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P00918

- CAH2_HUMAN

UniProt

P00918 - CAH2_HUMAN

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Protein

Carbonic anhydrase 2

Gene

CA2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Essential for bone resorption and osteoclast differentiation By similarity. Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. Stimulates the chloride-bicarbonate exchange activity of SLC26A6.By similarity3 Publications

Catalytic activityi

H2CO3 = CO2 + H2O.

Cofactori

Zinc. Can also use cobalt(II) with lower efficiency, but not copper(II), nickel(II) and manganese(II).1 Publication

Enzyme regulationi

Activated by X-ray, histamine, L-adrenaline, L- and D-phenylalanine, L- and D-histidine, L-His-OMe and beta-Ala-His (carnosine). Competitively inhibited by saccharin, thioxolone, coumarins, 667-coumate, celecoxib (Celebrex), valdecoxib (Bextra), SC-125, SC-560, diclofenac, acetate, azide, bromide, sulfonamide derivatives such as acetazolamide (AZA), methazolamide (MZA), ethoxzolamide (EZA), dichlorophenamide (DCP), brinzolamide, dansylamide, thiabendazole-5-sulfonamide, trifluoromethane sulfonamide and N-hydroxysulfamide, fructose-based sugar sulfamate RWJ-37497, and Foscarnet (phosphonoformate trisodium salt). Repressed strongly by hydrogen sulfide(HS) and weakly by nitrate (NO3). Esterase activity weakly reduced by cyanamide. N-hydroxyurea interfers with zinc binding and inhibit activity.27 Publications

Absorptioni

Abs(max)=550 nm10 Publications

At pH 7.0. Shows a second maximum at 618 nm.

Kineticsi

  1. KM=10 mM for CO210 Publications
  2. KM=82 mM for H2CO310 Publications
  3. KM=3 mM for 4-nitrophenyl acetate10 Publications

pH dependencei

Optimum pH is 6-8.10 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei62 – 621Activator
Active sitei64 – 641
Active sitei67 – 671
Binding sitei67 – 671Activator
Binding sitei92 – 921Activator
Metal bindingi94 – 941Zinc; catalytic1 Publication
Metal bindingi96 – 961Zinc; catalytic
Metal bindingi119 – 1191Zinc; catalytic
Active sitei127 – 1271

GO - Molecular functioni

  1. carbonate dehydratase activity Source: ProtInc
  2. zinc ion binding Source: UniProtKB

GO - Biological processi

  1. angiotensin-activated signaling pathway Source: UniProtKB
  2. bicarbonate transport Source: Reactome
  3. kidney development Source: Ensembl
  4. morphogenesis of an epithelium Source: Ensembl
  5. odontogenesis of dentin-containing tooth Source: Ensembl
  6. one-carbon metabolic process Source: InterPro
  7. positive regulation of bone resorption Source: Ensembl
  8. positive regulation of cellular pH reduction Source: Ensembl
  9. positive regulation of dipeptide transmembrane transport Source: UniProtKB
  10. positive regulation of osteoclast differentiation Source: Ensembl
  11. positive regulation of synaptic transmission, GABAergic Source: Ensembl
  12. regulation of anion transport Source: UniProtKB
  13. regulation of chloride transport Source: Ensembl
  14. regulation of intracellular pH Source: UniProtKB
  15. response to estrogen Source: Ensembl
  16. response to pH Source: Ensembl
  17. response to zinc ion Source: Ensembl
  18. secretion Source: Ensembl
  19. small molecule metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BRENDAi4.2.1.1. 2681.
ReactomeiREACT_121123. Reversible hydration of carbon dioxide.
REACT_121329. Erythrocytes take up carbon dioxide and release oxygen.
REACT_121380. Erythrocytes take up oxygen and release carbon dioxide.
SABIO-RKP00918.

Names & Taxonomyi

Protein namesi
Recommended name:
Carbonic anhydrase 2 (EC:4.2.1.1)
Alternative name(s):
Carbonate dehydratase II
Carbonic anhydrase C
Short name:
CAC
Carbonic anhydrase II
Short name:
CA-II
Gene namesi
Name:CA2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:1373. CA2.

Subcellular locationi

Cytoplasm 1 Publication. Cell membrane 1 Publication
Note: Colocalized with SLC26A6 at the surface of the cell membrane in order to form a bicarbonate transport metabolon. Displaced from the cytosolic surface of the cell membrane by PKC in phorbol myristate acetate (PMA)-induced cells.

GO - Cellular componenti

  1. apical part of cell Source: UniProtKB
  2. axon Source: Ensembl
  3. basolateral plasma membrane Source: Ensembl
  4. cytoplasm Source: UniProtKB
  5. cytosol Source: Reactome
  6. extracellular space Source: Ensembl
  7. extracellular vesicular exosome Source: UniProt
  8. microvillus Source: Ensembl
  9. myelin sheath Source: Ensembl
  10. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Involvement in diseasei

Osteopetrosis, autosomal recessive 3 (OPTB3) [MIM:259730]: A rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. Osteopetrosis occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Recessive osteopetrosis commonly manifests in early infancy with macrocephaly, feeding difficulties, evolving blindness and deafness, bone marrow failure, severe anemia, and hepatosplenomegaly. Deafness and blindness are generally thought to represent effects of pressure on nerves. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.5 Publications
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti92 – 921Q → P in OPTB3; in Czechoslovakia. 2 Publications
VAR_001381
Natural varianti94 – 941H → Y in OPTB3; partial loss of activity. 1 Publication
VAR_021009
Natural varianti107 – 1071H → Y in OPTB3; frequent mutation. 4 Publications
VAR_001382
Natural varianti144 – 1441G → R in OPTB3; complete loss of activity. 1 Publication
VAR_021010

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi5 – 51W → A: Impaired activity, not rescued by 4-methylimidazole (4-MI); when associated with W-64. 1 Publication
Mutagenesisi7 – 71Y → F: Enhanced activity. 2 Publications
Mutagenesisi7 – 71Y → H: Reduced proton transfer rate. 2 Publications
Mutagenesisi62 – 621N → A: Reduced activity. 3 Publications
Mutagenesisi62 – 621N → D: Strongly reduced activity. 3 Publications
Mutagenesisi62 – 621N → H: Reduced proton transfer; when associated with A-64. 3 Publications
Mutagenesisi62 – 621N → L: Reduced activity. 3 Publications
Mutagenesisi62 – 621N → T: Reduced activity. 3 Publications
Mutagenesisi62 – 621N → V: Reduced activity. 3 Publications
Mutagenesisi64 – 641H → A: Reduced CO(2) hydrase activity, rescued by 4-methylimidazole (4-MI). Reduced proton transfer; when associated with H-62. Enhanced proton transfer; when associated with H-67. Enhanced proton transfer capacity; when associated with H-99. 4 Publications
Mutagenesisi64 – 641H → G: Impaired activity, not rescued by 4-methylimidazole (4-MI). 4 Publications
Mutagenesisi64 – 641H → W: Impaired activity, rescued by 4-methylimidazole (4-MI). Impaired activity, not rescued by 4-methylimidazole (4-MI); when associated with A-5. 4 Publications
Mutagenesisi65 – 651A → F: Reduced activity. 1 Publication
Mutagenesisi65 – 651A → H, L or S: Normal activity. 1 Publication
Mutagenesisi67 – 671N → H: Enhanced proton transfer; when associated with A-64. 3 Publications
Mutagenesisi67 – 671N → L: Reduced activity. 3 Publications
Mutagenesisi67 – 671N → Q: Normal activity. 3 Publications
Mutagenesisi94 – 941H → C, D, E, N or Q: Strongly reduced CO(2) hydrase and p-nitrophenyl acetate esterase activities, impaired stability of zinc binding. 2 Publications
Mutagenesisi106 – 1061E → A or Q: Strongly reduced CO(2) hydrase activity. 2 Publications
Mutagenesisi106 – 1061E → D: Normal CO(2) hydrase activity. 2 Publications
Mutagenesisi117 – 1171E → Q: Strongly reduced activity and sulfonamide affinity. 1 Publication
Mutagenesisi119 – 1191H → D, N or Q: Reduced activity. 1 Publication
Mutagenesisi119 – 1191H → E: Strongly reduced activity. 1 Publication
Mutagenesisi121 – 1211V → A, G, I, L or S: Reduced CO(2) hydrase and p-nitrophenyl acetate esterase activities. 1 Publication
Mutagenesisi121 – 1211V → K or R: Strongly reduced CO(2) hydrase and p-nitrophenyl acetate esterase activities. 1 Publication
Mutagenesisi142 – 1421V → F or Y: Strongly impaired activity. 1 Publication
Mutagenesisi142 – 1421V → G: Weakly impaired activity. 1 Publication
Mutagenesisi142 – 1421V → H: Impaired activity. 1 Publication
Mutagenesisi197 – 1971L → A: Reduced CO(2) hydrase activity. 1 Publication
Mutagenesisi197 – 1971L → E, H or R: Strongly reduced CO(2) hydrase activity. 1 Publication
Mutagenesisi197 – 1971L → F: Normal activity. 1 Publication
Mutagenesisi198 – 1981T → A, C, H or P: Strongly reduced activity. 5 Publications
Mutagenesisi198 – 1981T → D or E: Strongly reduced activity, but enhanced zinc affinity. 5 Publications
Mutagenesisi198 – 1981T → S or V: Reduced activity. 5 Publications
Mutagenesisi199 – 1991T → H: Higher affinity for bicarbonate. Enhanced proton transfer capacity; when associated with A-64. 3 Publications
Mutagenesisi199 – 1991T → S: Enhanced p-nitrophenyl acetate esterase activity, but normal CO(2) hydrase activity. 3 Publications
Mutagenesisi201 – 2011P → A: Normal CO(2) hydrase activity, but impaired stability. 1 Publication

