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P00918

- CAH2_HUMAN

UniProt

P00918 - CAH2_HUMAN

Protein

Carbonic anhydrase 2

Gene

CA2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 188 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Essential for bone resorption and osteoclast differentiation By similarity. Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. Stimulates the chloride-bicarbonate exchange activity of SLC26A6.By similarity3 Publications

    Catalytic activityi

    H2CO3 = CO2 + H2O.

    Cofactori

    Zinc. Can also use cobalt(II) with lower efficiency, but not copper(II), nickel(II) and manganese(II).1 Publication

    Enzyme regulationi

    Activated by X-ray, histamine, L-adrenaline, L- and D-phenylalanine, L- and D-histidine, L-His-OMe and beta-Ala-His (carnosine). Competitively inhibited by saccharin, thioxolone, coumarins, 667-coumate, celecoxib (Celebrex), valdecoxib (Bextra), SC-125, SC-560, diclofenac, acetate, azide, bromide, sulfonamide derivatives such as acetazolamide (AZA), methazolamide (MZA), ethoxzolamide (EZA), dichlorophenamide (DCP), brinzolamide, dansylamide, thiabendazole-5-sulfonamide, trifluoromethane sulfonamide and N-hydroxysulfamide, fructose-based sugar sulfamate RWJ-37497, and Foscarnet (phosphonoformate trisodium salt). Repressed strongly by hydrogen sulfide(HS) and weakly by nitrate (NO3). Esterase activity weakly reduced by cyanamide. N-hydroxyurea interfers with zinc binding and inhibit activity.27 Publications

    Absorptioni

    Abs(max)=550 nm10 Publications

    At pH 7.0. Shows a second maximum at 618 nm.

    Kineticsi

    1. KM=10 mM for CO210 Publications
    2. KM=82 mM for H2CO310 Publications
    3. KM=3 mM for 4-nitrophenyl acetate10 Publications

    pH dependencei

    Optimum pH is 6-8.10 Publications

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei62 – 621Activator
    Active sitei64 – 641
    Active sitei67 – 671
    Binding sitei67 – 671Activator
    Binding sitei92 – 921Activator
    Metal bindingi94 – 941Zinc; catalytic1 Publication
    Metal bindingi96 – 961Zinc; catalytic
    Metal bindingi119 – 1191Zinc; catalytic
    Active sitei127 – 1271

    GO - Molecular functioni

    1. carbonate dehydratase activity Source: ProtInc
    2. protein binding Source: UniProtKB
    3. zinc ion binding Source: UniProtKB

    GO - Biological processi

    1. angiotensin-activated signaling pathway Source: UniProtKB
    2. bicarbonate transport Source: Reactome
    3. carbon dioxide transport Source: Ensembl
    4. kidney development Source: Ensembl
    5. morphogenesis of an epithelium Source: Ensembl
    6. odontogenesis of dentin-containing tooth Source: Ensembl
    7. one-carbon metabolic process Source: InterPro
    8. positive regulation of bone resorption Source: Ensembl
    9. positive regulation of cellular pH reduction Source: Ensembl
    10. positive regulation of dipeptide transmembrane transport Source: UniProtKB
    11. positive regulation of osteoclast differentiation Source: Ensembl
    12. regulation of anion transport Source: UniProtKB
    13. regulation of intracellular pH Source: UniProtKB
    14. response to estrogen Source: Ensembl
    15. response to pH Source: Ensembl
    16. response to zinc ion Source: Ensembl
    17. secretion Source: Ensembl
    18. small molecule metabolic process Source: Reactome

    Keywords - Molecular functioni

    Lyase

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BRENDAi4.2.1.1. 2681.
    ReactomeiREACT_121123. Reversible hydration of carbon dioxide.
    REACT_121329. Erythrocytes take up carbon dioxide and release oxygen.
    REACT_121380. Erythrocytes take up oxygen and release carbon dioxide.
    SABIO-RKP00918.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Carbonic anhydrase 2 (EC:4.2.1.1)
    Alternative name(s):
    Carbonate dehydratase II
    Carbonic anhydrase C
    Short name:
    CAC
    Carbonic anhydrase II
    Short name:
    CA-II
    Gene namesi
    Name:CA2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:1373. CA2.

    Subcellular locationi

    Cytoplasm 1 Publication. Cell membrane 1 Publication
    Note: Colocalized with SLC26A6 at the surface of the cell membrane in order to form a bicarbonate transport metabolon. Displaced from the cytosolic surface of the cell membrane by PKC in phorbol myristate acetate (PMA)-induced cells.

    GO - Cellular componenti

    1. apical part of cell Source: UniProtKB
    2. axon Source: Ensembl
    3. basolateral plasma membrane Source: Ensembl
    4. cytoplasm Source: UniProtKB
    5. cytosol Source: Reactome
    6. extracellular space Source: Ensembl
    7. extracellular vesicular exosome Source: UniProt
    8. microvillus Source: Ensembl
    9. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Osteopetrosis, autosomal recessive 3 (OPTB3) [MIM:259730]: A rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. Osteopetrosis occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Recessive osteopetrosis commonly manifests in early infancy with macrocephaly, feeding difficulties, evolving blindness and deafness, bone marrow failure, severe anemia, and hepatosplenomegaly. Deafness and blindness are generally thought to represent effects of pressure on nerves. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.5 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti92 – 921Q → P in OPTB3; in Czechoslovakia. 2 Publications
    VAR_001381
    Natural varianti94 – 941H → Y in OPTB3; partial loss of activity. 1 Publication
    VAR_021009
    Natural varianti107 – 1071H → Y in OPTB3; frequent mutation. 4 Publications
    VAR_001382
    Natural varianti144 – 1441G → R in OPTB3; complete loss of activity. 1 Publication
    VAR_021010

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi5 – 51W → A: Impaired activity, not rescued by 4-methylimidazole (4-MI); when associated with W-64. 1 Publication
    Mutagenesisi7 – 71Y → F: Enhanced activity. 2 Publications
    Mutagenesisi7 – 71Y → H: Reduced proton transfer rate. 2 Publications
    Mutagenesisi62 – 621N → A: Reduced activity. 3 Publications
    Mutagenesisi62 – 621N → D: Strongly reduced activity. 3 Publications
    Mutagenesisi62 – 621N → H: Reduced proton transfer; when associated with A-64. 3 Publications
    Mutagenesisi62 – 621N → L: Reduced activity. 3 Publications
    Mutagenesisi62 – 621N → T: Reduced activity. 3 Publications
    Mutagenesisi62 – 621N → V: Reduced activity. 3 Publications
    Mutagenesisi64 – 641H → A: Reduced CO(2) hydrase activity, rescued by 4-methylimidazole (4-MI). Reduced proton transfer; when associated with H-62. Enhanced proton transfer; when associated with H-67. Enhanced proton transfer capacity; when associated with H-99. 4 Publications
    Mutagenesisi64 – 641H → G: Impaired activity, not rescued by 4-methylimidazole (4-MI). 4 Publications
    Mutagenesisi64 – 641H → W: Impaired activity, rescued by 4-methylimidazole (4-MI). Impaired activity, not rescued by 4-methylimidazole (4-MI); when associated with A-5. 4 Publications
    Mutagenesisi65 – 651A → F: Reduced activity. 1 Publication
    Mutagenesisi65 – 651A → H, L or S: Normal activity. 1 Publication
    Mutagenesisi67 – 671N → H: Enhanced proton transfer; when associated with A-64. 3 Publications
    Mutagenesisi67 – 671N → L: Reduced activity. 3 Publications
    Mutagenesisi67 – 671N → Q: Normal activity. 3 Publications
    Mutagenesisi94 – 941H → C, D, E, N or Q: Strongly reduced CO(2) hydrase and p-nitrophenyl acetate esterase activities, impaired stability of zinc binding. 2 Publications
    Mutagenesisi106 – 1061E → A or Q: Strongly reduced CO(2) hydrase activity. 2 Publications
    Mutagenesisi106 – 1061E → D: Normal CO(2) hydrase activity. 2 Publications
    Mutagenesisi117 – 1171E → Q: Strongly reduced activity and sulfonamide affinity. 1 Publication
    Mutagenesisi119 – 1191H → D, N or Q: Reduced activity. 1 Publication
    Mutagenesisi119 – 1191H → E: Strongly reduced activity. 1 Publication
    Mutagenesisi121 – 1211V → A, G, I, L or S: Reduced CO(2) hydrase and p-nitrophenyl acetate esterase activities. 1 Publication
    Mutagenesisi121 – 1211V → K or R: Strongly reduced CO(2) hydrase and p-nitrophenyl acetate esterase activities. 1 Publication
    Mutagenesisi142 – 1421V → F or Y: Strongly impaired activity. 1 Publication
    Mutagenesisi142 – 1421V → G: Weakly impaired activity. 1 Publication
    Mutagenesisi142 – 1421V → H: Impaired activity. 1 Publication
    Mutagenesisi197 – 1971L → A: Reduced CO(2) hydrase activity. 1 Publication
    Mutagenesisi197 – 1971L → E, H or R: Strongly reduced CO(2) hydrase activity. 1 Publication
    Mutagenesisi197 – 1971L → F: Normal activity. 1 Publication
    Mutagenesisi198 – 1981T → A, C, H or P: Strongly reduced activity. 5 Publications
    Mutagenesisi198 – 1981T → D or E: Strongly reduced activity, but enhanced zinc affinity. 5 Publications
    Mutagenesisi198 – 1981T → S or V: Reduced activity. 5 Publications
    Mutagenesisi199 – 1991T → H: Higher affinity for bicarbonate. Enhanced proton transfer capacity; when associated with A-64. 3 Publications
    Mutagenesisi199 – 1991T → S: Enhanced p-nitrophenyl acetate esterase activity, but normal CO(2) hydrase activity. 3 Publications
    Mutagenesisi201 – 2011P → A: Normal CO(2) hydrase activity, but impaired stability. 1 Publication

    Keywords - Diseasei

    Disease mutation, Osteopetrosis

    Organism-specific databases

    MIMi259730. phenotype.
    Orphaneti2785. Osteopetrosis with renal tubular acidosis.
    PharmGKBiPA25989.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed2 Publications
    Chaini2 – 260259Carbonic anhydrase 2PRO_0000077418Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine2 Publications

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP00918.
    PaxDbiP00918.
    PeptideAtlasiP00918.
    PRIDEiP00918.

    2D gel databases

    OGPiP00918.
    REPRODUCTION-2DPAGEIPI00218414.
    P00918.
    UCD-2DPAGEP00918.

    PTM databases

    PhosphoSiteiP00918.

    Expressioni

    Gene expression databases

    ArrayExpressiP00918.
    BgeeiP00918.
    CleanExiHS_CA2.
    GenevestigatoriP00918.

    Organism-specific databases

    HPAiCAB010102.
    HPA001550.

    Interactioni

    Subunit structurei

    Interacts with SLC4A4. Interaction with SLC4A7 regulates SLC4A7 transporter activity. Interacts with SLC26A6 isoform 4 (via C-terminus cytoplasmic domain).90 Publications

    Protein-protein interaction databases

    BioGridi107215. 12 interactions.
    IntActiP00918. 5 interactions.
    MINTiMINT-1367766.
    STRINGi9606.ENSP00000285379.

    Structurei

    Secondary structure

    1
    260
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni9 – 113
    Turni13 – 153
    Helixi16 – 183
    Helixi21 – 244
    Beta strandi25 – 273
    Beta strandi31 – 333
    Turni35 – 373
    Beta strandi38 – 403
    Beta strandi42 – 443
    Beta strandi45 – 506
    Beta strandi56 – 616
    Beta strandi63 – 708
    Beta strandi73 – 753
    Beta strandi77 – 826
    Beta strandi88 – 9710
    Beta strandi106 – 1094
    Beta strandi115 – 12410
    Helixi125 – 1273
    Helixi130 – 1334
    Beta strandi139 – 15113
    Helixi154 – 1563
    Helixi157 – 1626
    Helixi163 – 1653
    Beta strandi172 – 1743
    Helixi180 – 1834
    Beta strandi190 – 1956
    Beta strandi206 – 2138
    Beta strandi215 – 2173
    Helixi219 – 2257
    Beta strandi229 – 2313
    Beta strandi233 – 2353
    Beta strandi256 – 2583

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    12CAX-ray2.40A1-260[»]
    1A42X-ray2.25A2-260[»]
    1AM6X-ray2.00A2-260[»]
    1AVNX-ray2.00A2-260[»]
    1BCDX-ray1.90A2-260[»]
    1BICX-ray1.90A2-260[»]
    1BN1X-ray2.10A2-260[»]
    1BN3X-ray2.20A2-260[»]
    1BN4X-ray2.10A2-260[»]
    1BNMX-ray2.60A2-260[»]
    1BNNX-ray2.30A2-260[»]
    1BNQX-ray2.40A2-260[»]
    1BNTX-ray2.15A2-260[»]
    1BNUX-ray2.15A2-260[»]
    1BNVX-ray2.40A2-260[»]
    1BNWX-ray2.25A2-260[»]
    1BV3X-ray1.85A2-260[»]
    1CA2X-ray2.00A2-260[»]
    1CA3X-ray2.30A1-260[»]
    1CAHX-ray1.88A2-260[»]
    1CAIX-ray1.80A2-260[»]
    1CAJX-ray1.90A2-260[»]
    1CAKX-ray1.90A2-260[»]
    1CALX-ray2.20A2-260[»]
    1CAMX-ray1.70A2-260[»]
    1CANX-ray1.90A2-260[»]
    1CAOX-ray1.90A2-260[»]
    1CAYX-ray2.10A2-260[»]
    1CAZX-ray1.90A2-260[»]
    1CCSX-ray2.35A2-260[»]
    1CCTX-ray2.20A2-260[»]
    1CCUX-ray2.25A2-260[»]
    1CILX-ray1.60A2-260[»]
    1CIMX-ray2.10A2-260[»]
    1CINX-ray2.10A2-260[»]
    1CNBX-ray2.35A2-260[»]
    1CNCX-ray2.20A2-260[»]
    1CNGX-ray1.90A2-260[»]
    1CNHX-ray2.05A2-260[»]
    1CNIX-ray1.80A2-260[»]
    1CNJX-ray1.80A2-260[»]
    1CNKX-ray2.15A2-260[»]
    1CNWX-ray2.00A1-260[»]
    1CNXX-ray1.90A1-260[»]
    1CNYX-ray2.30A1-260[»]
    1CRAX-ray1.90A2-260[»]
    1CVAX-ray2.25A2-260[»]
    1CVBX-ray2.40A2-260[»]
    1CVCX-ray2.30A2-260[»]
    1CVDX-ray2.20A5-259[»]
    1CVEX-ray2.25A2-260[»]
    1CVFX-ray2.25A2-260[»]
    1CVHX-ray2.30A5-259[»]
    1DCAX-ray2.20A1-260[»]
    1DCBX-ray2.10A1-260[»]
    1EOUX-ray2.10A1-260[»]
    1F2WX-ray1.90A2-260[»]
    1FQLX-ray2.00A1-260[»]
    1FQMX-ray2.00A1-260[»]
    1FQNX-ray2.00A1-260[»]
    1FQRX-ray2.00A1-260[»]
    1FR4X-ray1.60A1-260[»]
    1FR7X-ray1.50A/B1-260[»]
    1FSNX-ray2.00A/B1-260[»]
    1FSQX-ray2.00A/B1-260[»]
    1FSRX-ray2.00A/B1-260[»]
    1G0EX-ray1.60A1-260[»]
    1G0FX-ray1.60A1-260[»]
    1G1DX-ray2.04A2-260[»]
    1G3ZX-ray1.86A2-260[»]
    1G45X-ray1.83A2-260[»]
    1G46X-ray1.84A2-260[»]
    1G48X-ray1.86A2-260[»]
    1G4JX-ray1.84A2-260[»]
    1G4OX-ray1.96A2-260[»]
    1G52X-ray1.80A2-260[»]
    1G53X-ray1.94A2-260[»]
    1G54X-ray1.86A2-260[»]
    1H4NX-ray2.00A2-260[»]
    1H9NX-ray1.85A2-260[»]
    1H9QX-ray2.20A2-260[»]
    1HCAX-ray2.30A1-260[»]
    1HEAX-ray2.00A1-260[»]
    1HEBX-ray2.00A1-260[»]
    1HECX-ray2.00A1-260[»]
    1HEDX-ray2.00A1-260[»]
    1HVAX-ray2.30A1-260[»]
    1I8ZX-ray1.93A2-260[»]
    1I90X-ray2.00A2-260[»]
    1I91X-ray2.00A2-260[»]
    1I9LX-ray1.93A2-260[»]
    1I9MX-ray1.84A2-260[»]
    1I9NX-ray1.86A2-260[»]
    1I9OX-ray1.86A2-260[»]
    1I9PX-ray1.92A2-260[»]
    1I9QX-ray1.80A2-260[»]
    1IF4X-ray1.93A2-260[»]
    1IF5X-ray2.00A2-260[»]
    1IF6X-ray2.09A2-259[»]
    1IF7X-ray1.98A2-260[»]
    1IF8X-ray1.94A2-260[»]
    1IF9X-ray2.00A2-260[»]
    1KWQX-ray2.60A1-260[»]
    1KWRX-ray2.25A1-260[»]
    1LG5X-ray1.75A1-260[»]
    1LG6X-ray2.20A1-260[»]
    1LGDX-ray1.90A1-260[»]
    1LUGX-ray0.95A2-260[»]
    1LZVX-ray2.30A1-260[»]
    1MOOX-ray1.05A1-260[»]
    1MUAX-ray1.70A4-259[»]
    1OKLX-ray2.10A2-260[»]
    1OKMX-ray2.20A2-260[»]
    1OKNX-ray2.40A2-260[»]
    1OQ5X-ray1.50A2-259[»]
    1RAYX-ray1.80A2-260[»]
    1RAZX-ray1.90A2-260[»]
    1RZAX-ray1.90A2-260[»]
    1RZBX-ray1.80A2-260[»]
    1RZCX-ray1.90A2-260[»]
    1RZDX-ray1.90A2-260[»]
    1RZEX-ray1.90A2-260[»]
    1T9NX-ray2.00A1-259[»]
    1TB0X-ray2.00X1-259[»]
    1TBTX-ray2.00X1-259[»]
    1TE3X-ray2.00X1-260[»]
    1TEQX-ray2.00X1-260[»]
    1TEUX-ray2.00X1-260[»]
    1TG3X-ray1.80A1-260[»]
    1TG9X-ray1.90A1-260[»]
    1TH9X-ray1.63A1-260[»]
    1THKX-ray1.80A1-260[»]
    1TTMX-ray1.95A2-259[»]
    1UGAX-ray2.00A3-260[»]
    1UGBX-ray2.00A3-260[»]
    1UGCX-ray2.00A3-260[»]
    1UGDX-ray2.00A3-260[»]
    1UGEX-ray1.90A3-260[»]
    1UGFX-ray2.00A3-260[»]
    1UGGX-ray2.20A3-260[»]
    1XEGX-ray1.81A1-260[»]
    1XEVX-ray2.20A/B/C/D1-260[»]
    1XPZX-ray2.02A3-260[»]
    1XQ0X-ray1.76A2-260[»]
    1YDAX-ray2.10A2-260[»]
    1YDBX-ray1.90A2-260[»]
    1YDCX-ray1.95A2-260[»]
    1YDDX-ray2.10A2-260[»]
    1YO0X-ray1.80A1-260[»]
    1YO1X-ray1.70A1-260[»]
    1YO2X-ray1.80A1-259[»]
    1Z9YX-ray1.66A2-259[»]
    1ZE8X-ray2.00A2-260[»]
    1ZFKX-ray1.56A2-259[»]
    1ZFQX-ray1.55A2-259[»]
    1ZGEX-ray1.65A2-259[»]
    1ZGFX-ray1.75A2-259[»]
    1ZH9X-ray1.70A2-259[»]
    1ZSAX-ray2.50A2-260[»]
    1ZSBX-ray2.00A2-260[»]
    1ZSCX-ray1.80A2-260[»]
    2ABEX-ray2.00A2-259[»]
    2AW1X-ray1.46A2-260[»]
    2AX2X-ray1.50A1-259[»]
    2CA2X-ray1.90A2-260[»]
    2CBAX-ray1.54A2-260[»]
    2CBBX-ray1.67A2-260[»]
    2CBCX-ray1.88A2-260[»]
    2CBDX-ray1.67A2-260[»]
    2CBEX-ray1.82A2-260[»]
    2EU2X-ray1.15A1-260[»]
    2EU3X-ray1.60A1-260[»]
    2EZ7X-ray2.00A1-259[»]
    2F14X-ray1.71A2-259[»]
    2FMGX-ray1.60A1-259[»]
    2FMZX-ray1.60A1-259[»]
    2FNKX-ray1.80A1-260[»]
    2FNMX-ray1.80A1-260[»]
    2FNNX-ray1.80A1-260[»]
    2FOQX-ray1.25A1-259[»]
    2FOSX-ray1.10A1-259[»]
    2FOUX-ray0.99A1-259[»]
    2FOVX-ray1.15A1-259[»]
    2GD8X-ray1.46A2-259[»]
    2GEHX-ray2.00A1-259[»]
    2H15X-ray1.90A1-259[»]
    2H4NX-ray1.90A2-260[»]
    2HD6X-ray1.80A2-259[»]
    2HKKX-ray1.90A1-260[»]
    2HL4X-ray1.55A2-260[»]
    2HNCX-ray1.55A2-259[»]
    2HOCX-ray2.10A2-259[»]
    2ILIX-ray1.05A2-259[»]
    2NNGX-ray1.20A2-260[»]
    2NNOX-ray1.01A2-260[»]
    2NNSX-ray1.03A2-260[»]
    2NNVX-ray1.10A2-260[»]
    2NWOX-ray1.70A1-259[»]
    2NWPX-ray1.80A1-259[»]
    2NWYX-ray1.65A1-259[»]
    2NWZX-ray1.80A1-259[»]
    2NXRX-ray1.70A1-259[»]
    2NXSX-ray1.80A1-259[»]
    2NXTX-ray1.15A1-260[»]
    2O4ZX-ray2.10A1-260[»]
    2OSFX-ray1.60A2-260[»]
    2OSMX-ray1.60A2-260[»]
    2POUX-ray1.60A1-259[»]
    2POVX-ray1.60A1-258[»]
    2POWX-ray1.75A1-259[»]
    2Q1BX-ray1.70A1-260[»]
    2Q1QX-ray1.90A1-260[»]
    2Q38X-ray1.95A1-260[»]
    2QO8X-ray1.40A2-260[»]
    2QOAX-ray1.60A2-260[»]
    2QP6X-ray1.45A2-260[»]
    2VVAX-ray1.56X1-260[»]
    2VVBX-ray1.66X1-260[»]
    2WD2X-ray1.49A2-259[»]
    2WD3X-ray1.80A2-260[»]
    2WEGX-ray1.10A2-260[»]
    2WEHX-ray2.09A2-260[»]
    2WEJX-ray1.45A2-260[»]
    2WEOX-ray1.40A2-260[»]
    2X7SX-ray1.64A2-260[»]
    2X7TX-ray1.89A2-260[»]
    2X7UX-ray2.12A2-260[»]
    3B4FX-ray1.89A1-260[»]
    3BETX-ray1.85A2-260[»]
    3BL0X-ray1.90A1-260[»]
    3BL1X-ray2.10A1-260[»]
    3C7PX-ray1.70A1-260[»]
    3CA2X-ray2.00A2-260[»]
    3CAJX-ray1.80A1-260[»]
    3CYUX-ray1.70A1-260[»]
    3D8WX-ray1.70A1-260[»]
    3D92X-ray1.10A1-260[»]
    3D93X-ray1.10A1-260[»]
