SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P01002

- IPSG_CANFA

UniProt

P01002 - IPSG_CANFA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Double-headed protease inhibitor, submandibular gland

Gene
N/A
Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

This inhibitor is composed of two homologous actively inhibiting halves: one which inhibits trypsin, the other which inhibits elastase.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei26 – 272Reactive bond 1 for trypsin
Sitei77 – 782Reactive bond 2 for elastase

GO - Molecular functioni

  1. serine-type endopeptidase inhibitor activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI01.016.

Names & Taxonomyi

Protein namesi
Recommended name:
Double-headed protease inhibitor, submandibular gland
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 115115Double-headed protease inhibitor, submandibular glandPRO_0000073035Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi12 ↔ 46 By similarity
Disulfide bondi24 ↔ 43 By similarity
Disulfide bondi32 ↔ 64 By similarity
Disulfide bondi68 ↔ 97 By similarity
Disulfide bondi75 ↔ 94 By similarity
Disulfide bondi83 ↔ 115 By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000009968.

Structurei

3D structure databases

ProteinModelPortaliP01002.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 6661Kazal-like 1Add
BLAST
Domaini67 – 11549Kazal-like 2Add
BLAST

Sequence similaritiesi

Contains 2 Kazal-like domains.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG265458.
HOGENOMiHOG000202775.
HOVERGENiHBG006172.
InParanoidiP01002.

Family and domain databases

InterProiIPR002350. Kazal_dom.
IPR001239. Prot_inh_Kazal-m.
[Graphical view]
PfamiPF00050. Kazal_1. 2 hits.
[Graphical view]
PRINTSiPR00290. KAZALINHBTR.
SMARTiSM00280. KAZAL. 2 hits.
[Graphical view]
PROSITEiPS00282. KAZAL_1. 2 hits.
PS51465. KAZAL_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P01002-1 [UniParc]FASTAAdd to Basket

« Hide

GPPPAIGREV DCSNYKGKGS QIACPRLHQP ICGTDHKTYS NECMFCALTL    50
NKKFEVRKLQ DTACDIECTE YSDMCTMDYR PLCGSDGKNY SNKCSFCNAV 100
KKSRGTIFLA KHGEC 115
Length:115
Mass (Da):12,775
Last modified:August 1, 1988 - v1
Checksum:i1F901F163EE2A35C
GO

Sequence databases

PIRiC29654. TIDGS.

Cross-referencesi

Sequence databases

PIRi C29654. TIDGS.

3D structure databases

ProteinModelPortali P01002.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9615.ENSCAFP00000009968.

Protein family/group databases

MEROPSi I01.016.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi NOG265458.
HOGENOMi HOG000202775.
HOVERGENi HBG006172.
InParanoidi P01002.

Family and domain databases

InterProi IPR002350. Kazal_dom.
IPR001239. Prot_inh_Kazal-m.
[Graphical view ]
Pfami PF00050. Kazal_1. 2 hits.
[Graphical view ]
PRINTSi PR00290. KAZALINHBTR.
SMARTi SM00280. KAZAL. 2 hits.
[Graphical view ]
PROSITEi PS00282. KAZAL_1. 2 hits.
PS51465. KAZAL_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The amino-acid sequences of the double-headed proteinase inhibitors from cat, lion and dog submandibular glands."
    Reisinger P.W.M., Hochstrasser K., Gottlicher I., Eulitz M., Wachter E.
    Biol. Chem. Hoppe-Seyler 368:717-726(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.
    Tissue: Submandibular gland.
  2. "The amino acid sequence of the double-headed proteinase inhibitor from canine submandibular glands, III. Sequencing studies."
    Hochstrasser K., Bretzel G., Wachter E., Heindl S.
    Hoppe-Seyler's Z. Physiol. Chem. 356:1865-1877(1975) [PubMed] [Europe PMC] [Abstract]
    Cited for: PRELIMINARY PROTEIN SEQUENCE.
    Tissue: Submandibular gland.

Entry informationi

Entry nameiIPSG_CANFA
AccessioniPrimary (citable) accession number: P01002
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 1, 1988
Last modified: April 16, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Three very similar inhibitors found in the submandibular glands are secreted into the saliva. The sequence shown is one of the two main inhibitors.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi