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Protein

Carbonic anhydrase 2

Gene

CA2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide.By similarity

Catalytic activityi

H2CO3 = CO2 + H2O.

Cofactori

Zn2+1 Publication

Enzyme regulationi

Inhibited by acetazolamide.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei64Proton acceptorBy similarity1
Active sitei67By similarity1
Metal bindingi94Zinc; catalytic1 Publication1
Metal bindingi96Zinc; catalytic1 Publication1
Metal bindingi119Zinc; catalytic1 Publication1
Active sitei127By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Carbonic anhydrase 2 (EC:4.2.1.1)
Alternative name(s):
Carbonate dehydratase II
Carbonic anhydrase II
Short name:
CA-II
Gene namesi
Name:CA2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2283.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity2 Publications
ChainiPRO_00000774172 – 260Carbonic anhydrase 2Add BLAST259

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei2PhosphoserineBy similarity1
Modified residuei165PhosphoserineBy similarity1
Modified residuei172PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP00921.
PeptideAtlasiP00921.
PRIDEiP00921.

Interactioni

Subunit structurei

Interacts with SLC4A4. Interaction with SLC4A7 regulates SLC4A7 transporter activity (By similarity).By similarity

Protein-protein interaction databases

IntActiP00921. 1 interactor.
STRINGi9913.ENSBTAP00000023581.

Chemistry databases

BindingDBiP00921.

Structurei

Secondary structure

1260
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni9 – 11Combined sources3
Helixi13 – 15Combined sources3
Turni16 – 19Combined sources4
Helixi21 – 24Combined sources4
Beta strandi25 – 27Combined sources3
Beta strandi31 – 33Combined sources3
Helixi35 – 37Combined sources3
Beta strandi47 – 50Combined sources4
Beta strandi56 – 61Combined sources6
Beta strandi63 – 70Combined sources8
Beta strandi73 – 81Combined sources9
Beta strandi88 – 97Combined sources10
Beta strandi99 – 102Combined sources4
Beta strandi106 – 109Combined sources4
Beta strandi115 – 124Combined sources10
Helixi125 – 127Combined sources3
Helixi130 – 133Combined sources4
Beta strandi139 – 151Combined sources13
Helixi154 – 160Combined sources7
Helixi161 – 166Combined sources6
Beta strandi167 – 169Combined sources3
Beta strandi172 – 174Combined sources3
Helixi180 – 183Combined sources4
Beta strandi190 – 195Combined sources6
Beta strandi206 – 213Combined sources8
Beta strandi215 – 217Combined sources3
Helixi219 – 225Combined sources7
Beta strandi229 – 231Combined sources3
Beta strandi256 – 258Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1G6VX-ray3.50A1-254[»]
1V9EX-ray1.95A/B2-260[»]
1V9IX-ray2.95C2-260[»]
4CNRX-ray2.29A/B/C/D1-260[»]
4CNVX-ray1.62A1-260[»]
4CNWX-ray2.03A/B1-260[»]
4CNXX-ray1.23A1-260[»]
5A25X-ray1.90A/B1-260[»]
5EZTX-ray1.54X4-260[»]
ProteinModelPortaliP00921.
SMRiP00921.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00921.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 259Alpha-carbonic anhydrasePROSITE-ProRule annotationAdd BLAST257

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni198 – 199Substrate bindingBy similarity2

Sequence similaritiesi

Belongs to the alpha-carbonic anhydrase family.Curated
Contains 1 alpha-carbonic anhydrase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0382. Eukaryota.
COG3338. LUCA.
HOGENOMiHOG000112637.
HOVERGENiHBG002837.
InParanoidiP00921.
KOiK18245.

Family and domain databases

Gene3Di3.10.200.10. 1 hit.
InterProiIPR018443. CA2.
IPR001148. Carbonic_anhydrase_a.
IPR023561. Carbonic_anhydrase_a-class.
IPR018338. Carbonic_anhydrase_a-class_CS.
[Graphical view]
PANTHERiPTHR18952. PTHR18952. 1 hit.
PTHR18952:SF120. PTHR18952:SF120. 1 hit.
PfamiPF00194. Carb_anhydrase. 1 hit.
[Graphical view]
SMARTiSM01057. Carb_anhydrase. 1 hit.
[Graphical view]
SUPFAMiSSF51069. SSF51069. 1 hit.
PROSITEiPS00162. ALPHA_CA_1. 1 hit.
PS51144. ALPHA_CA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00921-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHHWGYGKH NGPEHWHKDF PIANGERQSP VDIDTKAVVQ DPALKPLALV
60 70 80 90 100
YGEATSRRMV NNGHSFNVEY DDSQDKAVLK DGPLTGTYRL VQFHFHWGSS
110 120 130 140 150
DDQGSEHTVD RKKYAAELHL VHWNTKYGDF GTAAQQPDGL AVVGVFLKVG
160 170 180 190 200
DANPALQKVL DALDSIKTKG KSTDFPNFDP GSLLPNVLDY WTYPGSLTTP
210 220 230 240 250
PLLESVTWIV LKEPISVSSQ QMLKFRTLNF NAEGEPELLM LANWRPAQPL
260
KNRQVRGFPK
Length:260
Mass (Da):29,114
Last modified:January 23, 2007 - v3
Checksum:iA89412C23FFD19A7
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti57R → Q in one of the major forms. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY240020 mRNA. Translation: AAO85140.1.
BC103260 mRNA. Translation: AAI03261.1.
PIRiA01144. CRBO2.
RefSeqiNP_848667.1. NM_178572.2.
UniGeneiBt.49731.

Genome annotation databases

GeneIDi280740.
KEGGibta:280740.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Worthington enzyme manual

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY240020 mRNA. Translation: AAO85140.1.
BC103260 mRNA. Translation: AAI03261.1.
PIRiA01144. CRBO2.
RefSeqiNP_848667.1. NM_178572.2.
UniGeneiBt.49731.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1G6VX-ray3.50A1-254[»]
1V9EX-ray1.95A/B2-260[»]
1V9IX-ray2.95C2-260[»]
4CNRX-ray2.29A/B/C/D1-260[»]
4CNVX-ray1.62A1-260[»]
4CNWX-ray2.03A/B1-260[»]
4CNXX-ray1.23A1-260[»]
5A25X-ray1.90A/B1-260[»]
5EZTX-ray1.54X4-260[»]
ProteinModelPortaliP00921.
SMRiP00921.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP00921. 1 interactor.
STRINGi9913.ENSBTAP00000023581.

Chemistry databases

BindingDBiP00921.
ChEMBLiCHEMBL2283.

Proteomic databases

PaxDbiP00921.
PeptideAtlasiP00921.
PRIDEiP00921.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi280740.
KEGGibta:280740.

Organism-specific databases

CTDi760.

Phylogenomic databases

eggNOGiKOG0382. Eukaryota.
COG3338. LUCA.
HOGENOMiHOG000112637.
HOVERGENiHBG002837.
InParanoidiP00921.
KOiK18245.

Miscellaneous databases

EvolutionaryTraceiP00921.
PROiP00921.

Family and domain databases

Gene3Di3.10.200.10. 1 hit.
InterProiIPR018443. CA2.
IPR001148. Carbonic_anhydrase_a.
IPR023561. Carbonic_anhydrase_a-class.
IPR018338. Carbonic_anhydrase_a-class_CS.
[Graphical view]
PANTHERiPTHR18952. PTHR18952. 1 hit.
PTHR18952:SF120. PTHR18952:SF120. 1 hit.
PfamiPF00194. Carb_anhydrase. 1 hit.
[Graphical view]
SMARTiSM01057. Carb_anhydrase. 1 hit.
[Graphical view]
SUPFAMiSSF51069. SSF51069. 1 hit.
PROSITEiPS00162. ALPHA_CA_1. 1 hit.
PS51144. ALPHA_CA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCAH2_BOVIN
AccessioniPrimary (citable) accession number: P00921
Secondary accession number(s): Q3ZBJ5, Q865Y7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 145 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

One minor and two major forms were isolated chromatographically.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.