SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P00912

- TRPF_YEAST

UniProt

P00912 - TRPF_YEAST

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
N-(5'-phosphoribosyl)anthranilate isomerase
Gene
TRP1, YDR007W
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. phosphoribosylanthranilate isomerase activity Source: SGD

GO - Biological processi

  1. tryptophan biosynthetic process Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

BioCyciYEAST:YDR007W-MONOMER.
UniPathwayiUPA00035; UER00042.

Names & Taxonomyi

Protein namesi
Recommended name:
N-(5'-phosphoribosyl)anthranilate isomerase (EC:5.3.1.24)
Short name:
PRAI
Gene namesi
Name:TRP1
Ordered Locus Names:YDR007W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome IV

Organism-specific databases

CYGDiYDR007w.
SGDiS000002414. TRP1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 224224N-(5'-phosphoribosyl)anthranilate isomeraseUniRule annotation
PRO_0000154337Add
BLAST

Proteomic databases

MaxQBiP00912.
PaxDbiP00912.

Expressioni

Gene expression databases

GenevestigatoriP00912.

Interactioni

Protein-protein interaction databases

BioGridi32060. 35 interactions.
DIPiDIP-2671N.
IntActiP00912. 1 interaction.
MINTiMINT-509744.

Structurei

3D structure databases

ProteinModelPortaliP00912.
SMRiP00912. Positions 14-215.

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpF family.

Phylogenomic databases

eggNOGiCOG0135.
KOiK01817.
OMAiKRNIDIN.
OrthoDBiEOG76MKM7.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00135. PRAI.
InterProiIPR013785. Aldolase_TIM.
IPR001240. PRAI_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00697. PRAI. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.

Sequencei

Sequence statusi: Complete.

P00912-1 [UniParc]FASTAAdd to Basket

« Hide

MSVINFTGSS GPLVKVCGLQ STEAAECALD SDADLLGIIC VPNRKRTIDP    50
VIARKISSLV KAYKNSSGTP KYLVGVFRNQ PKEDVLALVN DYGIDIVQLH 100
GDESWQEYQE FLGLPVIKRL VFPKDCNILL SAASQKPHSF IPLFDSEAGG 150
TGELLDWNSI SDWVGRQESP ESLHFMLAGG LTPENVGDAL RLNGVIGVDV 200
SGGVETNGVK DSNKIANFVK NAKK 224
Length:224
Mass (Da):24,144
Last modified:December 21, 2004 - v2
Checksum:i03353B85F24FA09D
GO

Sequence cautioni

The sequence AAA80674.1 differs from that shown. Reason: Erroneous initiation.
The sequence CAA88067.1 differs from that shown. Reason: Erroneous termination at position 67. Translated as Ser. This mutation is only found in the substrain S288c / AB972. Resequencing of the S288c reference strain showed that S288c does not contain this mutation.
The sequence CAA88068.1 differs from that shown. Reason: Erroneous termination at position 67. Translated as Ser. This mutation is only found in the substrain S288c / AB972. Resequencing of the S288c reference strain showed that S288c does not contain this mutation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti48 – 481I → V in strain: CLIB 556 haplotype Ha2 and CLIB 630 haplotype Ha2. 1 Publication
Natural varianti172 – 1721S → R in strain: CLIB 556 haplotype Ha1. 1 Publication
Natural varianti212 – 2121S → F in strain: CLIB 95, CLIB 382, CLIB 388, CLIB 556 haplotype Ha2, CLIB 630, K1, R12, R13, YIIc12 haplotype Ha2 and YIIc17 haplotype Ha1. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
V01341 Genomic DNA. Translation: CAA24634.1.
M74015 Genomic DNA. Translation: AAA72097.1.
U37458 Genomic DNA. Translation: AAA80674.1. Different initiation.
AJ585667 Genomic DNA. Translation: CAE52187.1.
AJ585668 Genomic DNA. Translation: CAE52188.1.
AJ585669 Genomic DNA. Translation: CAE52189.1.
AJ585670 Genomic DNA. Translation: CAE52190.1.
AJ585671 Genomic DNA. Translation: CAE52191.1.
AJ585672 Genomic DNA. Translation: CAE52192.1.
AJ585673 Genomic DNA. Translation: CAE52193.1.
AJ585674 Genomic DNA. Translation: CAE52194.1.
AJ585675 Genomic DNA. Translation: CAE52195.1.
AJ585676 Genomic DNA. Translation: CAE52196.1.
AJ585677 Genomic DNA. Translation: CAE52197.1.
AJ585678 Genomic DNA. Translation: CAE52198.1.
AJ585679 Genomic DNA. Translation: CAE52199.1.
AJ585680 Genomic DNA. Translation: CAE52200.1.
AJ585681 Genomic DNA. Translation: CAE52201.1.
AJ585682 Genomic DNA. Translation: CAE52202.1.
AJ585683 Genomic DNA. Translation: CAE52203.1.
AJ585684 Genomic DNA. Translation: CAE52204.1.
AJ585685 Genomic DNA. Translation: CAE52205.1.
Z48008 Genomic DNA. Translation: CAA88067.1. Sequence problems.
Z48008 Genomic DNA. Translation: CAA88068.1. Sequence problems.
M30386 Genomic DNA. Translation: AAA18406.1.
BK006938 Genomic DNA. Translation: DAA11855.1.
PIRiA01135. ISBYN.
RefSeqiNP_010290.3. NM_001180315.3.

