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Protein

Carbonic anhydrase 2

Gene

CA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. Stimulates the chloride-bicarbonate exchange activity of SLC26A6.By similarity3 Publications

Catalytic activityi

H2CO3 = CO2 + H2O.

Cofactori

Zn2+22 Publications, Co2+1 PublicationNote: Zinc. Can also use cobalt(II) with lower efficiency, but not copper(II), nickel(II) and manganese(II).1 Publication

Enzyme regulationi

Activated by X-ray, histamine, L-adrenaline, L- and D-phenylalanine, L- and D-histidine, L-His-OMe and beta-Ala-His (carnosine). Competitively inhibited by saccharin, thioxolone, coumarins, 667-coumate, celecoxib (Celebrex), valdecoxib (Bextra), SC-125, SC-560, diclofenac, acetate, azide, bromide, sulfonamide derivatives such as acetazolamide (AZA), methazolamide (MZA), ethoxzolamide (EZA), dichlorophenamide (DCP), brinzolamide, dansylamide, thiabendazole-5-sulfonamide, trifluoromethane sulfonamide and N-hydroxysulfamide, fructose-based sugar sulfamate RWJ-37497, and Foscarnet (phosphonoformate trisodium salt). Repressed strongly by hydrogen sulfide(HS) and weakly by nitrate (NO3). Esterase activity weakly reduced by cyanamide. N-hydroxyurea interfers with zinc binding and inhibit activity.27 Publications

Absorptioni

Abs(max)=~550 nm10 Publications

At pH 7.0. Shows a second maximum at 618 nm.

Kineticsi

  1. KM=10 mM for CO210 Publications
  2. KM=82 mM for H2CO310 Publications
  3. KM=3 mM for 4-nitrophenyl acetate10 Publications

    pH dependencei

    Optimum pH is 6-8.10 Publications

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei62 – 621Activator3 Publications
    Active sitei64 – 641Proton acceptor3 Publications
    Active sitei67 – 6713 Publications
    Binding sitei67 – 671Activator3 Publications
    Binding sitei92 – 921Activator3 Publications
    Metal bindingi94 – 941Zinc; catalytic23 Publications
    Metal bindingi96 – 961Zinc; catalytic22 Publications
    Metal bindingi119 – 1191Zinc; catalytic22 Publications
    Active sitei127 – 12713 Publications

    GO - Molecular functioni

    • arylesterase activity Source: CACAO
    • carbonate dehydratase activity Source: CACAO
    • zinc ion binding Source: UniProtKB

    GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Lyase

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BRENDAi4.2.1.1. 2681.
    ReactomeiR-HSA-1237044. Erythrocytes take up carbon dioxide and release oxygen.
    R-HSA-1247673. Erythrocytes take up oxygen and release carbon dioxide.
    R-HSA-1475029. Reversible hydration of carbon dioxide.
    SABIO-RKP00918.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Carbonic anhydrase 2 (EC:4.2.1.1)
    Alternative name(s):
    Carbonate dehydratase II
    Carbonic anhydrase C
    Short name:
    CAC
    Carbonic anhydrase II
    Short name:
    CA-II
    Gene namesi
    Name:CA2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    Proteomesi
    • UP000005640 Componenti: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:1373. CA2.

    Subcellular locationi

    • Cytoplasm 1 Publication
    • Cell membrane 1 Publication

    • Note: Colocalized with SLC26A6 at the surface of the cell membrane in order to form a bicarbonate transport metabolon. Displaced from the cytosolic surface of the cell membrane by PKC in phorbol myristate acetate (PMA)-induced cells.

    GO - Cellular componenti

    • apical part of cell Source: UniProtKB
    • axon Source: Ensembl
    • basolateral plasma membrane Source: Ensembl
    • cytoplasm Source: UniProtKB
    • cytosol Source: Reactome
    • extracellular exosome Source: UniProtKB
    • extracellular space Source: Ensembl
    • microvillus Source: Ensembl
    • myelin sheath Source: Ensembl
    • plasma membrane Source: UniProtKB
    Complete GO annotation...

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Osteopetrosis, autosomal recessive 3 (OPTB3)5 Publications
    The disease is caused by mutations affecting the gene represented in this entry.
    Disease descriptionA rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. Osteopetrosis occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Recessive osteopetrosis commonly manifests in early infancy with macrocephaly, feeding difficulties, evolving blindness and deafness, bone marrow failure, severe anemia, and hepatosplenomegaly. Deafness and blindness are generally thought to represent effects of pressure on nerves. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.
    See also OMIM:259730
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti92 – 921Q → P in OPTB3; in Czechoslovakia. 2 Publications
    VAR_001381
    Natural varianti94 – 941H → Y in OPTB3; partial loss of activity. 1 Publication
    VAR_021009
    Natural varianti107 – 1071H → Y in OPTB3; frequent mutation. 4 Publications
    VAR_001382
    Natural varianti144 – 1441G → R in OPTB3; complete loss of activity. 1 Publication
    VAR_021010

