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Protein

Ornithine decarboxylase

Gene

Odc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Key enzyme of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine.2 Publications

Catalytic activityi

L-ornithine = putrescine + CO2.

Cofactori

Enzyme regulationi

Inhibited by S-nitrosylation. Inhibited by antizyme OAZ1, OAZ2 and OAZ3 (By similarity).By similarity

Pathwayi: putrescine biosynthesis via L-ornithine pathway

This protein is involved in step 1 of the subpathway that synthesizes putrescine from L-ornithine.
Proteins known to be involved in this subpathway in this organism are:
  1. Ornithine decarboxylase (Odc1)
This subpathway is part of the pathway putrescine biosynthesis via L-ornithine pathway, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes putrescine from L-ornithine, the pathway putrescine biosynthesis via L-ornithine pathway and in Amine and polyamine biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei360Proton donor; shared with dimeric partner2 Publications1

GO - Molecular functioni

  • ornithine decarboxylase activity Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

  • kidney development Source: MGI
  • positive regulation of cell proliferation Source: MGI
  • putrescine biosynthetic process from ornithine Source: UniProtKB
  • regulation of protein catabolic process Source: UniProtKB
  • response to virus Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Polyamine biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BRENDAi4.1.1.17. 3474.
ReactomeiR-MMU-350562. Regulation of ornithine decarboxylase (ODC).
R-MMU-351202. Metabolism of polyamines.
UniPathwayiUPA00535; UER00288.

Names & Taxonomyi

Protein namesi
Recommended name:
Ornithine decarboxylase (EC:4.1.1.17)
Short name:
ODC
Gene namesi
Name:Odc1
Synonyms:Odc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:97402. Odc1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytosol Source: MGI
  • perinuclear region of cytoplasm Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi387G → A: Partial loss of activity. 1 Publication1
Mutagenesisi387G → C, D, E, F, H, I, K, L, M, N, P, Q, R, S, T, V, W or Y: Loss of activity. 1 Publication1

Chemistry databases

ChEMBLiCHEMBL2840.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001498921 – 461Ornithine decarboxylaseAdd BLAST461

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei69N6-(pyridoxal phosphate)lysine1
Modified residuei303Phosphoserine; by CK21 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP00860.
MaxQBiP00860.
PaxDbiP00860.
PRIDEiP00860.

PTM databases

iPTMnetiP00860.
PhosphoSitePlusiP00860.

Expressioni

Tissue specificityi

Expressed during testis development in the outer part of the seminiferous tubules.1 Publication

Gene expression databases

BgeeiENSMUSG00000011179.
CleanExiMM_ODC1.
GenevisibleiP00860. MM.

Interactioni

Subunit structurei

Monomer. Homodimer. Does not form a heterodimer with AZIN2.1 Publication

GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB

Protein-protein interaction databases

IntActiP00860. 1 interactor.
STRINGi10090.ENSMUSP00000128661.

Structurei

Secondary structure

1461
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 6Combined sources4
Beta strandi9 – 14Combined sources6
Helixi20 – 28Combined sources9
Beta strandi40 – 44Combined sources5
Helixi45 – 58Combined sources14
Beta strandi62 – 67Combined sources6
Helixi68 – 70Combined sources3
Helixi74 – 83Combined sources10
Beta strandi86 – 89Combined sources4
Helixi92 – 100Combined sources9
Helixi105 – 107Combined sources3
Beta strandi108 – 110Combined sources3
Helixi117 – 125Combined sources9
Beta strandi130 – 133Combined sources4
Helixi136 – 145Combined sources10
Beta strandi150 – 155Combined sources6
Helixi174 – 186Combined sources13
Beta strandi190 – 195Combined sources6
Helixi206 – 225Combined sources20
Beta strandi231 – 233Combined sources3
Beta strandi241 – 246Combined sources6
Helixi248 – 262Combined sources15
Helixi265 – 267Combined sources3
Beta strandi270 – 273Combined sources4
Helixi277 – 280Combined sources4
Helixi281 – 283Combined sources3
Beta strandi284 – 296Combined sources13
Beta strandi313 – 319Combined sources7
Turni322 – 326Combined sources5
Helixi327 – 331Combined sources5
Beta strandi339 – 342Combined sources4
Beta strandi350 – 356Combined sources7
Beta strandi358 – 360Combined sources3
Beta strandi365 – 373Combined sources9
Beta strandi380 – 383Combined sources4
Beta strandi388 – 390Combined sources3
Helixi391 – 393Combined sources3
Helixi397 – 399Combined sources3
Beta strandi404 – 410Combined sources7
Helixi411 – 417Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
7ODCX-ray1.60A1-424[»]
ProteinModelPortaliP00860.
SMRiP00860.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00860.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0622. Eukaryota.
COG0019. LUCA.
GeneTreeiENSGT00390000011560.
HOGENOMiHOG000274133.
HOVERGENiHBG005456.
InParanoidiP00860.
KOiK01581.
OMAiPACCGRE.
OrthoDBiEOG091G0AJV.
TreeFamiTF300760.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR002433. Orn_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PRINTSiPR01179. ODADCRBXLASE.
PR01182. ORNDCRBXLASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
PROSITEiPS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P00860-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSFTKDEFD CHILDEGFTA KDILDQKINE VSSSDDKDAF YVADLGDILK
60 70 80 90 100
KHLRWLKALP RVTPFYAVKC NDSRAIVSTL AAIGTGFDCA SKTEIQLVQG
110 120 130 140 150
LGVPAERVIY ANPCKQVSQI KYAASNGVQM MTFDSEIELM KVARAHPKAK
160 170 180 190 200
LVLRIATDDS KAVCRLSVKF GATLKTSRLL LERAKELNID VIGVSFHVGS
210 220 230 240 250
GCTDPETFVQ AVSDARCVFD MATEVGFSMH LLDIGGGFPG SEDTKLKFEE
260 270 280 290 300
ITSVINPALD KYFPSDSGVR IIAEPGRYYV ASAFTLAVNI IAKKTVWKEQ
310 320 330 340 350
PGSDDEDESN EQTFMYYVND GVYGSFNCIL YDHAHVKALL QKRPKPDEKY
360 370 380 390 400
YSSSIWGPTC DGLDRIVERC NLPEMHVGDW MLFENMGAYT VAAASTFNGF
410 420 430 440 450
QRPNIYYVMS RPMWQLMKQI QSHGFPPEVE EQDDGTLPMS CAQESGMDRH
460
PAACASARIN V
Length:461
Mass (Da):51,177
Last modified:July 27, 2011 - v2
Checksum:iB581753F57AC0A30
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti178R → W in AAA39846 (PubMed:3456155).Curated1
Sequence conflicti206E → D in AAA51638 (PubMed:2982844).Curated1
Sequence conflicti206E → D in AAA39845 (PubMed:3856848).Curated1
Sequence conflicti206E → D in CAA30301 (PubMed:3362685).Curated1
Sequence conflicti206E → D in AAA39849 (PubMed:3372502).Curated1
Sequence conflicti206E → D in AAB27809 (PubMed:8350350).Curated1
Sequence conflicti350Y → H in AAA39848 (PubMed:3456155).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20617 mRNA. Translation: AAA51638.1.
M10624 mRNA. Translation: AAA39845.1.
X07392 Genomic DNA. Translation: CAA30301.1.
J03733 Genomic DNA. Translation: AAA39849.1.
S64539 mRNA. Translation: AAB27809.1.
EU684749 mRNA. Translation: ACD81645.1.
AK139610 mRNA. Translation: BAE24082.1.
CH466582 Genomic DNA. Translation: EDK98494.1.
BC059826 mRNA. Translation: AAH59826.1.
BC083122 mRNA. Translation: AAH83122.1.
M12330 mRNA. Translation: AAA39846.1.
M12331 mRNA. Translation: AAA39848.1.
CCDSiCCDS25829.1.
PIRiA01077. DCMSO.
I56477.
RefSeqiNP_038642.2. NM_013614.2.
XP_017170479.1. XM_017314990.1.
UniGeneiMm.34102.
Mm.472891.