Keywords - Diseasei

Disease mutation, Osteopetrosis

Organism-specific databases

MIMi259730. phenotype.
Orphaneti2785. Osteopetrosis with renal tubular acidosis.
PharmGKBiPA25989.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 260259Carbonic anhydrase 2PRO_0000077418Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine2 Publications

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP00918.
PaxDbiP00918.
PeptideAtlasiP00918.
PRIDEiP00918.

2D gel databases

OGPiP00918.
REPRODUCTION-2DPAGEIPI00218414.
P00918.
UCD-2DPAGEP00918.

PTM databases

PhosphoSiteiP00918.

Expressioni

Gene expression databases

BgeeiP00918.
CleanExiHS_CA2.
ExpressionAtlasiP00918. baseline and differential.
GenevestigatoriP00918.

Organism-specific databases

HPAiCAB010102.
HPA001550.

Interactioni

Subunit structurei

Interacts with SLC4A4. Interaction with SLC4A7 regulates SLC4A7 transporter activity. Interacts with SLC26A6 isoform 4 (via C-terminus cytoplasmic domain).90 Publications

Protein-protein interaction databases

BioGridi107215. 12 interactions.
IntActiP00918. 5 interactions.
MINTiMINT-1367766.
STRINGi9606.ENSP00000285379.

Structurei

Secondary structure

1
260
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni9 – 113
Turni13 – 153
Helixi16 – 183
Helixi21 – 244
Beta strandi25 – 273
Beta strandi31 – 333
Turni35 – 373
Beta strandi38 – 403
Beta strandi42 – 443
Beta strandi45 – 506
Beta strandi56 – 616
Beta strandi63 – 708
Beta strandi73 – 753
Beta strandi77 – 826
Beta strandi88 – 9710
Beta strandi106 – 1094
Beta strandi115 – 12410
Helixi125 – 1273
Helixi130 – 1334
Beta strandi139 – 15113
Helixi154 – 1563
Helixi157 – 1626
Helixi163 – 1653
Beta strandi172 – 1743
Helixi180 – 1834
Beta strandi190 – 1956
Beta strandi206 – 2138
Beta strandi215 – 2173
Helixi219 – 2257
Beta strandi229 – 2313
Beta strandi233 – 2353
Beta strandi256 – 2583