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi5 – 51W → A: Impaired activity, not rescued by 4-methylimidazole (4-MI); when associated with W-64. 1 Publication
    Mutagenesisi7 – 71Y → F: Enhanced activity. 2 Publications
    Mutagenesisi7 – 71Y → H: Reduced proton transfer rate. 2 Publications
    Mutagenesisi62 – 621N → A: Reduced activity. 3 Publications
    Mutagenesisi62 – 621N → D: Strongly reduced activity. 3 Publications
    Mutagenesisi62 – 621N → H: Reduced proton transfer; when associated with A-64. 3 Publications
    Mutagenesisi62 – 621N → L: Reduced activity. 3 Publications
    Mutagenesisi62 – 621N → T: Reduced activity. 3 Publications
    Mutagenesisi62 – 621N → V: Reduced activity. 3 Publications
    Mutagenesisi64 – 641H → A: Reduced CO(2) hydrase activity, rescued by 4-methylimidazole (4-MI). Reduced proton transfer; when associated with H-62. Enhanced proton transfer; when associated with H-67. Enhanced proton transfer capacity; when associated with H-99. 4 Publications
    Mutagenesisi64 – 641H → G: Impaired activity, not rescued by 4-methylimidazole (4-MI). 4 Publications
    Mutagenesisi64 – 641H → W: Impaired activity, rescued by 4-methylimidazole (4-MI). Impaired activity, not rescued by 4-methylimidazole (4-MI); when associated with A-5. 4 Publications
    Mutagenesisi65 – 651A → F: Reduced activity. 1 Publication
    Mutagenesisi65 – 651A → H, L or S: Normal activity. 1 Publication
    Mutagenesisi67 – 671N → H: Enhanced proton transfer; when associated with A-64. 3 Publications
    Mutagenesisi67 – 671N → L: Reduced activity. 3 Publications
    Mutagenesisi67 – 671N → Q: Normal activity. 3 Publications
    Mutagenesisi94 – 941H → C, D, E, N or Q: Strongly reduced CO(2) hydrase and p-nitrophenyl acetate esterase activities, impaired stability of zinc binding. 2 Publications
    Mutagenesisi106 – 1061E → A or Q: Strongly reduced CO(2) hydrase activity. 2 Publications
    Mutagenesisi106 – 1061E → D: Normal CO(2) hydrase activity. 2 Publications
    Mutagenesisi117 – 1171E → Q: Strongly reduced activity and sulfonamide affinity. 1 Publication
    Mutagenesisi119 – 1191H → D, N or Q: Reduced activity. 1 Publication
    Mutagenesisi119 – 1191H → E: Strongly reduced activity. 1 Publication
    Mutagenesisi121 – 1211V → A, G, I, L or S: Reduced CO(2) hydrase and p-nitrophenyl acetate esterase activities. 1 Publication
    Mutagenesisi121 – 1211V → K or R: Strongly reduced CO(2) hydrase and p-nitrophenyl acetate esterase activities. 1 Publication
    Mutagenesisi142 – 1421V → F or Y: Strongly impaired activity. 1 Publication
    Mutagenesisi142 – 1421V → G: Weakly impaired activity. 1 Publication
    Mutagenesisi142 – 1421V → H: Impaired activity. 1 Publication
    Mutagenesisi197 – 1971L → A: Reduced CO(2) hydrase activity. 1 Publication
    Mutagenesisi197 – 1971L → E, H or R: Strongly reduced CO(2) hydrase activity. 1 Publication
    Mutagenesisi197 – 1971L → F: Normal activity. 1 Publication
    Mutagenesisi198 – 1981T → A, C, H or P: Strongly reduced activity. 5 Publications
    Mutagenesisi198 – 1981T → D or E: Strongly reduced activity, but enhanced zinc affinity. 5 Publications
    Mutagenesisi198 – 1981T → S or V: Reduced activity. 5 Publications
    Mutagenesisi199 – 1991T → H: Higher affinity for bicarbonate. Enhanced proton transfer capacity; when associated with A-64. 3 Publications
    Mutagenesisi199 – 1991T → S: Enhanced p-nitrophenyl acetate esterase activity, but normal CO(2) hydrase activity. 3 Publications
    Mutagenesisi201 – 2011P → A: Normal CO(2) hydrase activity, but impaired stability. 1 Publication

    Keywords - Diseasei

    Disease mutation, Osteopetrosis

    Organism-specific databases

    MalaCardsiCA2.
    MIMi259730. phenotype.
    Orphaneti2785. Osteopetrosis with renal tubular acidosis.
    PharmGKBiPA25989.

    Chemistry

    ChEMBLiCHEMBL2095180.
    DrugBankiDB00819. Acetazolamide.
    DB00436. Bendroflumethiazide.
    DB00562. Benzthiazide.
    DB01194. Brinzolamide.
    DB00880. Chlorothiazide.
    DB00606. Cyclothiazide.
    DB01119. Diazoxide.
    DB01144. Diclofenamide.
    DB00869. Dorzolamide.
    DB01031. Ethinamate.
    DB00695. Furosemide.
    DB00999. Hydrochlorothiazide.
    DB00774. Hydroflumethiazide.
    DB00703. Methazolamide.
    DB00232. Methyclothiazide.
    DB01325. Quinethazone.
    DB00273. Topiramate.
    DB01021. Trichlormethiazide.
    DB03904. Urea.
    DB00909. Zonisamide.

    Polymorphism and mutation databases

    BioMutaiCA2.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methionineiRemoved2 Publications
    Chaini2 – 260259Carbonic anhydrase 2PRO_0000077418Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine2 Publications
    Modified residuei2 – 21PhosphoserineBy similarity
    Modified residuei165 – 1651PhosphoserineCombined sources
    Modified residuei172 – 1721PhosphoserineCombined sources

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    EPDiP00918.
    PaxDbiP00918.
    PeptideAtlasiP00918.
    PRIDEiP00918.

    2D gel databases

    OGPiP00918.
    REPRODUCTION-2DPAGEIPI00218414.
    P00918.
    UCD-2DPAGEP00918.

    PTM databases

    iPTMnetiP00918.
    PhosphoSiteiP00918.

    Expressioni

    Gene expression databases

    BgeeiP00918.
    CleanExiHS_CA2.
    ExpressionAtlasiP00918. baseline and differential.
    GenevisibleiP00918. HS.

    Organism-specific databases

    HPAiCAB010102.
    HPA001550.

    Interactioni

    Subunit structurei

    Interacts with SLC4A4. Interaction with SLC4A7 regulates SLC4A7 transporter activity. Interacts with SLC26A6 isoform 4 (via C-terminus cytoplasmic domain).90 Publications

    Protein-protein interaction databases

    BioGridi107215. 14 interactions.
    IntActiP00918. 6 interactions.
    MINTiMINT-1367766.
    STRINGi9606.ENSP00000285379.

    Chemistry

    BindingDBiP00918.

    Structurei

    Secondary structure

    1
    260
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni9 – 113Combined sources
    Turni13 – 153Combined sources
    Helixi16 – 183Combined sources
    Helixi21 – 244Combined sources
    Beta strandi25 – 273Combined sources
    Beta strandi31 – 333Combined sources
    Turni35 – 373Combined sources
    Beta strandi38 – 403Combined sources
    Beta strandi42 – 443Combined sources
    Beta strandi45 – 506Combined sources
    Beta strandi56 – 616Combined sources
    Beta strandi63 – 708Combined sources
    Beta strandi73 – 753Combined sources
    Beta strandi77 – 826Combined sources
    Beta strandi88 – 9710Combined sources
    Beta strandi106 – 1094Combined sources
    Beta strandi115 – 12410Combined sources
    Helixi125 – 1273Combined sources
    Helixi130 – 1334Combined sources
    Beta strandi139 – 15113Combined sources
    Helixi154 – 1563Combined sources
    Helixi157 – 1626Combined sources
    Helixi163 – 1653Combined sources
    Beta strandi172 – 1743Combined sources
    Helixi180 – 1834Combined sources
    Beta strandi190 – 1956Combined sources
    Beta strandi206 – 2138Combined sources
    Beta strandi215 – 2173Combined sources
    Helixi219 – 2257Combined sources
    Turni226 – 2283Combined sources
    Beta strandi229 – 2313Combined sources
    Beta strandi233 – 2353Combined sources
    Beta strandi256 – 2583Combined sources

