UniProtKB - P00929 (TRPA_SALTY)
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Protein
Tryptophan synthase alpha chain
Gene
trpA
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Functioni
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
Catalytic activityi
L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O.UniRule annotation
: L-tryptophan biosynthesis Pathwayi
This protein is involved in step 5 of the subpathway that synthesizes L-tryptophan from chorismate.UniRule annotationProteins known to be involved in the 5 steps of the subpathway in this organism are:
- Bifunctional protein TrpGD (trpGD), Anthranilate synthase component 1 (trpE)
- Bifunctional protein TrpGD (trpGD)
- Tryptophan biosynthesis protein TrpCF (trpC)
- Tryptophan biosynthesis protein TrpCF (trpC)
- Tryptophan synthase beta chain (trpB), Tryptophan synthase alpha chain (trpA)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 49 | Proton acceptor | 1 | |
Active sitei | 60 | Proton acceptor | 1 |
GO - Molecular functioni
- tryptophan synthase activity Source: UniProtKB-EC
Keywordsi
Molecular function | Allosteric enzyme, Lyase |
Biological process | Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis |
Enzyme and pathway databases
BioCyci | SENT99287:G1FZD-1744-MONOMER. |
UniPathwayi | UPA00035; UER00044. |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:trpAUniRule annotation Ordered Locus Names:STM1727 |
Organismi | Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) |
Taxonomic identifieri | 99287 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Salmonella › |
Proteomesi |
|
Pathology & Biotechi
Chemistry databases
DrugBanki | DB07748. 2-({[4-(TRIFLUOROMETHOXY)PHENYL]SULFONYL}AMINO)ETHYL DIHYDROGEN PHOSPHATE. DB07732. 2-[(2-NAPHTHYLSULFONYL)AMINO]ETHYL DIHYDROGEN PHOSPHATE. DB07745. 2-{[4-(TRIFLUOROMETHOXY)BENZOYL]AMINO}ETHYL DIHYDROGEN PHOSPHATE. DB07894. 4-(2-HYDROXY-4-FLUOROPHENYLTHIO)-BUTYLPHOSPHONIC ACID. DB07925. 4-(2-HYDROXYPHENYLSULFINYL)-BUTYLPHOSPHONIC ACID. DB07890. 4-(2-HYDROXYPHENYLTHIO)-1-BUTENYLPHOSPHONIC ACID. DB07773. 5-FLUOROINDOLE PROPANOL PHOSPHATE. DB04143. Indole-3-Glycerol Phosphate. DB03171. Indole-3-Propanol Phosphate. DB07951. N-[1H-INDOL-3-YL-ACETYL]ASPARTIC ACID. DB07952. N-[1H-INDOL-3-YL-ACETYL]GLYCINE ACID. DB07953. N-[1H-INDOL-3-YL-ACETYL]VALINE ACID. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000098839 | 1 – 268 | Tryptophan synthase alpha chainAdd BLAST | 268 |
Proteomic databases
PaxDbi | P00929. |
PRIDEi | P00929. |
Interactioni
Subunit structurei
Tetramer of two alpha and two beta chains.
Binary interactionsi
With | Entry | #Exp. | IntAct | Notes |
---|---|---|---|---|
trpB | P0A2K1 | 24 | EBI-1028423,EBI-1028431 |
Protein-protein interaction databases
DIPi | DIP-1033N. |
IntActi | P00929. 1 interactor. |
MINTi | P00929. |
STRINGi | 99287.STM1727. |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more detailsFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Helixi | 3 – 13 | Combined sources | 11 | |
Beta strandi | 18 – 24 | Combined sources | 7 | |
Turni | 25 – 28 | Combined sources | 4 | |
Helixi | 30 – 42 | Combined sources | 13 | |
Beta strandi | 46 – 51 | Combined sources | 6 | |
Beta strandi | 58 – 60 | Combined sources | 3 | |
Helixi | 62 – 73 | Combined sources | 12 | |
Helixi | 78 – 91 | Combined sources | 14 | |
Beta strandi | 93 – 95 | Combined sources | 3 | |
Beta strandi | 97 – 101 | Combined sources | 5 | |
Helixi | 103 – 107 | Combined sources | 5 | |
Helixi | 111 – 121 | Combined sources | 11 | |
Beta strandi | 125 – 128 | Combined sources | 4 | |
Helixi | 133 – 135 | Combined sources | 3 | |
Helixi | 137 – 145 | Combined sources | 9 | |
Beta strandi | 149 – 151 | Combined sources | 3 | |
Helixi | 160 – 169 | Combined sources | 10 | |
Beta strandi | 174 – 181 | Combined sources | 8 | |
Beta strandi | 185 – 187 | Combined sources | 3 | |
Helixi | 194 – 202 | Combined sources | 9 | |
Beta strandi | 208 – 213 | Combined sources | 6 | |
Helixi | 217 – 225 | Combined sources | 9 | |
Beta strandi | 229 – 233 | Combined sources | 5 | |
Helixi | 235 – 243 | Combined sources | 9 | |
Turni | 244 – 246 | Combined sources | 3 | |
Helixi | 248 – 265 | Combined sources | 18 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1A50 | X-ray | 2.30 | A | 1-268 | [»] | |
1A5A | X-ray | 1.90 | A | 1-268 | [»] | |
1A5B | X-ray | 2.00 | A | 1-268 | [»] | |
1A5S | X-ray | 2.30 | A | 1-268 | [»] | |
1BEU | X-ray | 1.90 | A | 1-268 | [»] | |
1BKS | X-ray | 2.20 | A | 1-268 | [»] | |
1C29 | X-ray | 2.30 | A | 1-268 | [»] | |
1C8V | X-ray | 2.20 | A | 1-268 | [»] | |
1C9D | X-ray | 2.30 | A | 1-268 | [»] | |
1CW2 | X-ray | 2.00 | A | 1-268 | [»] | |
1CX9 | X-ray | 2.30 | A | 1-268 | [»] | |
1FUY | X-ray | 2.25 | A | 1-268 | [»] | |
1K3U | X-ray | 1.70 | A | 1-268 | [»] | |
1K7E | X-ray | 2.30 | A | 1-268 | [»] | |
1K7F | X-ray | 1.90 | A | 1-268 | [»] | |
1K7X | X-ray | 1.70 | A | 1-268 | [»] | |
1K8X | X-ray | 1.90 | A | 1-268 | [»] | |
1K8Y | X-ray | 1.50 | A | 1-268 | [»] | |
1K8Z | X-ray | 1.70 | A | 1-268 | [»] | |
1KFB | X-ray | 1.90 | A | 1-268 | [»] | |
1KFC | X-ray | 1.50 | A | 1-268 | [»] | |
1KFE | X-ray | 1.75 | A | 1-268 | [»] | |
1KFJ | X-ray | 1.80 | A | 1-268 | [»] | |
1KFK | X-ray | 2.40 | A | 1-268 | [»] | |
1QOP | X-ray | 1.40 | A | 1-268 | [»] | |
1QOQ | X-ray | 1.80 | A | 1-268 | [»] | |
1TJP | X-ray | 1.50 | A | 1-268 | [»] | |
1TTP | X-ray | 2.30 | A | 1-268 | [»] | |
1TTQ | X-ray | 2.00 | A | 1-268 | [»] | |
1UBS | X-ray | 1.90 | A | 1-268 | [»] | |
1WBJ | X-ray | 1.50 | A | 1-268 | [»] | |
2CLE | X-ray | 1.50 | A | 1-268 | [»] | |
2CLF | X-ray | 1.70 | A | 1-268 | [»] | |
2CLH | X-ray | 1.70 | A | 1-268 | [»] | |
2CLI | X-ray | 1.70 | A | 1-268 | [»] | |
2CLK | X-ray | 1.50 | A | 1-268 | [»] | |
2CLL | X-ray | 1.60 | A | 1-268 | [»] | |
2CLM | X-ray | 1.51 | A | 1-268 | [»] | |
2CLO | X-ray | 1.50 | A | 1-268 | [»] | |
2J9X | X-ray | 1.90 | A | 1-268 | [»] | |
2J9Y | X-ray | 1.80 | A | 1-268 | [»] | |
2J9Z | X-ray | 1.80 | A | 1-268 | [»] | |
2RH9 | X-ray | 1.70 | A | 1-268 | [»] | |
2RHG | X-ray | 2.00 | A | 1-268 | [»] | |
2TRS | X-ray | 2.04 | A | 1-268 | [»] | |
2TSY | X-ray | 2.50 | A | 1-268 | [»] | |
2TYS | X-ray | 1.90 | A | 1-268 | [»] | |
2WSY | X-ray | 3.05 | A | 1-268 | [»] | |
3CEP | X-ray | 2.10 | A | 1-268 | [»] | |
3PR2 | X-ray | 1.85 | A | 2-267 | [»] | |
4HN4 | X-ray | 1.64 | A | 1-268 | [»] | |
4HPJ | X-ray | 1.45 | A | 1-268 | [»] | |
4HPX | X-ray | 1.65 | A | 1-268 | [»] | |
4HT3 | X-ray | 1.30 | A | 1-268 | [»] | |
4KKX | X-ray | 1.77 | A | 1-268 | [»] | |
4WX2 | X-ray | 1.75 | A | 1-268 | [»] | |
4XUG | X-ray | 1.65 | A | 1-268 | [»] | |
4Y6G | X-ray | 1.65 | A | 1-268 | [»] | |
4ZQC | X-ray | 1.54 | A | 1-268 | [»] | |
5BW6 | X-ray | 1.82 | A | 1-268 | [»] | |
5CGQ | X-ray | 1.18 | A | 1-268 | [»] | |
ProteinModelPortali | P00929. | |||||
SMRi | P00929. | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P00929. |
Family & Domainsi
Sequence similaritiesi
Belongs to the TrpA family.UniRule annotation
Phylogenomic databases
eggNOGi | ENOG4105F6H. Bacteria. COG0159. LUCA. |
HOGENOMi | HOG000223814. |
KOi | K01695. |
OMAi | DYPPEEC. |
PhylomeDBi | P00929. |
Family and domain databases
CDDi | cd04724. Tryptophan_synthase_alpha. 1 hit. |
Gene3Di | 3.20.20.70. 1 hit. |
HAMAPi | MF_00131. Trp_synth_alpha. 1 hit. |
InterProi | View protein in InterPro IPR013785. Aldolase_TIM. IPR011060. RibuloseP-bd_barrel. IPR018204. Trp_synthase_alpha_AS. IPR002028. Trp_synthase_suA. |
Pfami | View protein in Pfam PF00290. Trp_syntA. 1 hit. |
SUPFAMi | SSF51366. SSF51366. 1 hit. |
TIGRFAMsi | TIGR00262. trpA. 1 hit. |
PROSITEi | View protein in PROSITE PS00167. TRP_SYNTHASE_ALPHA. 1 hit. |
i Sequence
Sequence statusi: Complete.
P00929-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MERYENLFAQ LNDRREGAFV PFVTLGDPGI EQSLKIIDTL IDAGADALEL
60 70 80 90 100
GVPFSDPLAD GPTIQNANLR AFAAGVTPAQ CFEMLALIRE KHPTIPIGLL
110 120 130 140 150
MYANLVFNNG IDAFYARCEQ VGVDSVLVAD VPVEESAPFR QAALRHNIAP
160 170 180 190 200
IFICPPNADD DLLRQVASYG RGYTYLLSRS GVTGAENRGA LPLHHLIEKL
210 220 230 240 250
KEYHAAPALQ GFGISSPEQV SAAVRAGAAG AISGSAIVKI IEKNLASPKQ
260
MLAELRSFVS AMKAASRA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | V01376 Genomic DNA. Translation: CAA24666.1. J01810 Genomic DNA. Translation: AAA27235.1. AE006468 Genomic DNA. Translation: AAL20645.1. |
PIRi | A93837. TSEBAT. |
RefSeqi | NP_460686.1. NC_003197.2. WP_000443030.1. NC_003197.2. |
Genome annotation databases
EnsemblBacteriai | AAL20645; AAL20645; STM1727. |
GeneIDi | 1253246. |
KEGGi | stm:STM1727. |
PATRICi | fig|99287.12.peg.1823. |
Similar proteinsi
Entry informationi
Entry namei | TRPA_SALTY | |
Accessioni | P00929Primary (citable) accession number: P00929 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | July 21, 1986 | |
Last modified: | February 28, 2018 | |
This is version 165 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |