P00911 (TRPC_ACIAD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Indole-3-glycerol phosphate synthase
Short name=IGPS
EC=4.1.1.48

Gene names

Name:	trpC
Ordered Locus Names:	ACIAD2463

Organism

Acinetobacter sp. (strain ADP1) [Complete proteome] [HAMAP]

Taxonomic identifier

62977 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter

Protein attributes

Sequence length	268 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP MF_00134_B
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP MF_00134_B
Sequence similarities	Belongs to the TrpC family.
Sequence caution	The sequence CAG69233.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	indole-3-glycerol-phosphate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 268	268	Indole-3-glycerol phosphate synthase HAMAP MF_00134_B		PRO_0000154205
Experimental info
	Sequence conflict	72	1	A → V in AAA21905. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P00911 [UniParc]. Last modified August 31, 2004. Version 2. Checksum: 50C41B42DBDE68AE	FASTA	268	30,189
	10 20 30 40 50 60 MIQIQNTILG KIVDRKHEEL ADRLKQRNLK DVEQWVKEAP PVRGFAQSLR SKRPGVIAEI 70 80 90 100 110 120 KKASPSKGVI RADFNPAEIA QQYEQAGAAC LSVLTDVDFF QGADENIAIA RQHCSLPALR 130 140 150 160 170 180 KDFLIDPYNV VEARALQADC ILLIVACLSD QQLEEMSKTA FEYDLDVLVE VHDEQELERA 190 200 210 220 230 240 LKLSEQCLLG VNNRNLKTFD VDLNTSLRLK KLLDPSRLLV TESGIATPQD VQLMQEHDIH 250 260 SFLVGESFMK QPRPDQAFTE LFGVPKLV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Nucleotide sequence of the Acinetobacter calcoaceticus trpGDC gene cluster." Kaplan J.B., Goncharoff P., Seibold A.M., Nichols B.P. Mol. Biol. Evol. 1:456-472(1984) [PubMed: 6599977] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium." Barbe V., Vallenet D., Fonknechten N., Kreimeyer A., Oztas S., Labarre L., Cruveiller S., Robert C., Duprat S., Wincker P., Ornston L.N., Weissenbach J., Marliere P., Cohen G.N., Medigue C. Nucleic Acids Res. 32:5766-5779(2004) [PubMed: 15514110] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ADP1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M36636 Genomic DNA. Translation: AAA21905.1. CR543861 Genomic DNA. Translation: CAG69233.1. Different initiation.
PIR	GWKECC. A01133.
RefSeq	YP_047055.1. NC_005966.1.
3D structure databases
ProteinModelPortal	P00911.
ModBase	Search...
Protein-protein interaction databases
STRING	P00911.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2880735.
GenomeReviews	Gene locus ACIAD2463 in contig CR543861_GR.
KEGG	aci:ACIAD2463.
NMPDR	fig|62977.3.peg.2064.
PATRIC	20742546. VBIAciSp98416_2215.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0134.
HOGENOM	HBG540956.
PhylomeDB	P00911.
ProtClustDB	PRK00278.
Enzyme and pathway databases
BioCyc	ASP62977:ACIAD2463-MONOMER.
Family and domain databases
HAMAP	MF_00134_B. IGPS_B. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR013798. Indole-3-glycerol_P_synth. IPR001468. Indole-3-GlycerolPSynthase_CS. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01609.
Pfam	PF00218. IGPS. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
PROSITE	PS00614. IGPS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPC_ACIAD

Accession

Primary (citable) accession number: P00911
Secondary accession number(s): Q6F9N1

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	August 31, 2004
Last modified:	January 25, 2012
This is version 75 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program