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    12CAX-ray2.40A1-260[»]
    1A42X-ray2.25A2-260[»]
    1AM6X-ray2.00A2-260[»]
    1AVNX-ray2.00A2-260[»]
    1BCDX-ray1.90A2-260[»]
    1BICX-ray1.90A2-260[»]
    1BN1X-ray2.10A2-260[»]
    1BN3X-ray2.20A2-260[»]
    1BN4X-ray2.10A2-260[»]
    1BNMX-ray2.60A2-260[»]
    1BNNX-ray2.30A2-260[»]
    1BNQX-ray2.40A2-260[»]
    1BNTX-ray2.15A2-260[»]
    1BNUX-ray2.15A2-260[»]
    1BNVX-ray2.40A2-260[»]
    1BNWX-ray2.25A2-260[»]
    1BV3X-ray1.85A2-260[»]
    1CA2X-ray2.00A2-260[»]
    1CA3X-ray2.30A1-260[»]
    1CAHX-ray1.88A2-260[»]
    1CAIX-ray1.80A2-260[»]
    1CAJX-ray1.90A2-260[»]
    1CAKX-ray1.90A2-260[»]
    1CALX-ray2.20A2-260[»]
    1CAMX-ray1.70A2-260[»]
    1CANX-ray1.90A2-260[»]
    1CAOX-ray1.90A2-260[»]
    1CAYX-ray2.10A2-260[»]
    1CAZX-ray1.90A2-260[»]
    1CCSX-ray2.35A2-260[»]
    1CCTX-ray2.20A2-260[»]
    1CCUX-ray2.25A2-260[»]
    1CILX-ray1.60A2-260[»]
    1CIMX-ray2.10A2-260[»]
    1CINX-ray2.10A2-260[»]
    1CNBX-ray2.35A2-260[»]
    1CNCX-ray2.20A2-260[»]
    1CNGX-ray1.90A2-260[»]
    1CNHX-ray2.05A2-260[»]
    1CNIX-ray1.80A2-260[»]
    1CNJX-ray1.80A2-260[»]
    1CNKX-ray2.15A2-260[»]
    1CNWX-ray2.00A1-260[»]
    1CNXX-ray1.90A1-260[»]
    1CNYX-ray2.30A1-260[»]
    1CRAX-ray1.90A2-260[»]
    1CVAX-ray2.25A2-260[»]
    1CVBX-ray2.40A2-260[»]
    1CVCX-ray2.30A2-260[»]
    1CVDX-ray2.20A5-259[»]
    1CVEX-ray2.25A2-260[»]
    1CVFX-ray2.25A2-260[»]
    1CVHX-ray2.30A5-259[»]
    1DCAX-ray2.20A1-260[»]
    1DCBX-ray2.10A1-260[»]
    1EOUX-ray2.10A1-260[»]
    1F2WX-ray1.90A2-260[»]
    1FQLX-ray2.00A1-260[»]
    1FQMX-ray2.00A1-260[»]
    1FQNX-ray2.00A1-260[»]
    1FQRX-ray2.00A1-260[»]
    1FR4X-ray1.60A1-260[»]
    1FR7X-ray1.50A/B1-260[»]
    1FSNX-ray2.00A/B1-260[»]
    1FSQX-ray2.00A/B1-260[»]
    1FSRX-ray2.00A/B1-260[»]
    1G0EX-ray1.60A1-260[»]
    1G0FX-ray1.60A1-260[»]
    1G1DX-ray2.04A2-260[»]
    1G3ZX-ray1.86A2-260[»]
    1G45X-ray1.83A2-260[»]
    1G46X-ray1.84A2-260[»]
    1G48X-ray1.86A2-260[»]
    1G4JX-ray1.84A2-260[»]
    1G4OX-ray1.96A2-260[»]
    1G52X-ray1.80A2-260[»]
    1G53X-ray1.94A2-260[»]
    1G54X-ray1.86A2-260[»]
    1H4NX-ray2.00A2-260[»]
    1H9NX-ray1.85A2-260[»]
    1H9QX-ray2.20A2-260[»]
    1HCAX-ray2.30A1-260[»]
    1HEAX-ray2.00A1-260[»]
    1HEBX-ray2.00A1-260[»]
    1HECX-ray2.00A1-260[»]
    1HEDX-ray2.00A1-260[»]
    1HVAX-ray2.30A1-260[»]
    1I8ZX-ray1.93A2-260[»]
    1I90X-ray2.00A2-260[»]
    1I91X-ray2.00A2-260[»]
    1I9LX-ray1.93A2-260[»]
    1I9MX-ray1.84A2-260[»]
    1I9NX-ray1.86A2-260[»]
    1I9OX-ray1.86A2-260[»]
    1I9PX-ray1.92A2-260[»]
    1I9QX-ray1.80A2-260[»]
    1IF4X-ray1.93A2-260[»]
    1IF5X-ray2.00A2-260[»]
    1IF6X-ray2.09A2-259[»]
    1IF7X-ray1.98A2-260[»]
    1IF8X-ray1.94A2-260[»]
    1IF9X-ray2.00A2-260[»]
    1KWQX-ray2.60A1-260[»]