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
12CAX-ray2.40A1-260[»]
1A42X-ray2.25A2-260[»]
1AM6X-ray2.00A2-260[»]
1AVNX-ray2.00A2-260[»]
1BCDX-ray1.90A2-260[»]
1BICX-ray1.90A2-260[»]
1BN1X-ray2.10A2-260[»]
1BN3X-ray2.20A2-260[»]
1BN4X-ray2.10A2-260[»]
1BNMX-ray2.60A2-260[»]
1BNNX-ray2.30A2-260[»]
1BNQX-ray2.40A2-260[»]
1BNTX-ray2.15A2-260[»]
1BNUX-ray2.15A2-260[»]
1BNVX-ray2.40A2-260[»]
1BNWX-ray2.25A2-260[»]
1BV3X-ray1.85A2-260[»]
1CA2X-ray2.00A2-260[»]
1CA3X-ray2.30A1-260[»]
1CAHX-ray1.88A2-260[»]
1CAIX-ray1.80A2-260[»]
1CAJX-ray1.90A2-260[»]
1CAKX-ray1.90A2-260[»]
1CALX-ray2.20A2-260[»]
1CAMX-ray1.70A2-260[»]
1CANX-ray1.90A2-260[»]
1CAOX-ray1.90A2-260[»]
1CAYX-ray2.10A2-260[»]
1CAZX-ray1.90A2-260[»]
1CCSX-ray2.35A2-260[»]
1CCTX-ray2.20A2-260[»]
1CCUX-ray2.25A2-260[»]
1CILX-ray1.60A2-260[»]
1CIMX-ray2.10A2-260[»]
1CINX-ray2.10A2-260[»]
1CNBX-ray2.35A2-260[»]
1CNCX-ray2.20A2-260[»]
1CNGX-ray1.90A2-260[»]
1CNHX-ray2.05A2-260[»]
1CNIX-ray1.80A2-260[»]
1CNJX-ray1.80A2-260[»]
1CNKX-ray2.15A2-260[»]
1CNWX-ray2.00A1-260[»]
1CNXX-ray1.90A1-260[»]
1CNYX-ray2.30A1-260[»]
1CRAX-ray1.90A2-260[»]
1CVAX-ray2.25A2-260[»]
1CVBX-ray2.40A2-260[»]
1CVCX-ray2.30A2-260[»]
1CVDX-ray2.20A5-259[»]
1CVEX-ray2.25A2-260[»]
1CVFX-ray2.25A2-260[»]
1CVHX-ray2.30A5-259[»]
1DCAX-ray2.20A1-260[»]
1DCBX-ray2.10A1-260[»]
1EOUX-ray2.10A1-260[»]
1F2WX-ray1.90A2-260[»]
1FQLX-ray2.00A1-260[»]
1FQMX-ray2.00A1-260[»]
1FQNX-ray2.00A1-260[»]
1FQRX-ray2.00A1-260[»]
1FR4X-ray1.60A1-260[»]
1FR7X-ray1.50A/B1-260[»]
1FSNX-ray2.00A/B1-260[»]
1FSQX-ray2.00A/B1-260[»]
1FSRX-ray2.00A/B1-260[»]
1G0EX-ray1.60A1-260[»]
1G0FX-ray1.60A1-260[»]
1G1DX-ray2.04A2-260[»]
1G3ZX-ray1.86A2-260[»]
1G45X-ray1.83A2-260[»]
1G46X-ray1.84A2-260[»]
1G48X-ray1.86A2-260[»]
1G4JX-ray1.84A2-260[»]
1G4OX-ray1.96A2-260[»]
1G52X-ray1.80A2-260[»]
1G53X-ray1.94A2-260[»]
1G54X-ray1.86A2-260[»]
1H4NX-ray2.00A2-260[»]
1H9NX-ray1.85A2-260[»]
1H9QX-ray2.20A2-260[»]
1HCAX-ray2.30A1-260[»]
1HEAX-ray2.00A1-260[»]
1HEBX-ray2.00A1-260[»]
1HECX-ray2.00A1-260[»]
1HEDX-ray2.00A1-260[»]
1HVAX-ray2.30A1-260[»]
1I8ZX-ray1.93A2-260[»]
1I90X-ray2.00A2-260[»]
1I91X-ray2.00A2-260[»]
1I9LX-ray1.93A2-260[»]
1I9MX-ray1.84A2-260[»]
1I9NX-ray1.86A2-260[»]
1I9OX-ray1.86A2-260[»]
1I9PX-ray1.92A2-260[»]
1I9QX-ray1.80A2-260[»]
1IF4X-ray1.93A2-260[»]
1IF5X-ray2.00A2-260[»]
1IF6X-ray2.09A2-259[»]
1IF7X-ray1.98A2-260[»]
1IF8X-ray1.94A2-260[»]
1IF9X-ray2.00A2-260[»]
1KWQX-ray2.60A1-260[»]
1KWRX-ray2.25A1-260[»]
1LG5X-ray1.75A1-260[»]
1LG6X-ray2.20A1-260[»]
1LGDX-ray1.90A1-260[»]
1LUGX-ray0.95A2-260[»]
1LZVX-ray2.30A1-260[»]
1MOOX-ray1.05A1-260[»]
1MUAX-ray1.70A4-259[»]
1OKLX-ray2.10A2-260[»]
1OKMX-ray2.20A2-260[»]
1OKNX-ray2.40A2-260[»]
1OQ5X-ray1.50A2-259[»]
1RAYX-ray1.80A2-260[»]
1RAZX-ray1.90A2-260[»]
1RZAX-ray1.90A2-260[»]
1RZBX-ray1.80A2-260[»]
1RZCX-ray1.90A2-260[»]
1RZDX-ray1.90A2-260[»]
1RZEX-ray1.90A2-260[»]
1T9NX-ray2.00A1-259[»]
1TB0X-ray2.00X1-259[»]
1TBTX-ray2.00X1-259[»]
1TE3X-ray2.00X1-260[»]
1TEQX-ray2.00X1-260[»]
1TEUX-ray2.00X1-260[»]
1TG3X-ray1.80A1-260[»]
1TG9X-ray1.90A1-260[»]
1TH9X-ray1.63A1-260[»]
1THKX-ray1.80A1-260[»]
1TTMX-ray1.95A2-259[»]
1UGAX-ray2.00A3-260[»]
1UGBX-ray2.00A3-260[»]
1UGCX-ray2.00A3-260[»]
1UGDX-ray2.00A3-260[»]
1UGEX-ray1.90A3-260[»]
1UGFX-ray2.00A3-260[»]
1UGGX-ray2.20A3-260[»]
1XEGX-ray1.81A1-260[»]
1XEVX-ray2.20A/B/C/D1-260[»]
1XPZX-ray2.02A3-260[»]
1XQ0X-ray1.76A2-260[»]
1YDAX-ray2.10A2-260[»]
1YDBX-ray1.90A2-260[»]
1YDCX-ray1.95A2-260[»]
1YDDX-ray2.10A2-260[»]
1YO0X-ray1.80A1-260[»]
1YO1X-ray1.70A1-260[»]
1YO2X-ray1.80A1-259[»]
1Z9YX-ray1.66A2-259[»]
1ZE8X-ray2.00A2-260[»]
1ZFKX-ray1.56A2-259[»]
1ZFQX-ray1.55A2-259[»]
1ZGEX-ray1.65A2-259[»]
1ZGFX-ray1.75A2-259[»]
1ZH9X-ray1.70A2-259[»]
1ZSAX-ray2.50A2-260[»]
1ZSBX-ray2.00A2-260[»]
1ZSCX-ray1.80A2-260[»]
2ABEX-ray2.00A2-259[»]
2AW1X-ray1.46A2-260[»]
2AX2X-ray1.50A1-259[»]
2CA2X-ray1.90A2-260[»]
2CBAX-ray1.54A2-260[»]
2CBBX-ray1.67A2-260[»]
2CBCX-ray1.88A2-260[»]
2CBDX-ray1.67A2-260[»]
2CBEX-ray1.82A2-260[»]
2EU2X-ray1.15A1-260[»]
2EU3X-ray1.60A1-260[»]
2EZ7X-ray2.00A1-259[»]
2F14X-ray1.71A2-259[»]
2FMGX-ray1.60A1-259[»]
2FMZX-ray1.60A1-259[»]
2FNKX-ray1.80A1-260[»]
2FNMX-ray1.80A1-260[»]
2FNNX-ray1.80A1-260[»]
2FOQX-ray1.25A1-259[»]
2FOSX-ray1.10A1-259[»]
2FOUX-ray0.99A1-259[»]
2FOVX-ray1.15A1-259[»]
2GD8X-ray1.46A2-259[»]
2GEHX-ray2.00A1-259[»]
2H15X-ray1.90A1-259[»]
2H4NX-ray1.90A2-260[»]
2HD6X-ray1.80A2-259[»]
2HKKX-ray1.90A1-260[»]
2HL4X-ray1.55A2-260[»]
2HNCX-ray1.55A2-259[»]
2HOCX-ray2.10A2-259[»]
2ILIX-ray1.05A2-259[»]
2NNGX-ray1.20A2-260[»]
2NNOX-ray1.01A2-260[»]
2NNSX-ray1.03A2-260[»]
2NNVX-ray1.10A2-260[»]
2NWOX-ray1.70A1-259[»]
2NWPX-ray1.80A1-259[»]
2NWYX-ray1.65A1-259[»]
2NWZX-ray1.80A1-259[»]
2NXRX-ray1.70A1-259[»]
2NXSX-ray1.80A1-259[»]
2NXTX-ray1.15A1-260[»]
2O4ZX-ray2.10A1-260[»]
2OSFX-ray1.60A2-260[»]
2OSMX-ray1.60A2-260[»]
2POUX-ray1.60A1-259[»]
2POVX-ray1.60A1-258[»]
2POWX-ray1.75A1-259[»]
2Q1BX-ray1.70A1-260[»]
2Q1QX-ray1.90A1-260[»]
2Q38X-ray1.95A1-260[»]
2QO8X-ray1.40A2-260[»]
2QOAX-ray1.60A2-260[»]
2QP6X-ray1.45A2-260[»]
2VVAX-ray1.56X1-260[»]
2VVBX-ray1.66X1-260[»]
2WD2X-ray1.49A2-259[»]
2WD3X-ray1.80A2-260[»]
2WEGX-ray1.10A2-260[»]
2WEHX-ray2.09A2-260[»]
2WEJX-ray1.45A2-260[»]
2WEOX-ray1.40A2-260[»]
2X7SX-ray1.64A2-260[»]
2X7TX-ray1.89A2-260[»]
2X7UX-ray2.12A2-260[»]
3B4FX-ray1.89A1-260[»]
3BETX-ray1.85A2-260[»]
3BL0X-ray1.90A1-260[»]
3BL1X-ray2.10A1-260[»]
3C7PX-ray1.70A1-260[»]
3CA2X-ray2.00A2-260[»]
3CAJX-ray1.80A1-260[»]
3CYUX-ray1.70A1-260[»]
3D8WX-ray1.70A1-260[»]
3D92X-ray1.10A1-260[»]
3D93X-ray1.10A1-260[»]
3D9ZX-ray1.65A1-260[»]
3DAZX-ray1.60A1-260[»]
3DBUX-ray1.70A1-260[»]
3DC3X-ray1.70A1-260[»]
