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Protein

Ovomucoid

Gene
N/A
Organism
Coturnix coturnix japonica (Japanese quail) (Coturnix japonica)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei89 – 902Reactive bond 2 for trypsin
Sitei148 – 1492Reactive bond 3 for trypsin

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI01.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Ovomucoid
OrganismiCoturnix coturnix japonica (Japanese quail) (Coturnix japonica)
Taxonomic identifieri93934 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePerdicinaeCoturnix

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 186186OvomucoidPRO_0000073087Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi5 ↔ 44
Glycosylationi10 – 101N-linked (GlcNAc...)
Disulfide bondi22 ↔ 41
Disulfide bondi30 ↔ 62
Glycosylationi53 – 531N-linked (GlcNAc...)
Disulfide bondi70 ↔ 109
Glycosylationi75 – 751N-linked (GlcNAc...)
Disulfide bondi87 ↔ 106
Disulfide bondi95 ↔ 127
Disulfide bondi138 ↔ 168
Disulfide bondi146 ↔ 165
Disulfide bondi154 ↔ 186
Glycosylationi175 – 1751N-linked (GlcNAc...)

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

Secondary structure

1
186
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi134 – 1363Combined sources
Beta strandi153 – 1553Combined sources
Beta strandi160 – 1634Combined sources
Helixi164 – 17310Combined sources
Turni174 – 1763Combined sources
Beta strandi180 – 1845Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OVOX-ray1.90A/B/C/D131-186[»]
3OVOX-ray1.55A131-186[»]
ProteinModelPortaliP01003.
SMRiP01003. Positions 131-186.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01003.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 6464Kazal-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini65 – 12965Kazal-like 2PROSITE-ProRule annotationAdd
BLAST
Domaini132 – 18655Kazal-like 3PROSITE-ProRule annotationAdd
BLAST

Domaini

Avian ovomucoid consists of three homologous, tandem Kazal family inhibitory domains. The first domain does not inhibit any tested protease. Domains 2 and 3 inhibit trypsin.

Sequence similaritiesi

Contains 3 Kazal-like domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

HOVERGENiHBG006172.

Family and domain databases

InterProiIPR002350. Kazal_dom.
IPR001239. Prot_inh_Kazal-m.
[Graphical view]
PfamiPF00050. Kazal_1. 3 hits.
[Graphical view]
PRINTSiPR00290. KAZALINHBTR.
SMARTiSM00280. KAZAL. 3 hits.
[Graphical view]
PROSITEiPS00282. KAZAL_1. 3 hits.
PS51465. KAZAL_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P01003-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
VEVDCSRFPN TTNEEGKDEV VCPDELRLIC GTDGVTYNHE CMLCFYNKEY
60 70 80 90 100
GTNISKEQDG ECGETVPMDC SRYPNTTSED GKVTILCTKD FSFVCGTDGV
110 120 130 140 150
TYDNECMLCA HNVVQGTSVG KKHDGECRKE LAAVSVDCSE YPKPACPKDY
160 170 180
RPVCGSDNKT YSNKCNFCNA VVESNGTLTL NHFGKC
Length:186
Mass (Da):20,477
Last modified:July 21, 1986 - v1
Checksum:iF2B25AE1A185A72E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti162 – 1621S → G.1 Publication

Sequence databases

PIRiB94430. TIQJM.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

PIRiB94430. TIQJM.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OVOX-ray1.90A/B/C/D131-186[»]
3OVOX-ray1.55A131-186[»]
ProteinModelPortaliP01003.
SMRiP01003. Positions 131-186.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiI01.001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG006172.

Miscellaneous databases

EvolutionaryTraceiP01003.

Family and domain databases

InterProiIPR002350. Kazal_dom.
IPR001239. Prot_inh_Kazal-m.
[Graphical view]
PfamiPF00050. Kazal_1. 3 hits.
[Graphical view]
PRINTSiPR00290. KAZALINHBTR.
SMARTiSM00280. KAZAL. 3 hits.
[Graphical view]
PROSITEiPS00282. KAZAL_1. 3 hits.
PS51465. KAZAL_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIOVO_COTJA
AccessioniPrimary (citable) accession number: P01003
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: October 14, 2015
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.