    1KWRX-ray2.25A1-260[»]
    1LG5X-ray1.75A1-260[»]
    1LG6X-ray2.20A1-260[»]
    1LGDX-ray1.90A1-260[»]
    1LUGX-ray0.95A2-260[»]
    1LZVX-ray2.30A1-260[»]
    1MOOX-ray1.05A1-260[»]
    1MUAX-ray1.70A4-259[»]
    1OKLX-ray2.10A2-260[»]
    1OKMX-ray2.20A2-260[»]
    1OKNX-ray2.40A2-260[»]
    1OQ5X-ray1.50A2-259[»]
    1RAYX-ray1.80A2-260[»]
    1RAZX-ray1.90A2-260[»]
    1RZAX-ray1.90A2-260[»]
    1RZBX-ray1.80A2-260[»]
    1RZCX-ray1.90A2-260[»]
    1RZDX-ray1.90A2-260[»]
    1RZEX-ray1.90A2-260[»]
    1T9NX-ray2.00A1-259[»]
    1TB0X-ray2.00X1-259[»]
    1TBTX-ray2.00X1-259[»]
    1TE3X-ray2.00X1-260[»]
    1TEQX-ray2.00X1-260[»]
    1TEUX-ray2.00X1-260[»]
    1TG3X-ray1.80A1-260[»]
    1TG9X-ray1.90A1-260[»]
    1TH9X-ray1.63A1-260[»]
    1THKX-ray1.80A1-260[»]
    1TTMX-ray1.95A2-259[»]
    1UGAX-ray2.00A3-260[»]
    1UGBX-ray2.00A3-260[»]
    1UGCX-ray2.00A3-260[»]
    1UGDX-ray2.00A3-260[»]
    1UGEX-ray1.90A3-260[»]
    1UGFX-ray2.00A3-260[»]
    1UGGX-ray2.20A3-260[»]
    1XEGX-ray1.81A1-260[»]
    1XEVX-ray2.20A/B/C/D1-260[»]
    1XPZX-ray2.02A3-260[»]
    1XQ0X-ray1.76A2-260[»]
    1YDAX-ray2.10A2-260[»]
    1YDBX-ray1.90A2-260[»]
    1YDCX-ray1.95A2-260[»]
    1YDDX-ray2.10A2-260[»]
    1YO0X-ray1.80A1-260[»]
    1YO1X-ray1.70A1-260[»]
    1YO2X-ray1.80A1-259[»]
    1Z9YX-ray1.66A2-259[»]
    1ZE8X-ray2.00A2-260[»]
    1ZFKX-ray1.56A2-259[»]
    1ZFQX-ray1.55A2-259[»]
    1ZGEX-ray1.65A2-259[»]
    1ZGFX-ray1.75A2-259[»]
    1ZH9X-ray1.70A2-259[»]
    1ZSAX-ray2.50A2-260[»]
    1ZSBX-ray2.00A2-260[»]
    1ZSCX-ray1.80A2-260[»]
    2ABEX-ray2.00A2-259[»]
    2AW1X-ray1.46A2-260[»]
    2AX2X-ray1.50A1-259[»]
    2CA2X-ray1.90A2-260[»]
    2CBAX-ray1.54A2-260[»]
    2CBBX-ray1.67A2-260[»]
    2CBCX-ray1.88A2-260[»]
    2CBDX-ray1.67A2-260[»]
    2CBEX-ray1.82A2-260[»]
    2EU2X-ray1.15A1-260[»]
    2EU3X-ray1.60A1-260[»]
    2EZ7X-ray2.00A1-259[»]
    2F14X-ray1.71A2-259[»]
    2FMGX-ray1.60A1-259[»]
    2FMZX-ray1.60A1-259[»]
    2FNKX-ray1.80A1-260[»]
    2FNMX-ray1.80A1-260[»]
    2FNNX-ray1.80A1-260[»]
    2FOQX-ray1.25A1-259[»]
    2FOSX-ray1.10A1-259[»]
    2FOUX-ray0.99A1-259[»]
    2FOVX-ray1.15A1-259[»]
    2GD8X-ray1.46A2-259[»]
    2GEHX-ray2.00A1-259[»]
    2H15X-ray1.90A1-259[»]
    2H4NX-ray1.90A2-260[»]
    2HD6X-ray1.80A2-259[»]
    2HKKX-ray1.90A1-260[»]
    2HL4X-ray1.55A2-260[»]
    2HNCX-ray1.55A2-259[»]
    2HOCX-ray2.10A2-259[»]
    2ILIX-ray1.05A2-259[»]
    2NNGX-ray1.20A2-260[»]
    2NNOX-ray1.01A2-260[»]
    2NNSX-ray1.03A2-260[»]
    2NNVX-ray1.10A2-260[»]
    2NWOX-ray1.70A1-259[»]
    2NWPX-ray1.80A1-259[»]
    2NWYX-ray1.65A1-259[»]
    2NWZX-ray1.80A1-259[»]
    2NXRX-ray1.70A1-259[»]
    2NXSX-ray1.80A1-259[»]
    2NXTX-ray1.15A1-260[»]
    2O4ZX-ray2.10A1-260[»]
    2OSFX-ray1.60A2-260[»]
    2OSMX-ray1.60A2-260[»]
    2POUX-ray1.60A1-259[»]
    2POVX-ray1.60A1-258[»]
