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Protein

ATP synthase protein 8

Gene

ATP8

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processATP synthesis, Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-34378-MONOMER

Protein family/group databases

TCDBi3.A.2.1.3 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase protein 8
Alternative name(s):
A6L
ATP-associated protein 1
F-ATPase subunit 8
Gene namesi
Name:ATP8
Synonyms:AAP1
Ordered Locus Names:Q0080
Encoded oniMitochondrion
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Mitochondrion

Organism-specific databases

SGDiS000007267 ATP8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei13 – 32HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

CF(0), Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001956071 – 48ATP synthase protein 8Add BLAST48

Proteomic databases

PaxDbiP00856

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. In yeast, the dimeric form of ATP synthase consists of 17 polypeptides: alpha, beta, gamma, delta, epsilon, 4 (B), 5 (OSCP), 6 (A), 8, 9 (C), d, E (Tim11), f, g, h, i/j and k.

Protein-protein interaction databases

BioGridi34792, 13 interactors
DIPiDIP-3040N
IntActiP00856, 2 interactors
STRINGi4932.Q0080

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6B2Zelectron microscopy3.60A/L1-48[»]
6B8Helectron microscopy3.60A/V1-48[»]
6CP3electron microscopy3.8081-48[»]
6CP5electron microscopy4.2081-48[»]
6CP6electron microscopy3.6081-48[»]
6CP7electron microscopy4.1081-48[»]
ProteinModelPortaliP00856
SMRiP00856
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase protein 8 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000034188
InParanoidiP00856
KOiK02125
OrthoDBiEOG092C60BR

Family and domain databases

InterProiView protein in InterPro
IPR009230 ATP_synth_su8_fun
PANTHERiPTHR36101 PTHR36101, 1 hit
PfamiView protein in Pfam
PF05933 Fun_ATP-synt_8, 1 hit

Sequencei

Sequence statusi: Complete.

P00856-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40 
MPQLVPFYFM NQLTYGFLLM ITLLILFSQF FLPMILRLYV SRLFISKL
Length:48
Mass (Da):5,822
Last modified:July 21, 1986 - v1
Checksum:i7E5483656089A4C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00895 Genomic DNA Translation: CAA25423.1
X00960 Genomic DNA Translation: CAA25473.1
KP263414 Genomic DNA Translation: AIZ98888.1
PIRiS05820 EWBY8
RefSeqiNP_009312.1, NC_001224.1
YP_009144707.1, NC_027264.1

Genome annotation databases

EnsemblFungiiQ0080; Q0080; Q0080
GeneIDi24573117
854600
KEGGisce:Q0080

Similar proteinsi

Entry informationi

Entry nameiATP8_YEAST
AccessioniPrimary (citable) accession number: P00856
Secondary accession number(s): A0A0A7P362
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: May 23, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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