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P01002

- IPSG_CANFA

UniProt

P01002 - IPSG_CANFA

Protein

Double-headed protease inhibitor, submandibular gland

Gene
N/A
Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Functioni

    This inhibitor is composed of two homologous actively inhibiting halves: one which inhibits trypsin, the other which inhibits elastase.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei26 – 272Reactive bond 1 for trypsin
    Sitei77 – 782Reactive bond 2 for elastase

    GO - Molecular functioni

    1. serine-type endopeptidase inhibitor activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Protease inhibitor, Serine protease inhibitor

    Protein family/group databases

    MEROPSiI01.016.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Double-headed protease inhibitor, submandibular gland
    OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
    Taxonomic identifieri9615 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
    ProteomesiUP000002254: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 115115Double-headed protease inhibitor, submandibular glandPRO_0000073035Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi12 ↔ 46PROSITE-ProRule annotation
    Disulfide bondi24 ↔ 43PROSITE-ProRule annotation
    Disulfide bondi32 ↔ 64PROSITE-ProRule annotation
    Disulfide bondi68 ↔ 97PROSITE-ProRule annotation
    Disulfide bondi75 ↔ 94PROSITE-ProRule annotation
    Disulfide bondi83 ↔ 115PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Interactioni

    Protein-protein interaction databases

    STRINGi9615.ENSCAFP00000009968.

    Structurei

    3D structure databases

    ProteinModelPortaliP01002.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini6 – 6661Kazal-like 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini67 – 11549Kazal-like 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 2 Kazal-like domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG265458.
    HOGENOMiHOG000202775.
    HOVERGENiHBG006172.
    InParanoidiP01002.

    Family and domain databases

    InterProiIPR002350. Kazal_dom.
    IPR001239. Prot_inh_Kazal-m.
    [Graphical view]
    PfamiPF00050. Kazal_1. 2 hits.
    [Graphical view]
    PRINTSiPR00290. KAZALINHBTR.
    SMARTiSM00280. KAZAL. 2 hits.
    [Graphical view]
    PROSITEiPS00282. KAZAL_1. 2 hits.
    PS51465. KAZAL_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P01002-1 [UniParc]FASTAAdd to Basket

    « Hide

    GPPPAIGREV DCSNYKGKGS QIACPRLHQP ICGTDHKTYS NECMFCALTL    50
    NKKFEVRKLQ DTACDIECTE YSDMCTMDYR PLCGSDGKNY SNKCSFCNAV 100
    KKSRGTIFLA KHGEC 115
    Length:115
    Mass (Da):12,775
    Last modified:August 1, 1988 - v1
    Checksum:i1F901F163EE2A35C
    GO

    Sequence databases

    PIRiC29654. TIDGS.

    Cross-referencesi

    Sequence databases

    PIRi C29654. TIDGS.

    3D structure databases

    ProteinModelPortali P01002.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9615.ENSCAFP00000009968.

    Protein family/group databases

    MEROPSi I01.016.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi NOG265458.
    HOGENOMi HOG000202775.
    HOVERGENi HBG006172.
    InParanoidi P01002.

    Family and domain databases

    InterProi IPR002350. Kazal_dom.
    IPR001239. Prot_inh_Kazal-m.
    [Graphical view ]
    Pfami PF00050. Kazal_1. 2 hits.
    [Graphical view ]
    PRINTSi PR00290. KAZALINHBTR.
    SMARTi SM00280. KAZAL. 2 hits.
    [Graphical view ]
    PROSITEi PS00282. KAZAL_1. 2 hits.
    PS51465. KAZAL_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The amino-acid sequences of the double-headed proteinase inhibitors from cat, lion and dog submandibular glands."
      Reisinger P.W.M., Hochstrasser K., Gottlicher I., Eulitz M., Wachter E.
      Biol. Chem. Hoppe-Seyler 368:717-726(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE.
      Tissue: Submandibular gland.
    2. "The amino acid sequence of the double-headed proteinase inhibitor from canine submandibular glands, III. Sequencing studies."
      Hochstrasser K., Bretzel G., Wachter E., Heindl S.
      Hoppe-Seyler's Z. Physiol. Chem. 356:1865-1877(1975) [PubMed] [Europe PMC] [Abstract]
      Cited for: PRELIMINARY PROTEIN SEQUENCE.
      Tissue: Submandibular gland.

    Entry informationi

    Entry nameiIPSG_CANFA
    AccessioniPrimary (citable) accession number: P01002
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: August 1, 1988
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Three very similar inhibitors found in the submandibular glands are secreted into the saliva. The sequence shown is one of the two main inhibitors.

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3