3DC9X-ray1.60A1-260[»]
3DCCX-ray1.60A1-260[»]
3DCSX-ray1.80A1-260[»]
3DCWX-ray1.50A1-260[»]
3DD0X-ray1.48A1-260[»]
3DD8X-ray1.90A1-260[»]
3DV7X-ray1.70A2-260[»]
3DVBX-ray1.70A2-260[»]
3DVCX-ray1.60A2-260[»]
3DVDX-ray1.60A2-260[»]
3EFIX-ray1.75A2-260[»]
3EFTX-ray1.85A1-260[»]
3F4XX-ray1.90A1-260[»]
3F8EX-ray2.00A1-260[»]
3FFPX-ray1.81X1-260[»]
3GZ0X-ray1.26A2-260[»]
3HFPX-ray2.10A1-260[»]
3HKNX-ray1.80A1-260[»]
3HKQX-ray1.70A1-260[»]
3HKTX-ray2.36A1-260[»]
3HKUX-ray1.80A1-260[»]
3HLJX-ray1.44A1-260[»]
3HS4X-ray1.10A1-260[»]
3IBIX-ray1.93A2-260[»]
3IBLX-ray1.55A2-260[»]
3IBNX-ray2.20A2-260[»]
3IBUX-ray1.41A2-260[»]
3IEOX-ray2.00A1-260[»]
3IGPX-ray1.65A1-260[»]
3K2FX-ray1.98A1-260[»]
3K34X-ray0.90A1-260[»]
3K7KX-ray1.90A1-260[»]
3KIGX-ray1.39A1-260[»]
3KKXneutron diffraction2.00A1-260[»]
3KNEX-ray1.35A1-260[»]
3KOIX-ray1.64A1-260[»]
3KOKX-ray1.50A1-260[»]
3KONX-ray1.50A1-260[»]
3KS3X-ray0.90A1-260[»]
3KWAX-ray2.00A1-260[»]
3L14X-ray1.22A1-260[»]
3M04X-ray1.40A1-260[»]
3M14X-ray1.38A1-260[»]
3M1JX-ray1.80A1-260[»]
3M1KX-ray1.35A1-260[»]
3M1QX-ray1.69A1-260[»]
3M1WX-ray1.38A1-260[»]
3M2NX-ray1.65A1-260[»]
3M2XX-ray1.87A1-260[»]
3M2YX-ray1.17A1-260[»]
3M2ZX-ray1.70A1-260[»]
3M3XX-ray1.68A1-260[»]
3M40X-ray1.60A1-260[»]
3M5EX-ray1.70A1-260[»]
3M5SX-ray1.40A1-260[»]
3M5TX-ray1.95A1-260[»]
3M67X-ray1.80A1-260[»]
3M96X-ray1.40A1-260[»]
3M98X-ray1.50A1-260[»]
3MHCX-ray1.70A1-260[»]
3MHIX-ray1.70A1-260[»]
3MHLX-ray1.90A1-260[»]
3MHMX-ray1.50A1-260[»]
3MHOX-ray1.15A1-260[»]
3ML2X-ray1.80A1-260[»]
3MMFX-ray1.50A1-260[»]
3MNAX-ray1.50A1-260[»]
3MNHX-ray1.65A1-260[»]
3MNIX-ray1.75A1-260[»]
3MNJX-ray1.75A1-260[»]
3MNKX-ray1.75A1-260[»]
3MNUX-ray1.80A2-260[»]
3MWOX-ray1.40A/B1-260[»]
3MYQX-ray1.35A1-260[»]
3MZCX-ray1.50A1-260[»]
3N0NX-ray1.50A1-260[»]
3N2PX-ray1.65A1-260[»]
3N3JX-ray1.50A1-260[»]
3N4BX-ray1.60A1-260[»]
3NB5X-ray1.80A1-260[»]
3NI5X-ray2.10A1-260[»]
3NJ9X-ray2.00A1-260[»]
3OIKX-ray1.50A1-260[»]
3OILX-ray1.50A1-260[»]
3OIMX-ray1.45A1-260[»]
3OKUX-ray1.45A1-260[»]
3OKVX-ray1.45A1-260[»]
3OY0X-ray1.60A1-260[»]
3OYQX-ray1.47A1-260[»]
3OYSX-ray1.54A1-260[»]
3P3HX-ray1.50A1-260[»]
3P3JX-ray1.60A1-260[»]
3P44X-ray2.20A1-260[»]
3P4VX-ray2.00A1-260[»]
3P55X-ray2.00A1-260[»]
3P58X-ray1.49A1-260[»]
3P5AX-ray1.49A1-260[»]
3P5LX-ray1.50A1-260[»]
3PJJX-ray1.80A2-260[»]
3PO6X-ray1.47A2-260[»]
3PYKX-ray1.30A1-260[»]
3QYKX-ray1.47A1-260[»]
3R16X-ray1.60A4-260[»]
3R17X-ray1.70B4-260[»]
3RG3X-ray1.90A1-260[»]
3RG4X-ray1.50A1-260[»]
3RGEX-ray2.10A1-260[»]
3RJ7X-ray1.20A3-260[»]
3RLDX-ray1.50A1-260[»]
3RYJX-ray1.39B2-260[»]
3RYVX-ray1.20B2-260[»]
3RYXX-ray1.60B2-260[»]
3RYYX-ray1.16A2-260[»]
3RYZX-ray1.37A2-260[»]
3RZ0X-ray1.80B2-260[»]
3RZ1X-ray1.51B2-260[»]
3RZ5X-ray1.65A2-260[»]
3RZ7X-ray1.80A2-260[»]
3RZ8X-ray1.70A2-260[»]
3S71X-ray1.25B3-260[»]
3S72X-ray1.60B3-260[»]
3S73X-ray1.75B3-260[»]
3S74X-ray1.40B3-260[»]
3S75X-ray1.50B3-260[»]
3S76X-ray1.60A3-260[»]
3S77X-ray1.86B3-260[»]
3S78X-ray1.98B3-260[»]
3S8XX-ray1.30A1-260[»]
3S9TX-ray1.30A1-260[»]
3SAPX-ray1.75A1-260[»]
3SAXX-ray1.10A1-260[»]
3SBHX-ray1.65A1-260[»]
3SBIX-ray1.40A1-260[»]
3T5UX-ray1.75A2-260[»]
3T5ZX-ray1.65A2-260[»]
3T82X-ray2.00A1-260[»]
3T83X-ray1.80A1-260[»]
3T84X-ray2.00A1-260[»]
3T85X-ray2.40A1-260[»]
3TMJOther2.00A3-260[»]
3TVNX-ray1.50X3-260[»]
3TVOX-ray1.60X3-260[»]
3U3AX-ray1.55X1-260[»]
3U45X-ray1.70X1-260[»]
3U47X-ray1.60A1-260[»]
3U7CX-ray0.93A1-260[»]
3V2JX-ray1.70A1-260[»]
3V2MX-ray1.47A1-260[»]
3V3FX-ray2.00A1-260[»]
3V3GX-ray1.56B1-260[»]
3V3HX-ray1.85B1-260[»]
3V3IX-ray1.73B1-260[»]
3V3JX-ray1.63A1-260[»]
3V5GX-ray1.50A1-260[»]
3V7XX-ray1.03A2-260[»]
3VBDX-ray1.05A2-260[»]
3ZP9X-ray1.31A1-260[»]
4BCWX-ray1.50A4-260[»]
4BF1X-ray1.35A2-260[»]
4BF6X-ray1.82A2-260[»]
4CA2X-ray2.10A1-260[»]
4CACX-ray2.20A2-260[»]
4CQ0X-ray1.45A1-260[»]
4DZ7X-ray1.49A1-260[»]
4DZ9X-ray1.49A1-260[»]
4E3DX-ray1.60A1-260[»]
4E3FX-ray1.50A1-260[»]
4E3GX-ray1.55A1-260[»]
4E3HX-ray1.50A1-260[»]
4E49X-ray1.45A1-260[»]
4E4AX-ray1.45A1-260[»]
4E5QX-ray1.70A1-260[»]
4FIKX-ray1.20A1-260[»]
4FL7X-ray1.85A2-260[»]
4FPTX-ray0.98A1-260[»]
4FRCX-ray0.98A1-260[»]
4FU5X-ray0.98A1-260[»]
4FVNX-ray1.05A1-260[»]
4FVOX-ray1.05A1-260[»]
4G0Cneutron diffraction2.00A4-260[»]
4GGEX-ray1.47A1-260[»]
4GL1X-ray1.50X1-260[»]
4HBAX-ray1.76A1-260[»]
4HEWX-ray1.70A1-260[»]
4HEYX-ray1.45A1-260[»]
4HEZX-ray1.34A1-260[»]
4HF3X-ray1.15A1-260[»]
4HT0X-ray1.60A1-260[»]
4IDRX-ray1.60X3-260[»]
4ILXX-ray1.60A4-260[»]
4ITOX-ray1.16A1-260[»]
4ITPX-ray1.70A4-260[»]
4IWZX-ray1.60A4-260[»]
4JS6X-ray1.55A1-260[»]
4JSAX-ray1.50A1-260[»]
4JSSX-ray1.50A1-260[»]
4JSWX-ray1.90A1-260[»]
4JSZX-ray1.90A1-260[»]
4K0SX-ray1.80A4-260[»]
4K0TX-ray1.78A4-260[»]
4K0ZX-ray1.80A3-260[»]
4K13X-ray1.60A4-260[»]
4K1QX-ray1.70A3-260[»]
4KAPX-ray1.45A5-260[»]
4KNIX-ray1.80A1-260[»]
4KNJX-ray2.00A1-260[»]
4KUVX-ray1.35A5-260[»]
4KUWX-ray1.55A4-260[»]
4KUYX-ray1.65A4-260[»]
4KV0X-ray1.55A4-260[»]
4L5UX-ray2.05A1-260[»]
4L5VX-ray1.63A1-260[»]
4L5WX-ray1.70A1-260[»]
4LHIX-ray1.60A1-260[»]
4LP6X-ray2.15A/B1-260[»]
4M2RX-ray1.99A4-260[»]
4M2UX-ray2.00A4-260[»]
4M2VX-ray1.72A4-260[»]
4M2WX-ray1.66A4-260[»]
4MDGX-ray1.35A3-260[»]
4MDLX-ray1.52A3-260[»]
4MDMX-ray1.55A3-260[»]
4MLTX-ray2.00A1-260[»]
4MLXX-ray1.65A1-260[»]
4MO8X-ray1.85A1-260[»]
4MTYX-ray1.00A1-260[»]
4N0XX-ray1.63B1-260[»]
4N16X-ray1.54A1-260[»]
5CA2X-ray2.10A1-260[»]
5CACX-ray2.20A2-260[»]
6CA2X-ray2.50A1-260[»]
7CA2X-ray2.40A1-260[»]
8CA2X-ray2.40A1-260[»]
9CA2X-ray2.80A1-260[»]
ProteinModelPortaliP00918.
SMRiP00918. Positions 3-260.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00918.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni198 – 1992Substrate binding

