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P00980 (IVBII_DENAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protease inhibitor 1 homolog
Alternative name(s):
Alpha-dendrotoxin
Short name=Alpha-DTX
Toxin C13S2C3
Venom basic protease inhibitor 1 homolog
OrganismDendroaspis angusticeps (Eastern green mamba) (Naja angusticeps)
Taxonomic identifier8618 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaElapidaeElapinaeDendroaspis

Protein attributes

Sequence length59 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This protease inhibitor homolog has very low toxicity. It blocks voltage-gated potassium channels and facilitate neurotransmitter release.

Subcellular location

Secreted.

Tissue specificity

Expressed by the venom gland.

Toxic dose

LD50 is 23 mg/kg by intravenous injection.

Sequence similarities

Belongs to the venom Kunitz-type family.

Contains 1 BPTI/Kunitz inhibitor domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 5959Protease inhibitor 1 homolog
PRO_0000155433

Regions

Domain7 – 5751BPTI/Kunitz inhibitor

Sites

Site17 – 182Reactive bond

Amino acid modifications

Modified residue11Pyrrolidone carboxylic acid Ref.1
Disulfide bond7 ↔ 57 Ref.1
Disulfide bond16 ↔ 40 Ref.1
Disulfide bond32 ↔ 53 Ref.1

Secondary structure

............ 59
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P00980 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: 96B60752E8AD81AE

FASTA597,071
        10         20         30         40         50 
QPRRKLCILH RNPGRCYDKI PAFYYNQKKK QCERFDWSGC GGNSNRFKTI EECRRTCIG 

« Hide

References

[1]"Snake venoms. The amino acid sequences of two proteinase inhibitor homologues from Dendroaspis angusticeps venom."
Joubert F.J., Taljaard N.
Hoppe-Seyler's Z. Physiol. Chem. 361:661-674(1980) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE.
Tissue: Venom.
[2]"Crystal structure of alpha-dendrotoxin from the green mamba venom and its comparison with the structure of bovine pancreatic trypsin inhibitor."
Skarzynski T.
J. Mol. Biol. 224:671-683(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS).

Cross-references

Sequence databases

PIRVIEPIA. A01212.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1DTXX-ray2.20A2-59[»]
ProteinModelPortalP00980.
SMRP00980. Positions 1-59.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSI02.056.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG006193.

Family and domain databases

Gene3D4.10.410.10. 1 hit.
InterProIPR002223. Prot_inh_Kunz-m.
IPR020901. Prtase_inh_Kunz-CS.
[Graphical view]
PfamPF00014. Kunitz_BPTI. 1 hit.
[Graphical view]
PRINTSPR00759. BASICPTASE.
SMARTSM00131. KU. 1 hit.
[Graphical view]
SUPFAMSSF57362. SSF57362. 1 hit.
PROSITEPS00280. BPTI_KUNITZ_1. 1 hit.
PS50279. BPTI_KUNITZ_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP00980.

Entry information

Entry nameIVBII_DENAN
AccessionPrimary (citable) accession number: P00980
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: April 16, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references