    2POWX-ray1.75A1-259[»]
    2Q1BX-ray1.70A1-260[»]
    2Q1QX-ray1.90A1-260[»]
    2Q38X-ray1.95A1-260[»]
    2QO8X-ray1.40A2-260[»]
    2QOAX-ray1.60A2-260[»]
    2QP6X-ray1.45A2-260[»]
    2VVAX-ray1.56X1-260[»]
    2VVBX-ray1.66X1-260[»]
    2WD2X-ray1.49A2-259[»]
    2WD3X-ray1.80A2-260[»]
    2WEGX-ray1.10A2-260[»]
    2WEHX-ray2.09A2-260[»]
    2WEJX-ray1.45A2-260[»]
    2WEOX-ray1.40A2-260[»]
    2X7SX-ray1.64A2-260[»]
    2X7TX-ray1.89A2-260[»]
    2X7UX-ray2.12A2-260[»]
    3B4FX-ray1.89A1-260[»]
    3BETX-ray1.85A2-260[»]
    3BL0X-ray1.90A1-260[»]
    3BL1X-ray2.10A1-260[»]
    3C7PX-ray1.70A1-260[»]
    3CA2X-ray2.00A2-260[»]
    3CAJX-ray1.80A1-260[»]
    3CYUX-ray1.70A1-260[»]
    3D8WX-ray1.70A1-260[»]
    3D92X-ray1.10A1-260[»]
    3D93X-ray1.10A1-260[»]
    3D9ZX-ray1.65A1-260[»]
    3DAZX-ray1.60A1-260[»]
    3DBUX-ray1.70A1-260[»]
    3DC3X-ray1.70A1-260[»]
    3DC9X-ray1.60A1-260[»]
    3DCCX-ray1.60A1-260[»]
    3DCSX-ray1.80A1-260[»]
    3DCWX-ray1.50A1-260[»]
    3DD0X-ray1.48A1-260[»]
    3DD8X-ray1.90A1-260[»]
    3DV7X-ray1.70A2-260[»]
    3DVBX-ray1.70A2-260[»]
    3DVCX-ray1.60A2-260[»]
    3DVDX-ray1.60A2-260[»]
    3EFIX-ray1.75A2-260[»]
    3EFTX-ray1.85A1-260[»]
    3F4XX-ray1.90A1-260[»]
    3F8EX-ray2.00A1-260[»]
    3FFPX-ray1.81X1-260[»]
    3GZ0X-ray1.26A2-260[»]
    3HFPX-ray2.10A1-260[»]
    3HKNX-ray1.80A1-260[»]
    3HKQX-ray1.70A1-260[»]
    3HKTX-ray2.36A1-260[»]
    3HKUX-ray1.80A1-260[»]
    3HLJX-ray1.44A1-260[»]
    3HS4X-ray1.10A1-260[»]
    3IBIX-ray1.93A2-260[»]
    3IBLX-ray1.55A2-260[»]
    3IBNX-ray2.20A2-260[»]
    3IBUX-ray1.41A2-260[»]
    3IEOX-ray2.00A1-260[»]
    3IGPX-ray1.65A1-260[»]
    3K2FX-ray1.98A1-260[»]
    3K34X-ray0.90A1-260[»]
    3K7KX-ray1.90A1-260[»]
    3KIGX-ray1.39A1-260[»]
    3KKXneutron diffraction2.00A1-260[»]
    3KNEX-ray1.35A1-260[»]
    3KOIX-ray1.64A1-260[»]
    3KOKX-ray1.50A1-260[»]
    3KONX-ray1.50A1-260[»]
    3KS3X-ray0.90A1-260[»]
    3KWAX-ray2.00A1-260[»]
    3L14X-ray1.22A1-260[»]
    3M04X-ray1.40A1-260[»]
    3M14X-ray1.38A1-260[»]
    3M1JX-ray1.80A1-260[»]
    3M1KX-ray1.35A1-260[»]
    3M1QX-ray1.69A1-260[»]
    3M1WX-ray1.38A1-260[»]
    3M2NX-ray1.65A1-260[»]
    3M2XX-ray1.87A1-260[»]
    3M2YX-ray1.17A1-260[»]
    3M2ZX-ray1.70A1-260[»]
    3M3XX-ray1.68A1-260[»]
    3M40X-ray1.60A1-260[»]
    3M5EX-ray1.70A1-260[»]
    3M5SX-ray1.40A1-260[»]
    3M5TX-ray1.95A1-260[»]
    3M67X-ray1.80A1-260[»]
    3M96X-ray1.40A1-260[»]
    3M98X-ray1.50A1-260[»]
    3MHCX-ray1.70A1-260[»]
    3MHIX-ray1.70A1-260[»]
    3MHLX-ray1.90A1-260[»]
    3MHMX-ray1.50A1-260[»]
    3MHOX-ray1.15A1-260[»]
    3ML2X-ray1.80A1-260[»]
    3MMFX-ray1.50A1-260[»]
    3MNAX-ray1.50A1-260[»]
    3MNHX-ray1.65A1-260[»]
    3MNIX-ray1.75A1-260[»]
    3MNJX-ray1.75A1-260[»]
    3MNKX-ray1.75A1-260[»]
    3MNUX-ray1.80A2-260[»]
