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Protein

N-(5'-phosphoribosyl)anthranilate isomerase

Gene

TRP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.

Pathwayi

GO - Molecular functioni

  1. phosphoribosylanthranilate isomerase activity Source: SGD

GO - Biological processi

  1. tryptophan biosynthetic process Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

BioCyciYEAST:YDR007W-MONOMER.
UniPathwayiUPA00035; UER00042.

Names & Taxonomyi

Protein namesi
Recommended name:
N-(5'-phosphoribosyl)anthranilate isomerase (EC:5.3.1.24)
Short name:
PRAI
Gene namesi
Name:TRP1
Ordered Locus Names:YDR007W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome IV

Organism-specific databases

CYGDiYDR007w.
SGDiS000002414. TRP1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 224224N-(5'-phosphoribosyl)anthranilate isomerasePRO_0000154337Add
BLAST

Proteomic databases

MaxQBiP00912.
PaxDbiP00912.

Expressioni

Gene expression databases

GenevestigatoriP00912.

Interactioni

Protein-protein interaction databases

BioGridi32060. 36 interactions.
DIPiDIP-2671N.
IntActiP00912. 1 interaction.
MINTiMINT-509744.

Structurei

3D structure databases

ProteinModelPortaliP00912.
SMRiP00912. Positions 14-215.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpF family.Curated

Phylogenomic databases

eggNOGiCOG0135.
KOiK01817.
OMAiDMIGLIF.
OrthoDBiEOG76MKM7.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00135. PRAI.
InterProiIPR013785. Aldolase_TIM.
IPR001240. PRAI.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00697. PRAI. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.

Sequencei

Sequence statusi: Complete.

P00912-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVINFTGSS GPLVKVCGLQ STEAAECALD SDADLLGIIC VPNRKRTIDP
60 70 80 90 100
VIARKISSLV KAYKNSSGTP KYLVGVFRNQ PKEDVLALVN DYGIDIVQLH
110 120 130 140 150
GDESWQEYQE FLGLPVIKRL VFPKDCNILL SAASQKPHSF IPLFDSEAGG
160 170 180 190 200
TGELLDWNSI SDWVGRQESP ESLHFMLAGG LTPENVGDAL RLNGVIGVDV
210 220
SGGVETNGVK DSNKIANFVK NAKK
Length:224
Mass (Da):24,144
Last modified:December 20, 2004 - v2
Checksum:i03353B85F24FA09D
GO

Sequence cautioni

The sequence AAA80674.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAA88067.1 differs from that shown. Reason: Erroneous termination at position 67. Translated as Ser. This mutation is only found in the substrain S288c / AB972. The S288c reference strain does not contain this mutation.Curated
The sequence CAA88068.1 differs from that shown. Reason: Erroneous termination at position 67. Translated as Ser. This mutation is only found in the substrain S288c / AB972. The S288c reference strain does not contain this mutation.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti48 – 481I → V in strain: CLIB 556 haplotype Ha2 and CLIB 630 haplotype Ha2. 1 Publication
Natural varianti172 – 1721S → R in strain: CLIB 556 haplotype Ha1. 1 Publication
Natural varianti212 – 2121S → F in strain: CLIB 95, CLIB 382, CLIB 388, CLIB 556 haplotype Ha2, CLIB 630, K1, R12, R13, YIIc12 haplotype Ha2 and YIIc17 haplotype Ha1. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01341 Genomic DNA. Translation: CAA24634.1.
M74015 Genomic DNA. Translation: AAA72097.1.
U37458 Genomic DNA. Translation: AAA80674.1. Different initiation.
AJ585667 Genomic DNA. Translation: CAE52187.1.
AJ585668 Genomic DNA. Translation: CAE52188.1.
AJ585669 Genomic DNA. Translation: CAE52189.1.
AJ585670 Genomic DNA. Translation: CAE52190.1.
AJ585671 Genomic DNA. Translation: CAE52191.1.
AJ585672 Genomic DNA. Translation: CAE52192.1.
AJ585673 Genomic DNA. Translation: CAE52193.1.
AJ585674 Genomic DNA. Translation: CAE52194.1.
AJ585675 Genomic DNA. Translation: CAE52195.1.
AJ585676 Genomic DNA. Translation: CAE52196.1.
AJ585677 Genomic DNA. Translation: CAE52197.1.
AJ585678 Genomic DNA. Translation: CAE52198.1.
AJ585679 Genomic DNA. Translation: CAE52199.1.
AJ585680 Genomic DNA. Translation: CAE52200.1.
AJ585681 Genomic DNA. Translation: CAE52201.1.
AJ585682 Genomic DNA. Translation: CAE52202.1.
AJ585683 Genomic DNA. Translation: CAE52203.1.
AJ585684 Genomic DNA. Translation: CAE52204.1.
AJ585685 Genomic DNA. Translation: CAE52205.1.
Z48008 Genomic DNA. Translation: CAA88067.1. Sequence problems.
Z48008 Genomic DNA. Translation: CAA88068.1. Sequence problems.
M30386 Genomic DNA. Translation: AAA18406.1.
BK006938 Genomic DNA. Translation: DAA11855.1.
PIRiA01135. ISBYN.
RefSeqiNP_010290.3. NM_001180315.3.