Genome annotation databases

EnsemblFungiiYDR007W; YDR007W; YDR007W.
GeneIDi851570.
KEGGisce:YDR007W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
V01341 Genomic DNA. Translation: CAA24634.1 .
M74015 Genomic DNA. Translation: AAA72097.1 .
U37458 Genomic DNA. Translation: AAA80674.1 . Different initiation.
AJ585667 Genomic DNA. Translation: CAE52187.1 .
AJ585668 Genomic DNA. Translation: CAE52188.1 .
AJ585669 Genomic DNA. Translation: CAE52189.1 .
AJ585670 Genomic DNA. Translation: CAE52190.1 .
AJ585671 Genomic DNA. Translation: CAE52191.1 .
AJ585672 Genomic DNA. Translation: CAE52192.1 .
AJ585673 Genomic DNA. Translation: CAE52193.1 .
AJ585674 Genomic DNA. Translation: CAE52194.1 .
AJ585675 Genomic DNA. Translation: CAE52195.1 .
AJ585676 Genomic DNA. Translation: CAE52196.1 .
AJ585677 Genomic DNA. Translation: CAE52197.1 .
AJ585678 Genomic DNA. Translation: CAE52198.1 .
AJ585679 Genomic DNA. Translation: CAE52199.1 .
AJ585680 Genomic DNA. Translation: CAE52200.1 .
AJ585681 Genomic DNA. Translation: CAE52201.1 .
AJ585682 Genomic DNA. Translation: CAE52202.1 .
AJ585683 Genomic DNA. Translation: CAE52203.1 .
AJ585684 Genomic DNA. Translation: CAE52204.1 .
AJ585685 Genomic DNA. Translation: CAE52205.1 .
Z48008 Genomic DNA. Translation: CAA88067.1 . Sequence problems.
Z48008 Genomic DNA. Translation: CAA88068.1 . Sequence problems.
M30386 Genomic DNA. Translation: AAA18406.1 .
BK006938 Genomic DNA. Translation: DAA11855.1 .
PIRi A01135. ISBYN.
RefSeqi NP_010290.3. NM_001180315.3.

3D structure databases

ProteinModelPortali P00912.
SMRi P00912. Positions 14-215.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 32060. 35 interactions.
DIPi DIP-2671N.
IntActi P00912. 1 interaction.
MINTi MINT-509744.

Proteomic databases

MaxQBi P00912.
PaxDbi P00912.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YDR007W ; YDR007W ; YDR007W .
GeneIDi 851570.
KEGGi sce:YDR007W.

Organism-specific databases

CYGDi YDR007w.
SGDi S000002414. TRP1.

Phylogenomic databases

eggNOGi COG0135.
KOi K01817.
OMAi KRNIDIN.
OrthoDBi EOG76MKM7.

Enzyme and pathway databases

UniPathwayi UPA00035 ; UER00042 .
BioCyci YEAST:YDR007W-MONOMER.

Miscellaneous databases

NextBioi 969022.

Gene expression databases

Genevestigatori P00912.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_00135. PRAI.
InterProi IPR013785. Aldolase_TIM.
IPR001240. PRAI_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00697. PRAI. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence of a yeast DNA fragment containing a chromosomal replicator and the TRP1 gene."
    Tschumper G., Carbon J.
    Gene 10:157-166(1980) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "A series of yeast shuttle vectors for expression of cDNAs and other DNA sequences."
    Brunelli J.P., Pall M.L.
    Yeast 9:1299-1308(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Lieberman B.
    Submitted (OCT-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Differential evolution of the Saccharomyces cerevisiae DUP240 paralogs and implication of recombination in phylogeny."
    Leh-Louis V., Wirth B., Despons L., Wain-Hobson S., Potier S., Souciet J.-L.
    Nucleic Acids Res. 32:2069-2078(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS VAL-48; ARG-172 AND PHE-212.
    Strain: ATCC 204508 / S288c, CLIB 219, CLIB 382, CLIB 388, CLIB 410, CLIB 413, CLIB 556, CLIB 630, CLIB 95, K1, R12, R13, Sigma 1278B, YIIc12 and YIIc17.
  5. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
    Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
    , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
    Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  6. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  7. "Bent DNA at a yeast autonomously replicating sequence."
    Snyder M., Buchman A.R., Davis R.W.
    Nature 324:87-89(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 206-224.
  8. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTRPF_YEAST
AccessioniPrimary (citable) accession number: P00912
Secondary accession number(s): D6VRZ5
, Q03448, Q12131, Q70DA4, Q70DA7, Q70DB2, Q7LHE0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: December 21, 2004
Last modified: May 14, 2014
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1850 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

External Data

Dasty 3

Similar proteinsi