    3D9ZX-ray1.65A1-260[»]
    3DAZX-ray1.60A1-260[»]
    3DBUX-ray1.70A1-260[»]
    3DC3X-ray1.70A1-260[»]
    3DC9X-ray1.60A1-260[»]
    3DCCX-ray1.60A1-260[»]
    3DCSX-ray1.80A1-260[»]
    3DCWX-ray1.50A1-260[»]
    3DD0X-ray1.48A1-260[»]
    3DD8X-ray1.90A1-260[»]
    3DV7X-ray1.70A2-260[»]
    3DVBX-ray1.70A2-260[»]
    3DVCX-ray1.60A2-260[»]
    3DVDX-ray1.60A2-260[»]
    3EFIX-ray1.75A2-260[»]
    3EFTX-ray1.85A1-260[»]
    3F4XX-ray1.90A1-260[»]
    3F8EX-ray2.00A1-260[»]
    3FFPX-ray1.81X1-260[»]
    3GZ0X-ray1.26A2-260[»]
    3HFPX-ray2.10A1-260[»]
    3HKNX-ray1.80A1-260[»]
    3HKQX-ray1.70A1-260[»]
    3HKTX-ray2.36A1-260[»]
    3HKUX-ray1.80A1-260[»]
    3HLJX-ray1.44A1-260[»]
    3HS4X-ray1.10A1-260[»]
    3IBIX-ray1.93A2-260[»]
    3IBLX-ray1.55A2-260[»]
    3IBNX-ray2.20A2-260[»]
    3IBUX-ray1.41A2-260[»]
    3IEOX-ray2.00A1-260[»]
    3IGPX-ray1.65A1-260[»]
    3K2FX-ray1.98A1-260[»]
    3K34X-ray0.90A1-260[»]
    3K7KX-ray1.90A1-260[»]
    3KIGX-ray1.39A1-260[»]
    3KKXneutron diffraction2.00A1-260[»]
    3KNEX-ray1.35A1-260[»]
    3KOIX-ray1.64A1-260[»]
    3KOKX-ray1.50A1-260[»]
    3KONX-ray1.50A1-260[»]
    3KS3X-ray0.90A1-260[»]
    3KWAX-ray2.00A1-260[»]
    3L14X-ray1.22A1-260[»]
    3M04X-ray1.40A1-260[»]
    3M14X-ray1.38A1-260[»]
    3M1JX-ray1.80A1-260[»]
    3M1KX-ray1.35A1-260[»]
    3M1QX-ray1.69A1-260[»]
    3M1WX-ray1.38A1-260[»]
    3M2NX-ray1.65A1-260[»]
    3M2XX-ray1.87A1-260[»]
    3M2YX-ray1.17A1-260[»]
    3M2ZX-ray1.70A1-260[»]
    3M3XX-ray1.68A1-260[»]
    3M40X-ray1.60A1-260[»]
    3M5EX-ray1.70A1-260[»]
    3M5SX-ray1.40A1-260[»]
    3M5TX-ray1.95A1-260[»]
    3M67X-ray1.80A1-260[»]
    3M96X-ray1.40A1-260[»]
    3M98X-ray1.50A1-260[»]
    3MHCX-ray1.70A1-260[»]
    3MHIX-ray1.70A1-260[»]
    3MHLX-ray1.90A1-260[»]
    3MHMX-ray1.50A1-260[»]
    3MHOX-ray1.15A1-260[»]
    3ML2X-ray1.80A1-260[»]
    3MMFX-ray1.50A1-260[»]
    3MNAX-ray1.50A1-260[»]
    3MNHX-ray1.65A1-260[»]
    3MNIX-ray1.75A1-260[»]
    3MNJX-ray1.75A1-260[»]
    3MNKX-ray1.75A1-260[»]
    3MNUX-ray1.80A2-260[»]
    3MWOX-ray1.40A/B1-260[»]
    3MYQX-ray1.35A1-260[»]
    3MZCX-ray1.50A1-260[»]
    3N0NX-ray1.50A1-260[»]
    3N2PX-ray1.65A1-260[»]
    3N3JX-ray1.50A1-260[»]
    3N4BX-ray1.60A1-260[»]
    3NB5X-ray1.80A1-260[»]
    3NI5X-ray2.10A1-260[»]
    3NJ9X-ray2.00A1-260[»]
    3OIKX-ray1.50A1-260[»]
    3OILX-ray1.50A1-260[»]
    3OIMX-ray1.45A1-260[»]
    3OKUX-ray1.45A1-260[»]
    3OKVX-ray1.45A1-260[»]
    3OY0X-ray1.60A1-260[»]
    3OYQX-ray1.47A1-260[»]
    3OYSX-ray1.54A1-260[»]
    3P3HX-ray1.50A1-260[»]
    3P3JX-ray1.60A1-260[»]
    3P44X-ray2.20A1-260[»]
    3P4VX-ray2.00A1-260[»]
    3P55X-ray2.00A1-260[»]
    3P58X-ray1.49A1-260[»]
    3P5AX-ray1.49A1-260[»]
    3P5LX-ray1.50A1-260[»]
    3PJJX-ray1.80A2-260[»]
    3PO6X-ray1.47A2-260[»]
    3PYKX-ray1.30A1-260[»]
    3QYKX-ray1.47A1-260[»]
    3R16X-ray1.60A4-260[»]
    3R17X-ray1.70B4-260[»]
    3RG3X-ray1.90A1-260[»]
    3RG4X-ray1.50A1-260[»]
    3RGEX-ray2.10A1-260[»]
    3RJ7X-ray1.20A3-260[»]
    3RLDX-ray1.50A1-260[»]
    3RYJX-ray1.39B2-260[»]
    3RYVX-ray1.20B2-260[»]
    3RYXX-ray1.60B2-260[»]
    3RYYX-ray1.16A2-260[»]
    3RYZX-ray1.37A2-260[»]
    3RZ0X-ray1.80B2-260[»]
    3RZ1X-ray1.51B2-260[»]
    3RZ5X-ray1.65A2-260[»]
    3RZ7X-ray1.80A2-260[»]
    3RZ8X-ray1.70A2-260[»]
    3S71X-ray1.25B3-260[»]
    3S72X-ray1.60B3-260[»]
    3S73X-ray1.75B3-260[»]
    3S74X-ray1.40B3-260[»]
    3S75X-ray1.50B3-260[»]
    3S76X-ray1.60A3-260[»]
    3S77X-ray1.86B3-260[»]
    3S78X-ray1.98B3-260[»]
    3S8XX-ray1.30A1-260[»]
    3S9TX-ray1.30A1-260[»]
    3SAPX-ray1.75A1-260[»]
    3SAXX-ray1.10A1-260[»]
    3SBHX-ray1.65A1-260[»]
    3SBIX-ray1.40A1-260[»]
    3T5UX-ray1.75A2-260[»]
    3T5ZX-ray1.65A2-260[»]
    3T82X-ray2.00A1-260[»]
    3T83X-ray1.80A1-260[»]
    3T84X-ray2.00A1-260[»]
    3T85X-ray2.40A1-260[»]
    3TMJOther2.00A3-260[»]
    3TVNX-ray1.50X3-260[»]
    3TVOX-ray1.60X3-260[»]
    3U3AX-ray1.55X1-260[»]
    3U45X-ray1.70X1-260[»]
    3U47X-ray1.60A1-260[»]
    3U7CX-ray0.93A1-260[»]
    3V2JX-ray1.70A1-260[»]
    3V2MX-ray1.47A1-260[»]
    3V3FX-ray2.00A1-260[»]
    3V3GX-ray1.56B1-260[»]
    3V3HX-ray1.85B1-260[»]
    3V3IX-ray1.73B1-260[»]
    3V3JX-ray1.63A1-260[»]
    3V5GX-ray1.50A1-260[»]
    3V7XX-ray1.03A2-260[»]
    3VBDX-ray1.05A2-260[»]
    3ZP9X-ray1.31A1-260[»]
    4BCWX-ray1.50A4-260[»]
    4BF1X-ray1.35A2-260[»]
    4BF6X-ray1.82A2-260[»]
    4CA2X-ray2.10A1-260[»]
    4CACX-ray2.20A2-260[»]
    4CQ0X-ray1.45A1-260[»]
    4DZ7X-ray1.49A1-260[»]
    4DZ9X-ray1.49A1-260[»]
    4E3DX-ray1.60A1-260[»]
    4E3FX-ray1.50A1-260[»]
    4E3GX-ray1.55A1-260[»]
    4E3HX-ray1.50A1-260[»]
    4E49X-ray1.45A1-260[»]
    4E4AX-ray1.45A1-260[»]
    4E5QX-ray1.70A1-260[»]
    4FIKX-ray1.20A1-260[»]
    4FL7X-ray1.85A2-260[»]
    4FPTX-ray0.98A1-260[»]
    4FRCX-ray0.98A1-260[»]
    4FU5X-ray0.98A1-260[»]
    4FVNX-ray1.05A1-260[»]
    4FVOX-ray1.05A1-260[»]
    4G0Cneutron diffraction2.00A4-260[»]
    4GGEX-ray1.47A1-260[»]
    4GL1X-ray1.50X1-260[»]
    4HBAX-ray1.76A1-260[»]
    4HEWX-ray1.70A1-260[»]
    4HEYX-ray1.45A1-260[»]
    4HEZX-ray1.34A1-260[»]
    4HF3X-ray1.15A1-260[»]
    4HT0X-ray1.60A1-260[»]
    4IDRX-ray1.60X3-260[»]
    4ILXX-ray1.60A4-260[»]
    4ITOX-ray1.16A1-260[»]
    4ITPX-ray1.70A4-260[»]
    4IWZX-ray1.60A4-260[»]
    4JS6X-ray1.55A1-260[»]
    4JSAX-ray1.50A1-260[»]
    4JSSX-ray1.50A1-260[»]
    4JSWX-ray1.90A1-260[»]
    4JSZX-ray1.90A1-260[»]
    4K0SX-ray1.80A4-260[»]
    4K0TX-ray1.78A4-260[»]
    4K0ZX-ray1.80A3-260[»]
    4K13X-ray1.60A4-260[»]
    4K1QX-ray1.70A3-260[»]
    4KAPX-ray1.45A5-260[»]
    4KNIX-ray1.80A1-260[»]
    4KNJX-ray2.00A1-260[»]
    4L5UX-ray2.05A1-260[»]
    4L5VX-ray1.63A1-260[»]
    4L5WX-ray1.70A1-260[»]
    4LP6X-ray2.15A/B1-260[»]
    4M2RX-ray1.99A4-260[»]
    4M2UX-ray2.00A4-260[»]
    4M2VX-ray1.72A4-260[»]
    4M2WX-ray1.66A4-260[»]
    4MDGX-ray1.35A3-260[»]
    4MDLX-ray1.52A3-260[»]
    4MDMX-ray1.55A3-260[»]
    4MO8X-ray1.85A1-260[»]
    4MTYX-ray1.00A1-260[»]
    4N0XX-ray1.63B1-260[»]
    4N16X-ray1.54A1-260[»]
    5CA2X-ray2.10A1-260[»]
    5CACX-ray2.20A2-260[»]
    6CA2X-ray2.50A1-260[»]
    7CA2X-ray2.40A1-260[»]
    8CA2X-ray2.40A1-260[»]
    9CA2X-ray2.80A1-260[»]
    ProteinModelPortaliP00918.
    SMRiP00918. Positions 3-260.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP00918.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni198 – 1992Substrate binding

