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Protein

ATP synthase protein 8

Gene

ATP8

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • ATP synthesis coupled proton transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

ATP synthesis, Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-34378-MONOMER.

Protein family/group databases

TCDBi3.A.2.1.3. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase protein 8
Alternative name(s):
A6L
ATP-associated protein 1
F-ATPase subunit 8
Gene namesi
Name:ATP8
Synonyms:AAP1
Ordered Locus Names:Q0080
Encoded oniMitochondrion
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Mitochondrion

Organism-specific databases

SGDiS000007267. ATP8.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei13 – 32HelicalSequence analysisAdd BLAST20

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

CF(0), Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001956071 – 48ATP synthase protein 8Add BLAST48

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. In yeast, the dimeric form of ATP synthase consists of 17 polypeptides: alpha, beta, gamma, delta, epsilon, 4 (B), 5 (OSCP), 6 (A), 8, 9 (C), d, E (Tim11), f, g, h, i/j and k.

Protein-protein interaction databases

BioGridi34792. 10 interactors.
DIPiDIP-3040N.
IntActiP00856. 3 interactors.
MINTiMINT-655778.

Structurei

3D structure databases

ProteinModelPortaliP00856.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase protein 8 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000034188.
InParanoidiP00856.
KOiK02125.
OrthoDBiEOG092C60BR.

Family and domain databases

InterProiIPR009230. ATP_synth_su8_fun.
[Graphical view]
PfamiPF05933. Fun_ATP-synt_8. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P00856-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40 
MPQLVPFYFM NQLTYGFLLM ITLLILFSQF FLPMILRLYV SRLFISKL
Length:48
Mass (Da):5,822
Last modified:July 21, 1986 - v1
Checksum:i7E5483656089A4C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00895 Genomic DNA. Translation: CAA25423.1.
X00960 Genomic DNA. Translation: CAA25473.1.
KP263414 Genomic DNA. Translation: AIZ98888.1.
PIRiS05820. EWBY8.
RefSeqiNP_009312.1. NC_001224.1.
YP_009144707.1. NC_027264.1.

Genome annotation databases

EnsemblFungiiQ0080; Q0080; Q0080.
GeneIDi24573117.
854600.
KEGGisce:Q0080.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00895 Genomic DNA. Translation: CAA25423.1.
X00960 Genomic DNA. Translation: CAA25473.1.
KP263414 Genomic DNA. Translation: AIZ98888.1.
PIRiS05820. EWBY8.
RefSeqiNP_009312.1. NC_001224.1.
YP_009144707.1. NC_027264.1.

3D structure databases

ProteinModelPortaliP00856.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34792. 10 interactors.
DIPiDIP-3040N.
IntActiP00856. 3 interactors.
MINTiMINT-655778.

Protein family/group databases

TCDBi3.A.2.1.3. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiQ0080; Q0080; Q0080.
GeneIDi24573117.
854600.
KEGGisce:Q0080.

Organism-specific databases

SGDiS000007267. ATP8.

Phylogenomic databases

HOGENOMiHOG000034188.
InParanoidiP00856.
KOiK02125.
OrthoDBiEOG092C60BR.

Enzyme and pathway databases

BioCyciYEAST:G3O-34378-MONOMER.

Miscellaneous databases

PROiP00856.

Family and domain databases

InterProiIPR009230. ATP_synth_su8_fun.
[Graphical view]
PfamiPF05933. Fun_ATP-synt_8. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATP8_YEAST
AccessioniPrimary (citable) accession number: P00856
Secondary accession number(s): A0A0A7P362
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 30, 2016
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.