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Protein

Xylose isomerase

Gene

xylA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

D-xylopyranose = D-xylulose.

Cofactori

Mg2+By similarityNote: Binds 2 magnesium ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei1011 Publication1
Active sitei104By similarity1
Metal bindingi232Magnesium 1By similarity1
Metal bindingi268Magnesium 1By similarity1
Metal bindingi268Magnesium 2By similarity1
Metal bindingi271Magnesium 2By similarity1
Metal bindingi296Magnesium 1By similarity1
Metal bindingi307Magnesium 2By similarity1
Metal bindingi309Magnesium 2By similarity1
Metal bindingi339Magnesium 1By similarity1

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • xylose isomerase activity Source: EcoCyc

GO - Biological processi

  • D-xylose catabolic process Source: EcoCyc

Keywordsi

Molecular functionIsomerase
Biological processCarbohydrate metabolism, Xylose metabolism
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciEcoCyc:XYLISOM-MONOMER
MetaCyc:XYLISOM-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Xylose isomerase (EC:5.3.1.5)
Alternative name(s):
D-xylulose keto-isomerase
Gene namesi
Name:xylA
Ordered Locus Names:b3565, JW3537
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11074 xylA

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001957741 – 440Xylose isomeraseAdd BLAST440

Proteomic databases

PaxDbiP00944
PRIDEiP00944

Interactioni

Subunit structurei

Homotetramer.

Protein-protein interaction databases

BioGridi4262540, 18 interactors
DIPiDIP-11149N
IntActiP00944, 9 interactors
MINTiP00944
STRINGi316385.ECDH10B_3746

Structurei

3D structure databases

ProteinModelPortaliP00944
SMRiP00944
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the xylose isomerase family.Curated

Phylogenomic databases

eggNOGiENOG4105C93 Bacteria
COG2115 LUCA
HOGENOMiHOG000252293
InParanoidiP00944
KOiK01805
OMAiHTFQHEL
PhylomeDBiP00944

Family and domain databases

HAMAPiMF_00455 Xylose_isom_A, 1 hit
InterProiView protein in InterPro
IPR036237 Xyl_isomerase-like_sf
IPR013452 Xylose_isom_bac
IPR001998 Xylose_isomerase
PANTHERiPTHR32176:SF0 PTHR32176:SF0, 1 hit
PRINTSiPR00688 XYLOSISMRASE
SUPFAMiSSF51658 SSF51658, 1 hit
TIGRFAMsiTIGR02630 xylose_isom_A, 1 hit
PROSITEiView protein in PROSITE
PS51415 XYLOSE_ISOMERASE, 1 hit

Sequencei

Sequence statusi: Complete.

P00944-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQAYFDQLDR VRYEGSKSSN PLAFRHYNPD ELVLGKRMEE HLRFAACYWH
60 70 80 90 100
TFCWNGADMF GVGAFNRPWQ QPGEALALAK RKADVAFEFF HKLHVPFYCF
110 120 130 140 150
HDVDVSPEGA SLKEYINNFA QMVDVLAGKQ EESGVKLLWG TANCFTNPRY
160 170 180 190 200
GAGAATNPDP EVFSWAATQV VTAMEATHKL GGENYVLWGG REGYETLLNT
210 220 230 240 250
DLRQEREQLG RFMQMVVEHK HKIGFQGTLL IEPKPQEPTK HQYDYDAATV
260 270 280 290 300
YGFLKQFGLE KEIKLNIEAN HATLAGHSFH HEIATAIALG LFGSVDANRG
310 320 330 340 350
DAQLGWDTDQ FPNSVEENAL VMYEILKAGG FTTGGLNFDA KVRRQSTDKY
360 370 380 390 400
DLFYGHIGAM DTMALALKIA ARMIEDGELD KRIAQRYSGW NSELGQQILK
410 420 430 440
GQMSLADLAK YAQEHHLSPV HQSGRQEQLE NLVNHYLFDK
Length:440
Mass (Da):49,742
Last modified:July 21, 1986 - v1
Checksum:i6841659B6EC0561F
GO

Sequence cautioni

The sequence CAA25347 differs from that shown. Reason: Frameshift at position 67.Curated
The sequence CAA28394 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti169Q → E in AAB20471 (PubMed:2132127).Curated1
Sequence conflicti299R → L in AAB20471 (PubMed:2132127).Curated1
Sequence conflicti342V → D in AAB20471 (PubMed:2132127).Curated1
Sequence conflicti378E → D in AAB20471 (PubMed:2132127).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K01996 Genomic DNA Translation: AAA24768.1
X04691 Genomic DNA Translation: CAA28394.1 Different initiation.
X00772 Genomic DNA Translation: CAA25346.1 Frameshift.
X00772 Genomic DNA Translation: CAA25347.1 Frameshift.
S68257 Genomic DNA Translation: AAB20471.2
U00039 Genomic DNA Translation: AAB18542.1
U00096 Genomic DNA Translation: AAC76589.1
AP009048 Genomic DNA Translation: BAE77728.1
PIRiA30252 ISECX1
RefSeqiNP_418022.1, NC_000913.3
WP_001149591.1, NZ_CP014272.1

Genome annotation databases

EnsemblBacteriaiAAC76589; AAC76589; b3565
BAE77728; BAE77728; BAE77728
GeneIDi948141
KEGGiecj:JW3537
eco:b3565
PATRICifig|1411691.4.peg.3147

Similar proteinsi

Entry informationi

Entry nameiXYLA_ECOLI
AccessioniPrimary (citable) accession number: P00944
Secondary accession number(s): P00945, Q2M7M8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: April 25, 2018
This is version 161 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

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