    Sequence similaritiesi

    Belongs to the alpha-carbonic anhydrase family.Curated

    Phylogenomic databases

    eggNOGiCOG3338.
    HOGENOMiHOG000112637.
    HOVERGENiHBG002837.
    InParanoidiP00918.
    KOiK18245.
    OMAiCFNAENE.
    OrthoDBiEOG7WMCK7.
    PhylomeDBiP00918.
    TreeFamiTF316425.

    Family and domain databases

    Gene3Di3.10.200.10. 1 hit.
    InterProiIPR018443. CA2.
    IPR001148. Carbonic_anhydrase_a.
    IPR023561. Carbonic_anhydrase_a-class.
    IPR018338. Carbonic_anhydrase_a-class_CS.
    [Graphical view]
    PANTHERiPTHR18952. PTHR18952. 1 hit.
    PTHR18952:SF90. PTHR18952:SF90. 1 hit.
    PfamiPF00194. Carb_anhydrase. 1 hit.
    [Graphical view]
    SMARTiSM01057. Carb_anhydrase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51069. SSF51069. 1 hit.
    PROSITEiPS00162. ALPHA_CA_1. 1 hit.
    PS51144. ALPHA_CA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P00918-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSHHWGYGKH NGPEHWHKDF PIAKGERQSP VDIDTHTAKY DPSLKPLSVS    50
    YDQATSLRIL NNGHAFNVEF DDSQDKAVLK GGPLDGTYRL IQFHFHWGSL 100
    DGQGSEHTVD KKKYAAELHL VHWNTKYGDF GKAVQQPDGL AVLGIFLKVG 150
    SAKPGLQKVV DVLDSIKTKG KSADFTNFDP RGLLPESLDY WTYPGSLTTP 200
    PLLECVTWIV LKEPISVSSE QVLKFRKLNF NGEGEPEELM VDNWRPAQPL 250
    KNRQIKASFK 260
    Length:260
    Mass (Da):29,246
    Last modified:January 23, 2007 - v2
    Checksum:i2EC2BB7548F10558
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti179 – 1802DP → AA in AAH11949. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti18 – 181K → E in Jogjakarta. 1 Publication
    VAR_001380
    Natural varianti92 – 921Q → P in OPTB3; in Czechoslovakia. 2 Publications
    VAR_001381
    Natural varianti94 – 941H → Y in OPTB3; partial loss of activity. 1 Publication
    VAR_021009
    Natural varianti107 – 1071H → Y in OPTB3; frequent mutation. 4 Publications
    VAR_001382
    Natural varianti144 – 1441G → R in OPTB3; complete loss of activity. 1 Publication
    VAR_021010
    Natural varianti236 – 2361P → H in Melbourne. 1 Publication
    VAR_001383
    Natural varianti252 – 2521N → D.
    Corresponds to variant rs2228063 [ dbSNP | Ensembl ].
    VAR_001384

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M77181
    , M77176, M77177, M77178, M77179, M77180 Genomic DNA. Translation: AAA51909.1.
    Y00339 mRNA. Translation: CAA68426.1.
    X03251 Genomic DNA. Translation: CAA27012.1.
    J03037 mRNA. Translation: AAA51908.1.
    CR536526 mRNA. Translation: CAG38763.1.
    CR541875 mRNA. Translation: CAG46673.1.
    AK312978 mRNA. Translation: BAG35815.1.
    CH471068 Genomic DNA. Translation: EAW87136.1.
    BC011949 mRNA. Translation: AAH11949.1.
    M36532 mRNA. Translation: AAA51911.1.
    CCDSiCCDS6239.1.
    PIRiA27175. CRHU2.
    RefSeqiNP_000058.1. NM_000067.2.
    UniGeneiHs.155097.

    Genome annotation databases

    EnsembliENST00000285379; ENSP00000285379; ENSG00000104267.
    GeneIDi760.
    KEGGihsa:760.
    UCSCiuc003ydk.2. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M77181
    , M77176 , M77177 , M77178 , M77179 , M77180 Genomic DNA. Translation: AAA51909.1 .
    Y00339 mRNA. Translation: CAA68426.1 .
    X03251 Genomic DNA. Translation: CAA27012.1 .
    J03037 mRNA. Translation: AAA51908.1 .
    CR536526 mRNA. Translation: CAG38763.1 .
    CR541875 mRNA. Translation: CAG46673.1 .
    AK312978 mRNA. Translation: BAG35815.1 .
    CH471068 Genomic DNA. Translation: EAW87136.1 .
    BC011949 mRNA. Translation: AAH11949.1 .
    M36532 mRNA. Translation: AAA51911.1 .
    CCDSi CCDS6239.1.
    PIRi A27175. CRHU2.
    RefSeqi NP_000058.1. NM_000067.2.
    UniGenei Hs.155097.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    12CA X-ray 2.40 A 1-260 [» ]
    1A42 X-ray 2.25 A 2-260 [» ]
    1AM6 X-ray 2.00 A 2-260 [» ]
    1AVN X-ray 2.00 A 2-260 [» ]
    1BCD X-ray 1.90 A 2-260 [» ]
    1BIC X-ray 1.90 A 2-260 [» ]
    1BN1 X-ray 2.10 A 2-260 [» ]
    1BN3 X-ray 2.20 A 2-260 [» ]
    1BN4 X-ray 2.10 A 2-260 [» ]
    1BNM X-ray 2.60 A 2-260 [» ]
    1BNN X-ray 2.30 A 2-260 [» ]
    1BNQ X-ray 2.40 A 2-260 [» ]
    1BNT X-ray 2.15 A 2-260 [» ]
    1BNU X-ray 2.15 A 2-260 [» ]
    1BNV X-ray 2.40 A 2-260 [» ]
    1BNW X-ray 2.25 A 2-260 [» ]
    1BV3 X-ray 1.85 A 2-260 [» ]
    1CA2 X-ray 2.00 A 2-260 [» ]
    1CA3 X-ray 2.30 A 1-260 [» ]
    1CAH X-ray 1.88 A 2-260 [» ]
    1CAI X-ray 1.80 A 2-260 [» ]
    1CAJ X-ray 1.90 A 2-260 [» ]
    1CAK X-ray 1.90 A 2-260 [» ]
    1CAL X-ray 2.20 A 2-260 [» ]
    1CAM X-ray 1.70 A 2-260 [» ]
    1CAN X-ray 1.90 A 2-260 [» ]
    1CAO X-ray 1.90 A 2-260 [» ]
    1CAY X-ray 2.10 A 2-260 [» ]
    1CAZ X-ray 1.90 A 2-260 [» ]
    1CCS X-ray 2.35 A 2-260 [» ]
    1CCT X-ray 2.20 A 2-260 [» ]
    1CCU X-ray 2.25 A 2-260 [» ]
    1CIL X-ray 1.60 A 2-260 [» ]
    1CIM X-ray 2.10 A 2-260 [» ]
    1CIN X-ray 2.10 A 2-260 [» ]
    1CNB X-ray 2.35 A 2-260 [» ]
    1CNC X-ray 2.20 A 2-260 [» ]
    1CNG X-ray 1.90 A 2-260 [» ]
    1CNH X-ray 2.05 A 2-260 [» ]
    1CNI X-ray 1.80 A 2-260 [» ]
    1CNJ X-ray 1.80 A 2-260 [» ]
    1CNK X-ray 2.15 A 2-260 [» ]
    1CNW X-ray 2.00 A 1-260 [» ]
    1CNX X-ray 1.90 A 1-260 [» ]
    1CNY X-ray 2.30 A 1-260 [» ]
    1CRA X-ray 1.90 A 2-260 [» ]
    1CVA X-ray 2.25 A 2-260 [» ]
    1CVB X-ray 2.40 A 2-260 [» ]
    1CVC X-ray 2.30 A 2-260 [» ]
    1CVD X-ray 2.20 A 5-259 [» ]
    1CVE X-ray 2.25 A 2-260 [» ]
    1CVF X-ray 2.25 A 2-260 [» ]
    1CVH X-ray 2.30 A 5-259 [» ]
    1DCA X-ray 2.20 A 1-260 [» ]
    1DCB X-ray 2.10 A 1-260 [» ]
    1EOU X-ray 2.10 A 1-260 [» ]
    1F2W X-ray 1.90 A 2-260 [» ]
    1FQL X-ray 2.00 A 1-260 [» ]
    1FQM X-ray 2.00 A 1-260 [» ]
    1FQN X-ray 2.00 A 1-260 [» ]
    1FQR X-ray 2.00 A 1-260 [» ]
    1FR4 X-ray 1.60 A 1-260 [» ]
    1FR7 X-ray 1.50 A/B 1-260 [» ]
    1FSN X-ray 2.00 A/B 1-260 [» ]
    1FSQ X-ray 2.00 A/B 1-260 [» ]
    1FSR X-ray 2.00 A/B 1-260 [» ]
    1G0E X-ray 1.60 A 1-260 [» ]
    1G0F X-ray 1.60 A 1-260 [» ]
    1G1D X-ray 2.04 A 2-260 [» ]
    1G3Z X-ray 1.86 A 2-260 [» ]
    1G45 X-ray 1.83 A 2-260 [» ]
    1G46 X-ray 1.84 A 2-260 [» ]
    1G48 X-ray 1.86 A 2-260 [» ]
    1G4J X-ray 1.84 A 2-260 [» ]
    1G4O X-ray 1.96 A 2-260 [» ]
    1G52 X-ray 1.80 A 2-260 [» ]
    1G53 X-ray 1.94 A 2-260 [» ]
    1G54 X-ray 1.86 A 2-260 [» ]
    1H4N X-ray 2.00 A 2-260 [» ]
    1H9N X-ray 1.85 A 2-260 [» ]
    1H9Q X-ray 2.20 A 2-260 [» ]
    1HCA X-ray 2.30 A 1-260 [» ]
    1HEA X-ray 2.00 A 1-260 [» ]
    1HEB X-ray 2.00 A 1-260 [» ]
    1HEC X-ray 2.00 A 1-260 [» ]
    1HED X-ray 2.00 A 1-260 [» ]
    1HVA X-ray 2.30 A 1-260 [» ]
    1I8Z X-ray 1.93 A 2-260 [» ]
    1I90 X-ray 2.00 A 2-260 [» ]
    1I91 X-ray 2.00 A 2-260 [» ]
    1I9L X-ray 1.93 A 2-260 [» ]
    1I9M X-ray 1.84 A 2-260 [» ]
    1I9N X-ray 1.86 A 2-260 [» ]
    1I9O X-ray 1.86 A 2-260 [» ]
    1I9P X-ray 1.92 A 2-260 [» ]
    1I9Q X-ray 1.80 A 2-260 [» ]
    1IF4 X-ray 1.93 A 2-260 [» ]
    1IF5 X-ray 2.00 A 2-260 [» ]
    1IF6 X-ray 2.09 A 2-259 [» ]
    1IF7 X-ray 1.98 A 2-260 [» ]
    1IF8 X-ray 1.94 A 2-260 [» ]
    1IF9 X-ray 2.00 A 2-260 [» ]
    1KWQ X-ray 2.60 A 1-260 [» ]
    1KWR X-ray 2.25 A 1-260 [» ]
    1LG5 X-ray 1.75 A 1-260 [» ]
    1LG6 X-ray 2.20 A 1-260 [» ]
    1LGD X-ray 1.90 A 1-260 [» ]
    1LUG X-ray 0.95 A 2-260 [» ]
    1LZV X-ray 2.30 A 1-260 [» ]
    1MOO X-ray 1.05 A 1-260 [» ]
    1MUA X-ray 1.70 A 4-259 [» ]
    1OKL X-ray 2.10 A 2-260 [» ]
    1OKM X-ray 2.20 A 2-260 [» ]
    1OKN X-ray 2.40 A 2-260 [» ]
    1OQ5 X-ray 1.50 A 2-259 [» ]
    1RAY X-ray 1.80 A 2-260 [» ]
    1RAZ X-ray 1.90 A 2-260 [» ]
    1RZA X-ray 1.90 A 2-260 [» ]
    1RZB X-ray 1.80 A 2-260 [» ]
    1RZC X-ray 1.90 A 2-260 [» ]
    1RZD X-ray 1.90 A 2-260 [» ]
    1RZE X-ray 1.90 A 2-260 [» ]
    1T9N X-ray 2.00 A 1-259 [» ]
    1TB0 X-ray 2.00 X 1-259 [» ]
    1TBT X-ray 2.00 X 1-259 [» ]
    1TE3 X-ray 2.00 X 1-260 [» ]
    1TEQ X-ray 2.00 X 1-260 [» ]
    1TEU X-ray 2.00 X 1-260 [» ]
    1TG3 X-ray 1.80 A 1-260 [» ]
    1TG9 X-ray 1.90 A 1-260 [» ]
    1TH9 X-ray 1.63 A 1-260 [» ]
    1THK X-ray 1.80 A 1-260 [» ]
    1TTM X-ray 1.95 A 2-259 [» ]
    1UGA X-ray 2.00 A 3-260 [» ]
    1UGB X-ray 2.00 A 3-260 [» ]
    1UGC X-ray 2.00 A 3-260 [» ]
    1UGD X-ray 2.00 A 3-260 [» ]
    1UGE X-ray 1.90 A 3-260 [» ]
    1UGF X-ray 2.00 A 3-260 [» ]
    1UGG X-ray 2.20 A 3-260 [» ]
    1XEG X-ray 1.81 A 1-260 [» ]
    1XEV X-ray 2.20 A/B/C/D 1-260 [» ]
    1XPZ X-ray 2.02 A 3-260 [» ]
    1XQ0 X-ray 1.76 A 2-260 [» ]
    1YDA X-ray 2.10 A 2-260 [» ]
    1YDB X-ray 1.90 A 2-260 [» ]
    1YDC X-ray 1.95 A 2-260 [» ]
    1YDD X-ray 2.10 A 2-260 [» ]
    1YO0 X-ray 1.80 A 1-260 [» ]
    1YO1 X-ray 1.70 A 1-260 [» ]
    1YO2 X-ray 1.80 A 1-259 [» ]
    1Z9Y X-ray 1.66 A 2-259 [» ]
    1ZE8 X-ray 2.00 A 2-260 [» ]
    1ZFK X-ray 1.56 A 2-259 [» ]
    1ZFQ X-ray 1.55 A 2-259 [» ]
    1ZGE X-ray 1.65 A 2-259 [» ]
    1ZGF X-ray 1.75 A 2-259 [» ]
    1ZH9 X-ray 1.70 A 2-259 [» ]
    1ZSA X-ray 2.50 A 2-260 [» ]
    1ZSB X-ray 2.00 A 2-260 [» ]
    1ZSC X-ray 1.80 A 2-260 [» ]
    2ABE X-ray 2.00 A 2-259 [» ]
    2AW1 X-ray 1.46 A 2-260 [» ]
    2AX2 X-ray 1.50 A 1-259 [» ]
    2CA2 X-ray 1.90 A 2-260 [» ]
    2CBA X-ray 1.54 A 2-260 [» ]
    2CBB X-ray 1.67 A 2-260 [» ]
    2CBC X-ray 1.88 A 2-260 [» ]
    2CBD X-ray 1.67 A 2-260 [» ]
    2CBE X-ray 1.82 A 2-260 [» ]
    2EU2 X-ray 1.15 A 1-260 [» ]
    2EU3 X-ray 1.60 A 1-260 [» ]
    2EZ7 X-ray 2.00 A 1-259 [» ]
    2F14 X-ray 1.71 A 2-259 [» ]
    2FMG X-ray 1.60 A 1-259 [» ]
    2FMZ X-ray 1.60 A 1-259 [» ]
    2FNK X-ray 1.80 A 1-260 [» ]
    2FNM X-ray 1.80 A 1-260 [» ]
    2FNN X-ray 1.80 A 1-260 [» ]
    2FOQ X-ray 1.25 A 1-259 [» ]
    2FOS X-ray 1.10 A 1-259 [» ]
    2FOU X-ray 0.99 A 1-259 [» ]
    2FOV X-ray 1.15 A 1-259 [» ]
    2GD8 X-ray 1.46 A 2-259 [» ]
    2GEH X-ray 2.00 A 1-259 [» ]
    2H15 X-ray 1.90 A 1-259 [» ]
    2H4N X-ray 1.90 A 2-260 [» ]
    2HD6 X-ray 1.80 A 2-259 [» ]
    2HKK X-ray 1.90 A 1-260 [» ]
    2HL4 X-ray 1.55 A 2-260 [» ]
    2HNC X-ray 1.55 A 2-259 [» ]
    2HOC X-ray 2.10 A 2-259 [» ]
    2ILI X-ray 1.05 A 2-259 [» ]
    2NNG X-ray 1.20 A 2-260 [» ]
    2NNO X-ray 1.01 A 2-260 [» ]
    2NNS X-ray 1.03 A 2-260 [» ]
    2NNV X-ray 1.10 A 2-260 [» ]
    2NWO X-ray 1.70 A 1-259 [» ]
    2NWP X-ray 1.80 A 1-259 [» ]
    2NWY X-ray 1.65 A 1-259 [» ]
    2NWZ X-ray 1.80 A 1-259 [» ]
    2NXR X-ray 1.70 A 1-259 [» ]
    2NXS X-ray 1.80 A 1-259 [» ]
    2NXT X-ray 1.15 A 1-260 [» ]
    2O4Z X-ray 2.10 A 1-260 [» ]
    2OSF X-ray 1.60 A 2-260 [» ]
    2OSM X-ray 1.60 A 2-260 [» ]
    2POU X-ray 1.60 A 1-259 [» ]
    2POV X-ray 1.60 A 1-258 [» ]
    2POW X-ray 1.75 A 1-259 [» ]
    2Q1B X-ray 1.70 A 1-260 [» ]
    2Q1Q X-ray 1.90 A 1-260 [» ]
    2Q38 X-ray 1.95 A 1-260 [» ]
    2QO8 X-ray 1.40 A 2-260 [» ]
    2QOA X-ray 1.60 A 2-260 [» ]
    2QP6 X-ray 1.45 A 2-260 [» ]
    2VVA X-ray 1.56 X 1-260 [» ]
    2VVB X-ray 1.66 X 1-260 [» ]
    2WD2 X-ray 1.49 A 2-259 [» ]
    2WD3 X-ray 1.80 A 2-260 [» ]
    2WEG X-ray 1.10 A 2-260 [» ]
    2WEH X-ray 2.09 A 2-260 [» ]
    2WEJ X-ray 1.45 A 2-260 [» ]
    2WEO X-ray 1.40 A 2-260 [» ]
    2X7S X-ray 1.64 A 2-260 [» ]
