Thibodeau S.N., Palmiter R.D., Walsh K.A.
      J. Biol. Chem. 253:9018-9023(1978) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 1-44.
    4. "A new strategy for identification of N-glycosylated proteins and unambiguous assignment of their glycosylation sites using HILIC enrichment and partial deglycosylation."
      Hagglund P., Bunkenborg J., Elortza F., Jensen O.N., Roepstorff P.
      J. Proteome Res. 3:556-566(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION AT ASN-77 AND ASN-199, IDENTIFICATION BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiIOVO_CHICK
    AccessioniPrimary (citable) accession number: P01005
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 119 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Allergens
      Nomenclature of allergens and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3