Sequence similaritiesi

Belongs to the alpha-carbonic anhydrase family.Curated

Phylogenomic databases

eggNOGiCOG3338.
HOGENOMiHOG000112637.
HOVERGENiHBG002837.
InParanoidiP00918.
KOiK18245.
OMAiCFNAENE.
OrthoDBiEOG7WMCK7.
PhylomeDBiP00918.
TreeFamiTF316425.

Family and domain databases

Gene3Di3.10.200.10. 1 hit.
InterProiIPR018443. CA2.
IPR001148. Carbonic_anhydrase_a.
IPR023561. Carbonic_anhydrase_a-class.
IPR018338. Carbonic_anhydrase_a-class_CS.
[Graphical view]
PANTHERiPTHR18952. PTHR18952. 1 hit.
PTHR18952:SF90. PTHR18952:SF90. 1 hit.
PfamiPF00194. Carb_anhydrase. 1 hit.
[Graphical view]
SMARTiSM01057. Carb_anhydrase. 1 hit.
[Graphical view]
SUPFAMiSSF51069. SSF51069. 1 hit.
PROSITEiPS00162. ALPHA_CA_1. 1 hit.
PS51144. ALPHA_CA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00918-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSHHWGYGKH NGPEHWHKDF PIAKGERQSP VDIDTHTAKY DPSLKPLSVS
60 70 80 90 100
YDQATSLRIL NNGHAFNVEF DDSQDKAVLK GGPLDGTYRL IQFHFHWGSL
110 120 130 140 150
DGQGSEHTVD KKKYAAELHL VHWNTKYGDF GKAVQQPDGL AVLGIFLKVG
160 170 180 190 200
SAKPGLQKVV DVLDSIKTKG KSADFTNFDP RGLLPESLDY WTYPGSLTTP
210 220 230 240 250
PLLECVTWIV LKEPISVSSE QVLKFRKLNF NGEGEPEELM VDNWRPAQPL
260
KNRQIKASFK
Length:260
Mass (Da):29,246
Last modified:January 23, 2007 - v2
Checksum:i2EC2BB7548F10558
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti179 – 1802DP → AA in AAH11949. (PubMed:15489334)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti18 – 181K → E in Jogjakarta. 1 Publication
VAR_001380
Natural varianti92 – 921Q → P in OPTB3; in Czechoslovakia. 2 Publications
VAR_001381
Natural varianti94 – 941H → Y in OPTB3; partial loss of activity. 1 Publication
VAR_021009
Natural varianti107 – 1071H → Y in OPTB3; frequent mutation. 4 Publications
VAR_001382
Natural varianti144 – 1441G → R in OPTB3; complete loss of activity. 1 Publication
VAR_021010
Natural varianti236 – 2361P → H in Melbourne. 1 Publication
VAR_001383
Natural varianti252 – 2521N → D.
Corresponds to variant rs2228063 [ dbSNP | Ensembl ].
VAR_001384

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M77181
, M77176, M77177, M77178, M77179, M77180 Genomic DNA. Translation: AAA51909.1.
Y00339 mRNA. Translation: CAA68426.1.
X03251 Genomic DNA. Translation: CAA27012.1.
J03037 mRNA. Translation: AAA51908.1.
CR536526 mRNA. Translation: CAG38763.1.
CR541875 mRNA. Translation: CAG46673.1.
AK312978 mRNA. Translation: BAG35815.1.
CH471068 Genomic DNA. Translation: EAW87136.1.
BC011949 mRNA. Translation: AAH11949.1.
M36532 mRNA. Translation: AAA51911.1.
CCDSiCCDS6239.1.
PIRiA27175. CRHU2.
RefSeqiNP_000058.1. NM_000067.2.
UniGeneiHs.155097.