Genome annotation databases

EnsemblFungiiYDR007W; YDR007W; YDR007W.
GeneIDi851570.
KEGGisce:YDR007W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01341 Genomic DNA. Translation: CAA24634.1.
M74015 Genomic DNA. Translation: AAA72097.1.
U37458 Genomic DNA. Translation: AAA80674.1. Different initiation.
AJ585667 Genomic DNA. Translation: CAE52187.1.
AJ585668 Genomic DNA. Translation: CAE52188.1.
AJ585669 Genomic DNA. Translation: CAE52189.1.
AJ585670 Genomic DNA. Translation: CAE52190.1.
AJ585671 Genomic DNA. Translation: CAE52191.1.
AJ585672 Genomic DNA. Translation: CAE52192.1.
AJ585673 Genomic DNA. Translation: CAE52193.1.
AJ585674 Genomic DNA. Translation: CAE52194.1.
AJ585675 Genomic DNA. Translation: CAE52195.1.
AJ585676 Genomic DNA. Translation: CAE52196.1.
AJ585677 Genomic DNA. Translation: CAE52197.1.
AJ585678 Genomic DNA. Translation: CAE52198.1.
AJ585679 Genomic DNA. Translation: CAE52199.1.
AJ585680 Genomic DNA. Translation: CAE52200.1.
AJ585681 Genomic DNA. Translation: CAE52201.1.
AJ585682 Genomic DNA. Translation: CAE52202.1.
AJ585683 Genomic DNA. Translation: CAE52203.1.
AJ585684 Genomic DNA. Translation: CAE52204.1.
AJ585685 Genomic DNA. Translation: CAE52205.1.
Z48008 Genomic DNA. Translation: CAA88067.1. Sequence problems.
Z48008 Genomic DNA. Translation: CAA88068.1. Sequence problems.
M30386 Genomic DNA. Translation: AAA18406.1.
BK006938 Genomic DNA. Translation: DAA11855.1.
PIRiA01135. ISBYN.
RefSeqiNP_010290.3. NM_001180315.3.

3D structure databases

ProteinModelPortaliP00912.
SMRiP00912. Positions 14-215.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32060. 36 interactions.
DIPiDIP-2671N.
IntActiP00912. 1 interaction.
MINTiMINT-509744.

Proteomic databases

MaxQBiP00912.
PaxDbiP00912.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR007W; YDR007W; YDR007W.
GeneIDi851570.
KEGGisce:YDR007W.

Organism-specific databases

CYGDiYDR007w.
SGDiS000002414. TRP1.

Phylogenomic databases

eggNOGiCOG0135.
KOiK01817.
OMAiDMIGLIF.
OrthoDBiEOG76MKM7.

Enzyme and pathway databases

UniPathwayiUPA00035; UER00042.
BioCyciYEAST:YDR007W-MONOMER.

Miscellaneous databases

NextBioi969022.

Gene expression databases

GenevestigatoriP00912.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00135. PRAI.
InterProiIPR013785. Aldolase_TIM.
IPR001240. PRAI.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00697. PRAI. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence of a yeast DNA fragment containing a chromosomal replicator and the TRP1 gene."
    Tschumper G., Carbon J.
    Gene 10:157-166(1979) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "A series of yeast shuttle vectors for expression of cDNAs and other DNA sequences."
    Brunelli J.P., Pall M.L.
    Yeast 9:1299-1308(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Lieberman B.
    Submitted (SEP-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Differential evolution of the Saccharomyces cerevisiae DUP240 paralogs and implication of recombination in phylogeny."
    Leh-Louis V., Wirth B., Despons L., Wain-Hobson S., Potier S., Souciet J.-L.
    Nucleic Acids Res. 32:2069-2078(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS VAL-48; ARG-172 AND PHE-212.
    Strain: ATCC 204508 / S288c, CLIB 219, CLIB 382, CLIB 388, CLIB 410, CLIB 413, CLIB 556, CLIB 630, CLIB 95, K1, R12, R13, Sigma 1278B, YIIc12 and YIIc17.
  5. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
    Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
    , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
    Nature 387:75-78(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  6. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  7. "Bent DNA at a yeast autonomously replicating sequence."
    Snyder M., Buchman A.R., Davis R.W.
    Nature 324:87-89(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 206-224.
  8. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTRPF_YEAST
AccessioniPrimary (citable) accession number: P00912
Secondary accession number(s): D6VRZ5
, Q03448, Q12131, Q70DA4, Q70DA7, Q70DB2, Q7LHE0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 20, 1986
Last sequence update: December 20, 2004
Last modified: March 31, 2015
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1850 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.