P00902 (TRPG_ACIAD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Anthranilate synthase component 2
EC=4.1.3.27

Alternative name(s):
Anthranilate synthase component II
Glutamine amido-transferase

Gene names

Name:	trpG
Ordered Locus Names:	ACIAD2461

Organism

Acinetobacter sp. (strain ADP1) [Complete proteome] [HAMAP]

Taxonomic identifier

62977 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter

Protein attributes

Sequence length	194 AA.
Sequence status	Complete.
Protein existence	Predicted

General annotation (Comments)

Catalytic activity	Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.
Subunit structure	Tetramer of two components I and two components II.
Miscellaneous	Component I catalyzes the formation of anthranilate using ammonia rather than glutamine, whereas component II provides glutamine amidotransferase activity.
Sequence similarities	Contains 1 glutamine amidotransferase type-1 domain.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Domain	Glutamine amidotransferase
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glutamine metabolic process Inferred from electronic annotation. Source: UniProtKB-KW tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	anthranilate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 194	194	Anthranilate synthase component 2		PRO_0000056869
Regions
	Domain	1 – 194	194	Glutamine amidotransferase type-1
Sites
	Active site	79	1	By similarity
	Active site	173	1	By similarity
	Active site	175	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P00902 [UniParc]. Last modified July 21, 1986. Version 1. Checksum: 7C2B60E3976FCFA3	FASTA	194	21,794
	10 20 30 40 50 60 MLLMIDNYDS FTYNIVQYFG ELNQDVKVVR NDQVTLEDIE RWQPKYLVVG PGPCSPTEAG 70 80 90 100 110 120 ISIPAIHHFA GRIPLLGVCL GHQAIGQAFG GNIIRAKTVM HGRLSDMYHT DKGIFSNLPS 130 140 150 160 170 180 PFSATRYHSL VIEQESLPEC LEVTCWTNQN DGSIEEIMGV KHKTLPVEGV QFHPESILSQ 190 HGHQIFKNFL EIYA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Nucleotide sequence of the Acinetobacter calcoaceticus trpGDC gene cluster." Kaplan J.B., Goncharoff P., Seibold A.M., Nichols B.P. Mol. Biol. Evol. 1:456-472(1984) [PubMed: 6599977] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium." Barbe V., Vallenet D., Fonknechten N., Kreimeyer A., Oztas S., Labarre L., Cruveiller S., Robert C., Duprat S., Wincker P., Ornston L.N., Weissenbach J., Marliere P., Cohen G.N., Medigue C. Nucleic Acids Res. 32:5766-5779(2004) [PubMed: 15514110] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ADP1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M36636 Genomic DNA. Translation: AAA21903.1. CR543861 Genomic DNA. Translation: CAG69231.1.
PIR	NNKE2C. A01123.
RefSeq	YP_047053.1. NC_005966.1.
3D structure databases
ProteinModelPortal	P00902.
ModBase	Search...
Protein-protein interaction databases
STRING	P00902.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2880739.
GenomeReviews	Gene locus ACIAD2461 in contig CR543861_GR.
KEGG	aci:ACIAD2461.
NMPDR	fig|62977.3.peg.2062.
PATRIC	20742542. VBIAciSp98416_2213.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0512.
HOGENOM	HBG292341.
OMA	SVDEIMG.
PhylomeDB	P00902.
ProtClustDB	CLSK2307483.
Enzyme and pathway databases
BioCyc	ASP62977:ACIAD2461-MONOMER.
Family and domain databases
InterPro	IPR017926. GATASE_1. IPR006221. TrpG_papA. [Graphical view]
KO	K01658.
Pfam	PF00117. GATase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00566. TrpG_papA. 1 hit.
PROSITE	PS51273. GATASE_TYPE_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPG_ACIAD

Accession

Primary (citable) accession number: P00902
Secondary accession number(s): Q6F9N3

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	January 25, 2012
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program