    2X7T X-ray 1.89 A 2-260 [» ]
    2X7U X-ray 2.12 A 2-260 [» ]
    3B4F X-ray 1.89 A 1-260 [» ]
    3BET X-ray 1.85 A 2-260 [» ]
    3BL0 X-ray 1.90 A 1-260 [» ]
    3BL1 X-ray 2.10 A 1-260 [» ]
    3C7P X-ray 1.70 A 1-260 [» ]
    3CA2 X-ray 2.00 A 2-260 [» ]
    3CAJ X-ray 1.80 A 1-260 [» ]
    3CYU X-ray 1.70 A 1-260 [» ]
    3D8W X-ray 1.70 A 1-260 [» ]
    3D92 X-ray 1.10 A 1-260 [» ]
    3D93 X-ray 1.10 A 1-260 [» ]
    3D9Z X-ray 1.65 A 1-260 [» ]
    3DAZ X-ray 1.60 A 1-260 [» ]
    3DBU X-ray 1.70 A 1-260 [» ]
    3DC3 X-ray 1.70 A 1-260 [» ]
    3DC9 X-ray 1.60 A 1-260 [» ]
    3DCC X-ray 1.60 A 1-260 [» ]
    3DCS X-ray 1.80 A 1-260 [» ]
    3DCW X-ray 1.50 A 1-260 [» ]
    3DD0 X-ray 1.48 A 1-260 [» ]
    3DD8 X-ray 1.90 A 1-260 [» ]
    3DV7 X-ray 1.70 A 2-260 [» ]
    3DVB X-ray 1.70 A 2-260 [» ]
    3DVC X-ray 1.60 A 2-260 [» ]
    3DVD X-ray 1.60 A 2-260 [» ]
    3EFI X-ray 1.75 A 2-260 [» ]
    3EFT X-ray 1.85 A 1-260 [» ]
    3F4X X-ray 1.90 A 1-260 [» ]
    3F8E X-ray 2.00 A 1-260 [» ]
    3FFP X-ray 1.81 X 1-260 [» ]
    3GZ0 X-ray 1.26 A 2-260 [» ]
    3HFP X-ray 2.10 A 1-260 [» ]
    3HKN X-ray 1.80 A 1-260 [» ]
    3HKQ X-ray 1.70 A 1-260 [» ]
    3HKT X-ray 2.36 A 1-260 [» ]
    3HKU X-ray 1.80 A 1-260 [» ]
    3HLJ X-ray 1.44 A 1-260 [» ]
    3HS4 X-ray 1.10 A 1-260 [» ]
    3IBI X-ray 1.93 A 2-260 [» ]
    3IBL X-ray 1.55 A 2-260 [» ]
    3IBN X-ray 2.20 A 2-260 [» ]
    3IBU X-ray 1.41 A 2-260 [» ]
    3IEO X-ray 2.00 A 1-260 [» ]
    3IGP X-ray 1.65 A 1-260 [» ]
    3K2F X-ray 1.98 A 1-260 [» ]
    3K34 X-ray 0.90 A 1-260 [» ]
    3K7K X-ray 1.90 A 1-260 [» ]
    3KIG X-ray 1.39 A 1-260 [» ]
    3KKX neutron diffraction 2.00 A 1-260 [» ]
    3KNE X-ray 1.35 A 1-260 [» ]
    3KOI X-ray 1.64 A 1-260 [» ]
    3KOK X-ray 1.50 A 1-260 [» ]
    3KON X-ray 1.50 A 1-260 [» ]
    3KS3 X-ray 0.90 A 1-260 [» ]
    3KWA X-ray 2.00 A 1-260 [» ]
    3L14 X-ray 1.22 A 1-260 [» ]
    3M04 X-ray 1.40 A 1-260 [» ]
    3M14 X-ray 1.38 A 1-260 [» ]
    3M1J X-ray 1.80 A 1-260 [» ]
    3M1K X-ray 1.35 A 1-260 [» ]
    3M1Q X-ray 1.69 A 1-260 [» ]
    3M1W X-ray 1.38 A 1-260 [» ]
    3M2N X-ray 1.65 A 1-260 [» ]
    3M2X X-ray 1.87 A 1-260 [» ]
    3M2Y X-ray 1.17 A 1-260 [» ]
    3M2Z X-ray 1.70 A 1-260 [» ]
    3M3X X-ray 1.68 A 1-260 [» ]
    3M40 X-ray 1.60 A 1-260 [» ]
    3M5E X-ray 1.70 A 1-260 [» ]
    3M5S X-ray 1.40 A 1-260 [» ]
    3M5T X-ray 1.95 A 1-260 [» ]
    3M67 X-ray 1.80 A 1-260 [» ]
    3M96 X-ray 1.40 A 1-260 [» ]
    3M98 X-ray 1.50 A 1-260 [» ]
    3MHC X-ray 1.70 A 1-260 [» ]
    3MHI X-ray 1.70 A 1-260 [» ]
    3MHL X-ray 1.90 A 1-260 [» ]
    3MHM X-ray 1.50 A 1-260 [» ]
    3MHO X-ray 1.15 A 1-260 [» ]
    3ML2 X-ray 1.80 A 1-260 [» ]
    3MMF X-ray 1.50 A 1-260 [» ]
    3MNA X-ray 1.50 A 1-260 [» ]
    3MNH X-ray 1.65 A 1-260 [» ]
    3MNI X-ray 1.75 A 1-260 [» ]
    3MNJ X-ray 1.75 A 1-260 [» ]
    3MNK X-ray 1.75 A 1-260 [» ]
    3MNU X-ray 1.80 A 2-260 [» ]
    3MWO X-ray 1.40 A/B 1-260 [» ]
    3MYQ X-ray 1.35 A 1-260 [» ]
    3MZC X-ray 1.50 A 1-260 [» ]
    3N0N X-ray 1.50 A 1-260 [» ]
    3N2P X-ray 1.65 A 1-260 [» ]
    3N3J X-ray 1.50 A 1-260 [» ]
    3N4B X-ray 1.60 A 1-260 [» ]
    3NB5 X-ray 1.80 A 1-260 [» ]
    3NI5 X-ray 2.10 A 1-260 [» ]
    3NJ9 X-ray 2.00 A 1-260 [» ]
    3OIK X-ray 1.50 A 1-260 [» ]
    3OIL X-ray 1.50 A 1-260 [» ]
    3OIM X-ray 1.45 A 1-260 [» ]
    3OKU X-ray 1.45 A 1-260 [» ]
    3OKV X-ray 1.45 A 1-260 [» ]
    3OY0 X-ray 1.60 A 1-260 [» ]
    3OYQ X-ray 1.47 A 1-260 [» ]
    3OYS X-ray 1.54 A 1-260 [» ]
    3P3H X-ray 1.50 A 1-260 [» ]
    3P3J X-ray 1.60 A 1-260 [» ]
    3P44 X-ray 2.20 A 1-260 [» ]
    3P4V X-ray 2.00 A 1-260 [» ]
    3P55 X-ray 2.00 A 1-260 [» ]
    3P58 X-ray 1.49 A 1-260 [» ]
    3P5A X-ray 1.49 A 1-260 [» ]
    3P5L X-ray 1.50 A 1-260 [» ]
    3PJJ X-ray 1.80 A 2-260 [» ]
    3PO6 X-ray 1.47 A 2-260 [» ]
    3PYK X-ray 1.30 A 1-260 [» ]
    3QYK X-ray 1.47 A 1-260 [» ]
    3R16 X-ray 1.60 A 4-260 [» ]
    3R17 X-ray 1.70 B 4-260 [» ]
    3RG3 X-ray 1.90 A 1-260 [» ]
    3RG4 X-ray 1.50 A 1-260 [» ]
    3RGE X-ray 2.10 A 1-260 [» ]
    3RJ7 X-ray 1.20 A 3-260 [» ]
    3RLD X-ray 1.50 A 1-260 [» ]
    3RYJ X-ray 1.39 B 2-260 [» ]
    3RYV X-ray 1.20 B 2-260 [» ]
    3RYX X-ray 1.60 B 2-260 [» ]
    3RYY X-ray 1.16 A 2-260 [» ]
    3RYZ X-ray 1.37 A 2-260 [» ]
    3RZ0 X-ray 1.80 B 2-260 [» ]
    3RZ1 X-ray 1.51 B 2-260 [» ]
    3RZ5 X-ray 1.65 A 2-260 [» ]
    3RZ7 X-ray 1.80 A 2-260 [» ]
    3RZ8 X-ray 1.70 A 2-260 [» ]
    3S71 X-ray 1.25 B 3-260 [» ]
    3S72 X-ray 1.60 B 3-260 [» ]
    3S73 X-ray 1.75 B 3-260 [» ]
    3S74 X-ray 1.40 B 3-260 [» ]
    3S75 X-ray 1.50 B 3-260 [» ]
    3S76 X-ray 1.60 A 3-260 [» ]
    3S77 X-ray 1.86 B 3-260 [» ]
    3S78 X-ray 1.98 B 3-260 [» ]
    3S8X X-ray 1.30 A 1-260 [» ]
    3S9T X-ray 1.30 A 1-260 [» ]
    3SAP X-ray 1.75 A 1-260 [» ]
    3SAX X-ray 1.10 A 1-260 [» ]
    3SBH X-ray 1.65 A 1-260 [» ]
    3SBI X-ray 1.40 A 1-260 [» ]
    3T5U X-ray 1.75 A 2-260 [» ]
    3T5Z X-ray 1.65 A 2-260 [» ]
    3T82 X-ray 2.00 A 1-260 [» ]
    3T83 X-ray 1.80 A 1-260 [» ]
    3T84 X-ray 2.00 A 1-260 [» ]
    3T85 X-ray 2.40 A 1-260 [» ]
    3TMJ Other 2.00 A 3-260 [» ]
    3TVN X-ray 1.50 X 3-260 [» ]
    3TVO X-ray 1.60 X 3-260 [» ]
    3U3A X-ray 1.55 X 1-260 [» ]
    3U45 X-ray 1.70 X 1-260 [» ]
    3U47 X-ray 1.60 A 1-260 [» ]
    3U7C X-ray 0.93 A 1-260 [» ]
    3V2J X-ray 1.70 A 1-260 [» ]
    3V2M X-ray 1.47 A 1-260 [» ]
    3V3F X-ray 2.00 A 1-260 [» ]
    3V3G X-ray 1.56 B 1-260 [» ]
    3V3H X-ray 1.85 B 1-260 [» ]
    3V3I X-ray 1.73 B 1-260 [» ]
    3V3J X-ray 1.63 A 1-260 [» ]
    3V5G X-ray 1.50 A 1-260 [» ]
    3V7X X-ray 1.03 A 2-260 [» ]
    3VBD X-ray 1.05 A 2-260 [» ]
    3ZP9 X-ray 1.31 A 1-260 [» ]
    4BCW X-ray 1.50 A 4-260 [» ]
    4BF1 X-ray 1.35 A 2-260 [» ]
    4BF6 X-ray 1.82 A 2-260 [» ]
    4CA2 X-ray 2.10 A 1-260 [» ]
    4CAC X-ray 2.20 A 2-260 [» ]
    4CQ0 X-ray 1.45 A 1-260 [» ]
    4DZ7 X-ray 1.49 A 1-260 [» ]
    4DZ9 X-ray 1.49 A 1-260 [» ]
    4E3D X-ray 1.60 A 1-260 [» ]
    4E3F X-ray 1.50 A 1-260 [» ]
    4E3G X-ray 1.55 A 1-260 [» ]
    4E3H X-ray 1.50 A 1-260 [» ]
    4E49 X-ray 1.45 A 1-260 [» ]
    4E4A X-ray 1.45 A 1-260 [» ]
    4E5Q X-ray 1.70 A 1-260 [» ]
    4FIK X-ray 1.20 A 1-260 [» ]
    4FL7 X-ray 1.85 A 2-260 [» ]
    4FPT X-ray 0.98 A 1-260 [» ]
    4FRC X-ray 0.98 A 1-260 [» ]
    4FU5 X-ray 0.98 A 1-260 [» ]
    4FVN X-ray 1.05 A 1-260 [» ]
    4FVO X-ray 1.05 A 1-260 [» ]
    4G0C neutron diffraction 2.00 A 4-260 [» ]
    4GGE X-ray 1.47 A 1-260 [» ]
    4GL1 X-ray 1.50 X 1-260 [» ]
    4HBA X-ray 1.76 A 1-260 [» ]
    4HEW X-ray 1.70 A 1-260 [» ]
    4HEY X-ray 1.45 A 1-260 [» ]
    4HEZ X-ray 1.34 A 1-260 [» ]
    4HF3 X-ray 1.15 A 1-260 [» ]
    4HT0 X-ray 1.60 A 1-260 [» ]
    4IDR X-ray 1.60 X 3-260 [» ]
    4ILX X-ray 1.60 A 4-260 [» ]
    4ITO X-ray 1.16 A 1-260 [» ]
    4ITP X-ray 1.70 A 4-260 [» ]
    4IWZ X-ray 1.60 A 4-260 [» ]
    4JS6 X-ray 1.55 A 1-260 [» ]
    4JSA X-ray 1.50 A 1-260 [» ]
    4JSS X-ray 1.50 A 1-260 [» ]
    4JSW X-ray 1.90 A 1-260 [» ]
    4JSZ X-ray 1.90 A 1-260 [» ]
    4K0S X-ray 1.80 A 4-260 [» ]
    4K0T X-ray 1.78 A 4-260 [» ]
    4K0Z X-ray 1.80 A 3-260 [» ]
    4K13 X-ray 1.60 A 4-260 [» ]
    4K1Q X-ray 1.70 A 3-260 [» ]
    4KAP X-ray 1.45 A 5-260 [» ]
    4KNI X-ray 1.80 A 1-260 [» ]
    4KNJ X-ray 2.00 A 1-260 [» ]
    4L5U X-ray 2.05 A 1-260 [» ]
    4L5V X-ray 1.63 A 1-260 [» ]
    4L5W X-ray 1.70 A 1-260 [» ]
    4LP6 X-ray 2.15 A/B 1-260 [» ]
    4M2R X-ray 1.99 A 4-260 [» ]
    4M2U X-ray 2.00 A 4-260 [» ]
    4M2V X-ray 1.72 A 4-260 [» ]
    4M2W X-ray 1.66 A 4-260 [» ]
    4MDG X-ray 1.35 A 3-260 [» ]
    4MDL X-ray 1.52 A 3-260 [» ]
    4MDM X-ray 1.55 A 3-260 [» ]
    4MO8 X-ray 1.85 A 1-260 [» ]
    4MTY X-ray 1.00 A 1-260 [» ]
    4N0X X-ray 1.63 B 1-260 [» ]
    4N16 X-ray 1.54 A 1-260 [» ]
    5CA2 X-ray 2.10 A 1-260 [» ]
    5CAC X-ray 2.20 A 2-260 [» ]
    6CA2 X-ray 2.50 A 1-260 [» ]
    7CA2 X-ray 2.40 A 1-260 [» ]
    8CA2 X-ray 2.40 A 1-260 [» ]
    9CA2 X-ray 2.80 A 1-260 [» ]
    ProteinModelPortali P00918.
    SMRi P00918. Positions 3-260.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107215. 12 interactions.
    IntActi P00918. 5 interactions.
    MINTi MINT-1367766.
    STRINGi 9606.ENSP00000285379.

