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P01005

- IOVO_CHICK

UniProt

P01005 - IOVO_CHICK

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Protein

Ovomucoid

Gene
N/A
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei48 – 492Reactive bond 1 for endoproteinase Lys-C
Sitei113 – 1142Reactive bond 2 for trypsin
Sitei172 – 1732Reactive bond 3

GO - Molecular functioni

  1. IgE binding Source: AgBase
  2. IgG binding Source: AgBase
  3. serine-type endopeptidase inhibitor activity Source: AgBase

GO - Biological processi

  1. negative regulation of endopeptidase activity Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI01.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Ovomucoid
Alternative name(s):
Allergen Gal d I
Allergen: Gal d 1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Chromosome 13

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
  2. protein complex Source: AgBase
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3291. Gal d 1.0101.
359. Gal d 1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 24241 PublicationAdd
BLAST
Chaini25 – 210186OvomucoidPRO_0000016579Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi29 ↔ 68
Glycosylationi34 – 341N-linked (GlcNAc...)
Disulfide bondi46 ↔ 65
Disulfide bondi54 ↔ 86
Glycosylationi77 – 771N-linked (GlcNAc...)1 Publication
Glycosylationi93 – 931N-linked (GlcNAc...)
Disulfide bondi94 ↔ 133
Glycosylationi99 – 991N-linked (GlcNAc...)
Disulfide bondi111 ↔ 130
Disulfide bondi119 ↔ 151
Disulfide bondi162 ↔ 192
Disulfide bondi170 ↔ 189
Disulfide bondi178 ↔ 210
Glycosylationi199 – 1991N-linked (GlcNAc...); partial1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP01005.
PRIDEiP01005.

PTM databases

UniCarbKBiP01005.

Expressioni

Gene expression databases

ExpressionAtlasiP01005. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliP01005.
SMRiP01005. Positions 27-86.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 8864Kazal-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini89 – 15365Kazal-like 2PROSITE-ProRule annotationAdd
BLAST
Domaini156 – 21055Kazal-like 3PROSITE-ProRule annotationAdd
BLAST

Domaini

Avian ovomucoid consists of three homologous, tandem Kazal family inhibitory domains.

Sequence similaritiesi

Contains 3 Kazal-like domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG265458.
GeneTreeiENSGT00510000048608.
HOGENOMiHOG000113088.
HOVERGENiHBG006172.
InParanoidiP01005.
OMAiCNFCNAV.
PhylomeDBiP01005.
TreeFamiTF352550.

Family and domain databases

InterProiIPR002350. Kazal_dom.
[Graphical view]
PfamiPF00050. Kazal_1. 3 hits.
[Graphical view]
SMARTiSM00280. KAZAL. 3 hits.
[Graphical view]
PROSITEiPS00282. KAZAL_1. 3 hits.
PS51465. KAZAL_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01005-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAMAGVFVLF SFVLCGFLPD AAFGAEVDCS RFPNATDKEG KDVLVCNKDL
60 70 80 90 100
RPICGTDGVT YTNDCLLCAY SIEFGTNISK EHDGECKETV PMNCSSYANT
110 120 130 140 150
TSEDGKVMVL CNRAFNPVCG TDGVTYDNEC LLCAHKVEQG ASVDKRHDGG
160 170 180 190 200
CRKELAAVSV DCSEYPKPDC TAEDRPLCGS DNKTYGNKCN FCNAVVESNG
210
TLTLSHFGKC
Length:210
Mass (Da):22,591
Last modified:July 21, 1986 - v1
Checksum:i8BE9516B6D38ACF9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti62 – 621T → N AA sequence (PubMed:3548816)Curated
Sequence conflicti64 – 641D → E AA sequence (PubMed:3548816)Curated
Sequence conflicti108 – 1081M → T AA sequence (PubMed:3548816)Curated
Sequence conflicti150 – 1501G → E AA sequence (PubMed:3548816)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti158 – 1592Missing Due to an ambiguous intron excision.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00902 mRNA. No translation available.
PIRiA92754. TICHM.
UniGeneiGga.5085.
Gga.51528.

Genome annotation databases

EnsembliENSGALT00000005554; ENSGALP00000005544; ENSGALG00000003512.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00902 mRNA. No translation available.
PIRi A92754. TICHM.
UniGenei Gga.5085.
Gga.51528.

3D structure databases

ProteinModelPortali P01005.
SMRi P01005. Positions 27-86.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

Allergomei 3291. Gal d 1.0101.
359. Gal d 1.
MEROPSi I01.001.

PTM databases

UniCarbKBi P01005.

Proteomic databases

PaxDbi P01005.
PRIDEi P01005.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSGALT00000005554 ; ENSGALP00000005544 ; ENSGALG00000003512 .

Phylogenomic databases

eggNOGi NOG265458.
GeneTreei ENSGT00510000048608.
HOGENOMi HOG000113088.
HOVERGENi HBG006172.
InParanoidi P01005.
OMAi CNFCNAV.
PhylomeDBi P01005.
TreeFami TF352550.

Gene expression databases

ExpressionAtlasi P01005. baseline and differential.

Family and domain databases

InterProi IPR002350. Kazal_dom.
[Graphical view ]
Pfami PF00050. Kazal_1. 3 hits.
[Graphical view ]
SMARTi SM00280. KAZAL. 3 hits.
[Graphical view ]
PROSITEi PS00282. KAZAL_1. 3 hits.
PS51465. KAZAL_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Primary sequence of ovomucoid messenger RNA as determined from cloned complementary DNA."
    Catterall J.F., Stein J.P., Kristo P., Means A.R., O'Malley B.W.
    J. Cell Biol. 87:480-487(1980) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Chicken ovomucoid: determination of its amino acid sequence, determination of the trypsin reactive site, and preparation of all three of its domains."
    Kato I., Schrode J., Kohr W.J., Laskowski M. Jr.
    Biochemistry 26:193-201(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 25-210.
  3. "Precursor of egg white ovomucoid. Amino acid sequence of an NH2-terminal extension."
    Thibodeau S.N., Palmiter R.D., Walsh K.A.
    J. Biol. Chem. 253:9018-9023(1978) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-44.
  4. "A new strategy for identification of N-glycosylated proteins and unambiguous assignment of their glycosylation sites using HILIC enrichment and partial deglycosylation."
    Hagglund P., Bunkenborg J., Elortza F., Jensen O.N., Roepstorff P.
    J. Proteome Res. 3:556-566(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION AT ASN-77 AND ASN-199, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiIOVO_CHICK
AccessioniPrimary (citable) accession number: P01005
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 26, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3