Reviewed, UniProtKB/Swiss-Prot P00896 (TRPE_CITFR)

Names and origin

Protein names

Recommended name:
    Anthranilate synthase component 1
    EC=4.1.3.27
Alternative name(s):
    Anthranilate synthase component I

Gene names

Name:

trpE

Organism

Citrobacter freundii

Taxonomic identifier

546 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Citrobacter

Protein attributes

Sequence length	150 AA.
Sequence status	Fragment.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.
Subunit structure	Tetramer of two components I and two components II By similarity.
Miscellaneous	Component I catalyzes the formation of anthranilate using ammonia rather than glutamine, whereas component II provides glutamine amidotransferase activity.
Sequence similarities	Belongs to the anthranilate synthase component I family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Lyase
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	anthranilate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›150	›150	Anthranilate synthase component 1		PRO_0000154089
Experimental info
	Non-terminal residue	150	1

Sequences

	Sequence		Length	Mass (Da)
	P00896-1 [UniParc]. Last modified July 21, 1986. Version 1. Checksum: 7E6B8E7F3DE6DDAF	FASTA	150	16,187
	10 20 30 40 50 60 MQTQKPTLEL VACDAAYREN PTALFHQVCG ARPATLLLES ADIDSKDDLK SLLLVDSALR 70 80 90 100 110 120 ITAIGDTVTI QALSANGASL LPLLDAALPA GVENKQQPNG RHLRFPAVSP LLDEDVRLRS 130 140 150 LSAPDAFRPL QELVNVPAQE REVMFLGGMF

References

[1]	"Evolutionary divergence of the Citrobacter freundii tryptophan operon regulatory region: comparison with other enteric bacteria." Blumenberg M., Yanofsky C. J. Bacteriol. 152:57-62(1982) [PubMed: 6749821] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	J01557 Genomic DNA. No translation available.
PIR	NNEB1C. A01116.
3D structure databases
SMR	P00896. Positions 5-150.
ModBase	Search...
Enzyme and pathway databases
BRENDA	4.1.3.27. 2347.
Family and domain databases
InterPro	IPR005801. ADC_synthase. [Graphical view]
Gene3D	G3DSA:3.60.120.10. TRPE_1_chor_bd. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TRPE_CITFR

Accession

Primary (citable) accession number: P00896

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	November 24, 2009
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)