    Chemistry

    BindingDBi P00918.
    ChEMBLi CHEMBL2096906.
    DrugBanki DB00819. Acetazolamide.
    DB00436. Bendroflumethiazide.
    DB00562. Benzthiazide.
    DB01194. Brinzolamide.
    DB00880. Chlorothiazide.
    DB00606. Cyclothiazide.
    DB01119. Diazoxide.
    DB00869. Dorzolamide.
    DB01031. Ethinamate.
    DB00999. Hydrochlorothiazide.
    DB00774. Hydroflumethiazide.
    DB00232. Methyclothiazide.
    DB01325. Quinethazone.
    DB00273. Topiramate.
    DB01021. Trichlormethiazide.

    PTM databases

    PhosphoSitei P00918.

    2D gel databases

    OGPi P00918.
    REPRODUCTION-2DPAGE IPI00218414.
    P00918.
    UCD-2DPAGE P00918.

    Proteomic databases

    MaxQBi P00918.
    PaxDbi P00918.
    PeptideAtlasi P00918.
    PRIDEi P00918.

    Protocols and materials databases

    DNASUi 760.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000285379 ; ENSP00000285379 ; ENSG00000104267 .
    GeneIDi 760.
    KEGGi hsa:760.
    UCSCi uc003ydk.2. human.

    Organism-specific databases

    CTDi 760.
    GeneCardsi GC08P086376.
    HGNCi HGNC:1373. CA2.
    HPAi CAB010102.
    HPA001550.
    MIMi 259730. phenotype.
    611492. gene.
    neXtProti NX_P00918.
    Orphaneti 2785. Osteopetrosis with renal tubular acidosis.
    PharmGKBi PA25989.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG3338.
    HOGENOMi HOG000112637.
    HOVERGENi HBG002837.
    InParanoidi P00918.
    KOi K18245.