Genome annotation databases

EnsembliENST00000285379; ENSP00000285379; ENSG00000104267.
GeneIDi760.
KEGGihsa:760.
UCSCiuc003ydk.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M77181
, M77176 , M77177 , M77178 , M77179 , M77180 Genomic DNA. Translation: AAA51909.1 .
Y00339 mRNA. Translation: CAA68426.1 .
X03251 Genomic DNA. Translation: CAA27012.1 .
J03037 mRNA. Translation: AAA51908.1 .
CR536526 mRNA. Translation: CAG38763.1 .
CR541875 mRNA. Translation: CAG46673.1 .
AK312978 mRNA. Translation: BAG35815.1 .
CH471068 Genomic DNA. Translation: EAW87136.1 .
BC011949 mRNA. Translation: AAH11949.1 .
M36532 mRNA. Translation: AAA51911.1 .
CCDSi CCDS6239.1.
PIRi A27175. CRHU2.
RefSeqi NP_000058.1. NM_000067.2.
UniGenei Hs.155097.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
12CA X-ray 2.40 A 1-260 [» ]
1A42 X-ray 2.25 A 2-260 [» ]
1AM6 X-ray 2.00 A 2-260 [» ]
1AVN X-ray 2.00 A 2-260 [» ]
1BCD X-ray 1.90 A 2-260 [» ]
1BIC X-ray 1.90 A 2-260 [» ]
1BN1 X-ray 2.10 A 2-260 [» ]
1BN3 X-ray 2.20 A 2-260 [» ]
1BN4 X-ray 2.10 A 2-260 [» ]
1BNM X-ray 2.60 A 2-260 [» ]
1BNN X-ray 2.30 A 2-260 [» ]
1BNQ X-ray 2.40 A 2-260 [» ]
1BNT X-ray 2.15 A 2-260 [» ]
1BNU X-ray 2.15 A 2-260 [» ]
1BNV X-ray 2.40 A 2-260 [» ]
1BNW X-ray 2.25 A 2-260 [» ]
1BV3 X-ray 1.85 A 2-260 [» ]
1CA2 X-ray 2.00 A 2-260 [» ]
1CA3 X-ray 2.30 A 1-260 [» ]
1CAH X-ray 1.88 A 2-260 [» ]
1CAI X-ray 1.80 A 2-260 [» ]
1CAJ X-ray 1.90 A 2-260 [» ]
1CAK X-ray 1.90 A 2-260 [» ]
1CAL X-ray 2.20 A 2-260 [» ]
1CAM X-ray 1.70 A 2-260 [» ]
1CAN X-ray 1.90 A 2-260 [» ]
1CAO X-ray 1.90 A 2-260 [» ]
1CAY X-ray 2.10 A 2-260 [» ]
1CAZ X-ray 1.90 A 2-260 [» ]
1CCS X-ray 2.35 A 2-260 [» ]
1CCT X-ray 2.20 A 2-260 [» ]
1CCU X-ray 2.25 A 2-260 [» ]
1CIL X-ray 1.60 A 2-260 [» ]
1CIM X-ray 2.10 A 2-260 [» ]
1CIN X-ray 2.10 A 2-260 [» ]
1CNB X-ray 2.35 A 2-260 [» ]
1CNC X-ray 2.20 A 2-260 [» ]
1CNG X-ray 1.90 A 2-260 [» ]
1CNH X-ray 2.05 A 2-260 [» ]
1CNI X-ray 1.80 A 2-260 [» ]
1CNJ X-ray 1.80 A 2-260 [» ]
1CNK X-ray 2.15 A 2-260 [» ]
1CNW X-ray 2.00 A 1-260 [» ]
1CNX X-ray 1.90 A 1-260 [» ]
1CNY X-ray 2.30 A 1-260 [» ]
1CRA X-ray 1.90 A 2-260 [» ]
1CVA X-ray 2.25 A 2-260 [» ]
1CVB X-ray 2.40 A 2-260 [» ]
1CVC X-ray 2.30 A 2-260 [» ]
1CVD X-ray 2.20 A 5-259 [» ]
1CVE X-ray 2.25 A 2-260 [» ]
1CVF X-ray 2.25 A 2-260 [» ]
1CVH X-ray 2.30 A 5-259 [» ]
1DCA X-ray 2.20 A 1-260 [» ]
1DCB X-ray 2.10 A 1-260 [» ]
1EOU X-ray 2.10 A 1-260 [» ]
1F2W X-ray 1.90 A 2-260 [» ]
1FQL X-ray 2.00 A 1-260 [» ]
1FQM X-ray 2.00 A 1-260 [» ]
1FQN X-ray 2.00 A 1-260 [» ]
1FQR X-ray 2.00 A 1-260 [» ]
1FR4 X-ray 1.60 A 1-260 [» ]
1FR7 X-ray 1.50 A/B 1-260 [» ]
1FSN X-ray 2.00 A/B 1-260 [» ]
1FSQ X-ray 2.00 A/B 1-260 [» ]
1FSR X-ray 2.00 A/B 1-260 [» ]
1G0E X-ray 1.60 A 1-260 [» ]
1G0F X-ray 1.60 A 1-260 [» ]
1G1D X-ray 2.04 A 2-260 [» ]
1G3Z X-ray 1.86 A 2-260 [» ]
1G45 X-ray 1.83 A 2-260 [» ]
1G46 X-ray 1.84 A 2-260 [» ]
1G48 X-ray 1.86 A 2-260 [» ]
1G4J X-ray 1.84 A 2-260 [» ]
1G4O X-ray 1.96 A 2-260 [» ]
1G52 X-ray 1.80 A 2-260 [» ]
1G53 X-ray 1.94 A 2-260 [» ]
1G54 X-ray 1.86 A 2-260 [» ]
1H4N X-ray 2.00 A 2-260 [» ]
1H9N X-ray 1.85 A 2-260 [» ]
1H9Q X-ray 2.20 A 2-260 [» ]
1HCA X-ray 2.30 A 1-260 [» ]
1HEA X-ray 2.00 A 1-260 [» ]
1HEB X-ray 2.00 A 1-260 [» ]
1HEC X-ray 2.00 A 1-260 [» ]
1HED X-ray 2.00 A 1-260 [» ]
1HVA X-ray 2.30 A 1-260 [» ]
1I8Z X-ray 1.93 A 2-260 [» ]
1I90 X-ray 2.00 A 2-260 [» ]
1I91 X-ray 2.00 A 2-260 [» ]
1I9L X-ray 1.93 A 2-260 [» ]
1I9M X-ray 1.84 A 2-260 [» ]
1I9N X-ray 1.86 A 2-260 [» ]
1I9O X-ray 1.86 A 2-260 [» ]
1I9P X-ray 1.92 A 2-260 [» ]
1I9Q X-ray 1.80 A 2-260 [» ]
1IF4 X-ray 1.93 A 2-260 [» ]
1IF5 X-ray 2.00 A 2-260 [» ]
1IF6 X-ray 2.09 A 2-259 [» ]
1IF7 X-ray 1.98 A 2-260 [» ]
1IF8 X-ray 1.94 A 2-260 [» ]
1IF9 X-ray 2.00 A 2-260 [» ]
1KWQ X-ray 2.60 A 1-260 [» ]
1KWR X-ray 2.25 A 1-260 [» ]
1LG5 X-ray 1.75 A 1-260 [» ]
1LG6 X-ray 2.20 A 1-260 [» ]
1LGD X-ray 1.90 A 1-260 [» ]
1LUG X-ray 0.95 A 2-260 [» ]
1LZV X-ray 2.30 A 1-260 [» ]
1MOO X-ray 1.05 A 1-260 [» ]
1MUA X-ray 1.70 A 4-259 [» ]
1OKL X-ray 2.10 A 2-260 [» ]
1OKM X-ray 2.20 A 2-260 [» ]
1OKN X-ray 2.40 A 2-260 [» ]
1OQ5 X-ray 1.50 A 2-259 [» ]
1RAY X-ray 1.80 A 2-260 [» ]
1RAZ X-ray 1.90 A 2-260 [» ]
1RZA X-ray 1.90 A 2-260 [» ]
1RZB X-ray 1.80 A 2-260 [» ]
1RZC X-ray 1.90 A 2-260 [» ]
1RZD X-ray 1.90 A 2-260 [» ]
1RZE X-ray 1.90 A 2-260 [» ]
1T9N X-ray 2.00 A 1-259 [» ]
1TB0 X-ray 2.00 X 1-259 [» ]
1TBT X-ray 2.00 X 1-259 [» ]
1TE3 X-ray 2.00 X 1-260 [» ]
1TEQ X-ray 2.00 X 1-260 [» ]
1TEU X-ray 2.00 X 1-260 [» ]
1TG3 X-ray 1.80 A 1-260 [» ]
1TG9 X-ray 1.90 A 1-260 [» ]
1TH9 X-ray 1.63 A 1-260 [» ]
1THK X-ray 1.80 A 1-260 [» ]
1TTM X-ray 1.95 A 2-259 [» ]
1UGA X-ray 2.00 A 3-260 [» ]
1UGB X-ray 2.00 A 3-260 [» ]
1UGC X-ray 2.00 A 3-260 [» ]
1UGD X-ray 2.00 A 3-260 [» ]
1UGE X-ray 1.90 A 3-260 [» ]
1UGF X-ray 2.00 A 3-260 [» ]
1UGG X-ray 2.20 A 3-260 [» ]
1XEG X-ray 1.81 A 1-260 [» ]
1XEV X-ray 2.20 A/B/C/D 1-260 [» ]
1XPZ X-ray 2.02 A 3-260 [» ]
1XQ0 X-ray 1.76 A 2-260 [» ]
1YDA X-ray 2.10 A 2-260 [» ]
1YDB X-ray 1.90 A 2-260 [» ]
1YDC X-ray 1.95 A 2-260 [» ]
1YDD X-ray 2.10 A 2-260 [» ]
1YO0 X-ray 1.80 A 1-260 [» ]
1YO1 X-ray 1.70 A 1-260 [» ]
1YO2 X-ray 1.80 A 1-259 [» ]
1Z9Y X-ray 1.66 A 2-259 [» ]
1ZE8 X-ray 2.00 A 2-260 [» ]
1ZFK X-ray 1.56 A 2-259 [» ]
1ZFQ X-ray 1.55 A 2-259 [» ]
1ZGE X-ray 1.65 A 2-259 [» ]
1ZGF X-ray 1.75 A 2-259 [» ]
1ZH9 X-ray 1.70 A 2-259 [» ]
1ZSA X-ray 2.50 A 2-260 [» ]
1ZSB X-ray 2.00 A 2-260 [» ]
1ZSC X-ray 1.80 A 2-260 [» ]
2ABE X-ray 2.00 A 2-259 [» ]
2AW1 X-ray 1.46 A 2-260 [» ]
2AX2 X-ray 1.50 A 1-259 [» ]
2CA2 X-ray 1.90 A 2-260 [» ]
2CBA X-ray 1.54 A 2-260 [» ]
2CBB X-ray 1.67 A 2-260 [» ]
2CBC X-ray 1.88 A 2-260 [» ]
2CBD X-ray 1.67 A 2-260 [» ]
2CBE X-ray 1.82 A 2-260 [» ]
2EU2 X-ray 1.15 A 1-260 [» ]
2EU3 X-ray 1.60 A 1-260 [» ]
2EZ7 X-ray 2.00 A 1-259 [» ]
2F14 X-ray 1.71 A 2-259 [» ]
2FMG X-ray 1.60 A 1-259 [» ]
2FMZ X-ray 1.60 A 1-259 [» ]
2FNK X-ray 1.80 A 1-260 [» ]
2FNM X-ray 1.80 A 1-260 [» ]
2FNN X-ray 1.80 A 1-260 [» ]
2FOQ X-ray 1.25 A 1-259 [» ]
2FOS X-ray 1.10 A 1-259 [» ]
2FOU X-ray 0.99 A 1-259 [» ]
2FOV X-ray 1.15 A 1-259 [» ]
2GD8 X-ray 1.46 A 2-259 [» ]
2GEH X-ray 2.00 A 1-259 [» ]
2H15 X-ray 1.90 A 1-259 [» ]
2H4N X-ray 1.90 A 2-260 [» ]
2HD6 X-ray 1.80 A 2-259 [» ]
2HKK X-ray 1.90 A 1-260 [» ]
2HL4 X-ray 1.55 A 2-260 [» ]
2HNC X-ray 1.55 A 2-259 [» ]
2HOC X-ray 2.10 A 2-259 [» ]
2ILI X-ray 1.05 A 2-259 [» ]
2NNG X-ray 1.20 A 2-260 [» ]
2NNO X-ray 1.01 A 2-260 [» ]
2NNS X-ray 1.03 A 2-260 [» ]
2NNV X-ray 1.10 A 2-260 [» ]
2NWO X-ray 1.70 A 1-259 [» ]
2NWP X-ray 1.80 A 1-259 [» ]
2NWY X-ray 1.65 A 1-259 [» ]
2NWZ X-ray 1.80 A 1-259 [» ]
2NXR X-ray 1.70 A 1-259 [» ]
2NXS X-ray 1.80 A 1-259 [» ]
2NXT X-ray 1.15 A 1-260 [» ]
2O4Z X-ray 2.10 A 1-260 [» ]
2OSF X-ray 1.60 A 2-260 [» ]
2OSM X-ray 1.60 A 2-260 [» ]
2POU X-ray 1.60 A 1-259 [» ]
2POV X-ray 1.60 A 1-258 [» ]
2POW X-ray 1.75 A 1-259 [» ]
2Q1B X-ray 1.70 A 1-260 [» ]
2Q1Q X-ray 1.90 A 1-260 [» ]
2Q38 X-ray 1.95 A 1-260 [» ]
2QO8 X-ray 1.40 A 2-260 [» ]
2QOA X-ray 1.60 A 2-260 [» ]
2QP6 X-ray 1.45 A 2-260 [» ]
2VVA X-ray 1.56 X 1-260 [» ]
2VVB X-ray 1.66 X 1-260 [» ]
2WD2 X-ray 1.49 A 2-259 [» ]
2WD3 X-ray 1.80 A 2-260 [» ]
2WEG X-ray 1.10 A 2-260 [» ]
2WEH X-ray 2.09 A 2-260 [» ]
2WEJ X-ray 1.45 A 2-260 [» ]
2WEO X-ray 1.40 A 2-260 [» ]
2X7S X-ray 1.64 A 2-260 [» ]
2X7T X-ray 1.89 A 2-260 [» ]
2X7U X-ray 2.12 A 2-260 [» ]
3B4F X-ray 1.89 A 1-260 [» ]
