Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P00906 (TRPG_SHIDY) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Anthranilate synthase component II

EC=4.1.3.27

Including the following 2 domains:

  1. Glutamine amidotransferase
  2. Anthranilate phosphoribosyltransferase
    EC=2.4.2.18
Gene names
Name:trpG-TRPD
OrganismShigella dysenteriae
Taxonomic identifier622 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeShigella

Protein attributes

Sequence length201 AA.
Sequence statusFragment.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existencePredicted

General annotation (Comments)

Catalytic activity

Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.

N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate.

Pathway

Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.

Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 2/5.

Subunit structure

Tetramer of two components I and two components II.

Miscellaneous

Component I catalyzes the formation of anthranilate using ammonia rather than glutamine, whereas component II provides glutamine amidotransferase activity.

In E.coli and certain other bacteria, component II is larger and its C-terminal two thirds has anthranilate phosphoribosyltransferase activity.

Sequence similarities

Contains 1 glutamine amidotransferase type-1 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed
Chain2 – ›201›200Anthranilate synthase component II
PRO_0000056899

Regions

Domain3 – 196194Glutamine amidotransferase type-1

Sites

Active site841For GATase activity By similarity
Active site1701For GATase activity By similarity
Active site1721For GATase activity By similarity

Experimental info

Non-terminal residue2011

Sequences

Sequence LengthMass (Da)Tools
P00906 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 943E3DBE4F0E59AF

FASTA20121,700
        10         20         30         40         50         60 
MADILLLDNI DSFTYNLADQ LRSNGHNVVI YRNHIPAQTL IERLATMSNP VLMLSPGPGV 

        70         80         90        100        110        120 
PSEAGCMPEL LTRLSGKLPI IGICLGHQAI VEAYGGYVGQ AGEILHGKAS SIEHDGQAMF 

       130        140        150        160        170        180 
AGLTNPLPVA RYHSLVGSNI PAGLTINAHF NGMVMAVRHD ADRICGFQFH PESILTTQGA 

       190        200 
RLLEQTLAWA QRKLEPTNTL Q 

« Hide

References

[1]"Nucleotide sequences of the trpG regions of Escherichia coli, Shigella dysenteriae, Salmonella typhimurium and Serratia marcescens."
Nichols B.P., Miozzari G.F., van Cleemput M., Bennett G.N., Yanofsky C.
J. Mol. Biol. 142:503-517(1980) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J01787 Genomic DNA. Translation: AAA57307.1.
PIRNNEB2D. B92860.

3D structure databases

ProteinModelPortalP00906.
SMRP00906. Positions 2-193.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00035; UER00040.
UPA00035; UER00041.

Family and domain databases

InterProIPR017926. GATASE.
IPR006221. TrpG/PapA_dom.
[Graphical view]
PfamPF00117. GATase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00566. trpG_papA. 1 hit.
PROSITEPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTRPG_SHIDY
AccessionPrimary (citable) accession number: P00906
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: October 16, 2013
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways