Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P01005 (IOVO_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 118. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ovomucoid
Alternative name(s):
Allergen Gal d I
Allergen=Gal d 1
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length210 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Secreted.

Domain

Avian ovomucoid consists of three homologous, tandem Kazal family inhibitory domains.

Allergenic properties

Causes an allergic reaction in human.

Sequence similarities

Contains 3 Kazal-like domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Ref.2
Chain25 – 210186Ovomucoid
PRO_0000016579

Regions

Domain25 – 8864Kazal-like 1
Domain89 – 15365Kazal-like 2
Domain156 – 21055Kazal-like 3

Sites

Site48 – 492Reactive bond 1 for endoproteinase Lys-C
Site113 – 1142Reactive bond 2 for trypsin
Site172 – 1732Reactive bond 3

Amino acid modifications

Glycosylation341N-linked (GlcNAc...)
Glycosylation771N-linked (GlcNAc...) Ref.4
Glycosylation931N-linked (GlcNAc...)
Glycosylation991N-linked (GlcNAc...)
Glycosylation1991N-linked (GlcNAc...); partial Ref.4
Disulfide bond29 ↔ 68
Disulfide bond46 ↔ 65
Disulfide bond54 ↔ 86
Disulfide bond94 ↔ 133
Disulfide bond111 ↔ 130
Disulfide bond119 ↔ 151
Disulfide bond162 ↔ 192
Disulfide bond170 ↔ 189
Disulfide bond178 ↔ 210

Natural variations

Natural variant158 – 1592Missing Due to an ambiguous intron excision.

Experimental info

Sequence conflict621T → N AA sequence Ref.2
Sequence conflict641D → E AA sequence Ref.2
Sequence conflict1081M → T AA sequence Ref.2
Sequence conflict1501G → E AA sequence Ref.2

Sequences

Sequence LengthMass (Da)Tools
P01005 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: 8BE9516B6D38ACF9

FASTA21022,591
        10         20         30         40         50         60 
MAMAGVFVLF SFVLCGFLPD AAFGAEVDCS RFPNATDKEG KDVLVCNKDL RPICGTDGVT 

        70         80         90        100        110        120 
YTNDCLLCAY SIEFGTNISK EHDGECKETV PMNCSSYANT TSEDGKVMVL CNRAFNPVCG 

       130        140        150        160        170        180 
TDGVTYDNEC LLCAHKVEQG ASVDKRHDGG CRKELAAVSV DCSEYPKPDC TAEDRPLCGS 

       190        200        210 
DNKTYGNKCN FCNAVVESNG TLTLSHFGKC 

« Hide

References

[1]"Primary sequence of ovomucoid messenger RNA as determined from cloned complementary DNA."
Catterall J.F., Stein J.P., Kristo P., Means A.R., O'Malley B.W.
J. Cell Biol. 87:480-487(1980) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Chicken ovomucoid: determination of its amino acid sequence, determination of the trypsin reactive site, and preparation of all three of its domains."
Kato I., Schrode J., Kohr W.J., Laskowski M. Jr.
Biochemistry 26:193-201(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 25-210.
[3]"Precursor of egg white ovomucoid. Amino acid sequence of an NH2-terminal extension."
Thibodeau S.N., Palmiter R.D., Walsh K.A.
J. Biol. Chem. 253:9018-9023(1978) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 1-44.
[4]"A new strategy for identification of N-glycosylated proteins and unambiguous assignment of their glycosylation sites using HILIC enrichment and partial deglycosylation."
Hagglund P., Bunkenborg J., Elortza F., Jensen O.N., Roepstorff P.
J. Proteome Res. 3:556-566(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION AT ASN-77 AND ASN-199, IDENTIFICATION BY MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J00902 mRNA. No translation available.
PIRTICHM. A92754.
UniGeneGga.5085.
Gga.51528.

3D structure databases

ProteinModelPortalP01005.
SMRP01005. Positions 27-86.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

Allergome3291. Gal d 1.0101.
359. Gal d 1.
MEROPSI01.001.

PTM databases

UniCarbKBP01005.

Proteomic databases

PaxDbP01005.
PRIDEP01005.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSGALT00000005554; ENSGALP00000005544; ENSGALG00000003512.

Phylogenomic databases

eggNOGNOG265458.
GeneTreeENSGT00510000048608.
HOGENOMHOG000113088.
HOVERGENHBG006172.
InParanoidP01005.
OMACNFCNAV.
PhylomeDBP01005.
TreeFamTF352550.

Gene expression databases

ArrayExpressP01005.

Family and domain databases

InterProIPR002350. Kazal_dom.
[Graphical view]
PfamPF00050. Kazal_1. 3 hits.
[Graphical view]
SMARTSM00280. KAZAL. 3 hits.
[Graphical view]
PROSITEPS00282. KAZAL_1. 3 hits.
PS51465. KAZAL_2. 3 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIOVO_CHICK
AccessionPrimary (citable) accession number: P01005
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: May 14, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Allergens

Nomenclature of allergens and list of entries