    3MWOX-ray1.40A/B1-260[»]
    3MYQX-ray1.35A1-260[»]
    3MZCX-ray1.50A1-260[»]
    3N0NX-ray1.50A1-260[»]
    3N2PX-ray1.65A1-260[»]
    3N3JX-ray1.50A1-260[»]
    3N4BX-ray1.60A1-260[»]
    3NB5X-ray1.80A1-260[»]
    3NI5X-ray2.10A1-260[»]
    3NJ9X-ray2.00A1-260[»]
    3OIKX-ray1.50A1-260[»]
    3OILX-ray1.50A1-260[»]
    3OIMX-ray1.45A1-260[»]
    3OKUX-ray1.45A1-260[»]
    3OKVX-ray1.45A1-260[»]
    3OY0X-ray1.60A1-260[»]
    3OYQX-ray1.47A1-260[»]
    3OYSX-ray1.54A1-260[»]
    3P3HX-ray1.50A1-260[»]
    3P3JX-ray1.60A1-260[»]
    3P44X-ray2.20A1-260[»]
    3P4VX-ray2.00A1-260[»]
    3P55X-ray2.00A1-260[»]
    3P58X-ray1.49A1-260[»]
    3P5AX-ray1.49A1-260[»]
    3P5LX-ray1.50A1-260[»]
    3PJJX-ray1.80A2-260[»]
    3PO6X-ray1.47A2-260[»]
    3PYKX-ray1.30A1-260[»]
    3QYKX-ray1.47A1-260[»]
    3R16X-ray1.60A4-260[»]
    3R17X-ray1.70B4-260[»]
    3RG3X-ray1.90A1-260[»]
    3RG4X-ray1.50A1-260[»]
    3RGEX-ray2.10A1-260[»]
    3RJ7X-ray1.20A3-260[»]
    3RLDX-ray1.50A1-260[»]
    3RYJX-ray1.39B2-260[»]
    3RYVX-ray1.20B2-260[»]
    3RYXX-ray1.60B2-260[»]
    3RYYX-ray1.16A2-260[»]
    3RYZX-ray1.37A2-260[»]
    3RZ0X-ray1.80B2-260[»]
    3RZ1X-ray1.51B2-260[»]
    3RZ5X-ray1.65A2-260[»]
    3RZ7X-ray1.80A2-260[»]
    3RZ8X-ray1.70A2-260[»]
    3S71X-ray1.25B3-260[»]
    3S72X-ray1.60B3-260[»]
    3S73X-ray1.75B3-260[»]
    3S74X-ray1.40B3-260[»]
    3S75X-ray1.50B3-260[»]
    3S76X-ray1.60A3-260[»]
    3S77X-ray1.86B3-260[»]
    3S78X-ray1.98B3-260[»]
    3S8XX-ray1.30A1-260[»]
    3S9TX-ray1.30A1-260[»]
    3SAPX-ray1.75A1-260[»]
    3SAXX-ray1.10A1-260[»]
    3SBHX-ray1.65A1-260[»]
    3SBIX-ray1.40A1-260[»]
    3T5UX-ray1.75A2-260[»]
    3T5ZX-ray1.65A2-260[»]
    3T82X-ray2.00A1-260[»]
    3T83X-ray1.80A1-260[»]
    3T84X-ray2.00A1-260[»]
    3T85X-ray2.40A1-260[»]
    3TMJOther2.00A3-260[»]
    3TVNX-ray1.50X3-260[»]
    3TVOX-ray1.60X3-260[»]
    3U3AX-ray1.55X1-260[»]
    3U45X-ray1.70X1-260[»]
    3U47X-ray1.60A1-260[»]
    3U7CX-ray0.93A1-260[»]
    3V2JX-ray1.70A1-260[»]
    3V2MX-ray1.47A1-260[»]
    3V3FX-ray2.00A1-260[»]
    3V3GX-ray1.56B1-260[»]
    3V3HX-ray1.85B1-260[»]
    3V3IX-ray1.73B1-260[»]
    3V3JX-ray1.63A1-260[»]
    3V5GX-ray1.50A1-260[»]
    3V7XX-ray1.03A2-260[»]
    3VBDX-ray1.05A2-260[»]
    3ZP9X-ray1.31A1-260[»]
    4BCWX-ray1.50A4-260[»]
    4BF1X-ray1.35A2-260[»]
    4BF6X-ray1.82A2-260[»]
    4CA2X-ray2.10A1-260[»]
    4CACX-ray2.20A2-260[»]
    4CQ0X-ray1.45A1-260[»]
    4DZ7X-ray1.49A1-260[»]
    4DZ9X-ray1.49A1-260[»]
    4E3DX-ray1.60A1-260[»]
    4E3FX-ray1.50A1-260[»]
    4E3GX-ray1.55A1-260[»]
    4E3HX-ray1.50A1-260[»]
    4E49X-ray1.45A1-260[»]
    4E4AX-ray1.45A1-260[»]
    4E5QX-ray1.70A1-260[»]
    4FIKX-ray1.20A1-260[»]
    4FL7X-ray1.85A2-260[»]
    4FPTX-ray0.98A1-260[»]
    4FRCX-ray0.98A1-260[»]
    4FU5X-ray0.98A1-260[»]