Genome annotation databases

EnsembliENSMUST00000171737; ENSMUSP00000128661; ENSMUSG00000011179.
GeneIDi18263.
KEGGimmu:18263.
UCSCiuc007ncv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20617 mRNA. Translation: AAA51638.1.
M10624 mRNA. Translation: AAA39845.1.
X07392 Genomic DNA. Translation: CAA30301.1.
J03733 Genomic DNA. Translation: AAA39849.1.
S64539 mRNA. Translation: AAB27809.1.
EU684749 mRNA. Translation: ACD81645.1.
AK139610 mRNA. Translation: BAE24082.1.
CH466582 Genomic DNA. Translation: EDK98494.1.
BC059826 mRNA. Translation: AAH59826.1.
BC083122 mRNA. Translation: AAH83122.1.
M12330 mRNA. Translation: AAA39846.1.
M12331 mRNA. Translation: AAA39848.1.
CCDSiCCDS25829.1.
PIRiA01077. DCMSO.
I56477.
RefSeqiNP_038642.2. NM_013614.2.
XP_017170479.1. XM_017314990.1.
UniGeneiMm.34102.
Mm.472891.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
7ODCX-ray1.60A1-424[»]
ProteinModelPortaliP00860.
SMRiP00860.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP00860. 1 interactor.
STRINGi10090.ENSMUSP00000128661.

Chemistry databases

ChEMBLiCHEMBL2840.

PTM databases

iPTMnetiP00860.
PhosphoSitePlusiP00860.

Proteomic databases

EPDiP00860.
MaxQBiP00860.
PaxDbiP00860.
PRIDEiP00860.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000171737; ENSMUSP00000128661; ENSMUSG00000011179.
GeneIDi18263.
KEGGimmu:18263.
UCSCiuc007ncv.1. mouse.

Organism-specific databases

CTDi4953.
MGIiMGI:97402. Odc1.

Phylogenomic databases

eggNOGiKOG0622. Eukaryota.
COG0019. LUCA.
GeneTreeiENSGT00390000011560.
HOGENOMiHOG000274133.
HOVERGENiHBG005456.
InParanoidiP00860.
KOiK01581.
OMAiPACCGRE.
OrthoDBiEOG091G0AJV.
TreeFamiTF300760.

Enzyme and pathway databases

UniPathwayiUPA00535; UER00288.
BRENDAi4.1.1.17. 3474.
ReactomeiR-MMU-350562. Regulation of ornithine decarboxylase (ODC).
R-MMU-351202. Metabolism of polyamines.

Miscellaneous databases

EvolutionaryTraceiP00860.
PROiP00860.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000011179.
CleanExiMM_ODC1.
GenevisibleiP00860. MM.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR002433. Orn_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PRINTSiPR01179. ODADCRBXLASE.
PR01182. ORNDCRBXLASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
PROSITEiPS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDCOR_MOUSE
AccessioniPrimary (citable) accession number: P00860
Secondary accession number(s): Q61997, Q61998, Q6PB87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 154 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.