3BET X-ray 1.85 A 2-260 [» ]
3BL0 X-ray 1.90 A 1-260 [» ]
3BL1 X-ray 2.10 A 1-260 [» ]
3C7P X-ray 1.70 A 1-260 [» ]
3CA2 X-ray 2.00 A 2-260 [» ]
3CAJ X-ray 1.80 A 1-260 [» ]
3CYU X-ray 1.70 A 1-260 [» ]
3D8W X-ray 1.70 A 1-260 [» ]
3D92 X-ray 1.10 A 1-260 [» ]
3D93 X-ray 1.10 A 1-260 [» ]
3D9Z X-ray 1.65 A 1-260 [» ]
3DAZ X-ray 1.60 A 1-260 [» ]
3DBU X-ray 1.70 A 1-260 [» ]
3DC3 X-ray 1.70 A 1-260 [» ]
3DC9 X-ray 1.60 A 1-260 [» ]
3DCC X-ray 1.60 A 1-260 [» ]
3DCS X-ray 1.80 A 1-260 [» ]
3DCW X-ray 1.50 A 1-260 [» ]
3DD0 X-ray 1.48 A 1-260 [» ]
3DD8 X-ray 1.90 A 1-260 [» ]
3DV7 X-ray 1.70 A 2-260 [» ]
3DVB X-ray 1.70 A 2-260 [» ]
3DVC X-ray 1.60 A 2-260 [» ]
3DVD X-ray 1.60 A 2-260 [» ]
3EFI X-ray 1.75 A 2-260 [» ]
3EFT X-ray 1.85 A 1-260 [» ]
3F4X X-ray 1.90 A 1-260 [» ]
3F8E X-ray 2.00 A 1-260 [» ]
3FFP X-ray 1.81 X 1-260 [» ]
3GZ0 X-ray 1.26 A 2-260 [» ]
3HFP X-ray 2.10 A 1-260 [» ]
3HKN X-ray 1.80 A 1-260 [» ]
3HKQ X-ray 1.70 A 1-260 [» ]
3HKT X-ray 2.36 A 1-260 [» ]
3HKU X-ray 1.80 A 1-260 [» ]
3HLJ X-ray 1.44 A 1-260 [» ]
3HS4 X-ray 1.10 A 1-260 [» ]
3IBI X-ray 1.93 A 2-260 [» ]
3IBL X-ray 1.55 A 2-260 [» ]
3IBN X-ray 2.20 A 2-260 [» ]
3IBU X-ray 1.41 A 2-260 [» ]
3IEO X-ray 2.00 A 1-260 [» ]
3IGP X-ray 1.65 A 1-260 [» ]
3K2F X-ray 1.98 A 1-260 [» ]
3K34 X-ray 0.90 A 1-260 [» ]
3K7K X-ray 1.90 A 1-260 [» ]
3KIG X-ray 1.39 A 1-260 [» ]
3KKX neutron diffraction 2.00 A 1-260 [» ]
3KNE X-ray 1.35 A 1-260 [» ]
3KOI X-ray 1.64 A 1-260 [» ]
3KOK X-ray 1.50 A 1-260 [» ]
3KON X-ray 1.50 A 1-260 [» ]
3KS3 X-ray 0.90 A 1-260 [» ]
3KWA X-ray 2.00 A 1-260 [» ]
3L14 X-ray 1.22 A 1-260 [» ]
3M04 X-ray 1.40 A 1-260 [» ]
3M14 X-ray 1.38 A 1-260 [» ]
3M1J X-ray 1.80 A 1-260 [» ]
3M1K X-ray 1.35 A 1-260 [» ]
3M1Q X-ray 1.69 A 1-260 [» ]
3M1W X-ray 1.38 A 1-260 [» ]
3M2N X-ray 1.65 A 1-260 [» ]
3M2X X-ray 1.87 A 1-260 [» ]
3M2Y X-ray 1.17 A 1-260 [» ]
3M2Z X-ray 1.70 A 1-260 [» ]
3M3X X-ray 1.68 A 1-260 [» ]
3M40 X-ray 1.60 A 1-260 [» ]
3M5E X-ray 1.70 A 1-260 [» ]
3M5S X-ray 1.40 A 1-260 [» ]
3M5T X-ray 1.95 A 1-260 [» ]
3M67 X-ray 1.80 A 1-260 [» ]
3M96 X-ray 1.40 A 1-260 [» ]
3M98 X-ray 1.50 A 1-260 [» ]
3MHC X-ray 1.70 A 1-260 [» ]
3MHI X-ray 1.70 A 1-260 [» ]
3MHL X-ray 1.90 A 1-260 [» ]
3MHM X-ray 1.50 A 1-260 [» ]
3MHO X-ray 1.15 A 1-260 [» ]
3ML2 X-ray 1.80 A 1-260 [» ]
3MMF X-ray 1.50 A 1-260 [» ]
3MNA X-ray 1.50 A 1-260 [» ]
3MNH X-ray 1.65 A 1-260 [» ]
3MNI X-ray 1.75 A 1-260 [» ]
3MNJ X-ray 1.75 A 1-260 [» ]
3MNK X-ray 1.75 A 1-260 [» ]
3MNU X-ray 1.80 A 2-260 [» ]
3MWO X-ray 1.40 A/B 1-260 [» ]
3MYQ X-ray 1.35 A 1-260 [» ]
3MZC X-ray 1.50 A 1-260 [» ]
3N0N X-ray 1.50 A 1-260 [» ]
3N2P X-ray 1.65 A 1-260 [» ]
3N3J X-ray 1.50 A 1-260 [» ]
3N4B X-ray 1.60 A 1-260 [» ]
3NB5 X-ray 1.80 A 1-260 [» ]
3NI5 X-ray 2.10 A 1-260 [» ]
3NJ9 X-ray 2.00 A 1-260 [» ]
3OIK X-ray 1.50 A 1-260 [» ]
3OIL X-ray 1.50 A 1-260 [» ]
3OIM X-ray 1.45 A 1-260 [» ]
3OKU X-ray 1.45 A 1-260 [» ]
3OKV X-ray 1.45 A 1-260 [» ]
3OY0 X-ray 1.60 A 1-260 [» ]
3OYQ X-ray 1.47 A 1-260 [» ]
3OYS X-ray 1.54 A 1-260 [» ]
3P3H X-ray 1.50 A 1-260 [» ]
3P3J X-ray 1.60 A 1-260 [» ]
3P44 X-ray 2.20 A 1-260 [» ]
3P4V X-ray 2.00 A 1-260 [» ]
3P55 X-ray 2.00 A 1-260 [» ]
3P58 X-ray 1.49 A 1-260 [» ]
3P5A X-ray 1.49 A 1-260 [» ]
3P5L X-ray 1.50 A 1-260 [» ]
3PJJ X-ray 1.80 A 2-260 [» ]
3PO6 X-ray 1.47 A 2-260 [» ]
3PYK X-ray 1.30 A 1-260 [» ]
3QYK X-ray 1.47 A 1-260 [» ]
3R16 X-ray 1.60 A 4-260 [» ]
3R17 X-ray 1.70 B 4-260 [» ]
3RG3 X-ray 1.90 A 1-260 [» ]
3RG4 X-ray 1.50 A 1-260 [» ]
3RGE X-ray 2.10 A 1-260 [» ]
3RJ7 X-ray 1.20 A 3-260 [» ]
3RLD X-ray 1.50 A 1-260 [» ]
3RYJ X-ray 1.39 B 2-260 [» ]
3RYV X-ray 1.20 B 2-260 [» ]
3RYX X-ray 1.60 B 2-260 [» ]
3RYY X-ray 1.16 A 2-260 [» ]
3RYZ X-ray 1.37 A 2-260 [» ]
3RZ0 X-ray 1.80 B 2-260 [» ]
3RZ1 X-ray 1.51 B 2-260 [» ]
3RZ5 X-ray 1.65 A 2-260 [» ]
3RZ7 X-ray 1.80 A 2-260 [» ]
3RZ8 X-ray 1.70 A 2-260 [» ]
3S71 X-ray 1.25 B 3-260 [» ]
3S72 X-ray 1.60 B 3-260 [» ]
3S73 X-ray 1.75 B 3-260 [» ]
3S74 X-ray 1.40 B 3-260 [» ]
3S75 X-ray 1.50 B 3-260 [» ]
3S76 X-ray 1.60 A 3-260 [» ]
3S77 X-ray 1.86 B 3-260 [» ]
3S78 X-ray 1.98 B 3-260 [» ]
3S8X X-ray 1.30 A 1-260 [» ]
3S9T X-ray 1.30 A 1-260 [» ]
3SAP X-ray 1.75 A 1-260 [» ]
3SAX X-ray 1.10 A 1-260 [» ]
3SBH X-ray 1.65 A 1-260 [» ]
3SBI X-ray 1.40 A 1-260 [» ]
3T5U X-ray 1.75 A 2-260 [» ]
3T5Z X-ray 1.65 A 2-260 [» ]
3T82 X-ray 2.00 A 1-260 [» ]
3T83 X-ray 1.80 A 1-260 [» ]
3T84 X-ray 2.00 A 1-260 [» ]
3T85 X-ray 2.40 A 1-260 [» ]
3TMJ Other 2.00 A 3-260 [» ]
3TVN X-ray 1.50 X 3-260 [» ]
3TVO X-ray 1.60 X 3-260 [» ]
3U3A X-ray 1.55 X 1-260 [» ]
3U45 X-ray 1.70 X 1-260 [» ]
3U47 X-ray 1.60 A 1-260 [» ]
3U7C X-ray 0.93 A 1-260 [» ]
3V2J X-ray 1.70 A 1-260 [» ]
3V2M X-ray 1.47 A 1-260 [» ]
3V3F X-ray 2.00 A 1-260 [» ]
3V3G X-ray 1.56 B 1-260 [» ]
3V3H X-ray 1.85 B 1-260 [» ]
3V3I X-ray 1.73 B 1-260 [» ]
3V3J X-ray 1.63 A 1-260 [» ]
3V5G X-ray 1.50 A 1-260 [» ]
3V7X X-ray 1.03 A 2-260 [» ]
3VBD X-ray 1.05 A 2-260 [» ]
3ZP9 X-ray 1.31 A 1-260 [» ]
4BCW X-ray 1.50 A 4-260 [» ]
4BF1 X-ray 1.35 A 2-260 [» ]
4BF6 X-ray 1.82 A 2-260 [» ]
4CA2 X-ray 2.10 A 1-260 [» ]
4CAC X-ray 2.20 A 2-260 [» ]
4CQ0 X-ray 1.45 A 1-260 [» ]
4DZ7 X-ray 1.49 A 1-260 [» ]
4DZ9 X-ray 1.49 A 1-260 [» ]
4E3D X-ray 1.60 A 1-260 [» ]
4E3F X-ray 1.50 A 1-260 [» ]
4E3G X-ray 1.55 A 1-260 [» ]
4E3H X-ray 1.50 A 1-260 [» ]
4E49 X-ray 1.45 A 1-260 [» ]
4E4A X-ray 1.45 A 1-260 [» ]
4E5Q X-ray 1.70 A 1-260 [» ]
4FIK X-ray 1.20 A 1-260 [» ]
4FL7 X-ray 1.85 A 2-260 [» ]
4FPT X-ray 0.98 A 1-260 [» ]
4FRC X-ray 0.98 A 1-260 [» ]
4FU5 X-ray 0.98 A 1-260 [» ]
4FVN X-ray 1.05 A 1-260 [» ]
4FVO X-ray 1.05 A 1-260 [» ]
4G0C neutron diffraction 2.00 A 4-260 [» ]
4GGE X-ray 1.47 A 1-260 [» ]
4GL1 X-ray 1.50 X 1-260 [» ]
4HBA X-ray 1.76 A 1-260 [» ]
4HEW X-ray 1.70 A 1-260 [» ]
4HEY X-ray 1.45 A 1-260 [» ]
4HEZ X-ray 1.34 A 1-260 [» ]
4HF3 X-ray 1.15 A 1-260 [» ]
4HT0 X-ray 1.60 A 1-260 [» ]
4IDR X-ray 1.60 X 3-260 [» ]
4ILX X-ray 1.60 A 4-260 [» ]
4ITO X-ray 1.16 A 1-260 [» ]
4ITP X-ray 1.70 A 4-260 [» ]
4IWZ X-ray 1.60 A 4-260 [» ]
4JS6 X-ray 1.55 A 1-260 [» ]
4JSA X-ray 1.50 A 1-260 [» ]
4JSS X-ray 1.50 A 1-260 [» ]
4JSW X-ray 1.90 A 1-260 [» ]
4JSZ X-ray 1.90 A 1-260 [» ]
4K0S X-ray 1.80 A 4-260 [» ]
4K0T X-ray 1.78 A 4-260 [» ]
4K0Z X-ray 1.80 A 3-260 [» ]
4K13 X-ray 1.60 A 4-260 [» ]
4K1Q X-ray 1.70 A 3-260 [» ]
4KAP X-ray 1.45 A 5-260 [» ]
4KNI X-ray 1.80 A 1-260 [» ]
4KNJ X-ray 2.00 A 1-260 [» ]
4KUV X-ray 1.35 A 5-260 [» ]
4KUW X-ray 1.55 A 4-260 [» ]
4KUY X-ray 1.65 A 4-260 [» ]
4KV0 X-ray 1.55 A 4-260 [» ]
4L5U X-ray 2.05 A 1-260 [» ]
4L5V X-ray 1.63 A 1-260 [» ]
4L5W X-ray 1.70 A 1-260 [» ]
4LHI X-ray 1.60 A 1-260 [» ]
4LP6 X-ray 2.15 A/B 1-260 [» ]
4M2R X-ray 1.99 A 4-260 [» ]
4M2U X-ray 2.00 A 4-260 [» ]
4M2V X-ray 1.72 A 4-260 [» ]
4M2W X-ray 1.66 A 4-260 [» ]
4MDG X-ray 1.35 A 3-260 [» ]
4MDL X-ray 1.52 A 3-260 [» ]
4MDM X-ray 1.55 A 3-260 [» ]
4MLT X-ray 2.00 A 1-260 [» ]
4MLX X-ray 1.65 A 1-260 [» ]
4MO8 X-ray 1.85 A 1-260 [» ]
4MTY X-ray 1.00 A 1-260 [» ]
4N0X X-ray 1.63 B 1-260 [» ]
4N16 X-ray 1.54 A 1-260 [» ]
5CA2 X-ray 2.10 A 1-260 [» ]
5CAC X-ray 2.20 A 2-260 [» ]
6CA2 X-ray 2.50 A 1-260 [» ]
7CA2 X-ray 2.40 A 1-260 [» ]
8CA2 X-ray 2.40 A 1-260 [» ]
9CA2 X-ray 2.80 A 1-260 [» ]
ProteinModelPortali P00918.
SMRi P00918. Positions 3-260.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107215. 12 interactions.
IntActi P00918. 5 interactions.
MINTi MINT-1367766.
STRINGi 9606.ENSP00000285379.