    4FVNX-ray1.05A1-260[»]
    4FVOX-ray1.05A1-260[»]
    4G0Cneutron diffraction2.00A4-260[»]
    4GL1X-ray1.50X1-260[»]
    4HBAX-ray1.76A1-260[»]
    4HEWX-ray1.70A1-260[»]
    4HEYX-ray1.45A1-260[»]
    4HEZX-ray1.34A1-260[»]
    4HF3X-ray1.15A1-260[»]
    4HT0X-ray1.60A1-260[»]
    4IDRX-ray1.60X3-260[»]
    4ILXX-ray1.60A4-260[»]
    4ITOX-ray1.16A1-260[»]
    4ITPX-ray1.70A4-260[»]
    4IWZX-ray1.60A4-260[»]
    4JS6X-ray1.55A1-260[»]
    4JSAX-ray1.50A1-260[»]
    4JSSX-ray1.50A1-260[»]
    4JSWX-ray1.90A1-260[»]
    4JSZX-ray1.90A1-260[»]
    4K0SX-ray1.80A4-260[»]
    4K0TX-ray1.78A4-260[»]
    4K0ZX-ray1.80A3-260[»]
    4K13X-ray1.60A4-260[»]
    4K1QX-ray1.70A3-260[»]
    4KAPX-ray1.45A5-260[»]
    4KNIX-ray1.80A1-260[»]
    4KNJX-ray2.00A1-260[»]
    4KUVX-ray1.35A5-260[»]
    4KUWX-ray1.55A4-260[»]
    4KUYX-ray1.65A4-260[»]
    4KV0X-ray1.55A4-260[»]
    4L5UX-ray2.05A1-260[»]
    4L5VX-ray1.63A1-260[»]
    4L5WX-ray1.70A1-260[»]
    4LHIX-ray1.60A1-260[»]
    4LP6X-ray2.15A/B1-260[»]
    4M2RX-ray1.99A4-260[»]
    4M2UX-ray2.00A4-260[»]
    4M2VX-ray1.72A4-260[»]
    4M2WX-ray1.66A4-260[»]
    4MDGX-ray1.35A3-260[»]
    4MDLX-ray1.52A3-260[»]
    4MDMX-ray1.55A3-260[»]
    4MLTX-ray2.00A1-260[»]
    4MLXX-ray1.65A1-260[»]
    4MO8X-ray1.85A1-260[»]
    4MTYX-ray1.00A1-260[»]
    4N0XX-ray1.63B1-260[»]
    4N16X-ray1.54A1-260[»]
    4PQ7X-ray1.85A1-260[»]
    4PXXX-ray1.85A1-260[»]
    4PYXX-ray1.80A1-260[»]
    4PYYX-ray1.75A1-260[»]
    4PZHX-ray1.06A1-260[»]
    4Q06X-ray1.15A1-260[»]
    4Q07X-ray1.15A1-260[»]
    4Q08X-ray1.07A1-260[»]
    4Q09X-ray1.20A1-260[»]
    4Q49neutron diffraction1.80A1-260[»]
    4Q6DX-ray1.12A1-260[»]
    4Q6EX-ray1.12A1-260[»]
    4Q78X-ray1.00A3-260[»]
    4Q7PX-ray1.65A1-260[»]
    4Q7SX-ray1.80A1-260[»]
    4Q7VX-ray1.60A1-260[»]
    4Q7WX-ray1.45A1-260[»]
    4Q81X-ray1.55A1-260[»]
    4Q83X-ray1.55A1-260[»]
    4Q87X-ray1.55A1-260[»]
    4Q8XX-ray1.55A1-260[»]
    4Q8YX-ray1.45A1-260[»]
    4Q8ZX-ray1.50A1-260[»]
    4Q90X-ray1.54A1-260[»]
    4Q99X-ray1.50A1-260[»]
    4Q9YX-ray1.55A1-260[»]
    4QEFX-ray1.47A1-260[»]
    4QIYX-ray1.30A/B/C/D1-260[»]
    4QJMX-ray1.75A1-260[»]
    4QK1X-ray1.60A1-260[»]
    4QK2X-ray1.52A1-260[»]
    4QK3X-ray1.34A1-260[»]
    4QSAX-ray1.50A1-260[»]
    4QSBX-ray1.40A1-260[»]
    4QSIX-ray1.95A1-260[»]
    4QTLX-ray1.80A1-260[»]
    4QY3X-ray1.50A2-260[»]
    4R59X-ray1.65A1-260[»]
    4R5AX-ray1.64A1-260[»]
    4R5BX-ray1.50A1-260[»]
    4RFCX-ray1.65A1-260[»]
    4RFDX-ray1.63A1-260[»]
    4RH2X-ray1.30A1-260[»]
    4RIUX-ray1.65A1-260[»]
    4RIVX-ray1.63A1-260[»]
    4RN4X-ray1.53A1-260[»]
    4RUXX-ray1.14A1-260[»]
    4RUYX-ray1.14A1-260[»]
    4RUZX-ray1.63A1-260[»]
    4WL4X-ray1.10A1-260[»]
    4WW6X-ray1.06A1-260[»]
    4XE1X-ray1.80A1-260[»]
    4Y0Jneutron diffraction2.00A3-260[»]
    4YGJX-ray1.10A