Chemistry

BindingDBi P00918.
ChEMBLi CHEMBL205.
DrugBanki DB00819. Acetazolamide.
DB00436. Bendroflumethiazide.
DB00562. Benzthiazide.
DB01194. Brinzolamide.
DB00880. Chlorothiazide.
DB00606. Cyclothiazide.
DB01119. Diazoxide.
DB01144. Diclofenamide.
DB00869. Dorzolamide.
DB01031. Ethinamate.
DB00695. Furosemide.
DB00999. Hydrochlorothiazide.
DB00774. Hydroflumethiazide.
DB00703. Methazolamide.
DB00232. Methyclothiazide.
DB01325. Quinethazone.
DB00273. Topiramate.
DB01021. Trichlormethiazide.
DB00909. Zonisamide.

PTM databases

PhosphoSitei P00918.

2D gel databases

OGPi P00918.
REPRODUCTION-2DPAGE IPI00218414.
P00918.
UCD-2DPAGE P00918.

Proteomic databases

MaxQBi P00918.
PaxDbi P00918.
PeptideAtlasi P00918.
PRIDEi P00918.

Protocols and materials databases

DNASUi 760.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000285379 ; ENSP00000285379 ; ENSG00000104267 .
GeneIDi 760.
KEGGi hsa:760.